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1awo

THE SOLUTION NMR STRUCTURE OF ABL SH3 AND ITS RELATIONSHIP TO SH2 IN THE SH(32) CONSTRUCT, 20 STRUCTURES

Method: SOLUTION NMR D_max: 47.5 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	1awo
deposition_date	1997-10-03
title	THE SOLUTION NMR STRUCTURE OF ABL SH3 AND ITS RELATIONSHIP TO SH2 IN THE SH(32) CONSTRUCT, 20 STRUCTURES
keywords	KINASE, SH3 DOMAIN, TRANSFERASE, PHOSPHOTRANSFERASE, PROTO-ONCOGENE, MULTIPLE DOMAIN, LEUKEMIA; KINASE
method	SOLUTION NMR

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	12.58 Å
rg_electron	12.02 Å
i0	225583000.00
molecular_weight	125520.0 kDa
excluded_volume	156620 Å³
envelope_volume	29045 Å³
shell_volume	15545 Å³
envelope_diameter	51.5 Å
shell_rg	21.77 Å
envelope_rg	15.80 Å
shape_rg	12.01 Å
total_rg	12.40 Å
total_atoms	17340
n_residues	1140
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	47.5 Å
rg_real	12.58 Å
rg_real_error	0.32 Å
i0_real	2.2560e+08
i0_real_error	2.4850e+06
rg_reciprocal	12.58 Å
i0_reciprocal	225600000.0000
total_estimate	0.7958
solution_quality	GOOD a GOOD solution
n_peaks	1
r_peak_primary	46.9 Å
skewness	0.464
kurtosis	0.147
angular_range	— – 0.5000 Å⁻¹
current_alpha	0.0000
highest_alpha	1162000.0000
n_real_points	80
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.491; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.870; Smooth: 0.999

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4. Crystallography & Experiment

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5. Entities & Polymer Info (1)

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6. Citations (7)

The solution structure of Abl SH3, and its relationship to SH2 in the SH(32) construct.

Structure (1995)

PMID: 8590002 · DOI: 10.1016/S0969-2126(01)00243-X PRIMARY

Mutagenic Analysis of the Roles of Sh2 and SH3 Domains in Regulation of the Abl Tyrosine Kinase

Mol.Cell.Biol. (1994)

High-Resolution Crystal Structures of Tyrosine Kinase SH3 Domains Complexed with Proline-Rich Peptides

Nat.Struct.Biol. (1994)

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

Science (1993)

;Crystal Structure of the SH3 Domain in Human Fyn; Comparison of the Three-Dimensional Structures of SH3 Domains in Tyrosine Kinases and Spectrin ;

Embo J. (1993)

Three-Dimensional Solution Structure of the Src Homology 2 Domain of C-Abl

Cell(Cambridge,Mass.) (1992)

Crystal Structure of a Src-Homology 3 (SH3) Domain

Nature (1992)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	1

space_group	P 1
int_tables_number	1
crystal_system	—

description	ABL TYROSINE KINASE
formula_weight	6637.3 kDa
ec_number	2.7.1.112
mutation	N64S, N120S
src_method	man
entity_count	1

type	polypeptide(L)
strand_id	A
atom_count	17340

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

THE SOLUTION NMR STRUCTURE OF ABL SH3 AND ITS RELATIONSHIP TO SH2 IN THE SH(32) CONSTRUCT, 20 STRUCTURES

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

5. Entities & Polymer Info (1)

Entity 1 polymer

Polymer

Source

6. Citations (7)

7. Files & Curves (10)

Files (7)

Curves (3)

fit	/app/data/saxs_computation/aw/1awo/1awo.fit
pddf	/app/data/pr_computation/aw/1awo/1awo.pr.out
profile	/app/data/saxs_computation/aw/1awo/1awo.dat