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1awy

NMR STRUCTURE OF CALCIUM BOUND CONFORMER OF CONANTOKIN G, MINIMIZED AVERAGE STRUCTURE

Method: SOLUTION NMR Dmax: 37.4 Å Quality: GOOD
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1. Protein Identity and Related Structures Protein Identity & Related Structures

CONANTOXIN G

Conus geographus

UniProt P07231

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count Chain A； UniProt 81–97 Non-standard monomer：Yes (specific site not provided by mmCIF) No other associated polymer SOLUTION NMR NMR measurement conditions：pH 5.6；298 K Resolution not provided

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 1AWY Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1AD7 NMR STRUCTURE OF METAL-FREE CONANTOKIN G, 1 STRUCTURE Deposited 1997-02-21 Parsed fields agree Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 81–97（17 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 5.6；298 K
Resolution not provided
1ONU NMDA RECEPTOR ANTAGONIST, CONANTOKIN-G, NMR, 17 STRUCTURES Deposited 1996-08-27 Different experimental conditions Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 81–97（17 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 3.5；280 K
Resolution not provided
2DPQ The crystal structures of the calcium-bound con-G and con-T(K7gamma) dimeric peptides demonstrate a novel metal-dependent helix-forming motif Deposited 2006-05-13 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 81–97（17 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CL CHLORIDE ION × 2 CA CALCIUM ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；35% dioxane, pH 8, VAPOR DIFFUSION, HANGING DROP
Resolution 1.25 Å R-free 0.161
2DPQ The crystal structures of the calcium-bound con-G and con-T(K7gamma) dimeric peptides demonstrate a novel metal-dependent helix-forming motif Deposited 2006-05-13 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 81–97（17 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CL CHLORIDE ION × 2 CA CALCIUM ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；35% dioxane, pH 8, VAPOR DIFFUSION, HANGING DROP
Resolution 1.25 Å R-free 0.161
2DPQ The crystal structures of the calcium-bound con-G and con-T(K7gamma) dimeric peptides demonstrate a novel metal-dependent helix-forming motif Deposited 2006-05-13 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 81–97（17 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CL CHLORIDE ION × 4 CA CALCIUM ION × 12 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；35% dioxane, pH 8, VAPOR DIFFUSION, HANGING DROP
Resolution 1.25 Å R-free 0.161

3 other PDB entries and 5 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name CXKG_CONGE
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–17； UniProt 81–97

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 1awy

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 1awy
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2. Structure Basics 2. Structure Basics

Entry ID entry_id1awy
Deposition date deposition_date1997-10-06
Structure title titleNMR STRUCTURE OF CALCIUM BOUND CONFORMER OF CONANTOKIN G, MINIMIZED AVERAGE STRUCTURE
Keywords keywordsGAMMA-CARBOXYGLUTAMIC ACID, CONANTOKIN G, CONOTOXIN, CALCIUM BOUND, VENOM; VENOM
Experimental Method methodSOLUTION NMR
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier10.14 Å
Radius of gyration Rg (electron density) rg_electron8.95 Å
Forward intensity I(0) i0219487.00
Molecular weight molecular_weight2270.0 kDa
Excluded volume excluded_volume2655 ų
Envelope volume envelope_volume3341 ų
Hydration-shell volume shell_volume3882 ų
Envelope diameter envelope_diameter34.5 Å
Shell Rg shell_rg12.67 Å
Envelope Rg envelope_rg9.56 Å
Shape Rg shape_rg8.92 Å
Total Rg total_rg10.34 Å
Total atoms total_atoms288
Residues n_residues12
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax37.4 Å
Rg (real space) rg_real10.28 Å
Rg uncertainty (real space) rg_real_error0.38 Å
I(0) (real space) i0_real2.1950e+05
I(0) uncertainty (real space) i0_real_error2.7150e+03
Rg (reciprocal space) rg_reciprocal10.28 Å
I(0) (reciprocal space) i0_reciprocal219500.0000
Solution quality estimate total_estimate0.7890
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks1
Primary peak position r_peak_primary36.4 Å
Skewness Skewness skewness0.653
Kurtosis Kurtosis kurtosis0.125
Angular range angular_range— – 0.5000 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha23660.0000
Real-space data points n_real_points80
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.653; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.463; Smooth: 0.831
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (1)

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7. Fold Classification (SCOP + CATH) 1 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd1awya_
Class classj — Peptides
Fold Fold foldj.31 — Conantokin
Superfamily Superfamily superfamilyj.31.1 — Conantokin
Family Family familyj.31.1.1 — Conantokin G (conatoxin G)
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8. Citations (1)

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9. Files and Curves (10)