Lactotransferrin
OrganismNot specified
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count | Chain A； UniProt 20–710 | Fragment：UNP residues 20-710 | CL CHLORIDE ION × 2 | X-RAY DIFFRACTION X-ray crystallization conditions：pH 7.8；pH 7.8 | Resolution 2.00 Å R-free 0.286 |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 1CB6 | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1B0L RECOMBINANT HUMAN DIFERRIC LACTOFERRIN Deposited 1998-11-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–710（691 aa）
|
Mutation：A10T | FE FE (III) ION × 2 CO3 CARBONATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；DIALYSIS AGAINST 10MM SODIUM PHOSPHATE PH 8.0, CONTAINING 10% ETHANOL
|
Resolution 2.20 Å R-free 0.274 |
| 1BKA OXALATE-SUBSTITUTED DIFERRIC LACTOFERRIN Deposited 1996-04-15 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–711（692 aa）
|
Not recorded | FE FE (III) ION × 2 OXL OXALATE ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.40 Å |
| 1DSN D60S N-TERMINAL LOBE HUMAN LACTOFERRIN Deposited 1995-12-13 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
21–353（333 aa）
Fragment：N-TERMINAL LOBE RESIDUES 1 - 333
|
Mutation：D60S | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；pH 8.0
|
Resolution 2.05 Å |
| 1EH3 R210K N-TERMINAL LOBE HUMAN LACTOFERRIN Deposited 2000-02-18 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
15–348（334 aa）
Fragment：N-TERMINAL LOBE
|
Mutation：R210K | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 8；277 K；HEPES, NaCl, pH 8.0, LIQUID DIFFUSION, temperature 4K
|
Resolution 2.00 Å R-free 0.250 |
| 1FCK STRUCTURE OF DICERIC HUMAN LACTOFERRIN Deposited 2000-07-18 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–711（692 aa）
|
Not recorded | CO3 CARBONATE ION × 2 CE CERIUM (III) ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.20 Å R-free 0.257 |
| 1H43 R210E N-TERMINAL LOBE HUMAN LACTOFERRIN Deposited 2002-10-02 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–353（334 aa）
Fragment：N-TERMINAL LOBE, RESIDUES 20-353
|
Mutation：YES | CO3 CARBONATE ION × 1 FE FE (III) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；HEPES, NACL, pH 8.00
|
Resolution 2.20 Å R-free 0.235 |
| 1H44 R210L N-TERMINAL LOBE HUMAN LACTOFERRIN Deposited 2002-10-03 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–353（334 aa）
Fragment：N-TERMINAL LOBE, RESIDUES 20-353
|
Mutation：YES | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；HEPES, NACL, pH 8.00
|
Resolution 2.00 Å R-free 0.241 |
| 1H45 R210G N-TERMINAL LOBE HUMAN LACTOFERRIN Deposited 2002-10-03 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–353（334 aa）
Fragment：N-TERMINAL LOBE, RESIDUES 20-353
|
Mutation：YES | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；HEPES, NACL, pH 8.00
|
Resolution 1.95 Å R-free 0.248 |
| 1HSE H253M N TERMINAL LOBE OF HUMAN LACTOFERRIN Deposited 1996-12-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
21–347（327 aa）
Fragment：N-TERMINAL HALF-MOLECULE
|
Mutation：H253M | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.20 Å |
| 1L5T Crystal Structure of a Domain-Opened Mutant (R121D) of the Human Lactoferrin N-lobe Refined From a Merohedrally-Twinned Crystal Form. Deposited 2002-03-07 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
21–352（332 aa）
Fragment：RESIDUES 21-352
|
Mutation：R121D | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICRODIALYSIS；pH 8；298 K；concentrated solution of the protein (50-80 mg mL-1), 0.01 M Tris-HCl, pH 8.0, 12% (v/v) isopropanol, MICRODIALYSIS, temperature 298K
|
Resolution 3.00 Å R-free 0.199 |
| 1L5T Crystal Structure of a Domain-Opened Mutant (R121D) of the Human Lactoferrin N-lobe Refined From a Merohedrally-Twinned Crystal Form. Deposited 2002-03-07 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
21–352（332 aa）
Fragment：RESIDUES 21-352
|
Mutation：R121D | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICRODIALYSIS；pH 8；298 K；concentrated solution of the protein (50-80 mg mL-1), 0.01 M Tris-HCl, pH 8.0, 12% (v/v) isopropanol, MICRODIALYSIS, temperature 298K
|
Resolution 3.00 Å R-free 0.199 |
| 1LCF CRYSTAL STRUCTURE OF COPPER-AND OXALATE-SUBSTITUTED HUMAN LACTOFERRIN AT 2.0 ANGSTROMS RESOLUTION Deposited 1994-01-11 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–711（690 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CU COPPER (II) ION × 2 CO3 CARBONATE ION × 1 OXL OXALATE ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1LCT STRUCTURE OF THE RECOMBINANT N-TERMINAL LOBE OF HUMAN LACTOFERRIN AT 2.0 ANGSTROMS RESOLUTION Deposited 1993-06-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
21–353（333 aa）
|
Not recorded | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1LFG Structure of diferric human lactoferrin Deposited 1992-02-05 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–711（690 aa）
|
Not recorded | FE FE (III) ION × 2 CO3 CARBONATE ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.20 Å |
| 1LFH MOLECULAR REPLACEMENT SOLUTION OF THE STRUCTURE OF APOLACTOFERRIN, A PROTEIN DISPLAYING LARGE-SCALE CONFORMATIONAL CHANGE Deposited 1991-09-04 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–711（690 aa）
|
Not recorded | CL CHLORIDE ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.80 Å |
| 1LFI METAL SUBSTITUTION IN TRANSFERRINS: THE CRYSTAL STRUCTURE OF HUMAN COPPER-LACTOFERRIN AT 2.1 ANGSTROMS RESOLUTION Deposited 1992-02-10 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–711（690 aa）
|
Not recorded | CU COPPER (II) ION × 2 CO3 CARBONATE ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.10 Å |
| 1LGB INTERACTION OF A LEGUME LECTIN WITH THE N2 FRAGMENT OF HUMAN LACTOTRANSFERRIN OR WITH THE ISOLATED BIANTENNARY GLYCOPEPTIDE: ROLE OF THE FUCOSE MOIETY Deposited 1994-01-07 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric |
Chain C
111–269（159 aa）
|
Not recorded | MN MANGANESE (II) ION × 2 CA CALCIUM ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 3.30 Å |
| 1LGB INTERACTION OF A LEGUME LECTIN WITH THE N2 FRAGMENT OF HUMAN LACTOTRANSFERRIN OR WITH THE ISOLATED BIANTENNARY GLYCOPEPTIDE: ROLE OF THE FUCOSE MOIETY Deposited 1994-01-07 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
111–269（159 aa）
|
Not recorded | MN MANGANESE (II) ION × 1 CA CALCIUM ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 3.30 Å |
| 1N76 CRYSTAL STRUCTURE OF HUMAN SEMINAL LACTOFERRIN AT 3.4 A RESOLUTION Deposited 2002-11-12 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–711（690 aa）
|
Not recorded | NA SODIUM ION × 1 FE FE (III) ION × 2 CO3 CARBONATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICRODIALYSIS；pH 8；298 K；Tris-HCl, ethanol, pH 8.0, MICRODIALYSIS, temperature 298.0K
|
Resolution 3.40 Å R-free 0.266 |
| 1SQY Structure of human diferric lactoferrin at 2.5A resolution using crystals grown at pH 6.5 Deposited 2004-03-22 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–710（691 aa）
|
Not recorded | FE FE (III) ION × 2 CO3 CARBONATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICRODIALYSIS；pH 6.5；277 K；Ethanol, Tris-HCL, pH 6.5, MICRODIALYSIS, temperature 277K
|
Resolution 2.50 Å R-free 0.215 |
| 1U62 NMR structure analysis of the lactoferrin-based peptide FQWQRNIRKVR in complex with lipopolysaccharide Deposited 2004-07-29 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
39–49（11 aa）
Fragment：LF11
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 5.5；303 K；Ionic strength (raw mmCIF value) 20；Pressure 1
NMR sample composition
2mM lacfotefficin; 20mM sodium phosphate buffer (pH=5.5); 95% H2O, 5% D2O | 95% H2O/5% D2O
|
Resolution not provided |
| 1VFD HUMAN LACTOFERRIN, N-TERMINAL LOBE MUTANT WITH ARG 121 REPLACED BY GLU (R121E) Deposited 1996-10-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–350（329 aa）
Fragment：N-TERMINAL HALF-MOLECULE
|
Mutation：R121E | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å R-free 0.310 |
| 1VFE HUMAN LACTOFERRIN, N-TERMINAL LOBE MUTANT WITH ARG 121 REPLACED BY SER (R121S) Deposited 1996-10-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–353（332 aa）
Fragment：N-TERMINAL HALF-MOLECULE
|
Mutation：R121S | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；50MM TRIS/HCL PH 8.0, 12% ISOPROPANOL
|
Resolution 2.30 Å R-free 0.270 |
| 1Z6V Human lactoferricin Deposited 2005-03-23 | Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–68（49 aa）
Fragment：N-terminal peptide
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 3；298 K；Ionic strength (raw mmCIF value) no salt added；Pressure ambient
NMR sample composition
1mM lactoferricin | 4:4:1 chloroform-d:methanol-d3:D2O
|
Resolution not provided |
| 1Z6W Human Lactoferricin Deposited 2005-03-23 | Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–68（49 aa）
Fragment：N-terminal peptide
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 3.5；298 K；Ionic strength (raw mmCIF value) no salt added；Pressure ambient
NMR sample composition
1mM lactoferricin | 90% H20, 10% D2O
|
Resolution not provided |
| 2BJJ Structure of recombinant human lactoferrin produced in the milk of transgenic cows Deposited 2005-02-03 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain X
20–711（692 aa）
|
Not recorded | FE FE (III) ION × 2 CO3 CARBONATE ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8.5；5 MM SODIUM PHOSPHATE PH 8.5, 10% (V/V) ETHANOL
|
Resolution 2.40 Å R-free 0.231 |
| 2DP4 Crystal structure of the complex formed between proteinase K and a human lactoferrin fragment at 2.9 A resolution Deposited 2006-05-05 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain I
528–535（8 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；298 K；0.2M Ammonium actate, 0.1M sodium acetate, 30% PEG 4000, pH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.90 Å R-free 0.235 |
| 7N88 The cryoEM structure of LbpB from N. gonorrhoeae in complex with lactoferrin Deposited 2021-06-14 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
20–710（691 aa）
|
Not recorded | FE FE (III) ION × 2 BCT BICARBONATE ION × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.70 Å |
26 other PDB entries and 28 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | TRFL_HUMAN |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–691； UniProt 20–710 |
