1dt7

SOLUTION STRUCTURE OF THE C-TERMINAL NEGATIVE REGULATORY DOMAIN OF P53 IN A COMPLEX WITH CA2+-BOUND S100B(BB)

Method: SOLUTION NMR

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1. Protein Identity and Related Structures Protein Identity & Related Structures

S100 CALCIUM-BINDING PROTEIN

Rattus norvegicus

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 4	CELLULAR TUMOR ANTIGEN P53 × 2 （P04637） CALCIUM ION × 4	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	S100B_RAT
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–92； UniProt 1–92 Author chain B； PDBConstruct 1–92； UniProt 1–92

CELLULAR TUMOR ANTIGEN P53

OrganismNot specified

UniProt P04637

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 4	S100 CALCIUM-BINDING PROTEIN × 2 （P04631） CALCIUM ION × 4	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	P53_HUMAN
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain X； PDBConstruct 1–22； UniProt 367–388 Author chain Y； PDBConstruct 1–22； UniProt 367–388

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	1dt7
Deposition date deposition_date	2000-01-11
Structure title title	SOLUTION STRUCTURE OF THE C-TERMINAL NEGATIVE REGULATORY DOMAIN OF P53 IN A COMPLEX WITH CA2+-BOUND S100B(BB)
Keywords keywords	;S100B, p53, C-terminal domain of p53, Calcium-binding, EF-hand, S100 protein, four helix bundle, helix loop helix, SIGNALING PROTEIN ;; SIGNALING PROTEIN
Experimental Method method	SOLUTION NMR

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1dt7__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1dt7__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

1dt7__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	20.29 Å
Rg (electron density)	19.04 Å
Total Rg	20.02 Å
Atom count	3684
Residues	228
Excluded volume	33069 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`1dt7__assembly_1__model_1`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	2	`1dt7__assembly_1__model_2`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	3	`1dt7__assembly_1__model_3`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	4	`1dt7__assembly_1__model_4`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	5	`1dt7__assembly_1__model_5`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	6	`1dt7__assembly_1__model_6`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	7	`1dt7__assembly_1__model_7`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	8	`1dt7__assembly_1__model_8`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	9	`1dt7__assembly_1__model_9`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	10	`1dt7__assembly_1__model_10`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	11	`1dt7__assembly_1__model_11`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	12	`1dt7__assembly_1__model_12`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	13	`1dt7__assembly_1__model_13`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	14	`1dt7__assembly_1__model_14`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	15	`1dt7__assembly_1__model_15`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	16	`1dt7__assembly_1__model_16`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	17	`1dt7__assembly_1__model_17`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	18	`1dt7__assembly_1__model_18`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	19	`1dt7__assembly_1__model_19`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	20	`1dt7__assembly_1__model_20`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	21	`1dt7__assembly_1__model_21`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	22	`1dt7__assembly_1__model_22`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	23	`1dt7__assembly_1__model_23`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	24	`1dt7__assembly_1__model_24`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	25	`1dt7__assembly_1__model_25`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	26	`1dt7__assembly_1__model_26`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	27	`1dt7__assembly_1__model_27`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	28	`1dt7__assembly_1__model_28`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	29	`1dt7__assembly_1__model_29`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	30	`1dt7__assembly_1__model_30`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	31	`1dt7__assembly_1__model_31`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	32	`1dt7__assembly_1__model_32`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	33	`1dt7__assembly_1__model_33`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	34	`1dt7__assembly_1__model_34`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	35	`1dt7__assembly_1__model_35`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	36	`1dt7__assembly_1__model_36`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	37	`1dt7__assembly_1__model_37`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	38	`1dt7__assembly_1__model_38`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	39	`1dt7__assembly_1__model_39`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	40	`1dt7__assembly_1__model_40`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

Entity 1 Entity 1 polymer

Description description	S100 CALCIUM-BINDING PROTEIN
Molecular weight formula_weight	10758.0 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B
Atom count atom_count	147360

MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDEDGDGECDFQEFMAFVSMVTTACHEFFEHE

Source Source

Source organism organism	Rattus norvegicus
Common name common_name	Norway rat
NCBI taxonomy ID ncbi_taxonomy_id	10116
Host organism host_organism	Escherichia coli

Entity 2 Entity 2 polymer

Description description	CELLULAR TUMOR ANTIGEN P53
Molecular weight formula_weight	2596.1 kDa
Source method src_method	syn
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	X,Y

SHLKSKKGQSTSRHKKLMFKTE

Entity 3 Entity 3 non-polymer

Description description	CALCIUM ION
Molecular weight formula_weight	40.1 kDa
Source method src_method	syn
Copy count entity_count	4

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6. Fold Classification (SCOP + CATH) 6 domains

SCOP 2.08 (4 domains)

Domain ID domain_id	d1dt7a_
Class class	a — All alpha proteins
Fold Fold fold	a.39 — EF Hand-like
Superfamily Superfamily superfamily	a.39.1 — EF-hand
Family Family family	a.39.1.2 — S100 proteins

Domain ID domain_id	d1dt7b_
Class class	a — All alpha proteins
Fold Fold fold	a.39 — EF Hand-like
Superfamily Superfamily superfamily	a.39.1 — EF-hand
Family Family family	a.39.1.2 — S100 proteins

Domain ID domain_id	d1dt7x_
Class class	j — Peptides
Fold Fold fold	j.69 — Tumor suppressor p53 fragments
Superfamily Superfamily superfamily	j.69.1 — Tumor suppressor p53 fragments
Family Family family	j.69.1.1 — Tumor suppressor p53 fragments

Domain ID domain_id	d1dt7y_
Class class	j — Peptides
Fold Fold fold	j.69 — Tumor suppressor p53 fragments
Superfamily Superfamily superfamily	j.69.1 — Tumor suppressor p53 fragments
Family Family family	j.69.1.1 — Tumor suppressor p53 fragments

CATH v4.4 (2 domains)

Domain ID domain_id	1dt7A00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	238 — Recoverin; domain 1
Homologous superfamily homologous superfamily	10 — EF-hand

Domain ID domain_id	1dt7B00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	238 — Recoverin; domain 1
Homologous superfamily homologous superfamily	10 — EF-hand

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Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	1

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

SOLUTION STRUCTURE OF THE C-TERMINAL NEGATIVE REGULATORY DOMAIN OF P53 IN A COMPLEX WITH CA2+-BOUND S100B(BB)

1. Protein Identity and Related Structures Protein Identity & Related Structures

S100 CALCIUM-BINDING PROTEIN

State in the Current Structure

Other States of the Same Protein in the Database

CELLULAR TUMOR ANTIGEN P53

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

1dt7__assembly_1__model_1

1dt7__assembly_1__model_1 | I(q)

1dt7__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

5. Entities and Polymers Entities & Polymers (3)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 polymer

Polymer Polymer

Entity 3 Entity 3 non-polymer

6. Fold Classification (SCOP + CATH) 6 domains

SCOP 2.08 (4 domains)

CATH v4.4 (2 domains)

7. Citations (1)

SOLUTION STRUCTURE OF THE C-TERMINAL NEGATIVE REGULATORY DOMAIN OF P53 IN A COMPLEX WITH CA2+-BOUND S100B(BB)

1. Protein Identity and Related Structures Protein Identity & Related Structures

S100 CALCIUM-BINDING PROTEIN

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

CELLULAR TUMOR ANTIGEN P53

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

1dt7__assembly_1__model_1

1dt7__assembly_1__model_1 | I(q)

1dt7__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

5. Entities and Polymers Entities & Polymers (3)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 polymer

Polymer Polymer

Entity 3 Entity 3 non-polymer

6. Fold Classification (SCOP + CATH) 6 domains

SCOP 2.08 (4 domains)

CATH v4.4 (2 domains)

7. Citations (1)