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1e4h

Structure of human transthyretin complexed with bromophenols: a new mode of binding

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

TRANSTHYRETIN

OrganismNot specified

UniProt P02766

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 4 GLYCEROL × 4 PENTABROMOPHENOL × 4 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2nbo 2nbp

2 assemblies

Homodimer
1bmz 1eta 1etb 1f86 1ijn 1soq 1ttr 1tyr 1tz8 2f8i 2pab 3cfm

42 assemblies; showing the first 12

Homotetramer
1bm7 1bmz 1bz8 1bzd 1bze 1dvq 1dvs 1dvt 1dvu 1dvx 1dvy 1dvz

419 assemblies; showing the first 12

Other homooligomers
2m5n 6sdz 7ob4 7y1i 7y1i 7y1i 8ade 8e7d 8e7e 8e7h 8e7i 8e7j

34 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
1qab 1rlb 2wqa 3bsz 8z9v

5 assemblies

View Construct and Data Evidence
UniProt name TTHY_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–127； UniProt 21–147 Author chain B； PDBConstruct 1–127； UniProt 21–147

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1e4h
Deposition date deposition_date2000-07-04
Structure title titleStructure of human transthyretin complexed with bromophenols: a new mode of binding
Keywords keywordsTRANSPORT PROTEIN, TRANSPORT(THYROXINE), ENVIRONMENTAL POLLUTANTS, BROMOPHENOLS; TRANSPORT PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1e4h__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1e4h__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1e4h__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）22.28 Å
Rg (electron density)21.36 Å
Total Rg21.85 Å
Atom count3584
Residues464
Excluded volume63945 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1e4h__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 4 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd1e4ha_
Class classb — All beta proteins
Fold Fold foldb.3 — Prealbumin-like
Superfamily Superfamily superfamilyb.3.4 — Transthyretin (synonym: prealbumin)
Family Family familyb.3.4.1 — Transthyretin (synonym: prealbumin)
Domain ID domain_idd1e4hb_
Class classb — All beta proteins
Fold Fold foldb.3 — Prealbumin-like
Superfamily Superfamily superfamilyb.3.4 — Transthyretin (synonym: prealbumin)
Family Family familyb.3.4.1 — Transthyretin (synonym: prealbumin)

CATH v4.4 (2 domains)

Domain ID domain_id1e4hA00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily180 — Transthyretin/hydroxyisourate hydrolase domain
Domain ID domain_id1e4hB00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily180 — Transthyretin/hydroxyisourate hydrolase domain
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7. Citations (4)