1i10

HUMAN MUSCLE L-LACTATE DEHYDROGENASE M CHAIN, TERNARY COMPLEX WITH NADH AND OXAMATE

Method: X-RAY DIFFRACTION Dmax: 170.4 Å Quality: REASONABLE

SAXS 散射曲线 SAXS Profile

SAXS profile for 1i10

P(r) 距离分布 P(r) Distribution

P(r) distribution for 1i10
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1. 结构基本信息 1. Structure Basics

条目编号 entry_id1i10
沉积日期 deposition_date2001-01-30
结构标题 titleHUMAN MUSCLE L-LACTATE DEHYDROGENASE M CHAIN, TERNARY COMPLEX WITH NADH AND OXAMATE
关键词 keywordsDEHYDROGENASE, ROSSMANN FOLD, OXIDOREDUCTASE; OXIDOREDUCTASE
实验方法 methodX-RAY DIFFRACTION

2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)

回转半径 Rg (Guinier) rg_guinier55.16
回转半径 Rg (电子) rg_electron55.54
零角强度 I(0) i01210510000.00
分子量 molecular_weight298320.0 kDa
排除体积 excluded_volume376490 ų
包络体积 envelope_volume481610 ų
水化壳体积 shell_volume72373 ų
包络直径 envelope_diameter187.2
壳层 Rg shell_rg57.17
包络 Rg envelope_rg54.62
形状 Rg shape_rg55.56
总 Rg total_rg55.52
总原子数 total_atoms20929
残基数 n_residues2642
球谐函数阶数 n_harmonics20
q 范围 q_range— – 0.5000 −1
数据点数 n_points101
壳层类型 shell_typedirectional
溶剂电子密度 solvent_density0.3340 e/ų
壳层衬度 contrast_shell0.0300 e/ų
CRYSOL 版本 crysol_version4.1.3

3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)

最大尺寸 Dmax dmax170.4
Rg (实空间) rg_real55.55
Rg 误差 (实空间) rg_real_error1.62
I(0) (实空间) i0_real1.2110e+09
I(0) 误差 (实空间) i0_real_error2.3610e+07
Rg (倒空间) rg_reciprocal54.79
I(0) (倒空间) i0_reciprocal1209000000.0000
解质量估计 total_estimate0.7460
解质量评级 solution_quality REASONABLE a REASONABLE solution
P(r) 峰数 n_peaks3
主峰位置 r_peak_primary41.1
偏度 Skewness skewness0.382
峰度 Kurtosis kurtosis-0.864
角度范围 angular_range— – 0.1450 −1
当前正则化参数 α current_alpha0.0000
最高正则化参数 α highest_alpha217000000.0000
实空间数据点数 n_real_points30
GNOM 版本 gnom_version4.1.3
质量判据 quality_criteria AN1: 0.000; Oscil: 0.615; Stabil: 0.998; Sysdev: 1.000; Positv: 1.000; Valcen: 0.848; Smooth: 0.008

4. 晶体学与实验 4. Crystallography & Experiment

5. 实体与聚合体信息 (5)

6. 折叠分类 (SCOP + CATH) 32 domains

SCOP 2.08 (16 domains)

结构域编号 domain_idd1i10a1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.5 — LDH N-terminal domain-like
结构域编号 domain_idd1i10a2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.162 — LDH C-terminal domain-like
超家族 Superfamily superfamilyd.162.1 — LDH C-terminal domain-like
家族 Family familyd.162.1.1 — Lactate & malate dehydrogenases, C-terminal domain
结构域编号 domain_idd1i10b1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.5 — LDH N-terminal domain-like
结构域编号 domain_idd1i10b2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.162 — LDH C-terminal domain-like
超家族 Superfamily superfamilyd.162.1 — LDH C-terminal domain-like
家族 Family familyd.162.1.1 — Lactate & malate dehydrogenases, C-terminal domain
结构域编号 domain_idd1i10c1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.5 — LDH N-terminal domain-like
结构域编号 domain_idd1i10c2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.162 — LDH C-terminal domain-like
超家族 Superfamily superfamilyd.162.1 — LDH C-terminal domain-like
家族 Family familyd.162.1.1 — Lactate & malate dehydrogenases, C-terminal domain
结构域编号 domain_idd1i10d1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.5 — LDH N-terminal domain-like
结构域编号 domain_idd1i10d2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.162 — LDH C-terminal domain-like
超家族 Superfamily superfamilyd.162.1 — LDH C-terminal domain-like
家族 Family familyd.162.1.1 — Lactate & malate dehydrogenases, C-terminal domain
结构域编号 domain_idd1i10e1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.5 — LDH N-terminal domain-like
结构域编号 domain_idd1i10e2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.162 — LDH C-terminal domain-like
超家族 Superfamily superfamilyd.162.1 — LDH C-terminal domain-like
家族 Family familyd.162.1.1 — Lactate & malate dehydrogenases, C-terminal domain
结构域编号 domain_idd1i10f1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.5 — LDH N-terminal domain-like
结构域编号 domain_idd1i10f2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.162 — LDH C-terminal domain-like
超家族 Superfamily superfamilyd.162.1 — LDH C-terminal domain-like
家族 Family familyd.162.1.1 — Lactate & malate dehydrogenases, C-terminal domain
结构域编号 domain_idd1i10g1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.5 — LDH N-terminal domain-like
结构域编号 domain_idd1i10g2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.162 — LDH C-terminal domain-like
超家族 Superfamily superfamilyd.162.1 — LDH C-terminal domain-like
家族 Family familyd.162.1.1 — Lactate & malate dehydrogenases, C-terminal domain
结构域编号 domain_idd1i10h1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
超家族 Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
家族 Family familyc.2.1.5 — LDH N-terminal domain-like
结构域编号 domain_idd1i10h2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.162 — LDH C-terminal domain-like
超家族 Superfamily superfamilyd.162.1 — LDH C-terminal domain-like
家族 Family familyd.162.1.1 — Lactate & malate dehydrogenases, C-terminal domain

CATH v4.4 (16 domains)

结构域编号 domain_id1i10A01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1i10A02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology110 — L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily10 — Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
结构域编号 domain_id1i10B01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1i10B02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology110 — L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily10 — Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
结构域编号 domain_id1i10C01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1i10C02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology110 — L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily10 — Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
结构域编号 domain_id1i10D01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1i10D02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology110 — L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily10 — Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
结构域编号 domain_id1i10E01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1i10E02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology110 — L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily10 — Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
结构域编号 domain_id1i10F01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1i10F02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology110 — L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily10 — Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
结构域编号 domain_id1i10G01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1i10G02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology110 — L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily10 — Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
结构域编号 domain_id1i10H01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
结构域编号 domain_id1i10H02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology110 — L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily10 — Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

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