8rbx

Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA-directed RNA polymerase subunit

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A7M4DUC2_PIG
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain A； PDBConstruct 1–1970； UniProt 1–1984 Author chain Y； PDBConstruct 1–1970； UniProt 1–1984

DNA-directed RNA polymerase subunit beta

OrganismNot specified

UniProt I3LGP4

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	I3LGP4_PIG
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain B； PDBConstruct 1–1174； UniProt 78–1251

DNA-directed RNA polymerase II subunit RPB3

OrganismNot specified

UniProt I3LCH3

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	I3LCH3_PIG
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain C； PDBConstruct 1–275； UniProt 1–275

RNA polymerase II subunit D

OrganismNot specified

UniProt A0A287ADR4

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A287ADR4_PIG
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain D； PDBConstruct 1–142； UniProt 43–184

DNA-directed RNA polymerase II subunit E

OrganismNot specified

UniProt I3LSI7

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	I3LSI7_PIG
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain E； PDBConstruct 1–210； UniProt 1–210

DNA-directed RNA polymerases I, II, and III subunit RPABC2

OrganismNot specified

UniProt A0A8D1KNW4

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A8D1KNW4_PIG
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain F； PDBConstruct 1–127； UniProt 1–127

DNA-directed RNA polymerase II subunit RPB7

OrganismNot specified

UniProt A0A4X1VKG7

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A4X1VKG7_PIG
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain G； PDBConstruct 1–172； UniProt 1–172

DNA-directed RNA polymerases I, II, and III subunit RPABC3

OrganismNot specified

UniProt I3LCB2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	I3LCB2_PIG
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain H； PDBConstruct 1–150； UniProt 1–150

DNA-directed RNA polymerase II subunit RPB9

OrganismNot specified

UniProt P60899

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPB9_PIG
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain I； PDBConstruct 1–125； UniProt 1–125

DNA-directed RNA polymerases I, II, and III subunit RPABC5

OrganismNot specified

UniProt A0A4X1VYD0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A4X1VYD0_PIG
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain J； PDBConstruct 1–67； UniProt 1–67

DNA-directed RNA polymerase II subunit RPB11-a

OrganismNot specified

UniProt F1RKE4

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	F1RKE4_PIG
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain K； PDBConstruct 1–117； UniProt 1–117

RNA polymerase II subunit K

OrganismNot specified

UniProt A0A8D0JYF1

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A8D0JYF1_PIG
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain L； PDBConstruct 1–58； UniProt 1–58

Histone H3.3C

Homo sapiens

UniProt Q6NXT2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	H3C_HUMAN
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain M； PDBConstruct 1–135； UniProt 1–135 Author chain S； PDBConstruct 1–135； UniProt 1–135

Histone H4

Homo sapiens

UniProt P62805

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	H4_HUMAN
Isoform	—
PDB entities	16
Chains and sequence ranges	Author chain O； PDBConstruct 1–103； UniProt 1–103 Author chain U； PDBConstruct 1–103； UniProt 1–103

Histone H2A type 1

Homo sapiens

UniProt P02262

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	H2A1_RAT
Isoform	—
PDB entities	18
Chains and sequence ranges	Author chain Q； PDBConstruct 1–130； UniProt 1–130 Author chain V； PDBConstruct 1–130； UniProt 1–130

Histone H2B type 1-J

Homo sapiens

UniProt P06899

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	H2B1J_HUMAN
Isoform	—
PDB entities	19
Chains and sequence ranges	Author chain R； PDBConstruct 1–126； UniProt 1–126 Author chain W； PDBConstruct 1–126； UniProt 1–126

Transcription elongation factor SPT5

Homo sapiens

UniProt O00267

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SPT5H_HUMAN
Isoform	—
PDB entities	21
Chains and sequence ranges	Author chain Z； PDBConstruct 1–1087； UniProt 1–1087

Integrator complex subunit 1

Homo sapiens

UniProt Q8N201

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	INT1_HUMAN
Isoform	—
PDB entities	22
Chains and sequence ranges	Author chain a； PDBConstruct 3–2192； UniProt 1–2190

Integrator complex subunit 2

Homo sapiens

UniProt Q9H0H0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	INT2_HUMAN
Isoform	—
PDB entities	23
Chains and sequence ranges	Author chain b； PDBConstruct 1–1204； UniProt 1–1204

Integrator complex subunit 4

Homo sapiens

UniProt Q96HW7

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	INT4_HUMAN
Isoform	—
PDB entities	24
Chains and sequence ranges	Author chain d； PDBConstruct 1–963； UniProt 1–963

Integrator complex subunit 5

Homo sapiens

UniProt Q6P9B9

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	INT5_HUMAN
Isoform	—
PDB entities	25
Chains and sequence ranges	Author chain e； PDBConstruct 3–1021； UniProt 1–1019

Integrator complex subunit 6

Homo sapiens

UniProt Q9UL03

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	INT6_HUMAN
Isoform	—
PDB entities	26
Chains and sequence ranges	Author chain f； PDBConstruct 3–889； UniProt 1–887

Integrator complex subunit 7

Homo sapiens

UniProt Q9NVH2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	INT7_HUMAN
Isoform	—
PDB entities	27
Chains and sequence ranges	Author chain g； PDBConstruct 3–964； UniProt 1–962

Integrator complex subunit 8

Homo sapiens

UniProt Q75QN2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	INT8_HUMAN
Isoform	—
PDB entities	28
Chains and sequence ranges	Author chain h； PDBConstruct 1–995； UniProt 1–995

Integrator complex subunit 9

Homo sapiens

UniProt Q9NV88

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	INT9_HUMAN
Isoform	—
PDB entities	29
Chains and sequence ranges	Author chain i； PDBConstruct 1–658； UniProt 1–658

Integrator complex subunit 10

Homo sapiens

UniProt Q9NVR2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	INT10_HUMAN
Isoform	—
PDB entities	30
Chains and sequence ranges	Author chain j； PDBConstruct 1–710； UniProt 1–710

Integrator complex subunit 11

Homo sapiens

UniProt Q5TA45

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	INT11_HUMAN
Isoform	—
PDB entities	31
Chains and sequence ranges	Author chain k； PDBConstruct 3–602； UniProt 1–600

Integrator complex subunit 13

Homo sapiens

UniProt Q9NVM9

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	INT13_HUMAN
Isoform	—
PDB entities	32
Chains and sequence ranges	Author chain m； PDBConstruct 1–706； UniProt 1–706

Integrator complex subunit 14

Homo sapiens

UniProt Q96SY0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	INT14_HUMAN
Isoform	—
PDB entities	33
Chains and sequence ranges	Author chain n； PDBConstruct 1–518； UniProt 1–518

Integrator complex subunit 15

Homo sapiens

UniProt Q96N11

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	INT15_HUMAN
Isoform	—
PDB entities	34
Chains and sequence ranges	Author chain o； PDBConstruct 3–451； UniProt 1–449

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

Homo sapiens

UniProt P30153

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	2AAA_HUMAN
Isoform	—
PDB entities	35
Chains and sequence ranges	Author chain p； PDBConstruct 3–591； UniProt 1–589

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Homo sapiens

UniProt P67775

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PP2AA_HUMAN
Isoform	—
PDB entities	36
Chains and sequence ranges	Author chain q； PDBConstruct 3–311； UniProt 1–309

Negative elongation factor A

Homo sapiens

UniProt Q9H3P2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NELFA_HUMAN
Isoform	—
PDB entities	38
Chains and sequence ranges	Author chain u； PDBConstruct 1–528； UniProt 1–528

;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ;

Homo sapiens

UniProt Q8WX92

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） Negative elongation factor C/D × 1 （Q8IXH7） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NELFB_HUMAN
Isoform	—
PDB entities	39
Chains and sequence ranges	Author chain v； PDBConstruct 34–613； UniProt 1–580

Negative elongation factor C/D

Homo sapiens

UniProt Q8IXH7

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 43 DNA 2 RNA 1	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 DNA-directed RNA polymerase subunit × 2 （A0A7M4DUC2） DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RNA polymerase II subunit D × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerases I, II, and III subunit RPABC2 × 1 （A0A8D1KNW4） DNA-directed RNA polymerase II subunit RPB7 × 1 （A0A4X1VKG7） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （I3LCB2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） DNA-directed RNA polymerase II subunit RPB11-a × 1 （F1RKE4） RNA polymerase II subunit K × 1 （A0A8D0JYF1） Histone H3.3C × 2 （Q6NXT2） non-template DNA × 1 Histone H4 × 2 （P62805） RNA × 1 Histone H2A type 1 × 2 （P02262） Histone H2B type 1-J × 2 （P06899） Template DNA × 1 Transcription elongation factor SPT5 × 1 （O00267） Integrator complex subunit 1 × 1 （Q8N201） Integrator complex subunit 2 × 1 （Q9H0H0） Integrator complex subunit 4 × 1 （Q96HW7） Integrator complex subunit 5 × 1 （Q6P9B9） Integrator complex subunit 6 × 1 （Q9UL03） Integrator complex subunit 7 × 1 （Q9NVH2） Integrator complex subunit 8 × 1 （Q75QN2） Integrator complex subunit 9 × 1 （Q9NV88） Integrator complex subunit 10 × 1 （Q9NVR2） Integrator complex subunit 11 × 1 （Q5TA45） Integrator complex subunit 13 × 1 （Q9NVM9） Integrator complex subunit 14 × 1 （Q96SY0） Integrator complex subunit 15 × 1 （Q96N11） Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform × 1 （P30153） Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform × 1 （P67775） DSS1 × 1 Negative elongation factor A × 1 （Q9H3P2） ;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ; × 1 （Q8WX92） UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK × 1 ZINC ION × 10 MAGNESIUM ION × 1 MANGANESE (II) ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NELFD_HUMAN
Isoform	—
PDB entities	40
Chains and sequence ranges	Author chain w； PDBConstruct 3–583； UniProt 10–590

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	8rbx
Deposition date deposition_date	2023-12-05
Structure title title	Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex
Keywords keywords	Integrator complex, Pre-termination complex, TRANSCRIPTION; TRANSCRIPTION
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8rbx__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8rbx__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

8rbx__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	0.00 Å
Rg (electron density)	98.74 Å
Total Rg	98.72 Å
Atom count	129226
Residues	17295
Excluded volume	2260000 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`8rbx__assembly_1__model_1`	46-meric （46）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (44)

Entity 1 Entity 1 polymer

Description description	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK
Molecular weight formula_weight	698.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	1
Atom count atom_count	129226

XXXXXXXX

Entity 2 Entity 2 polymer

Description description	DNA-directed RNA polymerase subunit
Molecular weight formula_weight	217450.1 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,Y

MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDPRQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKGHGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEPRYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMPDFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIRIMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTGMFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPGYSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN

Entity 3 Entity 3 polymer

Description description	DNA-directed RNA polymerase subunit beta
Molecular weight formula_weight	134041.4 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Entity 4 Entity 4 polymer

Description description	DNA-directed RNA polymerase II subunit RPB3
Molecular weight formula_weight	31439.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C

MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLHDEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDLISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTAGVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLRPETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

Entity 5 Entity 5 polymer

Description description	RNA polymerase II subunit D
Molecular weight formula_weight	16331.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEVFMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEGRFEDEELQQILDDIQTKRSFQY

Entity 6 Entity 6 polymer

Description description	DNA-directed RNA polymerase II subunit E
Molecular weight formula_weight	24644.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E

MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTVLVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVDMAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVARYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Entity 7 Entity 7 polymer

Description description	DNA-directed RNA polymerases I, II, and III subunit RPABC2
Molecular weight formula_weight	14477.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F

MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKYERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGVDELIISD

Entity 8 Entity 8 polymer

Description description	DNA-directed RNA polymerase II subunit RPB7
Molecular weight formula_weight	19314.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G

MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQPGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFDPNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Entity 9 Entity 9 polymer

Description description	DNA-directed RNA polymerases I, II, and III subunit RPABC3
Molecular weight formula_weight	17162.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H

MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGGLLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Entity 10 Entity 10 polymer

Description description	DNA-directed RNA polymerase II subunit RPB9
Molecular weight formula_weight	14541.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I

MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITHEVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCGHRWTE

Entity 11 Entity 11 polymer

Description description	DNA-directed RNA polymerases I, II, and III subunit RPABC5
Molecular weight formula_weight	7655.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J

MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLLNYAPLEK

Entity 12 Entity 12 polymer

Description description	DNA-directed RNA polymerase II subunit RPB11-a
Molecular weight formula_weight	13310.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K

MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAGYKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Entity 13 Entity 13 polymer

Description description	RNA polymerase II subunit K
Molecular weight formula_weight	7018.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L

MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Entity 14 Entity 14 polymer

Description description	Histone H3.3C
Molecular weight formula_weight	15350.0 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M,S

MARTKQTARKSTGGKAPRKQLATKAARKSTPSTCGVKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLLEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Entity 15 Entity 15 polymer

Description description	non-template DNA
Molecular weight formula_weight	45938.3 kDa
Source method src_method	syn
Copy count entity_count	1

Polymer Polymer

Polymer type type	polydeoxyribonucleotide
Chain IDs strand_id	N

GATATCGATGTATATATCTGACACGTGCCTGGAGACTAGGGAGTAATCCCCTTGGCGGTTAAAACGCGGGGGACAGCGCGTACGTGCGTTTAAGCGGTGCTAGAGCTGTCTACGACCAATTGAGCGGCCTCGGCACCGGGATTCTGAT

Entity 16 Entity 16 polymer

Description description	Histone H4
Molecular weight formula_weight	11394.4 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	O,U

MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Entity 17 Entity 17 polymer

Description description	RNA
Molecular weight formula_weight	5549.3 kDa
Source method src_method	syn
Copy count entity_count	1

Polymer Polymer

Polymer type type	polyribonucleotide
Chain IDs strand_id	P

GUGUGUCUGGGUGGUGG

Entity 18 Entity 18 polymer

Description description	Histone H2A type 1
Molecular weight formula_weight	14093.5 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Q,V

MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKAKGK

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Entity 19 Entity 19 polymer

Description description	Histone H2B type 1-J
Molecular weight formula_weight	13981.3 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	R,W

MPEPSKSAPAPKKGSKKAITKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Entity 20 Entity 20 polymer

Description description	Template DNA
Molecular weight formula_weight	56757.2 kDa
Source method src_method	syn
Copy count entity_count	1

Polymer Polymer

Polymer type type	polydeoxyribonucleotide
Chain IDs strand_id	T

ATCAGAATCCCGGTGCCGAGGCCGCTCAATTGGTCGTAGACAGCTCTAGCACCGCTTAAACGCACGTACGCGCTGTCCCCCGCGTTTTAACCGCCAAGGGGATTACTCCCTAGTCTCCAGGCACGTGTCAGATATATACATCGATATCGGCCACCACCCAGACACACCAAACACAAGACAGTGAT

Entity 21 Entity 21 polymer

Description description	Transcription elongation factor SPT5
Molecular weight formula_weight	121145.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Z

MSDSEDSNFSEEEDSERSSDGEEAEVDEERRSAAGSEKEEEPEDEEEEEEEEEYDEEEEEEDDDRPPKKPRHGGFILDEADVDDEYEDEDQWEDGAEDILEKEEIEASNIDNVVLDEDRSGARRLQNLWRDQREEELGEYYMKKYAKSSVGETVYGGSDELSDDITQQQLLPGVKDPNLWTVKCKIGEERATAISLMRKFIAYQFTDTPLQIKSVVAPEHVKGYIYVEAYKQTHVKQAIEGVGNLRLGYWNQQMVPIKEMTDVLKVVKEVANLKPKSWVRLKRGIYKDDIAQVDYVEPSQNTISLKMIPRIDYDRIKARMSLKDWFAKRKKFKRPPQRLFDAEKIRSLGGDVASDGDFLIFEGNRYSRKGFLFKSFAMSAVITEGVKPTLSELEKFEDQPEGIDLEVVTESTGKEREHNFQPGDNVEVCEGELINLQGKILSVDGNKITIMPKHEDLKDMLEFPAQELRKYFKMGDHVKVIAGRFEGDTGLIVRVEENFVILFSDLTMHELKVLPRDLQLCSETASGVDVGGQHEWGELVQLDPQTVGVIVRLERETFQVLNMYGKVVTVRHQAVTRKKDNRFAVALDSEQNNIHVKDIVKVIDGPHSGREGEIRHLFRSFAFLHCKKLVENGGMFVCKTRHLVLAGGSKPRDVTNFTVGGFAPMSPRISSPMHPSAGGQRGGFGSPGGGSGGMSRGRGRRDNELIGQTVRISQGPYKGYIGVVKDATESTARVELHSTCQTISVDRQRLTTVGSRRPGGMTSTYGRTPMYGSQTPMYGSGSRTPMYGSQTPLQDGSRTPHYGSQTPLHDGSRTPAQSGAWDPNNPNTPSRAEEEYEYAFDDEPTPSPQAYGGTPNPQTPGYPDPSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPASYHPTPSPMAYQASPSPSPVGYSPMTPGAPSPGGYNPHTPGSGIEQNSSDWVTTDIQVKVRDTYLDTQVVGQTGVIRSVTGGMCSVYLKDSEKVVSISSEHLEPITPTKNNKVKVILGEDREATGVLLSIDGEDGIVRMDLDEQLKILNLRFLGKLLEA

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Entity 22 Entity 22 polymer

Description description	Integrator complex subunit 1
Molecular weight formula_weight	244776.1 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	a

SNMNRAKPTTVRRPSAAAKPSGHPPPGDFIALGSKGQANESKTASTLLKPAPSGLPSERKRDAAAALSSASALTGLTKRPKLSSTPPLSALGRLAEAAVAEKRAISPSIKEPSVVPIEVLPTVLLDEIEAAELEGNDDRIEGVLCGAVKQLKVTRAKPDSTLYLSLMYLAKIKPNIFATEGVIEALCSLLRRDASINFKAKGNSLVSVLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSPHCKTFVDNIQTAFNTRMPPRSVLLQGEAGRVAGDLGAGSSPHPSLTEEEDSQTELLIAEEKLSPEQEGQLMPRYEELAESVEEYVLDMLRDQLNRRQPIDNVSRNLLRLLTSTCGYKEVRLLAVQKLEMWLQNPKLTRPAQDLLMSVCMNCNTHGSEDMDVISHLIKIRLKPKVLLNHFMLCIRELLSAHKDNLGTTIKLVIFNELSSARNPNNMQVLYTALQHSSELAPKFLAMVFQDLLTNKDDYLRASRALLREIIKQTKHEINFQAFCLGLMQERKEPQYLEMEFKERFVVHITDVLAVSMMLGITAQVKEAGIAWDKGEKRNLEVLRSFQNQIAAIQRDAVWWLHTVVPSISKLAPKDYVHCLHKVLFTEQPETYYKWDNWPPESDRNFFLRLCSEVPILEDTLMRILVIGLSRELPLGPADAMELADHLVKRAAAVQADDVEVLKVGRTQLIDAVLNLCTYHHPENIQLPPGYQPPNLAISTLYWKAWPLLLVVAAFNPENIGLAAWEEYPTLKMLMEMVMTNNYSYPPCTLTDEETRTEMLNRELQTAQREKQEILAFEGHLAAASTKQTITESSSLLLSQLTSLDPQGPPRRPPPHILDQVKSLNQSLRLGHLLCRSRNPDFLLHIIQRQASSQSMPWLADLVQSSEGSLDVLPVQCLCEFLLHDAVDDAASGEEDDEGESKEQKAKKRQRQQKQRQLLGRLQDLLLGPKADEQTTCEVLDYFLRRLGSSQVASRVLAMKGLSLVLSEGSLRDGEEKEPPMEEDVGDTDVLQGYQWLLRDLPRLPLFDSVRSTTALALQQAIHMETDPQTISAYLIYLSQHTPVEEQAQHSDLALDVARLVVERSTIMSHLFSKLSPSAASDAVLSALLSIFSRYVRRMRQSKEGEEVYSWSESQDQVFLRWSSGETATMHILVVHAMVILLTLGPPRADDSEFQALLDIWFPEEKPLPTAFLVDTSEEALLLPDWLKLRMIRSEVLRLVDAALQDLEPQQLLLFVQSFGIPVSSMSKLLQFLDQAVAHDPQTLEQNIMDKNYMAHLVEVQHERGASGGQTFHSLLTASLPPRRDSTEAPKPKSSPEQPIGQGRIRVGTQLRVLGPEDDLAGMFLQIFPLSPDPRWQSSSPRPVALALQQALGQELARVVQGSPEVPGITVRVLQALATLLSSPHGGALVMSMHRSHFLACPLLRQLCQYQRCVPQDTGFSSLFLKVLLQMLQWLDSPGVEGGPLRAQLRMLASQASAGRRLSDVRGGLLRLAEALAFRQDLEVVSSTVRAVIATLRSGEQCSVEPDLISKVLQGLIEVRSPHLEELLTAFFSATADAASPFPACKPVVVVSSLLLQEEEPLAGGKPGADGGSLEAVRLGPSSGLLVDWLEMLDPEVVSSCPDLQLRLLFSRRKGKGQAQVPSFRPYLLTLFTHQSSWPTLHQCIRVLLGKSREQRFDPSASLDFLWACIHVPRIWQGRDQRTPQKRREELVLRVQGPELISLVELILAEAETRSQDGDTAACSLIQARLPLLLSCCCGDDESVRKVTEHLSGCIQQWGDSVLGRRCRDLLLQLYLQRPELRVPVPEVLLHSEGAASSSVCKLDGLIHRFITLLADTSDSRALENRGADASMACRKLAVAHPLLLLRHLPMIAALLHGRTHLNFQEFRQQNHLSCFLHVLGLLELLQPHVFRSEHQGALWDCLLSFIRLLLNYRKSSRHLAAFINKFVQFIHKYITYNAPAAISFLQKHADPLHDLSFDNSDLVMLKSLLAGLSLPSRDDRTDRGLDEEGEEESSAGSLPLVSVSLFTPLTAAEMAPYMKRLSRGQTVEDLLEVLSDIDEMSRRRPEILSFFSTNLQRLMSSAEECCRNLAFSLALRSMQNSPSIAAAFLPTFMYCLGSQDFEVVQTALRNLPEYALLCQEHAAVLLHRAFLVGMYGQMDPSAQISEALRILHMEAVM

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 23 Entity 23 polymer

Description description	Integrator complex subunit 2
Molecular weight formula_weight	134451.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	b

MKDQQTVIMTECTSLQFVSPFAFEAMQKVDVVCLASLSDPELRLLLPCLVRMALCAPADQSQSWAQDKKLILRLLSGVEAVNSIVALLSVDFHALEQDASKEQQLRHKLGGGSGESILVSQLQHGLTLEFEHSDSPRRLRLVLSELLAIMNKVSESNGEFFFKSSELFESPVYLEEAADVLCILQAELPSLLPIVDVAEALLHVRNGAWFLCLLVANVPDSFNEVCRGLIKNGERQDEESLGGRRRTDALRFLCKMNPSQALKVRGMVVEECHLPGLGVALTLDHTKNEACEDGVSDLVCFVSGLLLGTNAKVRTWFGTFIRNGQQRKRETSSSVLWQMRRQLLLELMGILPTVRSTRIVEEADVDMEPNVSVYSGLKEEHVVKASALLRLYCALMGIAGLKPTEEEAEQLLQLMTSRPPATPAGVRFVSLSFCMLLAFSTLVSTPEQEQLMVVWLSWMIKEEAYFESTSGVSASFGEMLLLVAMYFHSNQLSAIIDLVCSTLGMKIVIKPSSLSRMKTIFTQEIFTEQVVTAHAVRVPVTSNLSANITGFLPIHCIYQLLRSRSFTKHKVSIKDWIYRQLCETSTPLHPQLLPLIDVYINSILTPASKSNPEATNQPVTEQEILNIFQGVIGGDNIRLNQRFSITAQLLVLYYILSYEEALLANTKTLAAMQRKPKSYSSSLMDQIPIKFLIRQAQGLQQELGGLHSALLRLLATNYPHLCIVDDWICEEEITGTDALLRRMLLTNNAKNHSPKQLQEAFSAVPVNNTQVMQIIEHLTLLSASELIPYAEVLTSNMSQLLNSGVPRRILQTVNKLWMVLNTVMPRRLWVMTVNALQPSIKFVRQQKYTQNDLMIDPLIVLRCDQRVHRCPPLMDITLHMLNGYLLASKAYLSAHLKETEQDRPSQNNTIGLVGQTDAPEVTREELKNALLAAQDSAAVQILLEICLPTEEEKANGVNPDSLLRNVQSVITTSAPNKGMEEGEDNLLCNLREVQCLICCLLHQMYIADPNIAKLVHFQGYPCELLPLTVAGIPSMHICLDFIPELIAQPELEKQIFAIQLLSHLCIQYALPKSLSVARLAVNVMGTLLTVLTQAKRYAFFMPTLPSLVSFCRAFPPLYEDIMSLLIQIGQVCASDVATQTRDIDPIITRLQQIKEKPSGWSQICKDSSYKNGSRDTGSMDPDVQLCHCIERTVIEIINMSVSGI

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 24 Entity 24 polymer

Description description	Integrator complex subunit 4
Molecular weight formula_weight	108306.8 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	d

MAAHLKKRVYEEFTKVVQPQEEIATKKLRLTKPSKSAALHIDLCKATSPADALQYLLQFARKPVEAESVEGVVRILLEHYYKENDPSVRLKIASLLGLLSKTAGFSPDCIMDDAINILQNEKSHQVLAQLLDTLLAIGTKLPENQAIQMRLVDVACKHLTDTSHGVRNKCLQLLGNLGSLEKSVTKDAEGLAARDVQKIIGDYFSDQDPRVRTAAIKAMLQLHERGLKLHQTIYNQACKLLSDDYEQVRSAAVQLIWVVSQLYPESIVPIPSSNEEIRLVDDAFGKICHMVSDGSWVVRVQAAKLLGSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPKEEVDTGAVNLIESGACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFLVDMFNDEIEEVRLQSIHTMRKISNNITLREDQLDTVLAVLEDSSRDIREALHELLCCTNVSTKEGIHLALVELLKNLTKYPTDRDSIWKCLKFLGSRHPTLVLPLVPELLSTHPFFDTAEPDMDDPAYIAVLVLIFNAAKTCPTMPALFSDHTFRHYAYLRDSLSHLVPALRLPGRKLVSSAVSPSIIPQEDPSQQFLQQSLERVYSLQHLDPQGAQELLEFTIRDLQRLGELQSELAGVADFSATYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVVIIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFVDKLLDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSGLVVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQVYLSHTAWTEACQVEVRLLLAYNSSARIPKCPWMEGGEMSPQVETSIEGTIPFSKPVKVYIMPKPARR

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 25 Entity 25 polymer

Description description	Integrator complex subunit 5
Molecular weight formula_weight	108316.4 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	e

SNMSALCDPPGAPGPPGPAPATHGPAPLSAQELSQEIKAFLTGVDPILGHQLSAREHARCGLLLLRSLPPARAAVLDHLRGVFDESVRAHLAALDETPVAGPPHLRPPPPSHVPAGGPGLEDVVQEVQQVLSEFIRANPKAWAPVISAWSIDLMGQLSSTYSGQHQRVPHATGALNELLQLWMGCRATRTLMDIYVQCLSALIGSCPDACVDALLDTSVQHSPHFDWVVAHIGSSFPGTIISRVLSCGLKDFCVHGGAGGGAGSSGGSSSQTPSTDPFPGSPAIPAEKRVPKIASVVGILGHLASRHGDSIRRELLRMFHDSLAGGSGGRSGDPSLQATVPFLLQLAVMSPALLGTVSGELVDCLKPPAVLSQLQQHLQGFPREELDNMLNLAVHLVSQASGAGAYRLLQFLVDTAMPASVITTQGLAVPDTVREACDRLIQLLLLHLQKLVHHRGGSPGEGVLGPPPPPRLVPFLDALKNHVGELCGETLRLERKRFLWQHQLLGLLSVYTRPSCGPEALGHLLSRARSPEELSLATQLYAGLVVSLSGLLPLAFRSCLARVHAGTLQPPFTARFLRNLALLVGWEQQGGEGPAALGAHFGESASAHLSDLAPLLLHPEEEVAEAAASLLAICPFPSEALSPSQLLGLVRAGVHRFFASLRLHGPPGVASACQLLTRLSQTSPAGLKAVLQLLVEGALHRGNTELFGGQVDGDNETLSVVSASLASASLLDTNRRHTAAVPGPGGIWSVFHAGVIGRGLKPPKFVQSRNQQEVIYNTQSLLSLLVHCCSAPGGTECGECWGAPILSPEAAKAVAVTLVESVCPDAAGAELAWPPEEHARATVERDLRIGRRFREQPLLFELLKLVAAAPPALCYCSVLLRGLLAALLGHWEASRHPDTTHSPWHLEASCTLVAVMAEGSLLPPALGNMHEVFSQLAPFEVRLLLLSVWGFLREHGPLPQKFIFQSERGRFIRDFSREGGGEGGPHLAVLHSVLHRNIDRLGLFSGRFQAPSPSTLLRQGT

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 26 Entity 26 polymer

Description description	Integrator complex subunit 6
Molecular weight formula_weight	100728.2 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	f

SNMPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPASRGDRYMLVTFEEPPYAIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQGRNPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGTMSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQKVQSGVVINFEKAGPDPSPVEDGQPDISRPFGSQPWHSCHKLIYVRPNPKTGVPIGHWPVPESFWPDQNSPTLPPRTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILERKSPQTCWQVYVSNSAKYSELGHPFGYLKASTALNCVNLFVMPYNYPVLLPLLDDLFKVHKAKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQQAKIESDRVIGSVGKKVVQETGIKVRSRSHGLSMAYRKDFQQLLQGISEDVPHRLLDLNMKEYTGFQVALLNKDLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKSTRRFLKGQDEDQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTFGNPFKLDKKGMMIDEADEFVAGPQNKHKRPGEPNMQGIPKRRRCMSPLLRGRQQNPVVNNHIGGKGPPAPTTQAQPDLIKPLPLHKISETTNDSIIHDVVENHVADQLSSDITPNAMDTEFSASSPASLLERPTNHMEALGHDHLGTNDLTVGGFLENHEEPRDKEQCAEENIPASSLNKGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGSLQTRLIFLQNVIKEASRFKKRMLIEQLENFLDEIHRRANQINHINSN

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 27 Entity 27 polymer

Description description	Integrator complex subunit 7
Molecular weight formula_weight	107153.8 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	g

SNMASNSTKSFLADAGYGEQELDANSALMELDKGLRSGKLGEQCEAVVRFPRLFQKYPFPILINSAFLKLADVFRVGNNFLRLCVLKVTQQSEKHLEKILNVDEFVKRIFSVIHSNDPVARAITLRMLGSLASIIPERKNAHHSIRQSLDSHDNVEVEAAVFAAANFSAQSKDFAVGICNKISEMIQGLATPVDLKLKLIPILQHMHHDAILASSARQLLQQLVTSYPSTKMVIVSLHTFTLLAASSLVDTPKQIQLLLQYLKNDPRKAVKRLAIQDLKLLANKTPHTWSRENIQALCECALQTPYDSLKLGMLSVLSTLSGTIAIKHYFSIVPGNVSSSPRSSDLVKLAQECCYHNNRGIAAHGVRVLTNITVSCQEKDLLALEQDAVFGLESLLVLCSQDDSPGAQATLKIALNCMVKLAKGRPHLSQSVVETLLTQLHSAQDAARILMCHCLAAIAMQLPVLGDGMLGDLMELYKVIGRSATDKQQELLVSLATVIFVASQKALSVESKAVIKQQLESVSNGWTVYRIARQASRMGNHDMAKELYQSLLTQVASEHFYFWLNSLKEFSHAEQCLTGLQEENYSSALSCIAESLKFYHKGIASLTAASTPLNPLSFQCEFVKLRIDLLQAFSQLICTCNSLKTSPPPAIATTIAMTLGNDLQRCGRISNQMKQSMEEFRSLASRYGDLYQASFDADSATLRNVELQQQSCLLISHAIEALILDPESASFQEYGSTGTAHADSEYERRMMSVYNHVLEEVESLNRKYTPVSYMHTACLCNAIIALLKVPLSFQRYFFQKLQSTSIKLALSPSPRNPAEPIAVQNNQQLALKVEGVVQHGSKPGLFRKIQSVCLNVSSTLQSKSGQDYKIPIDNMTNEMEQRVEPHNDYFSTQFLLNFAILGTHNITVESSVKDANGIVWKTGPRTTIFVKSLEDPYSQQIRLQQQQAQQPLQQQQQRNAYTRF

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 28 Entity 28 polymer

Description description	Integrator complex subunit 8
Molecular weight formula_weight	113219.9 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	h

MSAEAADREAATSSRPCTPPQTCWFEFLLEESLLEKHLRKPCPDPAPVQLIVQFLEQASKPSVNEQNQVQPPPDNKRNRILKLLALKVAAHLKWDLDILEKSLSVPVLNMLLNELLCISKVPPGTKHVDMDLATLPPTTAMAVLLYNRWAIRTIVQSSFPVKQAKPGPPQLSVMNQMQQEKELTENILKVLKEQAADSILVLEAALKLNKDLYVHTMRTLDLLAMEPGMVNGETESSTAGLKVKTEEMQCQVCYDLGAAYFQQGSTNSAVYENAREKFFRTKELIAEIGSLSLHCTIDEKRLAGYCQACDVLVPSSDSTSQQLTPYSQVHICLRSGNYQEVIQIFIEDNLTLSLPVQFRQSVLRELFKKAQQGNEALDEICFKVCACNTVRDILEGRTISVQFNQLFLRPNKEKIDFLLEVCSRSVNLEKASESLKGNMAAFLKNVCLGLEDLQYVFMISSHELFITLLKDEERKLLVDQMRKRSPRVNLCIKPVTSFYDIPASASVNIGQLEHQLILSVDPWRIRQILIELHGMTSERQFWTVSNKWEVPSVYSGVILGIKDNLTRDLVYILMAKGLHCSTVKDFSHAKQLFAACLELVTEFSPKLRQVMLNEMLLLDIHTHEAGTGQAGERPPSDLISRVRGYLEMRLPDIPLRQVIAEECVAFMLNWRENEYLTLQVPAFLLQSNPYVKLGQLLAATCKELPGPKESRRTAKDLWEVVVQICSVSSQHKRGNDGRVSLIKQRESTLGIMYRSELLSFIKKLREPLVLTIILSLFVKLHNVREDIVNDITAEHISIWPSSIPNLQSVDFEAVAITVKELVRYTLSINPNNHSWLIIQADIYFATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHTQVAILCQFLREIDYKTAFKSLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRGETDKRQIAIKAIGQTELNASNPEEVLQLAAQRRKKKFLQAMAKLYF

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 29 Entity 29 polymer

Description description	Integrator complex subunit 9
Molecular weight formula_weight	73891.2 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	i

MKLYCLSGHPTLPCNVLKFKSTTIMLDCGLDMTSTLNFLPLPLVQSPRLSNLPGWSLKDGNAFLDKELKECSGHVFVDSVPEFCLPETELIDLSTVDVILISNYHCMMALPYITEHTGFTGTVYATEPTVQIGRLLMEELVNFIERVPKAQSASLWKNKDIQRLLPSPLKDAVEVSTWRRCYTMQEVNSALSKIQLVGYSQKIELFGAVQVTPLSSGYALGSSNWIIQSHYEKVSYVSGSSLLTTHPQPMDQASLKNSDVLVLTGLTQIPTANPDGMVGEFCSNLALTVRNGGNVLVPCYPSGVIYDLLECLYQYIDSAGLSSVPLYFISPVANSSLEFSQIFAEWLCHNKQSKVYLPEPPFPHAELIQTNKLKHYPSIHGDFSNDFRQPCVVFTGHPSLRFGDVVHFMELWGKSSLNTVIFTEPDFSYLEALAPYQPLAMKCIYCPIDTRLNFIQVSKLLKEVQPLHVVCPEQYTQPPPAQSHRMDLMIDCQPPAMSYRRAEVLALPFKRRYEKIEIMPELADSLVPMEIKPGISLATVSAVLHTKDNKHLLQPPPRPAQPTSGKKRKRVSDDVPDCKVLKPLLSGSIPVEQFVQTLEKHGFSDIKVEDTAKGHIVLLQEAETLIQIEEDSTHIICDNDEMLRVRLRDLVLKFLQKF

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 30 Entity 30 polymer

Description description	Integrator complex subunit 10
Molecular weight formula_weight	82339.9 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	j

MSAQGDCEFLVQRARELVPQDLWAAKAWLITARSLYPADFNIQYEMYTIERNAERTATAGRLLYDMFVNFPDQPVVWREISIITSALRNDSQDKQTQFLRSLFETLPGRVQCEMLLKVTEQCFNTLERSEMLLLLLRRFPETVVQHGVGLGEALLEAETIEEQESPVNCFRKLFVCDVLPLIINNHDVRLPANLLYKYLNKAAEFYINYVTRSTQIENQHQGAQDTSDLMSPSKRSSQKYIIEGLTEKSSQIVDPWERLFKILNVVGMRCEWQMDKGRRSYGDILHRMKDLCRYMNNFDSEAHAKYKNQVVYSTMLVFFKNAFQYVNSIQPSLFQGPNAPSQVPLVLLEDVSNVYGDVEIDRNKHIHKKRKLAEGREKTMSSDDEDCSAKGRNRHIVVNKAELANSTEVLESFKLARESWELLYSLEFLDKEFTRICLAWKTDTWLWLRIFLTDMIIYQGQYKKAIASLHHLAALQGSISQPQITGQGTLEHQRALIQLATCHFALGEYRMTCEKVLDLMCYMVLPIQDGGKSQEEPSKVKPKFRKGSDLKLLPCTSKAIMPYCLHLMLACFKLRAFTDNRDDMALGHVIVLLQQEWPRGENLFLKAVNKICQQGNFQYENFFNYVTNIDMLEEFAYLRTQEGGKIHLELLPNQGMLIKHHTVTRGITKGVKEDFRLAMERQVSRCGENLMVVLHRFCINEKILLLQTLT

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 31 Entity 31 polymer

Description description	Integrator complex subunit 11
Molecular weight formula_weight	67956.8 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	k

SNMPEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYITQNGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITQSTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQETALRVYSHLKSVLKDHCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKKGLPQAPS

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 32 Entity 32 polymer

Description description	Integrator complex subunit 13
Molecular weight formula_weight	80345.2 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	m

MKIFSESHKTVFVVDHCPYMAESCRQHVEFDMLVKNRTQGIIPLAPISKSLWTCSVESSMEYCRIMYDIFPFKKLVNFIVSDSGAHVLNSWTQEDQNLQELMAALAAVGPPNPRADPECCSILHGLVAAVETLCKITEYQHEARTLLMENAERVGNRGRIICITNAKSDSHVRMLEDCVQETIHEHNKLAANSDHLMQIQKCELVLIHTYPVGEDSLVSDRSKKELSPVLTSEVHSVRAGRHLATKLNILVQQHFDLASTTITNIPMKEEQHANTSANYDVELLHHKDAHVDFLKSGDSHLGGGSREGSFKETITLKWCTPRTNNIELHYCTGAYRISPVDVNSRPSSCLTNFLLNGRSVLLEQPRKSGSKVISHMLSSHGGEIFLHVLSSSRSILEDPPSISEGCGGRVTDYRITDFGEFMRENRLTPFLDPRYKIDGSLEVPLERAKDQLEKHTRYWPMIISQTTIFNMQAVVPLASVIVKESLTEEDVLNCQKTIYNLVDMERKNDPLPISTVGTRGKGPKRDEQYRIMWNELETLVRAHINNSEKHQRVLECLMACRSKPPEEEERKKRGRKREDKEDKSEKAVKDYEQEKSWQDSERLKGILERGKEELAEAEIIKDSPDSPEPPNKKPLVEMDETPQVEKSKGPVSLLSLWSNRINTANSRKHQEFAGRLNSVNNRAELYQHLKEENGMETTENGKASRQ

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 33 Entity 33 polymer

Description description	Integrator complex subunit 14
Molecular weight formula_weight	57526.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	n

MPTVVVMDVSLSMTRPVSIEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALVGVCNIVQQEWGGAIPCQVVLVTDGCLGIGRGSLRHSLATQNQRSESNRFPLPFPFPSKLYIMCMANLEELQSTDSLECLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAVLKCGHLTADVQVFPRPEPFVVDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGTGITDDNEDENSANQIAGKIPNFCVLLHGSLKVEGMVAIVQLGPEWHGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMAQLGPISDAKENPYGEDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPETAHPDAAFQLTHAAQQLKLASTGTSEYAAYDQNITPLHTDFSGSSTERI

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 34 Entity 34 polymer

Description description	Integrator complex subunit 15
Molecular weight formula_weight	50303.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	o

SNMSDIRHSLLRRDALSAAKEVLYHLDIYFSSQLQSAPLPIVDKGPVELLEEFVFQVPKERSAQPKRLNSLQELQLLEIMCNYFQEQTKDSVRQIIFSSLFSPQGNKADDSRMSLLGKLVSMAVAVCRIPVLECAASWLQRTPVVYCVRLAKALVDDYCCLVPGSIQTLKQIFSASPRFCCQFITSVTALYDLSSDDLIPPMDLLEMIVTWIFEDPRLILITFLNTPIAANLPIGFLELTPLVGLIRWCVKAPLAYKRKKKPPLSNGHVSNKVTKDPGVGMDRDSHLLYSKLHLSVLQVLMTLQLHLTEKNLYGRLGLILFDHMVPLVEEINRLADELNPLNASQEIELSLDRLAQALQVAMASGALLCTRDDLRTLCSRLPHNNLLQLVISGPVQQSPHAALPPGFYPHIHTPPLGYGAVPAHPAAHPALPTHPGHTFISGVTFPFRPIR

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 35 Entity 35 polymer

Description description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Molecular weight formula_weight	65579.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	p

SNMAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 36 Entity 36 polymer

Description description	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Molecular weight formula_weight	35836.3 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	q

SNMDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVNRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 37 Entity 37 polymer

Description description	DSS1
Molecular weight formula_weight	3558.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	r

DVSVWEENWEDDIVQDDFNQQLRLEMFR

Entity 38 Entity 38 polymer

Description description	Negative elongation factor A
Molecular weight formula_weight	57343.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	u

MASMRESDTGLWLHNKLGATDELWAPPSIASLLTAAVIDNIRLCFHGLSSAVKLKLLLGTLHLPRRTVDEMKGALMEIIQLASLDSDPWVLMVADILKSFPDTGSLNLELEEQNPNVQDILGELREKVGECEASAMLPLECQYLNKNALTTLAGPLTPPVKHFQLKRKPKSATLRAELLQKSTETAQQLKRSAGVPFHAKGRGLLRKMDTTTPLKGIPKQAPFRSPTAPSVFSPTGNRTPIPPSRTLLRKERGVKLLDISELDMVGAGREAKRRRKTLDAEVVEKPAKEETVVENATPDYAAGLVSTQKLGSLNNEPALPSTSYLPSTPSVVPASSYIPSSETPPAPSSREASRPPEEPSAPSPTLPAQFKQRAPMYNSGLSPATPTPAAPTSPLTPTTPPAVAPTTQTPPVAMVAPQTQAPAQQQPKKNLSLTREQMFAAQEMFKTANKVTRPEKALILGFMAGSRENPCQEQGDVIQIKLSEHTEDLPKADGQGSTTMLVDTVFEMNYATGQWTRFKKYKPMTNVS

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 39 Entity 39 polymer

Description description	;NELF-B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B,Negative elongation factor B ;
Molecular weight formula_weight	68587.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	v

XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMFAGLQDLGVANGEDLKETLTNCTEPLKAIEQFQTENGVLLPSLQSALPFLDLHGTPRLEFHQSVFDELRDKLLERVSAIASEGKAEERYKKLEDLLEKSFSLVKMPSLQPVVMCVMKHLPKVPEKKLKLVMADKELYRACAVEVKRQIWQDNQALFGDEVSPLLKQYILEKESALFSTELSVLHNFFSPSPKTRRQGEVVQRLTRMVGKNVKLYDMVLQFLRTLFLRTRNVHYCTLRAELLMSLHDLDVGEICTVDPCHKFTWCLDACIRERFVDSKRARELQGFLDGVKKGQEQVLGDLSMILCDPFAINTLALSTVRHLQELVGQETLPRDSPDLLLLLRLLALGQGAWDMIDSQVFKEPKMEVELITRFLPMLMSFLVDDYTFNVDQKLPAEEKAPVSYPNTLPESFTKFLQEQRMACEVGLYYVLHITKQRNKNALLRLLPGLVETFGDLAFGDIFLHLLTGNLALLADEFALEDFCSSLFDGFFLTASPRKENVHRHALRLLIHLHPRVAPSKLEALQKALEPTGQSGEAVKELYSQLGEKLEQLDHRKPSPAQAAETPALELPLPSVPAPAPL

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 40 Entity 40 polymer

Description description	Negative elongation factor C/D
Molecular weight formula_weight	65748.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	w

SNMDEDYYGSAAEWGDEADGGQQEDDSGEGEDDAEVQQECLHKFSTRDYIMEPSIFNTLKRYFQAGGSPENVIQLLSENYTAVAQTVNLLAEWLIQTGVEPVQVQETVENHLKSLLIKHFDPRKADSIFTEEGETPAWLEQMIAHTTWRDLFYKLAEAHPDCLMLNFTVKLISDAGYQGEITSVSTACQQLEVFSRVLRTSLATILDGGEENLEKNLPEFAKMVCHGEHTYLFAQAMMSVLAQEEQGGSAVRRIAQEVQRFAQEKGHDASQITLALGTAASYPRACQALGAMLSKGALNPADITVLFKMFTSMDPPPVELIRVPAFLDLFMQSLFKPGARINQDHKHKYIHILAYAASVVETWKKNKRVSINKDELKSTSKAVETVHNLCCNENKGASELVAELSTLYQCIRFPVVAMGVLKWVDWTVSEPRYFQLQTDHTPVHLALLDEISTCHQLLHPQVLQLLVKLFETEHSQLDVMEQLELKKTLLDRMVHLLSRGYVLPVVSYIRKCLEKLDTDISLIRYFVTEVLDVIAPPYTSDFVQLFLPILENDSIAGTIKTEGEHDPVTEFIAHCKSNFIMVN

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 41 Entity 41 polymer

Description description	UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK
Molecular weight formula_weight	1890.3 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	x

XXXXXXXXXXXXXXXXXXXXXX

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 42 Entity 42 non-polymer

Description description	ZINC ION
Molecular weight formula_weight	65.4 kDa
Source method src_method	syn
Copy count entity_count	10

Entity 43 Entity 43 non-polymer

Description description	MAGNESIUM ION
Molecular weight formula_weight	24.3 kDa
Source method src_method	syn
Copy count entity_count	1

Entity 44 Entity 44 non-polymer

Description description	MANGANESE (II) ION
Molecular weight formula_weight	54.9 kDa
Source method src_method	syn
Copy count entity_count	2

▶

Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	—

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	4.10 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	80717

Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex

1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA-directed RNA polymerase subunit

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerase subunit beta

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerase II subunit RPB3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

RNA polymerase II subunit D

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerase II subunit E

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerases I, II, and III subunit RPABC2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerase II subunit RPB7

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerases I, II, and III subunit RPABC3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerase II subunit RPB9

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA-directed RNA polymerases I, II, and III subunit RPABC5

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer