8uev

In-situ complex I, Deactive class04

Method: ELECTRON MICROSCOPY D_max: 218.1 Å Quality: GOOD

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

下载 Download SAXS (.dat) P(r) (.pr.out) CIF

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1. 结构基本信息 1. Structure Basics

条目编号 entry_id	8uev
沉积日期 deposition_date	2023-10-02
结构标题 title	In-situ complex I, Deactive class04
关键词 keywords	in-situ cryo-EM structure, mammalian, mitochondria, respiratory supercomplex, proton pumping, membrane protein, electron transport; ELECTRON TRANSPORT
实验方法 method	ELECTRON MICROSCOPY

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2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)

回转半径 Rg (Guinier) rg_guinier	80.50 Å
回转半径 Rg (电子) rg_electron	80.59 Å
零角强度 I(0) i0	11755100000.00
分子量 molecular_weight	956140.0 kDa
排除体积 excluded_volume	1209700 Å³
包络体积 envelope_volume	1686100 Å³
水化壳体积 shell_volume	178660 Å³
包络直径 envelope_diameter	295.6 Å
壳层 Rg shell_rg	74.44 Å
包络 Rg envelope_rg	79.48 Å
形状 Rg shape_rg	80.63 Å
总 Rg total_rg	80.36 Å
总原子数 total_atoms	67103
残基数 n_residues	8233
球谐函数阶数 n_harmonics	20
q 范围 q_range	— – 0.5000 Å⁻¹
数据点数 n_points	101
壳层类型 shell_type	directional
溶剂电子密度 solvent_density	0.3340 e/Å³
壳层衬度 contrast_shell	0.0300 e/Å³
CRYSOL 版本 crysol_version	4.1.3

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3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)

最大尺寸 Dmax dmax	218.1 Å
Rg (实空间) rg_real	77.29 Å
Rg 误差 (实空间) rg_real_error	0.86 Å
I(0) (实空间) i0_real	1.1450e+10
I(0) 误差 (实空间) i0_real_error	2.1390e+08
Rg (倒空间) rg_reciprocal	78.37 Å
I(0) (倒空间) i0_reciprocal	11690000000.0000
解质量估计 total_estimate	0.8733
解质量评级 solution_quality	GOOD a GOOD solution
P(r) 峰数 n_peaks	2
主峰位置 r_peak_primary	80.3 Å
偏度 Skewness skewness	0.340
峰度 Kurtosis kurtosis	-0.697
角度范围 angular_range	— – 0.0950 Å⁻¹
当前正则化参数 α current_alpha	0.0874
最高正则化参数 α highest_alpha	582900000.0000
实空间数据点数 n_real_points	20
GNOM 版本 gnom_version	4.1.3
质量判据 quality_criteria	AN1: 0.000; Oscil: 0.951; Stabil: 0.981; Sysdev: 1.000; Positv: 1.000; Valcen: 1.000; Smooth: 0.001

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合体信息 (58)

Entity 1 polymer

描述 description	NADH-ubiquinone oxidoreductase chain 3
分子量 formula_weight	13026.5 kDa
EC 编号 ec_number	7.1.1.2
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1A
原子数 atom_count	67103

MNIMLTLLTNVTLASLLVLIAFWLPQLNAYSEKTSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWASQTNNLKTMLTMALFLLILLAASLAYEWTQKGLEWAE

Entity 2 polymer

描述 description	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
分子量 formula_weight	28500.2 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1B

MRNVSTQVPVSAHRPSRFGQRPRIPGALQRTDRRGCLKAEAEMAALAASGLLRPILALRSSMGAAVQVRFVHPSAATDSPSSSQPAVSQAGAVVSKPTTLPSSRGEYVVAKLDDLVNWARRSSLWPMTFGLACCAVEMMHMAAPRYDMDRFGVVFRASPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRYVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPTAEALLYGILQLQRKIKREKRLRIWYRR

Entity 3 polymer

描述 description	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
分子量 formula_weight	30154.3 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1C

MAAAAAARGCWRGLVGPAAVARVSGRPSVLLLPVRKESAAADTRPTIRPRNDVVHKQLSAFGQYVAEILPKYVQQVQVSCFNELEIFIHPDGVIPVLTFLRDHTNAQFKSLADLTAVDVPTRQNRFEIVYNLLSLRFNSQIRVKTYTDELTPIESSVTVYKAANWYEREIWDMFGVFFANHPDLRRILTGYGFEGHPFRKDFPLSGYVELRYDDEVKRVVAEPVELAQEFRKFDLNSPWEAFPAYRQPPEDLKLEAGDKKPETK

Entity 4 polymer

描述 description	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
分子量 formula_weight	54168.1 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1D

MAALRALCSLRGVAAQVLRPGAGARLPIQPSRGARQWQPDVEWAEQFGGAVMYPTKETAHWKPPPWNGNYYWPNYFPLLSDVDPPKDTLVSNLTLNFGPQHPAAHGVLRLVMELSGEMVRKCDPHIGLLHRGTEKLIEYKTYLQALPYFDRLDYVSMMCNEQAYSLAVEKLLNIQPPPRAQWIRVLFGEITRLLNHIMAVTTHALDIGAMTPFFWMFEEREKMFEFYERVSGARMHAAYIRPGGVHQDLPLGLLDDIYEFSKNFSFRIDELEEMLTNNRIWRNRTVDIGVVTAEDALNYGFSGVMLRGSGIQWDLRKTQPYDVYDQVEFDVPIGSRGDCYDRYLCRVEEMRQSLRIISQCLNKMPPGEIKVDDAKVSPPKRAEMKTSMESLIHHFKLYTEGYQVPPGATYTAIEAPKGEFGVYLVSDGSSRPYRCKIKAPGFAHLAGLDKMSKGHMLADVVAIIGTQDIVFGEVDR

Entity 5 polymer

描述 description	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
分子量 formula_weight	27439.5 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1E

MFLTAALRARATGFTAQWGRHVRNLHKTAVQNGAGGALFVHRDTPENNPDTPFDFTPENYKRIEAIVKNYPEGHKAAAVLPVLDLAQRQNGWLPISAMNKVAEILQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRNSDSILEAIQKKLGIKVGETTPDKLFTLIEVECLGACVNAPMVQINDNYYEDLTPKDIEEIIDELKAGKIPKPGPRSGRFSCEPAGGLTSLTEPPKGPGFGVQAGL

Entity 6 polymer

描述 description	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
分子量 formula_weight	50637.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1F

MLAARRLLGGSLPARVSVRFSGDTTAPKKTSFGSLKDEDRIFTNLYGRHDWRLKGAQSRGDWYKTKEILLKGPDWILGEVKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEGEPGTCKDREIIRHDPHKLVEGCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYEAGLIGKNACGSGYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGVFGCPTTVANVETVAVSPTICRRGGAWFASFGRERNSGTKLFNISGHVNHPCTVEEEMSVPLKELIEKHAGGVIGGWDNLLAVIPGGSSTPLIPKSVCETVLMDFDALVQAQTGLGTAAVIVMDRSTDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFVKGDARPAEIDSLWEISKQIEGHTICALGDGAAWPVQGLIRHFRPELEERMQQFALQHQARQAAS

Entity 7 polymer

描述 description	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
分子量 formula_weight	79627.4 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1G

MLRIPVTRALIGLSKSPKGCVRTTATAASNLIEVFVDGQSVMVEPGTTVLQACEKVGMQIPRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMMFGSDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCTRCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPVGALTSKPYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQRLTQPMIRNEKGLLTYTTWEDALSRVAGMLQSFQGNDVAAIAGGLVDAEALVALKDLLNRVDSDSLCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVILLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYRYDHLGDSPKILQDIASGNHPFSQILKEAKKPMVVLGSSALQRSDGTAILAAVSNIAQNIRLSSGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVLFLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPMADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLPYDTLDQVRSRLEEVSPNLVRYDDVEGANYFQQANELSKLVNQQLLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGIQAVEEPSIC

Entity 8 polymer

描述 description	NADH-ubiquinone oxidoreductase chain 1
分子量 formula_weight	35619.4 kDa
EC 编号 ec_number	7.1.1.2
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1H

MFMINILSLIIPILLAVAFLTLVERKVLGYMQLRKGPNVVGPYGLLQPIADALKLVTKEPLRPGTSSISMFIIAPILGLSLALTMWVPLPMPYPLINMNLGVLFMLAMSSLAVYSILWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSVLLMNGSYTLSTLITTQEHIWMIFTSWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFAMFFMAEYANIIMMNAFTAILFLGASHDPHTPELYTINFVLKTLALTITFLWIRASYPRFRYDQLMHLLWKSFLPLTLALCMWHISLPIMTASIPPQS

Entity 9 polymer

描述 description	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
分子量 formula_weight	27135.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1I

MEASQECRLRLSVDRPPPHGKERQRFKMRCLSTPMLLRALAQAQAAHAGHPSARTLHSSAVAATYKFVNMREPSMDMKSVTDRAAQTLLWTELVRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAVCPAQAITIEAEPRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLNNGDKWEAEIAANIQADYLYR

Entity 10 polymer

描述 description	NADH-ubiquinone oxidoreductase chain 6
分子量 formula_weight	19049.3 kDa
EC 编号 ec_number	7.1.1.2
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1J

MTMYIAFILSTIFVIGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLNFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEMYPEVWVSNKTVFGAFVSGLMMEFCMVYYALKEEEVEIIFKFNGLGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWSLLIGVVVIMEITRGN

Entity 11 polymer

描述 description	NADH-ubiquinone oxidoreductase chain 4L
分子量 formula_weight	10855.3 kDa
EC 编号 ec_number	7.1.1.2
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1K

MPLVYMNIIMAFAIALAGLLMYRSHLMSSLLCLEGMMLSLFIMSTLIILNTHFTLANMMPIILLVFAACEAALGLSLLVMVSNTYGTDYVQNLNLLQC

Entity 12 polymer

描述 description	NADH-ubiquinone oxidoreductase chain 5
分子量 formula_weight	68723.5 kDa
EC 编号 ec_number	7.1.1.2
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1L

MNPFASLTLTTLIILTIPIMMSNSNIYKTNLYPNYVKTTVSYAFTLSLVPLLMFMHTGQEMIISNWHWMTLQTVELSLSFKMDYFSVMFIPVALFVTWSIMEFSMWYMHSDPFINRFFKYLVLFLITMMILVTANNLFQLFIGWEGVGIMSFLLIGWWHGRTDANTAALQAILYNRIGDIGFVLSMAWFLTHSNAWDLQQIFMLNNECPNMPLIGLLLAAAGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGVFLLIRFYPLMETNKLVQTMTLCLGAITTLFTALCAITQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICMHAFFKAMLFMCSGSIIHSLNDEQDIRKMGGLYKAMPFTTTALIIGSLALTGMPYLTGFYSKDLIIEAVNMSYTNAWALLMTLIATSLTAAYSTRIIFFAFLGKPRFPPLVLINENNPLLINSIKRLLIGSIFAGFIISNNIPPMTVPNTTMPLYMKMTALIVTIMGFMLALELNNTTYYLKFKYPSQTYKFSNMLGYYPSIMHRLPTYHNLSMSQKSASSLLDLIWLETILPKTTSFIQMKMSIMVSNQKGLIKLYFLSFLITIMISMTLFNYHE

Entity 13 polymer

描述 description	NADH-ubiquinone oxidoreductase chain 4
分子量 formula_weight	51887.4 kDa
EC 编号 ec_number	7.1.1.2
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1M

MLKIIIPTTMLLPMTWMSKHNMIWINATVHSLLISLISLSLLNQLGENSLNFSLTFFSDSLSAPLLVLTTWLLPLMLMASQSHLSKETTTRKKLYITMLILLQLFLIMTFTATELILFYILFEATLVPTLIIITRWGNQTERLNAGLYFLFYTLAGSLPLLVALVYIQNTTGSLNFLIIHYWSHPLSNSWSNIFMWLACIMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAVLLKLGGYGMMRITTILNPLTNYMAYPFLMLSMWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAIMIQTPWSFMGATALMIAHGLTSSMLFCLANTNYERVHSRTMILARGLQTLLPLMATWWLMASLTNLALPPSINLIGELFIITASFSWSNITIILMGMNMMITALYSLYMLITTQRGKYTHHINNIKASFTRENALMALHILPLLLLTLNPKMILGPLY

Entity 14 polymer

描述 description	NADH-ubiquinone oxidoreductase chain 2
分子量 formula_weight	39105.5 kDa
EC 编号 ec_number	7.1.1.2
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1N

MNPIIYTTLIMTVMSGTMLVMISSHWLLIWIGFEMNLLAMIPVLMKNFNPRATEAATKYFLTQATASMMLMMAIIINLLYSGQWTITKMFNPVAMTMMTMALAMKLGLSPFHFWVPEVTQGISLQAGLLLLTWQKLAPLSVLCQISQSINPNLMLTMAMLSILIGGWGGLNQTQLRKIMAYSSIAHMGWMTAVLPYNTTMTILNLLIYITMTLAMFMLLIHSSATTTLSLSHTWNKMPVITSLMMVTLLSMGGLPPLSGFMPKWMIIQEMTKNESIIMPTLMAMTALLNLYFYMRLAYSSSLTMFPSTNNMKMKWQFEHTKQMKLLPTMIVLSTLVLPMTPALSSLN

Entity 15 polymer

描述 description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
分子量 formula_weight	40476.1 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1O

MALRLLRLAPASASAVPRGLGAVAQRVGGIHTGAPCRLQYGPLAFVLGERTTRKLTETSKVITVDGNICSGKGRLAREIAEKLGLRHFPEAGIHYADSTTGDGKPLDVQLSGNCSLEKFYDDPKSNDGNSYRLQSWLYASRLLQYADALEHLLSTGQGVVLERSIYSDFVFLEAMYRQGFIRKQCVEHYNEVKKVTACEYLPPHVVVYVDVPVPEIQSRIQKKGNPHEMKITAAYLQDIENAYKKTFLPEMSEKCEVLQYSAREAEDAEKVVEDIEYLKCDKGPWPDQDDRTFHRLRMLVQNKLEVLNYTTIPVYLPEITIGAHQSDRVFQKFTELPGRKYSPGYNEDVGDKWIWLK

Entity 16 polymer

描述 description	NADH:ubiquinone oxidoreductase subunit A9
分子量 formula_weight	42606.3 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1P

MAAAVHPRVVRAVPMSRSCLAAVATSVSYGPPQRQLHHALIPHGKGGRSSVSGIVATVFGATGFLGRYVVNHLGRMGSQVIVPYRCEPYDTMHLRPMGDLGQIIFMEWNGKDKDSIRKVVEHSNVVINLVGREWETKNFDFEDVFVKIPHAIAQVSKEAGVEKLIHISHLNADIKSPSRYLRSKAVGEKEVRAAFPEATIIKPSDIFGREDRFLNYFASMRWFGGVPLISLGKETVKQPVYIVDVSKGIINAIKDPDAKGKTFAFVGPNRYLLFDLVQYIFAVAYRPFLPYPLPHFAYRWVGRLFEVSPFEPWTTRDKVERVHMSDMTLPHLPGLEDLGIQATPLELKAIEVLRRHRTYRWLTSEMEDVKPAKTVNI

Entity 17 polymer

描述 description	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
分子量 formula_weight	19746.5 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1Q

MAAVSMSVALKQALWGRRAAAVGAVSVSKVPTRLLSTSTWRLAQDQTQDTQLIAVDEKLDITTLTGVPEEHIKTRKVRIFVPARNNMQSGVNNTKKWKMEFDTRERWENPLMGWSSTADPLSNLVLTFSTKEDAVAFAEKNGWSFDVEERKVPKPKSKSYGANFSWNKRTRVSTK

Entity 18 polymer

描述 description	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
分子量 formula_weight	13349.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1R

MAAVTFLRLLGRSGAGARNLLGGSRCFGVRTSPTGEKVTHTGQAYDDGDYRRVRFSDRQKEVNENFAIDLIAEQPVSEVGSRVISCDGGGGALGHPRVYINLDKETKTGTCGYCGLQFRQPHH

Entity 19 polymer

描述 description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
分子量 formula_weight	11099.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1S

MAAAAASRGIRAKLGLREIRIHLCQRSPGSQGVRDFIEKRYVELKKANPDLPILIRECSDVQPKLWARYAFGQEKNVSLNNFSADQVTRTLENVLSGKA

Entity 20 polymer

描述 description	NADH:ubiquinone oxidoreductase subunit AB1
分子量 formula_weight	17338.2 kDa
来源方法 src_method	nat
拷贝数 entity_count	2

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1T,1U

MAARVLCACVRRLPAAFAPLPRIPTVVAARPLSTTLFPTGAQARSRALQPALVLAQAPSGVTQLCRRYSDAPPLTLEAIKDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKKDVYE

Entity 21 polymer

描述 description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1
分子量 formula_weight	13321.6 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1V

MAGLLKKTTGLVGLAVCETPHERLKILYTKILDVLGQIPKNAAYRKYTEQITNEKLGMVKAEPDVKKLEEQLQGGQIEEVILQAENELSLARKMLRWKPWEPLVEEPPANQWKWPI

Entity 22 polymer

描述 description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
分子量 formula_weight	14953.3 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1W

MAASGLPRAAAAAGTSVKPIFSRDMNEAKRRVRELYRAWYREVPNTVHLFQLDISVKQGRDKVREMFMKNAHVTDPRVVDLLVIKGKMELEETINVWKQRTHIMRFFHETEAPRPTDFLSKFYVGHDP

Entity 23 polymer

描述 description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
分子量 formula_weight	20064.1 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1X

MPGIVELPTLEDLKVQEVKVSSSVLKAAAHHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNQCALDFFRQIKRHCAEPFTEYWTCIDYSGLQLFRHCRKQQAKFDECVLDKLGWVRPDLGELSKVTKVKTDRPLPENPYHSRARPEPNPEAEGDLKPAKHGSRLFFWTM

Entity 24 polymer

描述 description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
分子量 formula_weight	14686.9 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1Y

MAKTLLHKYSDIPEGTECHRKAYASTSIGGATGLIVSAYSIALKPPASFLEGVARTGRYTFTSAAIGAIFGLTSCISAQVREKPDDPLNYFIGGCAGGLTLGARTRSYGIGAAACAYMGLTAALVKMGQLEGWQVFAEPKV

Entity 25 polymer

描述 description	NADH:ubiquinone oxidoreductase subunit A13
分子量 formula_weight	16911.6 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1Z

MAASKVKQDMPPPGGYGPIDYKRNLPRRGLSGYSMFAVGIGTLLFGYWSMMKWNRERRRLQIEDFEARIALMPLFQAEKDRRVLQMLRENLEEEAIIMKDVPDWKVGESVFHTTRWVTPMMGELYGLRTNEEILSATYGFIWYT

Entity 26 polymer

描述 description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
分子量 formula_weight	8034.4 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1a

MWFEILPGIAVMAACLFIPGMATAHIHKFTNGGKEKRVAHFSYQWNLMERDRCISGVNRYHVTKGLENID

Entity 27 polymer

描述 description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
分子量 formula_weight	9225.6 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1b

MAGRIASFLKNAWAKEPVLVASFAIGGLAIILPSLSPYTNYAIRINRATPYNYPVPLRDDGNMPDVPSHPQDPQGPSLEWLKNL

Entity 28 polymer

描述 description	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
分子量 formula_weight	8664.1 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1c

MAASALFRPFSKLLSSARLPSGSSARSKFYIREPPHGSPDWLKVGLTLGTSVFLWIYLIKQHKEDVLEYKRRNGLE

Entity 29 polymer

描述 description	NADH dehydrogenase [ubiquinone] 1 subunit C2
分子量 formula_weight	14353.7 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1d

XMTMMSGRPGRVPLQFLPNEARSLPPPKLTDPRLVYMGFLGYCSGLIDNAIRRRPVVSAGLHRQLLYVTSFVFFGYYLLKRQDYMYALRDHDMFAYVKSHPEDFPEKDKKTYGEILEEFHPVR

Entity 30 polymer

描述 description	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
分子量 formula_weight	12506.6 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1e

MPFFDVQKRLGLDLDRWMTIQSAEQPHKIPGRCHAFEKEWIECAHGIGGIRAEKECKIEFDDFVECLLRQKTMKRLSAIKRQRDKLIKEGKYTPPPHHLGKEDPRP

Entity 31 polymer

描述 description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [Sus scrofa]
分子量 formula_weight	15371.9 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1f

MAAAILKLEETRGGGEKCDKNQGVKGRRFMISRSHPSLRAGPANGRSRGHSFRRRWWLGSPLPLVVGVVVGSEAAAFMMNVLQIVRDHWVHILVPVGFVFGCYLDRRSDEKLTAFRNKSLLFKRELRPNEEVTWK

Entity 32 polymer

描述 description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
分子量 formula_weight	17384.7 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1g

MAAGVLGLCARRLLAAAATRGLPAARVRWESGSSRAVIAPSALVGKRPPEPTIRLQEDPDPEDENLYEKNPDSHGYDKDPIVDLWNMRVVFFFGFSIVLVLGSTFVAYLPDYRMQEWARREAERLVKYREANGLPLMESNCFDPNKIQLPEDED

Entity 33 polymer

描述 description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
分子量 formula_weight	21587.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1h

MAAMSLLQRASVTAVATLSRSRLGTRFGFGGFLTHGFPKTGAPVRHSGDHGKRLFIIKPSGFYDRRFLKLMRFYILLTGIPVAIGITLVNVFIGEAELADIPEGYVPEHWEYFKHPISRWIARTFYDGPEKNYEKTMAILQIEAEKAELRLKELEVRRLMRARGDGPWYQYPTIDKALIDHSPKTTPDN

Entity 34 polymer

描述 description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
分子量 formula_weight	15645.2 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1i

MSGYTPDEKLRLQQLRELRRRWLKDQELSPREPVLPPRRVWPMEQFWNKFLQDGAPWKNVIYKTYRHSIFAVTHVLIPVWIIHYYLKYHVTAKPYTVVERKPRIFPGDTILETGEVIPLMKEFPDQHH

Entity 35 polymer

描述 description	NADH:ubiquinone oxidoreductase subunit B2
分子量 formula_weight	11939.4 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1j

MSPLQRLAPFTRVGGRFLRGRGAGVAGGGGVRHAGGGVHIEPRYRQFPQLTRSQLIQAEFFSATMWFWILWRFWHDSDAVLGHFPYPDPSQWTDEELGILPDDED

Entity 36 polymer

描述 description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
分子量 formula_weight	11128.5 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1k

MAHGHGHEHGHSKMELPDYKQWKIEGTPLETVQEKLAARGLRDPWGRNEAWRYSGGFANNVSFVGALLKGFKWGFAAFVVAVGAEYYLESQNKDKKHH

Entity 37 polymer

描述 description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
分子量 formula_weight	21658.4 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1l

MASAKAGVLGVRWLQRAARKVVPLGARTASHVTKDMFPGPYPKTPEERAAAAKKYNMRVEDYEPYPDDGMGYGDYPKLPDRSQQERDPWYDWDHPDLRLNWGEPIHWDLDMYIRNRVDTSPTPVSWNTMCKHLSGFVAFMLFMFWVGEIYPSYQPVGPKQYPYNDLYLERGGDPTKEPEPVVHYEI

Entity 38 polymer

描述 description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
分子量 formula_weight	15117.4 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1m

MSFPKYKPSRLATLPATLDPAEYDISPETRKAQAERLAIRSRLKREYLLQYNDPNRLGVIEDPALIRWTYARSANIYPNFRPTPKTSLLGALFGIGPLFFWYYVFKTDRDKKEKLIQEGKLDQTFNISY

Entity 39 polymer

描述 description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
分子量 formula_weight	21864.9 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1n

MAFSAPAAYLTHQQKVLRLYKRALRHLESWCVHRDKYRYFACLMRARFDEHKNEKDMVKATQLLRQAEEEFWYGQHPQPYIFPESPGGTSYERYECYKVPEWCLDDWHPSEKAMYPDYFAKREQWKRLRRESWEREVKQLQEETPPGGPRTEALPPARKEGDLPPLWWHIVTRPRERPM

Entity 40 polymer

描述 description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
分子量 formula_weight	16487.9 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1o

MGAHLARRYLGDASKEPDPLRMPTFPPDYGFPERKEREMVATQQEMNDAQLMLQQRDYCAHYLIQLLKCKRDSFPNFLACKHEQHDWDYCEHLDYVKRMKEFERERRLLQRKKRREQREAEMARGQGPGEVAPEMAL

Entity 41 polymer

描述 description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
分子量 formula_weight	20944.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1p

MPDSWDKDVYPEPPRRTPAPAPQTSLPNPVTYLTKIFDLLVDRPVTLAREFIEQQHAKNRYYYYHREFRRVPDITECEEKDILCMFEAEMQWRRDYKVDQEIVNIIQERLKACQQREGESYRQNCAKELEQFTQVSKAFQDRYSDLGAHYSARKCLAKQKQRMLAERKAAKEAAAA

Entity 42 polymer

描述 description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
分子量 formula_weight	17162.4 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1q

MELVQVLRRGLQQVSGHGGLRGYLRVLFRANDVRVGTLVGEDKYGNKYYEDNKQFFGRHRWVIYTTEMNGRDTFWDVDGSMVPPEWHRWLHCMTDDPPTTKPPTARKYIWTNHKFNVSGTPQQYVPYSTTRKKIQEWVPPSTPYK

Entity 43 polymer

描述 description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
分子量 formula_weight	12674.6 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1r

MXASATRVIQLLRNWASGRDLQAKLQLRYQEISKRTQPPPKLPVGPSHKLSNNYYCTRDGRREAMPPSIVMSSQKVLASGKPAESSAVAETEKKAVTPAPPIKRWELSKDQPYL

Entity 44 polymer

描述 description	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
分子量 formula_weight	48217.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	1s

MAASLLLRQGRARALKTVLLEGGVFRGLAPAVSLSAESGRNEKERPPNPKKQSPPKNVVAAQEGGTPLATPAAPELSQQLSSPTSPPAAARPGGTLAPPNPGDSTLFTDRGRPRFPSRKTLVEFPRKVLSPFSQQGSDSAATQASRGRAGDATSSSSSSSSSDSESDDEEEGDGSEAVRPVKSTSPGGSPKAEAPRSLAGGAPQTGVPAEARPGPQQPHPDLAAAERPRQAKGKGGSGAPEDRRAPKAAAPGSRGGPGAARQSETPSQKIPRSEEADAESQKPPEVKTSLPDPTKSGLSTAPRGGPASAEPAATPAGARLPATPLETGERPLGERVPEPGGQVASPLFSRAPLGGQAAEGVAEAKGELLEGRPLVQGPKAVPDGQDEGAEKKALRPEEEAGIAGDAAPGTAGRDATQEPTPAAAAAEPFDNSTYRNLQHHEYSTYTFLDLNVELSKFRMPQPSSGRQSPRH

Entity 45 non-polymer

描述 description	1,2-Distearoyl-sn-glycerophosphoethanolamine
分子量 formula_weight	748.1 kDa
来源方法 src_method	syn
拷贝数 entity_count	6

Entity 46 non-polymer

描述 description	IRON/SULFUR CLUSTER
分子量 formula_weight	351.6 kDa
来源方法 src_method	syn
拷贝数 entity_count	6

Entity 47 non-polymer

描述 description	FE2/S2 (INORGANIC) CLUSTER
分子量 formula_weight	175.8 kDa
来源方法 src_method	syn
拷贝数 entity_count	2

Entity 48 non-polymer

描述 description	FLAVIN MONONUCLEOTIDE
分子量 formula_weight	456.3 kDa
来源方法 src_method	syn
拷贝数 entity_count	1

Entity 49 non-polymer

描述 description	POTASSIUM ION
分子量 formula_weight	39.1 kDa
来源方法 src_method	syn
拷贝数 entity_count	1

Entity 50 non-polymer

描述 description	1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE
分子量 formula_weight	790.1 kDa
来源方法 src_method	syn
拷贝数 entity_count	5

Entity 51 non-polymer

描述 description	MYRISTIC ACID
分子量 formula_weight	228.4 kDa
来源方法 src_method	syn
拷贝数 entity_count	1

Entity 52 non-polymer

描述 description	(1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE
分子量 formula_weight	751.0 kDa
来源方法 src_method	syn
拷贝数 entity_count	1

Entity 53 non-polymer

描述 description	CARDIOLIPIN
分子量 formula_weight	1464.0 kDa
来源方法 src_method	syn
拷贝数 entity_count	2

Entity 54 non-polymer

描述 description	GUANOSINE-5'-TRIPHOSPHATE
分子量 formula_weight	523.2 kDa
来源方法 src_method	syn
拷贝数 entity_count	1

Entity 55 non-polymer

描述 description	MAGNESIUM ION
分子量 formula_weight	24.3 kDa
来源方法 src_method	syn
拷贝数 entity_count	1

Entity 56 non-polymer

描述 description	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
分子量 formula_weight	745.4 kDa
来源方法 src_method	syn
拷贝数 entity_count	1

Entity 57 non-polymer

描述 description	ZINC ION
分子量 formula_weight	65.4 kDa
来源方法 src_method	syn
拷贝数 entity_count	1

Entity 58 non-polymer

描述 description	;~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate ;
分子量 formula_weight	584.7 kDa
来源方法 src_method	syn
拷贝数 entity_count	2

▶

7. 引用文献 (1)

▶

晶胞边长 a length_a	1.000 Å
晶胞边长 b length_b	1.000 Å
晶胞边长 c length_c	1.000 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	90.00 °
晶胞夹角 γ angle_gamma	90.00 °
晶胞分子数 Z z_pdb	—

空间群 space_group	P 1
空间群编号 int_tables_number	1
晶系 crystal_system	—

分辨率 resolution	3.70 Å
分辨率测定方法 resolution_method	—
颗粒数 num_particles	37000

fit	/app/data/saxs_computation/ue/8uev/8uev.fit
pddf	/app/data/pr_computation/ue/8uev/8uev.pr.out
profile	/app/data/saxs_computation/ue/8uev/8uev.dat

In-situ complex I, Deactive class04

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

1. 结构基本信息 1. Structure Basics

2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)

3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

冷冻电镜 EM 3D

5. 实体与聚合体信息 (58)

Entity 1 polymer

聚合体 Polymer

Entity 2 polymer

聚合体 Polymer

Entity 3 polymer

聚合体 Polymer

Entity 4 polymer

聚合体 Polymer

Entity 5 polymer

聚合体 Polymer

Entity 6 polymer

聚合体 Polymer

Entity 7 polymer

聚合体 Polymer

Entity 8 polymer

聚合体 Polymer

Entity 9 polymer

聚合体 Polymer

Entity 10 polymer

聚合体 Polymer

Entity 11 polymer

聚合体 Polymer

Entity 12 polymer

聚合体 Polymer

Entity 13 polymer

聚合体 Polymer

Entity 14 polymer

聚合体 Polymer

Entity 15 polymer

聚合体 Polymer

Entity 16 polymer

聚合体 Polymer

Entity 17 polymer

聚合体 Polymer

Entity 18 polymer

聚合体 Polymer

Entity 19 polymer

聚合体 Polymer

Entity 20 polymer

聚合体 Polymer

Entity 21 polymer

聚合体 Polymer

Entity 22 polymer

聚合体 Polymer

Entity 23 polymer

聚合体 Polymer

Entity 24 polymer

聚合体 Polymer

Entity 25 polymer

聚合体 Polymer

Entity 26 polymer

聚合体 Polymer

Entity 27 polymer

聚合体 Polymer

Entity 28 polymer

聚合体 Polymer

Entity 29 polymer

聚合体 Polymer

Entity 30 polymer

聚合体 Polymer

Entity 31 polymer

聚合体 Polymer

Entity 32 polymer

聚合体 Polymer

Entity 33 polymer

聚合体 Polymer

Entity 34 polymer

聚合体 Polymer

Entity 35 polymer