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9k6q

"Cryo-EM Structure of hAGO2D669A-siRNA-target (14-nt, sesqui-lobed)

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Protein argonaute-2

Homo sapiens

UniProt Q9UKV8

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Monomer Protein 1 RNA 2 ;RNA (5'-R(P*UP*AP*CP*AP*AP*GP*AP*GP*CP*CP*UP*UP*UP*CP*UP*GP*U)-3') ; × 1 ;RNA (5'-R(P*GP*AP*AP*AP*GP*GP*CP*UP*CP*UP*UP*GP*U)-3') ; × 1 MAGNESIUM ION × 1 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
3luc 3luc 3luc 3lud 3lud 3lud 3lug 3lug 3lug 3luh 3luh 3luh

39 assemblies; showing the first 12

Homodimer

None

Homotetramer

None

Other homooligomers
9bez 9bf0 9bf2

3 assemblies

Heteromeric or nucleic-acid complex
10be 11gi 11gj 11gk 4f3t 4ola 4olb 4w5n 4w5o 4w5q 4w5r 4w5t

55 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name AGO2_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain A； PDBConstruct 1–859； UniProt 1–859

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9k6q
Deposition date deposition_date2024-10-22
Last revision last_revision2025-06-25
Structure title title"Cryo-EM Structure of hAGO2D669A-siRNA-target (14-nt, sesqui-lobed)
Keywords keywordsArgonaute protein, siRNA, RNA BINDING PROTEIN/RNA, RNA BINDING PROTEIN; RNA BINDING PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9k6q__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9k6q__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9k6q__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）28.27 Å
Rg (electron density)28.31 Å
Total Rg28.97 Å
Atom count6276
Residues737
Excluded volume109650 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9k6q__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)