9n5t

Mycobacterium smegmatis 70S ribosome with small molecule drug MK-7762

Method: ELECTRON MICROSCOPY D_max: 294.2 Å Quality: EXCELLENT

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

下载 Download SAXS (.dat) P(r) (.pr.out) CIF

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1. 结构基本信息 1. Structure Basics

条目编号 entry_id	9n5t
沉积日期 deposition_date	2025-02-04
结构标题 title	Mycobacterium smegmatis 70S ribosome with small molecule drug MK-7762
关键词 keywords	Mycobacterium smegmatis, 70S ribosome, small molecule drug, RIBOSOME; RIBOSOME
实验方法 method	ELECTRON MICROSCOPY

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2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)

回转半径 Rg (Guinier) rg_guinier	85.37 Å
回转半径 Rg (电子) rg_electron	85.45 Å
零角强度 I(0) i0	230018000000.00
分子量 molecular_weight	2112100.0 kDa
排除体积 excluded_volume	1720700 Å³
包络体积 envelope_volume	4053500 Å³
水化壳体积 shell_volume	359920 Å³
包络直径 envelope_diameter	276.7 Å
壳层 Rg shell_rg	100.60 Å
包络 Rg envelope_rg	84.11 Å
形状 Rg shape_rg	85.65 Å
总 Rg total_rg	85.25 Å
总原子数 total_atoms	149258
残基数 n_residues	10698
球谐函数阶数 n_harmonics	20
q 范围 q_range	— – 0.5000 Å⁻¹
数据点数 n_points	101
壳层类型 shell_type	directional
溶剂电子密度 solvent_density	0.3340 e/Å³
壳层衬度 contrast_shell	0.0300 e/Å³
CRYSOL 版本 crysol_version	4.1.3

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3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)

最大尺寸 Dmax dmax	294.2 Å
Rg (实空间) rg_real	87.06 Å
Rg 误差 (实空间) rg_real_error	1.52 Å
I(0) (实空间) i0_real	2.2730e+11
I(0) 误差 (实空间) i0_real_error	4.5680e+09
Rg (倒空间) rg_reciprocal	86.99 Å
I(0) (倒空间) i0_reciprocal	231100000000.0000
解质量估计 total_estimate	0.9033
解质量评级 solution_quality	EXCELLENT a EXCELLENT solution
P(r) 峰数 n_peaks	2
主峰位置 r_peak_primary	114.4 Å
偏度 Skewness skewness	0.306
峰度 Kurtosis kurtosis	-0.065
角度范围 angular_range	— – 0.0900 Å⁻¹
当前正则化参数 α current_alpha	1.2530
最高正则化参数 α highest_alpha	7772000000.0000
实空间数据点数 n_real_points	19
GNOM 版本 gnom_version	4.1.3
质量判据 quality_criteria	AN1: 0.000; Oscil: 0.795; Stabil: 0.921; Sysdev: 1.000; Positv: 1.000; Valcen: 0.907; Smooth: 0.695

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合体信息 (61)

Entity 1 polymer

描述 description	50S Ribosomal Protein L27
分子量 formula_weight	2841.4 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	3
原子数 atom_count	156393

MAKRGRKKRDRKHSKANHGKRPNA

Entity 2 polymer

描述 description	23S rRNA
分子量 formula_weight	1012140.9 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polyribonucleotide
链编号 strand_id	A

UAAGUGUUUAAGGGCGCAUGGUGGAUGCCUUGGCACUGGGAGCCGAUGAAGGACGUAGGAGGCUGCGAUAAGCCUCGGGGAGCUGUCAACCGAGCGUUGAUCCGAGGAUGUCCGAAUGGGGAAACCCGGCACGAGUGAUGUCGUGUCACCAGGCGCUGAAUAUAUAGGCGUCUGGGGGGAACGCGGGGAAGUGAAACAUCUCAGUACCCGUAGGAAGAGAAAACAAAAUGUGAUUCCGUGAGUAGUGGCGAGCGAAAGCGGAGGAUGGCUAAACCGUAUGCAUGUGAUACCGGGUAGGGGUUGUGUGUGCGGGGUUGUGGGACCUAUCUUUCCGGCUCUACCUGGCUGGAGGGCAGUGAGAAAAUGUUGUGGUUAGCGGAAAUGGCUUGGGAUGGCCUGCCGUAGACGGUGAGAGCCCGGUACGUGAAAACCCGACGUCUGUCUUGAUGGUGUUCCCGAGUAGCAGCGGGCCCGUGGAAUCUGCUGUGAAUCUGCCGGGACCACCCGGUAAGCCUGAAUACUUCCCAGUGACCGAUAGCGGAUUAGUACCGUGAGGGAAUGGUGAAAAGUACCCCGGGAGGGGAGUGAAAGAGUACCUGAAACCGUGCGCUUACAAUCCGUCAGAGCCCUCGACGUGUCGUGGGGUGAUGGCGUGCCUUUUGAAGAAUGAGCCUGCGAGUCAGGGACAUGUCGCGAGGUUAACCCGGGUGGGGUAGCCGCAGCGAAAGCGAGUCUGAAUAGGGCGUAUCCACACAAGAGUGUGUGGUGUAGUGGUGUGUUCUGGACCCGAAGCGGAGUGAUCUACCCAUGGCCAGGGUGAAGCGCGGGUAAGACCGCGUGGAGGCCCGAACCCACUUAGGUUGAAGACUGAGGGGAUGAGCUGUGGGUAGGGGUGAAAGGCCAAUCAAACUCCGUGAUAGCUGGUUCUCCCCGAAAUGCAUUUAGGUGCAGCGUCGCAUGUUUCUUGCCGGAGGUAGAGCUACUGGAUGGCCGAUGGGCCCCACAGGGUUACUGACGUCAGCCAAACUCCGAAUGCCGGUAAGUCCAAGAGUGCGGCAGUGAGACGGCGGGGGAUAAGCUCCGUGCGUCGAGAGGGAAACAGCCCAGAUCGCCGGCUAAGGCCCCUAAGCGUGUGCUAAGUGGAAAAGGAUGUGCAGUCGCGAAGACAACCAGGAGGUUGGCUUAGAAGCAGCCACCCUUGAAAGAGUGCGUAAUAGCUCACUGGUCAAGUGAUUGUGCGCCGAUAAUGUAGCGGGGCUCAAGCACACCGCCGAAGCCGCGGCAGCCAACGUGUUGGCUGGGUAGGGGAGCGUCCUGCAUCCGGUGAAGCCGCCGAGUGAUCGAGUGGUGGAGGGUGUGGGAGUGAGAAUGCAGGCAUGAGUAGCGAUUAGGCAAGUGAGAACCUUGCCCGCCGAAAGACCAAGGGUUCCUGGGCCAGGCCAGUCCGCCCAGGGUGAGUCGGGACCUAAGGCGAGGCCGACAGGCGUAGUCGAUGGACAACGGGUUGAUAUUCCCGUACCCGUGUAUGUGCGUCCAUGAUGAAUCAGCGGUACUAACCAUCCAAAACCACCGUGACCGCACCUUUCGGGGUGUGGCGUUGGUGGGGCUGCAUGGGACCUUCGUUGGUAGUAGUCAAGCGAUGGGGUGACGCAGGAAGGUAGCCGUACCGGUCAGUGGUAAUACCGGGGUAAGCCUGUAGGGAGUCAGAUAGGUAAAUCCGUCUGGCAUAUAUCCUGAGAGGUGAUGCAUAGCCGAGUGAGGCGAAUUCGGUGAUCCUAUGCUGCCGAGAAAAGCCUCUAGCGAGGACAUACACGGCCCGUACCCCAAACCAACACAGGUGGUCAGGUAGAGAAUACUAAGGCGUACGAGUGAACUAUGGUUAAGGAACUCGGCAAAAUGCCCCCGUAACUUCGGGAGAAGGGGGACCCACAUGGCGUGUAAGCCUUUACGGCCCAAGCGUGAGUGGGUGGCACAAACCAGUGAGAAGCGACUGUUUACUAAAAACACAGGUCCGUGCGAAGUCGCAAGACGAUGUAUACGGACUGACGCCUGCCCGGUGCUGGAAGGUUAAGAGGACCCGUUAACUCCCUUUGGGGGUGAAGCGGAGAAUUUAAGCCCCAGUAAACGGCGGUGGUAACUAUAACCAUCCUAAGGUAGCGAAAUUCCUUGUCGGGUAAGUUCCGACCUGCACGAAUGGCGUAACGACUUCUCAACUGUCUCAACCAUAGACUCGGCGAAAUUGCACUACGAGUAAAGAUGCUCGUUACGCGCGGCAGGACGAAAAGACCCCGGGACCUUCACUACAACUUGGUAUUGGUGCUCGAUACGGUUUGUGUAGGAUAGGUGGGAGACUGUGAAGCUCACACGCCAGUGUGGGUGGAGUCGUUGUUGAAAUACCACUCUGAUCGUAUUGGGCCUCUAACCUCGGACCGUAUAUCCGGUUCAGGGACAGUGCCUGGUGGGUAGUUUAACUGGGGCGGUUGCCUCCUAAAAUGUAACGGAGGCGCCCAAAGGUUCCCUCAACCUGGACGGCAAUCAGGUGUUGAGUGUAAGUGCACAAGGGAGCUUGACUGCGAGACGGACAUGUCGAGCAGGGACGAAAGUCGGGACUAGUGAUCCGGCACCUCUGAGUGGAAGGGGUGUCGCUCAACGGAUAAAAGGUACCCCGGGGAUAACAGGCUGAUCUUCCCCAAGAGUCCAUAUCGACGGGAUGGUUUGGCACCUCGAUGUCGGCUCGUCGCAUCCUGGGGCUGGAGCAGGUCCCAAGGGUUGGGCUGUUCGCCCAUUAAAGCGGCACGCGAGCUGGGUUUAGAACGUCGUGAGACAGUUCGGUCUCUAUCCGCCGCGCGCGUCAGAAGCUUGAGGAAACCUGUCCCUAGUACGAGAGGACCGGGACGGACGAACCUCUGGUAUACCAGUUGUCCCACCAGGGGCACGGCUGGAUAGCCACGUUCGGACAGGAUAACCGCUGAAAGCAUCUAAGCGGGAAACCUCUUCCAAGACCAGGCUUCUCACCCUCUAGGAGGGAUAAGGCCCCCCGCAGACCACGGGAUUGAUAGACCAGACCUGGAAGCCUAGUAAUAGGUGCAGGGAACUGGCACUAACCGGCCGAAAACUUAC

Entity 3 polymer

描述 description	5S rRNA
分子量 formula_weight	38061.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polyribonucleotide
链编号 strand_id	B

GUUACGGCGGUCCAUAGCGGCAGGGAAACGCCCGGUCCCAUCCCGAACCCGGAAGCUAAGCCUGCCAGCGCCGAUGAUACUACCCAUCCGGGUGGAAAAGUAGGACACCGCCGAACAC

Entity 4 polymer

描述 description	16S rRNA
分子量 formula_weight	495373.7 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polyribonucleotide
链编号 strand_id	BA

UUUUUGUUUGGAGAGUUUGAUCCUGGCUCAGGACGAACGCUGGCGGCGUGCUUAACACAUGCAAGUCGAACGGAAAGGCCCUUUCGGGGGUACUCGAGUGGCGAACGGGUGAGUAACACGUGGGUGAUCUGCCCUGCACUUUGGGAUAAGCCUGGGAAACUGGGUCUAAUACCGAAUACACCCUGCUGGUCGCAUGGCCUGGUAGGGGAAAGCUUUUGCGGUGUGGGAUGGGCCCGCGGCCUAUCAGCUUGUUGGUGGGGUGAUGGCCUACCAAGGCGACGACGGGUAGCCGGCCUGAGAGGGUGACCGGCCACACUGGGACUGAGAUACGGCCCAGACUCCUACGGGAGGCAGCAGUGGGGAAUAUUGCACAAUGGGCGCAAGCCUGAUGCAGCGACGCCGCGUGAGGGAUGACGGCCUUCGGGUUGUAAACCUCUUUCAGCACAGACGAAGCGCAAGUGACGGUAUGUGCAGAAGAAGGACCGGCCAACUACGUGCCAGCAGCCGCGGUAAUACGUAGGGUCCGAGCGUUGUCCGGAAUUACUGGGCGUAAAGAGCUCGUAGGUGGUUUGUCGCGUUGUUCGUGAAAACUCACAGCUUAACUGUGGGCGUGCGGGCGAUACGGGCAGACUAGAGUACUGCAGGGGAGACUGGAAUUCCUGGUGUAGCGGUGGAAUGCGCAGAUAUCAGGAGGAACACCGGUGGCGAAGGCGGGUCUCUGGGCAGUAACUGACGCUGAGGAGCGAAAGCGUGGGGAGCGAACAGGAUUAGAUACCCUGGUAGUCCACGCCGUAAACGGUGGGUACUAGGUGUGGGUUUCCUUCCUUGGGAUCCGUGCCGUAGCUAACGCAUUAAGUACCCCGCCUGGGGAGUACGGCCGCAAGGCUAAAACUCAAAGGAAUUGACGGGGGCCCGCACAAGCGGCGGAGCAUGUGGAUUAAUUCGAUGCAACGCGAAGAACCUUACCUGGGUUUGACAUGCACAGGACGCCGGCAGAGAUGUCGGUUCCCUUGUGGCCUGUGUGCAGGUGGUGCAUGGCUGUCGUCAGCUCGUGUCGUGAGAUGUUGGGUUAAGUCCCGCAACGAGCGCAACCCUUGUCUCAUGUUGCCAGCACGUUAUGGUGGGGACUCGUGAGAGACUGCCGGGGUCAACUCGGAGGAAGGUGGGGAUGACGUCAAGUCAUCAUGCCCCUUAUGUCCAGGGCUUCACACAUGCUACAAUGGCCGGUACAAAGGGCUGCGAUGCCGUGAGGUGGAGCGAAUCCUUUCAAAGCCGGUCUCAGUUCGGAUCGGGGUCUGCAACUCGACCCCGUGAAGUCGGAGUCGCUAGUAAUCGCAGAUCAGCAACGCUGCGGUGAAUACGUUCCCGGGCCUUGUACACACCGCCCGUCACGUCAUGAAAGUCGGUAACACCCGAAGCCGGUGGCCUAACCCUUGUGGAGGGAGCCGUCGAAGGUGGGAUCGGCGAUUGGGACGAAGUCGUAACAAGGUAGCCGUACCGGAAGGUGCGGCUGGAUCACCUCCUUUCU

Entity 5 polymer

描述 description	Conserved domain protein
分子量 formula_weight	4164.3 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	BB

MGSVIKKRRKRMSKKKHRKLLRRTRVQRRKLGK

Entity 6 polymer

描述 description	30S ribosomal protein S3
分子量 formula_weight	30191.2 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	BC

MGQKINPHGFRLGITTEWKSRWYADKQYKDYVKEDVAIRKLLATGLERAGIADVEIERTRDRVRVDIHTARPGIVIGRRGTEADRIRADLEKLTGKQVQLNILEVKNPESQAQLVAQGVAEQLSNRVAFRRAMRKAIQSAMRQPNVKGIRVQCSGRLGGAEMSRSEFYREGRVPLHTLRADIDYGLYEAKTTFGRIGVKVWIYKGDIVGGKRELAAAAPASDRPRRERPSGTRPRRSGSAGTTATSTEAGRAATSDAPAAGTAAAAEAPAESTES

Entity 7 polymer

描述 description	30S ribosomal protein S4
分子量 formula_weight	23415.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	BD

MARYTGPATRKSRRLGVDLVGGDQSFEKRPYPPGQHGRARIKESEYRQQLQEKQKARFSYGVMEKQFRRYYEEANRQPGKTGDNLLRILESRLDNVVYRAGLARTRRMARQLVSHGHFLVNGVKVDIPSYRVSQYDIIDVKEKSLNTLPFQIARETAGERPIPSWLQVVGERQRILVHQLPERAQIDVPLTEQLIVELYSK

Entity 8 polymer

描述 description	30S Ribosomal Protein S5
分子量 formula_weight	21946.1 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	BE

MAEQAGAGSAQDNRGGRGRRDDRGGRGRDGGDKSNYIERVVSINRVSKVVKGGRRFSFTALVIVGDGKGMVGVGYGKAKEVPAAIAKGVEEARKNFFRVPLIGSTITHPVQGEAAAGVVMLRPASPGTGVIAGGAARAVLECAGVHDILAKSLGSDNAINVVHATVAALKLLQRPEEVAARRGLPIEDVAPAGMLKARRESEALAAAAAREGSA

Entity 9 polymer

描述 description	30S ribosomal protein S6
分子量 formula_weight	10991.6 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	BF

MRPYEIMVILDPTLDERTVAPSLETFLNVIRKDGGTVDKVDIWGRRRLAYEIAKHAEGIYAVIDVKAEPATVSELDRQLNLNESVLRTKVLRTDKH

Entity 10 polymer

描述 description	30S ribosomal protein S7
分子量 formula_weight	17660.4 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	BG

MPRKGPAPKRPLVNDPVYGSQLVTQLVNKVLLEGKKSLAERIVYGALEQAREKTGTDPVVTLKRALDNVKPALEVRSRRVGGATYQVPVEVRPDRSTTLALRWLVNFSRQRREKTMVERLANEILDASNGLGASVKRREDTHKMAEANRAFAHYRW

Entity 11 polymer

描述 description	30S Ribosomal Protein S8
分子量 formula_weight	14492.6 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	BH

MTMTDPIADFLTRLRNANSAYHDEVTLPHSKLKANIAEILKREGYISDYRTEDARVGKSLVVQLKYGPSRERSIAGLRRVSKPGLRVYAKSTNLPRVLGGLGVAIISTSSGLLTDRQAARQGVGGEVLAYVW

Entity 12 polymer

描述 description	30S ribosomal protein S9
分子量 formula_weight	16794.4 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	BI

MTDVTETEVVTESAEPREPVIIDRPIQTVGRRKEAVVRVRLVPGTGQFNLDGRTLENYFPNKVHQQLIKAPLVTVDRVDQFDIYAHLDGGGPSGQAGALRLAIARALILVQPEDRPALKKAGFLTRDPRAIERKKYGLKKARKAPQYSKR

Entity 13 polymer

描述 description	30S ribosomal protein S10
分子量 formula_weight	11454.3 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	BJ

MAGQKIRIRLKAYDHEAIDASARKIVETVTRTGASVVGPVPLPTEKNVYCVIRSPHKYKDSREHFEMRTHKRLIDILDPTPKTVDALMRIDLPASVDVNIQ

Entity 14 polymer

描述 description	30S ribosomal protein S11
分子量 formula_weight	14671.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	BK

MAQAKKGGTAAKKGQKTRRREKKNVPHGAAHIKSTFNNTIVSITDPQGNVIAWASSGHVGFKGSRKSTPFAAQLAAENAARKAQEHGVKKVDVFVKGPGSGRETAIRSLQAAGLEVGTISDVTPQPHNGCRPPKRRRV

Entity 15 polymer

描述 description	30S ribosomal protein S12
分子量 formula_weight	13896.4 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	BL

MPTIQQLVRKGRRDKIAKVKTAALKGSPQRRGVCTRVYTTTPKKPNSALRKVARVKLTSQVEVTAYIPGEGHNLQEHSMVLVRGGRVKDLPGVRYKIIRGSLDTQGVKNRKQARSRYGAKKEKS

Entity 16 polymer

描述 description	30S ribosomal protein S13
分子量 formula_weight	14249.6 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	BM

MARLVGVDLPRDKRMEIALTYIYGIGRTRSNEILAATGIDKNMRTKDLTDDQVTVLRDYIEGNLKVEGDLRREVQADIRRKIEIGCYQGLRHRRGLPVRGQRTKTNARTRKGPKRTIAGKKKAR

Entity 17 polymer

描述 description	30S Ribosomal Protein S14
分子量 formula_weight	6976.4 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	BN

MAKKALVHKANKKPKFAVRAYTRCNKCGRPHSVYRKFGLCRICLREMAHAGELPGVQKSSW

Entity 18 polymer

描述 description	30S Ribosomal Protein S15
分子量 formula_weight	10368.1 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	BO

MALTAEQKKEILGQYGLHDTDTGSPEAQVALLTKRIQDLTEHLKVHKHDHHSRRGLLLLVGRRRRLLKYVAQVDVARYRSLIERLGLRR

Entity 19 polymer

描述 description	30S ribosomal protein S16
分子量 formula_weight	16795.2 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	BP

MAVKIKLTRLGKIRNPQYRIIVADARTRRDGRAIEVIGRYHPKEEPSLIQIDSERAQYWLGVGAQPTEPVLALLKITGDWQKFKGLPGAEGTLKVKEPKPSKLDLFNAALAEAESGTTAAATTPKKKKAPKKDEAAEAPAEAAEAPAEAADAASES

Entity 20 polymer

描述 description	30S ribosomal protein S17
分子量 formula_weight	11127.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	BQ

MADQKGPKYTPAAEKPRGRRKTAIGYVVSDKMQKTIVVELEDRKSHPLYGKIIRTTKKVKAHDENGEAGIGDRVSLMETRPLSATKRWRLVEILEKAK

Entity 21 polymer

描述 description	30S Ribosomal Protein S18
分子量 formula_weight	9524.2 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	BR

MAKSNKRRPAPEKPVKTRKCVFCSKKGQTIDYKDTALLRTYISERGKIRARRVTGNCVQHQRDIAVAVKNAREVALLPFGSSTR

Entity 22 polymer

描述 description	30S ribosomal protein S19
分子量 formula_weight	10800.6 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	BS

MPRSLKKGPFVDDHLLKKVDVQNEKNTKQVIKTWSRRSTIIPDFIGHTFAVHDGRKHVPVFVTEAMVGHKLGEFAPTRTFKGHIKDDRKSKRR

Entity 23 polymer

描述 description	30S ribosomal protein S20
分子量 formula_weight	9556.1 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	BT

MANIKSQIKRIRTNERRRLRNQSVKSSLRTAIRGFREAVDAGDKDKASELLHATSRKLDKAASKGVIHPNQAANKKSALALALNKL

Entity 24 polymer

描述 description	30S Ribosomal Protein S2
分子量 formula_weight	30145.2 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	BV

MAVVTMKQLLDSGAHFGHQTRRWNPKMKRFIFTDRNGIYIIDLQQTLTYIDKAYEFVKETVAHGGTVLFVGTKKQAQESIAEEATRVGMPYVNQRWLGGMLTNFSTVHKRLQRLKELEAMEQTGGFEGRTKKEILMLTREKNKLERSLGGIRDMQKVPSAVWVVDTNKEHIAVGEARKLGIPVIAILDTNCDPDVVDYPIPGNDDAIRSAALLTKVIASAVAEGLQARAGQGSGEKPAEGAEPLAEWEQELLAGATAGAADASAEGAAAPESSTDAS

Entity 25 polymer

描述 description	P/P-site Phe-tRNA
分子量 formula_weight	24485.5 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polyribonucleotide
链编号 strand_id	BW

GCCCGGAUAGCUCAGUCGGUAGAGCAGGGGAUUGAAAAUCCCCGUGUCCUUGGUUCGAUUCCGAGUCCGGGCACCA

Entity 26 polymer

描述 description	mRNA fragment
分子量 formula_weight	4737.9 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polyribonucleotide
链编号 strand_id	I

AUGUUCAAAGCAUUC

Entity 27 polymer

描述 description	50S ribosomal protein L2
分子量 formula_weight	30425.9 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	C

MGIRKYKPTTPGRRGASVSDFAEITRSTPEKSLVRPLHGKGGRNAHGRITTRHKGGGHKRAYRVIDFRRHDKDGVNAKVAHIEYDPNRTANIALLHYLDGEKRYIIAPQGLKQGDVIESGANADIKPGNNLPLRNIPAGTVIHAVELRPGGGAKLARSAGVSIQLLGKEGTYAALRMPSGEIRRVDVRCRATVGEVGNAEQSNINWGKAGRMRWKGKRPTVRGVVMNPVDHPHGGGEGKTSGGRHPVSPWGKPEGRTRKPNKPSDKLIVRRRRTGKKR

Entity 28 polymer

描述 description	50S ribosomal protein L3
分子量 formula_weight	23011.4 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	D

MARKGILGTKLGMTQVFDENNKVVPVTVVKAGPNVVTRIRTTERDGYSAVQLAYGEISPRKVIKPVAGQFAAAGVNPRRHVAELRLDDEAAVAEYEVGQELTAEIFSDGAYVDVTGTSKGKGFAGTMKRHGFRGQGAAHGAQAVHRRPGSIGGCATPGRVFKGTRMSGRMGNDRVTTQNLKVHKVDAENGVLLIKGAIPGRNGGLVVVRSAIKRGEK

Entity 29 polymer

描述 description	Large ribosomal subunit protein uL4
分子量 formula_weight	22920.9 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	E

MTLKVDVKTPAGKTDGSVELPAELFDVEPNIALMHQVVTAQLAAKRQGTHSTKTRGEVSGGGKKPYRQKGTGRARQGSTRAPQFTGGGTVHGPKPRDYSQRTPKKMIAAALRGALSDRARNDRIHAVTELVEGQTPSTKSAKTFLGTLTENKKVLVVIGRTDEVGAKSVRNLPGVHVISPDQLNTYDVLNADDVVFSVEALNAYISANSKEGASV

Entity 30 polymer

描述 description	50S Ribosomal Protein L5
分子量 formula_weight	21152.3 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	F

MTTTEKALPRLKQRYREEIREALQQEFNYANVMQIPGVVKVVVNMGVGDAARDAKLINGAINDLALITGQKPEVRRARKSIAQFKLREGMPIGARVTLRGDRMWEFLDRLISIALPRIRDFRGLSPKQFDGTGNYTFGLNEQSMFHEIDVDSIDRPRGMDITVVTTATNDAEGRALLRALGFPFKEN

Entity 31 polymer

描述 description	50S ribosomal protein L6
分子量 formula_weight	19483.4 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	G

MSRIGKQPVPVPSGVDVTINGQNLSVKGPKGTLTLDVAEPISVSRAEDGAIVVTRPDDERRSRSLHGLSRTLIANLVTGVTEGYTQKMEIFGVGYRVQLKGQNLEFALGYSHPVLIEAPEGITFAVESPTKFSVSGIDKQKVGQISAVIRRLRRPDPYKGKGVRYEGEQIRRKVGKTGK

Entity 32 polymer

描述 description	50S ribosomal protein L9
分子量 formula_weight	15949.3 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	H

MKLILTAEVEHLGAAGDTVEVKDGYGRNYLLPRGLAIVASRGAERQAEEIRRARESKVIRDIEHANELKTALEGLGDVTLSVNAAGDTGKLFGSVTAADVVNAIKKAGGPNLDKRTVQLAKAHIKSVGTHPVTVKLHTGVEAKVSLNVVAQ

Entity 33 polymer

描述 description	50S ribosomal protein L11
分子量 formula_weight	15023.4 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	J

MAPKKKVAGLIKLQIQAGQANPAPPVGPALGQHGVNIMEFCKAYNAATESQRGNVIPVEITVYEDRSFTFALKTPPAAKLLLKAAGVQKGSGEPHKTKVAKVTWDQVREIAETKKADLNANDIDAAAKIIAGTARSMGITVE

Entity 34 polymer

描述 description	Large ribosomal subunit protein uL13
分子量 formula_weight	16146.7 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	K

MPTYTPKAGDTTRSWYVIDASDVVLGRLASAAATLLRGKHKPTFTPNVDGGDFVIVINADKIAVSGDKLTKKFAYRHSGYPGGLRKRTIGELLEKHPTRVVENAIIGMLPHNKLGRQIQKKLKVYAGPDHPHAAQQPIPFEIKQVAQ

Entity 35 polymer

描述 description	50S ribosomal protein L14
分子量 formula_weight	13400.6 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	L

MIQQESRLKVADNTGAKEILCIRVLGGSSRRYAGIGDVIVATVKDAIPGGNVKRGDVVKAVVVRTVKERRRADGSYIKFDENAAVIIKNDNDPRGTRIFGPVGRELREKKFMKIVSLAPEVL

Entity 36 polymer

描述 description	50S ribosomal protein L15
分子量 formula_weight	15602.2 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	M

MSVIKLHDLKPAPGEKKAKTRVGRGEGSKGKTAGRGTKGTKARKNVPVMFEGGQMPIHMRLPKLKGFKNRFRTEYQVVNVGDINKAFPQGGTVGVDELVAKGLVRKNSLVKVLGDGKLTVKVDVTANKFSGSAREAITAAGGSATEL

Entity 37 polymer

描述 description	Large ribosomal subunit protein uL16
分子量 formula_weight	15774.2 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	N

MLIPRKVKHRKQHHPEQRGIASGGTSVSFGDYGIQALEHAYITNRQIESARIAINRHIKRGGKVWINIFPDRPLTKKPAETRMGSGKGSPEWWVANVKPGRVLFELSYPDEKTARDALTRAIHKLPIKARIVTREEQF

Entity 38 polymer

描述 description	50S ribosomal protein L17
分子量 formula_weight	21892.2 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	O

MPKPTKGPRLGGSSSHQSALLANLATSLFEHGRIKTTEPKARALRPYAEKLITHAKKGALHNRREVMKKIRDKDVVHTLFAEIGPFYADRNGGYTRIIKVENRKGDNAPMAVIELVREKTVTDEANRARRAAASQAKADERADEKADEKAEETVEETTEAPAEESTEAAAEETVEETTEAPAEESTEAAEESEAKDDTK

Entity 39 polymer

描述 description	Large ribosomal subunit protein uL18
分子量 formula_weight	13711.7 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	P

MAHKPVGQNISEVRRNARLRRHARLRKKVAGTAEVPRLVVNRSARHIHVQLVNDLNGTTLAAASSIEADVRAIDGDKKAHSVRVGQLIAERAKAAGVETVVFDRGGYTYGGRIAALADAAREAGLKF

Entity 40 polymer

描述 description	50S ribosomal protein L19
分子量 formula_weight	12892.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	Q

MNTLDFVDQASLRDDIPTFSPGDTVNVHVKVIEGSKERIQVFKGVVIRRQGGGISETFTVRKESYGVGVERTFPVHSPNIDHIDVLTRGDVRRAKLYYLRELRGKKAKIKEKR

Entity 41 polymer

描述 description	Large ribosomal subunit protein bL20
分子量 formula_weight	14494.7 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	R

MARVKRALNAQKKRRTVLKASKGYRGQRSRLYRKAKEQQLHSLTYAYRDRRARKGEFRKLWISRINAAARANDITYNRLIQGLKAAGVEVDRKNLAELAVSDPAAFTALVDVARAALPEDVNAPSGEAA

Entity 42 polymer

描述 description	Large ribosomal subunit protein bL21
分子量 formula_weight	11055.9 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	S

MATYAIVKTGGKQYKVAAGDVVKVEKLDSEPGASVSLPVALVVDGANVTSKADDLAKVAVTAEVLEHTKGPKIRIHKFKNKTGYHKRQGHRQQLTVLKVTGIK

Entity 43 polymer

描述 description	Large ribosomal subunit protein uL22
分子量 formula_weight	16353.6 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	T

MSTVTEFPSATAKARYVRVSATKARRVIDLVRGKSVEEALDILRWAPQAASEPVAKVIASAAANAQNNEGLDPSTLVVATVYADEGPTAKRIRPRAQGRAFRIRKRTSHITVIVESRPPKQKGASAASARSRRAQGSKAAATKKSAETKEGSE

Entity 44 polymer

描述 description	Large ribosomal subunit protein uL23
分子量 formula_weight	11047.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	U

MATITDPRDIILAPVISEKSYGLIEDNVYTFVVHPDSNKTQIKIAIEKIFDVKVDSVNTANRQGKRKRTRTGFGKRKSTKRAIVKLAAGSKPIDLFGAPA

Entity 45 polymer

描述 description	50S ribosomal protein L24
分子量 formula_weight	11228.9 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	V

MKVHKGDTVLVISGKDKGAKGKVLVAYPDRNKVLVEGVNRIKKHTAVSANERGASSGGIVTQEAPIHVSNVMVVDSDGKPTRVGYRIDDETGKKVRIAKTNGKDI

Entity 46 polymer

描述 description	50S ribosomal protein L25
分子量 formula_weight	22571.1 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	W

MAKTANIPNKLTANVRTRTGKGASRQARRDGKVPAVLYGHGTDPQHLELNARDFAAVLRSHGTNAILTLDIEGTEQLALTKALDVHPIRRNIQHADLLVVQRGEKVTVEVTVLVEGDATPGTLVTQDANTIEIEAEALSIPEQLTVSVEGVEAGTQITAGQISLPEGVNLISDPELLVVNVVEAPSAEALEEEGAGETGAAEAPAEEAPAEEPAE

Entity 47 polymer

描述 description	50S ribosomal protein L27
分子量 formula_weight	9249.6 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	X

MAHKKGASSSRNGRDSAAQRLGVKRFGGQVVKAGEILVRQRGTHFHPGVNVGRGGDDTLFALAPGAVEFGAKRGRKTVNIVPVARPEA

Entity 48 polymer

描述 description	Large ribosomal subunit protein bL28
分子量 formula_weight	6891.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	Y

MAAVCDICGKGPGFGKSVSHSHRRTSRRWNPNIQPVRAVTRPGGNKQRINACTSCIKAGKVSRA

Entity 49 polymer

描述 description	50S ribosomal protein L29
分子量 formula_weight	8790.9 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	Z

MAVGTTPGELRELTDDELKDKLRESKEELFNLRFQMATGQLSNNRRLRTVRQEIARVYTVLRERELGLASGPAGEES

Entity 50 polymer

描述 description	50S ribosomal protein L30
分子量 formula_weight	7022.1 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	a

MAELKITQVRSTIGARWKQRESLRTLGLKKIRQSVVREDNAQTRGLINTVHHLVEVEEVGK

Entity 51 polymer

描述 description	50S ribosomal protein L32
分子量 formula_weight	6467.7 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	b

MAVPKRRMSRANTRSRRAQWKAEAPGLVTVSVAGQQRKVPRRLLKAARLGLVDLDKR

Entity 52 polymer

描述 description	50S Ribosomal Protein L33
分子量 formula_weight	6468.5 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	c

MASSTDVRPKITLACEVCKHRNYITKKNRRNDPDRLEIKKFCPNCGTHQPHKESR

Entity 53 polymer

描述 description	50S ribosomal protein L34
分子量 formula_weight	5522.6 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	d

MAKGKRTFQPNNRRRARVHGFRLRMRTRAGRAIVANRRSKGRRALTA

Entity 54 polymer

描述 description	50S ribosomal protein L35
分子量 formula_weight	7298.5 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	e

MPKAKTHSGASKRFRRTGTGKIVRQKANRRHLLEHKPTKRTRRLDGRTTVSAADNSRINKLLNG

Entity 55 polymer

描述 description	50S ribosomal protein L36
分子量 formula_weight	4341.3 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	f

MKVNPSVKPICDKCRVIRRHGRVMVICSDPRHKQRQG

Entity 56 polymer

描述 description	50S Ribosomal Protein L31
分子量 formula_weight	8312.5 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	g

MKTGIHPEYVDTTVQCGCGHSFTTRSTKQSGTIVVEVCSQCHPFYTGKQKILDSGGRVARFEKRYGKRNKAAADK

Entity 57 polymer

描述 description	Nascent peptide
分子量 formula_weight	643.8 kDa
来源方法 src_method	nat
拷贝数 entity_count	1

聚合体 Polymer

聚合体类型 type	polypeptide(L)
链编号 strand_id	s

MFKAF

Entity 58 non-polymer

描述 description	MAGNESIUM ION
分子量 formula_weight	24.3 kDa
来源方法 src_method	syn
拷贝数 entity_count	347

Entity 59 non-polymer

描述 description	methyl ({(5S)-3-[4-(1,1-dioxo-1lambda~6~-thiomorpholin-4-yl)-3,5-difluorophenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)carbamate
分子量 formula_weight	419.4 kDa
来源方法 src_method	syn
拷贝数 entity_count	1

Entity 60 non-polymer

描述 description	ZINC ION
分子量 formula_weight	65.4 kDa
来源方法 src_method	syn
拷贝数 entity_count	6

Entity 61 water

描述 description	water
分子量 formula_weight	18.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	7135

▶

7. 引用文献 (1)

▶

晶胞边长 a length_a	1.000 Å
晶胞边长 b length_b	1.000 Å
晶胞边长 c length_c	1.000 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	90.00 °
晶胞夹角 γ angle_gamma	90.00 °
晶胞分子数 Z z_pdb	—

空间群 space_group	P 1
空间群编号 int_tables_number	1
晶系 crystal_system	triclinic

分辨率 resolution	2.01 Å
分辨率测定方法 resolution_method	—
颗粒数 num_particles	638803

fit	/app/data/saxs_computation/n5/9n5t/9n5t.fit
pddf	/app/data/pr_computation/n5/9n5t/9n5t.pr.out
profile	/app/data/saxs_computation/n5/9n5t/9n5t.dat

Mycobacterium smegmatis 70S ribosome with small molecule drug MK-7762

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

1. 结构基本信息 1. Structure Basics

2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)

3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

冷冻电镜 EM 3D

5. 实体与聚合体信息 (61)

Entity 1 polymer

聚合体 Polymer

Entity 2 polymer

聚合体 Polymer

Entity 3 polymer

聚合体 Polymer

Entity 4 polymer

聚合体 Polymer

Entity 5 polymer

聚合体 Polymer

Entity 6 polymer

聚合体 Polymer

Entity 7 polymer

聚合体 Polymer

Entity 8 polymer

聚合体 Polymer

Entity 9 polymer

聚合体 Polymer

Entity 10 polymer

聚合体 Polymer

Entity 11 polymer

聚合体 Polymer

Entity 12 polymer

聚合体 Polymer

Entity 13 polymer

聚合体 Polymer

Entity 14 polymer

聚合体 Polymer

Entity 15 polymer

聚合体 Polymer

Entity 16 polymer

聚合体 Polymer

Entity 17 polymer

聚合体 Polymer

Entity 18 polymer

聚合体 Polymer

Entity 19 polymer

聚合体 Polymer

Entity 20 polymer

聚合体 Polymer

Entity 21 polymer

聚合体 Polymer

Entity 22 polymer

聚合体 Polymer

Entity 23 polymer

聚合体 Polymer

Entity 24 polymer

聚合体 Polymer

Entity 25 polymer

聚合体 Polymer

Entity 26 polymer

聚合体 Polymer

Entity 27 polymer

聚合体 Polymer

Entity 28 polymer

聚合体 Polymer

Entity 29 polymer

聚合体 Polymer

Entity 30 polymer

聚合体 Polymer

Entity 31 polymer

聚合体 Polymer

Entity 32 polymer

聚合体 Polymer

Entity 33 polymer

聚合体 Polymer

Entity 34 polymer

聚合体 Polymer

Entity 35 polymer