Locally-refined structure of alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and compound Z7149

Method: ELECTRON MICROSCOPY D_max: 68.8 Å Quality: REASONABLE

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9pqd
deposition_date	2025-07-22
title	Locally-refined structure of alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and compound Z7149
keywords	GPCR, Complex, Drug, Small Molecule, Polypharmacology, MEMBRANE PROTEIN; MEMBRANE PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	20.52 Å
rg_electron	19.60 Å
i0	24197300.00
molecular_weight	26780.0 kDa
excluded_volume	26848 Å³
envelope_volume	43829 Å³
shell_volume	18977 Å³
envelope_diameter	68.9 Å
shell_rg	25.78 Å
envelope_rg	20.14 Å
shape_rg	19.58 Å
total_rg	20.36 Å
total_atoms	2044
n_residues	263
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	68.8 Å
rg_real	20.51 Å
rg_real_error	0.45 Å
i0_real	2.4200e+07
i0_real_error	2.8830e+05
rg_reciprocal	20.51 Å
i0_reciprocal	24200000.0000
total_estimate	0.7396
solution_quality	REASONABLE a REASONABLE solution
n_peaks	2
r_peak_primary	23.9 Å
skewness	0.359
kurtosis	-0.281
angular_range	— – 0.3850 Å⁻¹
current_alpha	0.0000
highest_alpha	2552000.0000
n_real_points	70
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.823; Stabil: 1.000; Sysdev: 0.387; Positv: 1.000; Valcen: 0.990; Smooth: 0.992

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4. Crystallography & Experiment

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5. Entities & Polymer Info (2)

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	3.290 Å
resolution_low	— Å
r_factor	—
r_work	—
r_free	—

resolution	3.29 Å
resolution_method	—
num_particles	38025

description	Alpha-2A adrenergic receptor
formula_weight	53643.9 kDa
src_method	man
entity_count	1

Locally-refined structure of alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and compound Z7149

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

EM 3D

5. Entities & Polymer Info (2)

Entity 1 polymer

Polymer

Source

Entity 2 non-polymer

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Spodoptera frugiperda

description	(6M)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1H-indole
formula_weight	212.3 kDa
src_method	syn
entity_count	1

fit	/app/data/saxs_computation/pq/9pqd/9pqd.fit
pddf	/app/data/pr_computation/pq/9pqd/9pqd.pr.out
profile	/app/data/saxs_computation/pq/9pqd/9pqd.dat

type	polypeptide(L)
strand_id	R
atom_count	2058