← Back to search
9s1z

Crystal structure of human SIRT2 in complex with the covalent adduct of SirReal-triazole inhibitor Mz242 and ADP-ribose

Method: X-RAY DIFFRACTION Dmax: 69.8 Å Quality: REASONABLE

SAXS Profile

SAXS profile for 9s1z

P(r) Distribution

P(r) distribution for 9s1z

1. Structure Basics

entry_id9s1z
deposition_date2025-07-21
titleCrystal structure of human SIRT2 in complex with the covalent adduct of SirReal-triazole inhibitor Mz242 and ADP-ribose
keywordsSirtuins, Inhibitor, Covalent adduct, Deacetylation, HYDROLASE; HYDROLASE
methodX-RAY DIFFRACTION

Download Data

2. SAXS Parameters (CRYSOL)

rg_guinier21.03
rg_electron20.04
i020232300.00
molecular_weight34608.0 kDa
excluded_volume43384 ų
envelope_volume48753 ų
shell_volume20545 ų
envelope_diameter70.7
shell_rg26.41
envelope_rg20.41
shape_rg19.99
total_rg21.01
total_atoms4806
n_residues295
n_harmonics20
q_range— – 0.5000 −1
n_points101
shell_typedirectional
solvent_density0.3340 e/ų
contrast_shell0.0300 e/ų
crysol_version4.1.3

3. P(r) Analysis (GNOM)

dmax69.8
rg_real21.01
rg_real_error0.39
i0_real2.0230e+07
i0_real_error2.2010e+05
rg_reciprocal21.02
i0_reciprocal20230000.0000
total_estimate0.6873
solution_quality REASONABLE a REASONABLE solution
n_peaks2
r_peak_primary24.3
skewness0.361
kurtosis-0.280
angular_range— – 0.3800 −1
current_alpha0.0000
highest_alpha3445000.0000
n_real_points70
gnom_version4.1.3
quality_criteria AN1: 0.000; Oscil: 0.818; Stabil: 1.000; Sysdev: 0.177; Positv: 1.000; Valcen: 0.995; Smooth: 0.951

4. Crystallography & Experiment

5. Entities & Polymer Info (5)

6. Citations (1)

7. Files & Curves (10)