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9s20

Crystal structure of human SIRT2 in complex with SirReal-triazole inhibitor SH10

Method: X-RAY DIFFRACTION Dmax: 70.8 Å Quality: GOOD

SAXS Profile

SAXS profile for 9s20

P(r) Distribution

P(r) distribution for 9s20

1. Structure Basics

entry_id9s20
deposition_date2025-07-21
titleCrystal structure of human SIRT2 in complex with SirReal-triazole inhibitor SH10
keywordsSirtuins, Inhibitor, Deacetylation, HYDROLASE; HYDROLASE
methodX-RAY DIFFRACTION

Download Data

2. SAXS Parameters (CRYSOL)

rg_guinier20.88
rg_electron20.09
i036945700.00
molecular_weight31696.0 kDa
excluded_volume30819 ų
envelope_volume49839 ų
shell_volume20921 ų
envelope_diameter71.7
shell_rg26.37
envelope_rg20.34
shape_rg20.06
total_rg20.77
total_atoms2391
n_residues292
n_harmonics20
q_range— – 0.5000 −1
n_points101
shell_typedirectional
solvent_density0.3340 e/ų
contrast_shell0.0300 e/ų
crysol_version4.1.3

3. P(r) Analysis (GNOM)

dmax70.8
rg_real20.85
rg_real_error0.42
i0_real3.6950e+07
i0_real_error4.7590e+05
rg_reciprocal20.85
i0_reciprocal36950000.0000
total_estimate0.8767
solution_quality GOOD a GOOD solution
n_peaks2
r_peak_primary23.6
skewness0.334
kurtosis-0.343
angular_range— – 0.3800 −1
current_alpha0.0000
highest_alpha7411000.0000
n_real_points70
gnom_version4.1.3
quality_criteria AN1: 0.000; Oscil: 0.803; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.987; Smooth: 0.995

4. Crystallography & Experiment

5. Entities & Polymer Info (6)

6. Citations (1)

7. Files & Curves (10)