9x7c
Crystal Structure of BRD2 BD1 domain in complex with small molecule inhibitor Mivebresib ABBV-075
SAXS Profile
P(r) Distribution
1. Structure Basics
| entry_id | 9x7c |
| deposition_date | 2025-10-16 |
| last_revision | 2025-10-29 |
| title | Crystal Structure of BRD2 BD1 domain in complex with small molecule inhibitor Mivebresib ABBV-075 |
| keywords | BRD2, Cancer Ligand bound, Inhbitor, TRANSCRIPTION; TRANSCRIPTION |
| method | X-RAY DIFFRACTION |
Download Data
2. SAXS Parameters (CRYSOL)
| rg_guinier | 23.76 Å |
| rg_electron | 23.15 Å |
| i0 | 24951800.00 |
| molecular_weight | 39622.0 kDa |
| excluded_volume | 50120 ų |
| envelope_volume | 59549 ų |
| shell_volume | 22264 ų |
| envelope_diameter | 82.7 Å |
| shell_rg | 29.45 Å |
| envelope_rg | 23.29 Å |
| shape_rg | 23.16 Å |
| total_rg | 23.93 Å |
| total_atoms | 2838 |
| n_residues | 321 |
| n_harmonics | 20 |
| q_range | — – 0.5000 Å−1 |
| n_points | 101 |
| shell_type | directional |
| solvent_density | 0.3340 e/ų |
| contrast_shell | 0.0300 e/ų |
| crysol_version | 4.1.3 |
3. P(r) Analysis (GNOM)
| dmax | 78.9 Å |
| rg_real | 23.81 Å |
| rg_real_error | 0.55 Å |
| i0_real | 2.4950e+07 |
| i0_real_error | 3.6560e+05 |
| rg_reciprocal | 23.80 Å |
| i0_reciprocal | 24950000.0000 |
| total_estimate | 0.8853 |
| solution_quality | GOOD a GOOD solution |
| n_peaks | 0 |
| r_peak_primary | — Å |
| skewness | 0.374 |
| kurtosis | -0.435 |
| angular_range | — – 0.3350 Å−1 |
| current_alpha | 0.0000 |
| highest_alpha | 13840000.0000 |
| n_real_points | 65 |
| gnom_version | 4.1.3 |
| quality_criteria | AN1: 0.000; Oscil: 0.870; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.916; Smooth: 0.979 |