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9zz6

The ER membrane protein complex acts as a chaperone to promote voltage-gated calcium channel assembly

Method: ELECTRON MICROSCOPY D_max: 201.0 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9zz6
deposition_date	2026-01-06
title	The ER membrane protein complex acts as a chaperone to promote voltage-gated calcium channel assembly
keywords	protein biogenesis, endoplasmic reticulum, ER, chaperone, insertase, complex, membrane protein, CHAPERONE-IMMUNE SYSTEM complex; CHAPERONE/IMMUNE SYSTEM
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	61.40 Å
rg_electron	61.70 Å
i0	1179470000.00
molecular_weight	291900.0 kDa
excluded_volume	367320 Å³
envelope_volume	545140 Å³
shell_volume	81034 Å³
envelope_diameter	226.5 Å
shell_rg	54.55 Å
envelope_rg	59.93 Å
shape_rg	61.72 Å
total_rg	61.42 Å
total_atoms	41010
n_residues	2585
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	201.0 Å
rg_real	62.14 Å
rg_real_error	2.06 Å
i0_real	1.1790e+09
i0_real_error	2.2120e+07
rg_reciprocal	60.70 Å
i0_reciprocal	1177000000.0000
total_estimate	0.7815
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	46.4 Å
skewness	0.483
kurtosis	-0.580
angular_range	— – 0.1300 Å⁻¹
current_alpha	0.0000
highest_alpha	109400000.0000
n_real_points	27
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.730; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.905; Smooth: 0.062

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4. Crystallography & Experiment

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5. Entities & Polymer Info (13)

Entity 1 polymer

description	ER membrane protein complex subunit 1
formula_weight	111886.1 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	41010

MAAEWASRFWLWATLLIPAAAVYEDQVGKFDWRQQYVGKVKFASLEFSPGSKKLVVATEKNVIAALNSRTGEILWRHVDKGTAEGAVDAMLLHGQDVITVSNGGRIMRSWETNIGGLNWEITLDSGSFQALGLVGLQESVRYIAVLKKTTLALHHLSSGHLKWVEHLPESDSIHYQMVYSYGSGVVWALGVVPFSHVNIVKFNVEDGEIVQQVRVSTPWLQHLSGACGVVDEAVLVCPDPSSRSLQTLALETEWELRQIPLQSLDLEFGSGFQPRVLPTQPNPVDASRAQFFLHLSPSHYALLQYHYGTLSLLKNFPQTALVSFATTGEKTVAAVMACRNEVQKSSSSEDGSMGSFSEKSSSKDSLACFNQTYTINLYLVETGRRLLDTTITFSLEQSGTRPERLYIQVFLKKDDSVGYRALVQTEDHLLLFLQQLAGKVVLWSREESLAEVVCLEMVDLPLTGAQAELEGEFGKKADGLLGMFLKRLSSQLILLQAWTSHLWKMFYDARKPRSQIKNEINIDTLARDEFNLQKMMVMVTASGKLFGIESSSGTILWKQYLPNVKPDSSFKLMVQRTTAHFPHPPQCTLLVKDKESGMSSLYVFNPIFGKWSQVAPPVLKRPILQSLLLPVMDQDYAKVLLLIDDEYKVTAFPATRNVLRQLHELAPSIFFYLVDAEQGRLCGYRLRKDLTTELSWELTIPPEVQRIVKVKGKRSSEHVHSQGRVMGDRSVLYKSLNPNLLAVVTESTDAHHERTFIGIFLIDGVTGRIIHSSVQKKAKGPVHIVHSENWVVYQYWNTKARRNEFTVLELYEGTEQYNATAFSSLDRPQLPQVLQQSYIFPSSISAMEATITERGITSRHLLIGLPSGAILSLPKALLDPRRPEIPTEQSREENLIPYSPDVQIHAERFINYNQTVSRMRGIYTAPSGLESTCLVVAYGLDIYQTRVYPSKQFDVLKDDYDYVLISSVLFGLVFATMITKRLAQVKLLNRAWR

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 2 polymer

description	ER membrane protein complex subunit 2
formula_weight	34882.5 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	B

MAKVSELYDVTWEEMRDKMRKWREENSRNSEQIVEVGEELINEYASKLGDDIWIIYEQVMIAALDYGRDDLALFCLQELRRQFPGSHRVKRLTGMRFEAMERYDDAIQLYDRILQEDPTNTAARKRKIAIRKAQGKNVEAIRELNEYLEQFVGDQEAWHELAELYINEHDYAKAAFCLEELMMTNPHNHLYCQQYAEVKYTQGGLENLELSRKYFAQALKLNNRNMRALFGLYMSASHIASNPKASAKTKKDNMKYASWAASQINRAYQFAGRSKKETKYSLKAVEDMLETLQITQS

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 3 polymer

description	ER membrane protein complex subunit 3
formula_weight	29981.9 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	C

MAGPELLLDSNIRLWVVLPIVIITFFVGMIRHYVSILLQSDKKLTQEQVSDSQVLIRSRVLRENGKYIPKQSFLTRKYYFNNPEDGFFKKTKRKVVPPSPMTDPTMLTDMMKGNVTNVLPMILIGGWINMTFSGFVTTKVPFPLTLRFKPMLQQGIELLTLDASWVSSASWYFLNVFGLRSIYSLILGQDNAADQSRMMQEQMTGAAMAMPADTNKAFKTEWEALELTDHQWALDDVEEELMAKDLHFEGMFKKELQTSIF

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 4 polymer

description	ER membrane protein complex subunit 4
formula_weight	20104.6 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	D

MTAQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMAGNTISIFPTMMVCMMAWRPIQALMAISATFKMLESSSQKFLQGLVYLIGNLMGLALAVYKCQSMGLLPTHASDWLAFIEPPERMEFSGGGLLL

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 5 polymer

description	Membrane magnesium transporter 1
formula_weight	14706.8 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	E

MAPSLWKGLVGIGLFALAHAAFSAAQHRSYMRLTEKEDESLPIDIVLQTLLAFAVTCYGIVHIAGEFKDMDATSELKNKTFDTLRNHPSFYVFNHRGRVLFRPSDTANSSNQDALSSNTSLKLRKLESLRR

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 6 polymer

description	ER membrane protein complex subunit 6
formula_weight	12029.2 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	F

MAAVVAKREGPPFISEAAVRGNAAVLDYCRTSVSALSGATAGILGLTGLYGFIFYLLASVLLSLLLILKAGRRWNKYFKSRRPLFTGGLIGGLFTYVLFWTFLYGMVHVY

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 7 polymer

description	ER membrane protein complex subunit 7
formula_weight	26501.6 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	G

MAAALWGFFPVLLLLLLSGDVQSSEVPGAAAEGSGGSGVGIGDRFKIEGRAVVPGVKPQDWISAARVLVDGEEHVGFLKTDGSFVVHDIPSGSYVVEVVSPAYRFDPVRVDITSKGKMRARYVNYIKTSEVVRLPYPLQMKSSGPPSYFIKRESWGWTDFLMNPMVMMMVLPLLIFVLLPKVVNTSDPDMRREMEQSMNMLNSNHELPDVSEFMTRLFSSKSSGKSSSGSSKTGKSGAGKRR

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 8 polymer

description	ER membrane protein complex subunit 8
formula_weight	23807.1 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	H

MPGVKLTTQAYCKMVLHGAKYPHCAVNGLLVAEKQKPRKEHLPLGGPGAHHTLFVDCIPLFHGTLALAPMLEVALTLIDSWCKDHSYVIAGYYQANERVKDASPNQVAEKVASRIAEGFSDTALIMVDNTKFTMDCVAPTIHVYEHHENRWRCRDPHHDYCEDWPEAQRISASLLDSRSYETLVDFDNHLDDIRNDWTNPEINKAVLHLC

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 9 polymer

description	ER membrane protein complex subunit 10
formula_weight	27375.8 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	I

MAAASAGATRLLLLLLMAVAAPSRARGSGCRAGTGARGAGAEGREGEACGTVGLLLEHSFEIDDSANFRKRGSLLWNQQDGTLSLSQRQLSEEERGRLRDVAALNGLYRVRIPRRPGALDGLEAGGYVSSFVPACSLVESHLSDQLTLHVDVAGNVVGVSVVTHPGGCRGHEVEDVDLELFNTSVQLQPPTTAPGPETAAFIERLEMEQAQKAKNPQEQKSFFAKYWMYIIPVVLFLMMSGAPDTGGQGGGGGGGGGGGSGR

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 10 polymer

description	Nanobody G9
formula_weight	16805.3 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	K

GSGSGGSGGTSGSSSGSCSSQVQLVESGGGLVQPGGSLRLSCAASGNIFGIYPMGWHRQAPGKQREFVASTTTYNYTSYADSAKGRFTIARDNAKNTVYLQMNSLKPEDTAIYYCYILIRAKVYRGQGTLVTVSSTSSSGSGSGGSGETGSHHHHHHHHHH

Source

organism	Lama glama
common_name	llama
ncbi_taxonomy_id	9844
host_organism	Escherichia coli

Entity 11 polymer

description	Nanobody E2
formula_weight	13699.9 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	L

GSGSGGSGGSGGSGGSTSQVQLVESGGGLVQVGGSLRLSCAASGFEFSLFPMSWHRQAPGKEREFVAAISNTGGNTNYADSVKGRFTISRDNAKNTAYLQMNSLKPEDTAVYYCNARSREYWGQGTQVTVSS

Source

organism	Lama glama
common_name	llama
ncbi_taxonomy_id	9844
host_organism	Escherichia coli

Entity 12 branched

description	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
formula_weight	424.4 kDa
src_method	man
entity_count	3

Entity 13 non-polymer

description	2-acetamido-2-deoxy-beta-D-glucopyranose
formula_weight	221.2 kDa
src_method	syn
entity_count	1

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	4.16 Å
resolution_method	—
num_particles	43012

fit	/app/data/saxs_computation/zz/9zz6/9zz6.fit
pddf	/app/data/pr_computation/zz/9zz6/9zz6.pr.out
profile	/app/data/saxs_computation/zz/9zz6/9zz6.dat

The ER membrane protein complex acts as a chaperone to promote voltage-gated calcium channel assembly

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

EM 3D

5. Entities & Polymer Info (13)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 polymer

Polymer

Source

Entity 4 polymer

Polymer

Source

Entity 5 polymer

Polymer

Source

Entity 6 polymer

Polymer

Source

Entity 7 polymer

Polymer

Source

Entity 8 polymer

Polymer

Source

Entity 9 polymer

Polymer

Source

Entity 10 polymer

Polymer

Source

Entity 11 polymer

Polymer

Source

Entity 12 branched

Entity 13 non-polymer

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)