{ "code": "SASDE24", "status": "Published", "type_of_curve": "SEC-SAS", "angular_unit": "1/nm", "project": { "title": "Inhibitor-induced dimerization of an essential oxidoreductase from African Trypanosomes.", "publication": { "title": "Inhibitor-induced dimerization of an essential oxidoreductase from African Trypanosomes.", "author_list": "Wagner A, Le TA, Brennich M, Klein P, Bader N, Diehl E, Paszek D, Weickhmann AK, Dirdjaja N, Krauth-Siegel RL, Engels B, Opatz T, Schindelin H, Hellmich UA", "journal": "Angew Chem Int Ed Engl", "doi": "10.1002/anie.201810470", "pmid": "30605929", "published_date": "2019 Jan 3" }, "status": "released", "submitted_date": "2018-09-06", "released_date": "2019-01-08" }, "pddf_data": "https://www.sasbdb.org/media/p_of_R_files/SASDE24.out", "intensities_data": "https://www.sasbdb.org/media/intensities_files/SASDE24.dat", "intensities_log_plot": "https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDE24_dat_img.png", "intensities_kratky_plot": "https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDE24_kratky_img.png", "pddf_plot": "https://www.sasbdb.org/media/p_of_R_files/pofr_images/SASDE24_pofr_img.png", "intensities_guinier_plot": "https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDE24_guinier_img.png", "sascif_data": "https://www.sasbdb.org/media/sascif/sascif_files/SASDE24.sascif", "experiment": { "instrument": { "detector": { "type": "Dectris", "name": "Pilatus 1M", "resolution": 172.0 }, "name": "ESRF", "city": "Grenoble", "country": "France", "beamline_name": "BM29", "beam_geometry": "", "type_of_source": "X-ray synchrotron", "point_source": null, "line_collimation": null, "sample_path_length": null, "line_collimation_slitlength": null, "line_collimation_integrationwidth": null, "xray_energy": null, "beam_profile_ah": null, "beam_profile_al": null }, "sample": { "molecule": [ { "long_name": "Tryparedoxin", "short_name": null, "sequence": "GSGLAKYLPGATNLLSKSGEVSLGSLVGKTVFLYFSASWCPPCRG\r\nFTPVLAEFYEKHHVAKNFEVVLISWDENESDFHDYYGKMPWLALPFDQRSTVSELGKTFG\r\nVESIPTLITINADTGAIIGTQARTRVIEDPDGANFPWPN", "organism": "Trypanosoma brucei brucei", "uniprot_code": "O77404", "uniprot_range_first": 2, "uniprot_range_last": 144, "oligomerization": "unknown", "molecular_type": "protein", "uniprot_sequence": "MSGLAKYLPGATNLLSKSGEVSLGSLVGKTVFLYFSASWCPPCRGFTPVLAEFYEKHHVA\nKNFEVVLISWDENESDFHDYYGKMPWLALPFDQRSTVSELGKTFGVESIPTLITINADTG\nAIIGTQARTRVIEDPDGANFPWPN", "mw": 15.817, "total_mw": 15.817, "number_molecules": 0, "complex_state": false, "deuteration": null, "molecule_source": "biological", "molecule_description": null } ], "buffer": { "name": "10 mM HEPES pH 7.5, 50 mM NaCl", "concentration_unit": null, "comment": null, "additive": null, "concentration": null, "pka": null, "ph": 7.5, "deuteration": null }, "purity_method": null, "name": "Tryparedoxin, in the presence of inhibitor CFT (2-(chloromethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4(3H)-one)", "ext_coefficient": null, "contrast": null, "specific_vol": null, "dry_vol": null, "absorbption": null, "deuteration": null, "mixture": null }, "contributor": [ { "affiliation": [ { "short_name": "EMBL", "address": "Grenoble, France", "full_name": "European Molecular Biology Laboratory (EMBL) - 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