SAXSdb — 10bt

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1. Protein Identity and Related Structures Protein Identity & Related Structures

No usable UniProt protein identity is available for this entry.

七张关系表仍保留该条目的 assembly 与组成信息，但缺少统一蛋白身份时，不能可靠建立跨 PDB 的同蛋白Chain接。

Assembly Composition of the Current Entry

Assembly	Oligomeric State	实体与Construct证据	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein heterocomplex Heteromer 蛋白 2 / DNA 0 / RNA 0 / 其他Polymer 0 PDB declaration: dimeric	Entity 1：Antibody Heavy Chain × 1 Entity 2：Antibody Light Chain × 1 缺少 UniProt 身份时不显示参考序列区间	Not recorded	N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine × 1 CHLORIDE ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed experimental conditions	Resolution 1.99 Å R-free 0.233
2	Protein heterocomplex Heteromer 蛋白 2 / DNA 0 / RNA 0 / 其他Polymer 0 PDB declaration: dimeric	Entity 1：Antibody Heavy Chain × 1 Entity 2：Antibody Light Chain × 1 缺少 UniProt 身份时不显示参考序列区间	Not recorded	N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine × 1 CHLORIDE ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed experimental conditions	Resolution 1.99 Å R-free 0.233
3	Protein heterocomplex Heteromer 蛋白 2 / DNA 0 / RNA 0 / 其他Polymer 0 PDB declaration: dimeric	Entity 1：Antibody Heavy Chain × 1 Entity 2：Antibody Light Chain × 1 缺少 UniProt 身份时不显示参考序列区间	Not recorded	N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine × 1 CHLORIDE ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed experimental conditions	Resolution 1.99 Å R-free 0.233
4	Protein heterocomplex Heteromer 蛋白 2 / DNA 0 / RNA 0 / 其他Polymer 0 PDB declaration: dimeric	Entity 1：Antibody Heavy Chain × 1 Entity 2：Antibody Light Chain × 1 缺少 UniProt 身份时不显示参考序列区间	Not recorded	N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine × 1 CHLORIDE ION × 1	X-RAY DIFFRACTION mmCIF provides none of the parsed experimental conditions	Resolution 1.99 Å R-free 0.233

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	10bt
Deposition date deposition_date	2026-01-10
最后修订 last_revision	2026-06-10
Structure title title	X-ray Crystal Structure of A High-Affinity Monoclonal Antibody Sequesters Xylazine
Keywords keywords	monoclonal antibody, IMMUNE SYSTEM; IMMUNE SYSTEM
Experimental Method method	X-RAY DIFFRACTION

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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier	44.59 Å
Radius of gyration Rg (electron density) rg_electron	44.44 Å
Forward intensity I(0) i0	1062450000.00
Molecular weight molecular_weight	177050.0 kDa
Excluded volume excluded_volume	170470 Å³
Envelope volume envelope_volume	336920 Å³
Hydration-shell volume shell_volume	64058 Å³
Envelope diameter envelope_diameter	155.6 Å
Shell Rg shell_rg	48.71 Å
Envelope Rg envelope_rg	43.52 Å
Shape Rg shape_rg	44.42 Å
Total Rg total_rg	44.62 Å
Total atoms total_atoms	13435
Residues n_residues	1737
Spherical-harmonic order n_harmonics	20
q range q_range	— – 0.5000 Å⁻¹
Data points n_points	101
Shell type shell_type	directional
Solvent electron density solvent_density	0.3340 e/Å³
Shell contrast contrast_shell	0.0300 e/Å³
CRYSOL version crysol_version	4.1.3

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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax	150.1 Å
Rg (real space) rg_real	44.63 Å
Rg uncertainty (real space) rg_real_error	1.22 Å
I(0) (real space) i0_real	1.0620e+09
I(0) uncertainty (real space) i0_real_error	1.9250e+07
Rg (reciprocal space) rg_reciprocal	44.59 Å
I(0) (reciprocal space) i0_reciprocal	1062000000.0000
Solution quality estimate total_estimate	0.6369
Solution quality rating solution_quality	REASONABLE a REASONABLE solution
P(r) peaks n_peaks	1
Primary peak position r_peak_primary	55.7 Å
Skewness Skewness skewness	0.364
Kurtosis Kurtosis kurtosis	-0.215
Angular range angular_range	— – 0.1750 Å⁻¹
Current regularization parameter α current_alpha	0.0000
Highest regularization parameter α highest_alpha	41030000.0000
Real-space data points n_real_points	36
GNOM version gnom_version	4.1.3
Quality Criteria quality_criteria	AN1: 0.000; Oscil: 0.850; Stabil: 1.000; Sysdev: 0.010; Positv: 1.000; Valcen: 0.989; Smooth: 0.708

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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (5)

Entity 1 Entity 1 polymer

Description description	Antibody Heavy Chain
Molecular weight formula_weight	25435.3 kDa
Source method src_method	man
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B,C,D
Atom count atom_count	14334

EVKLEESGGGLVQPGGSMRLSCVASGFTFSNYWMNWVRQSPEKGLEWVAEIRLKSNNYATHYAESVKGRFTISRDDSTSSGYLQMNNLRTEDTGIHYCTLTLITDYDVMEYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHHHHHH

来源 Source

来源生物 organism	Homo sapiens
通用名 common_name	human
NCBI Class编号 ncbi_taxonomy_id	9606
宿主生物 host_organism	Homo sapiens

Entity 2 Entity 2 polymer

Description description	Antibody Light Chain
Molecular weight formula_weight	23627.3 kDa
Source method src_method	man
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E,F,G,H

DIQMTQSPSSLSASLGGKVTITCKANQDINKYIAWYQHKPGQGPRLLIHYASALQPGIPSRFSGSGSGRDYSFSISNLEPEDIATYYCLQYDNLYTFGGGTKLEIKRARTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

来源 Source

来源生物 organism	Homo sapiens
通用名 common_name	human
NCBI Class编号 ncbi_taxonomy_id	9606
宿主生物 host_organism	Homo sapiens

Entity 3 Entity 3 non-polymer

Description description	N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine
Molecular weight formula_weight	220.3 kDa
Source method src_method	syn
Copy count entity_count	4

Entity 4 Entity 4 non-polymer

Description description	CHLORIDE ION
Molecular weight formula_weight	35.5 kDa
Source method src_method	syn
Copy count entity_count	4

Entity 5 Entity 5 water

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	890

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8. Citations (1)

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Unit-cell length a length_a	89.178 Å
Unit-cell length b length_b	121.034 Å
Unit-cell length c length_c	95.621 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	112.45 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	8

Space group space_group	P 1 21 1
Space-group number int_tables_number	4
Crystal system crystal_system	—

Resolution resolution	1.990 Å
Low-resolution limit resolution_low	41.990 Å
R factor r_factor	0.1795
R_work r_work	0.1767
R_free r_free	0.2332

fit	/app/data/saxs_computation/0b/10bt/10bt.fit
pddf	/app/data/pr_computation/0b/10bt/10bt.pr.out
profile	/app/data/saxs_computation/0b/10bt/10bt.dat

X-ray Crystal Structure of A High-Affinity Monoclonal Antibody Sequesters Xylazine

1. Protein Identity and Related Structures Protein Identity & Related Structures

Assembly Composition of the Current Entry

SAXS scattering curve SAXS Profile

P(r) Distance Distribution P(r) Distribution

2. Structure Basics 2. Structure Basics

3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

5. Crystallography and Experiment 5. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

6. Entities and Polymers Entities & Polymers (5)

Entity 1 Entity 1 polymer

Polymer Polymer

来源 Source

Entity 2 Entity 2 polymer

Polymer Polymer

来源 Source

Entity 3 Entity 3 non-polymer

Entity 4 Entity 4 non-polymer

Entity 5 Entity 5 water

8. Citations (1)

9. Files and Curves (10)

Files (7)

Curves (3)