X-ray Crystal Structure of A High-Affinity Monoclonal Antibody Sequesters Xylazine

entry_id	10bt
deposition_date	2026-01-10
last_revision	2026-06-10
title	X-ray Crystal Structure of A High-Affinity Monoclonal Antibody Sequesters Xylazine
keywords	monoclonal antibody, IMMUNE SYSTEM; IMMUNE SYSTEM
method	X-RAY DIFFRACTION

rg_guinier	44.59 Å
rg_electron	44.44 Å
i0	1062450000.00
molecular_weight	177050.0 kDa
excluded_volume	170470 ų
envelope_volume	336920 ų
shell_volume	64058 ų
envelope_diameter	155.6 Å
shell_rg	48.71 Å
envelope_rg	43.52 Å
shape_rg	44.42 Å
total_rg	44.62 Å
total_atoms	13435
n_residues	1737
n_harmonics	20
q_range	— – 0.5000 Å−1
n_points	101
shell_type	directional
solvent_density	0.3340 e/ų
contrast_shell	0.0300 e/ų
crysol_version	4.1.3

dmax	150.1 Å
rg_real	44.63 Å
rg_real_error	1.22 Å
i0_real	1.0620e+09
i0_real_error	1.9250e+07
rg_reciprocal	44.59 Å
i0_reciprocal	1062000000.0000
total_estimate	0.6369
solution_quality	REASONABLE a REASONABLE solution
n_peaks	1
r_peak_primary	55.7 Å
skewness	0.364
kurtosis	-0.215
angular_range	— – 0.1750 Å−1
current_alpha	0.0000
highest_alpha	41030000.0000
n_real_points	36
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.850; Stabil: 1.000; Sysdev: 0.010; Positv: 1.000; Valcen: 0.989; Smooth: 0.708

Unit Cell

length_a	89.178 Å
length_b	121.034 Å
length_c	95.621 Å
angle_alpha	90.00 °
angle_beta	112.45 °
angle_gamma	90.00 °
z_pdb	8

Symmetry

space_group	P 1 21 1
int_tables_number	4
crystal_system	—

Refinement

resolution	1.990 Å
resolution_low	41.990 Å
r_factor	0.1795
r_work	0.1767
r_free	0.2332

Diffraction

temperature

100.0 K

Files (7)

• pr_distribution /app/data/pr_computation/0b/10bt/pr_distribution.json
• pr_output /app/data/pr_computation/0b/10bt/10bt.pr.out
• pr_plot /app/data/visualization/pr_computation/0b/10bt/10bt_pr_distribution.png
• saxs_curve_dat /app/data/saxs_computation/0b/10bt/10bt.dat
• saxs_fit /app/data/saxs_computation/0b/10bt/10bt.fit
• saxs_log /app/data/saxs_computation/0b/10bt/10bt.log
• saxs_plot /app/data/visualization/saxs_computation/0b/10bt/10bt_saxs_profile.png

Curves (3)

fit	/app/data/saxs_computation/0b/10bt/10bt.fit
pddf	/app/data/pr_computation/0b/10bt/10bt.pr.out
profile	/app/data/saxs_computation/0b/10bt/10bt.dat