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13yr

PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z198195770

Method: X-RAY DIFFRACTION Dmax: 77.4 Å Quality: GOOD
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1. Protein Identity and Related Structures Protein Identity & Related Structures

3Dpol RNA Dependent RNA Polymerase

enterovirus D68

UniProt F1T146

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count Chain A； UniProt 1732–2188 Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 LJA N-[3-(carbamoylamino)phenyl]acetamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol Resolution 1.83 Å R-free 0.234

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 13YR Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
13XK PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z111507846 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 AWP 1-cyclohexyl-3-(2-pyridin-4-ylethyl)urea × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.77 Å R-free 0.252
13XL PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1143279263 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 UR7 1-(3-fluoro-4-methylphenyl)methanesulfonamide × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.64 Å R-free 0.240
13XM PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1198177230 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 K6U (2M)-2-(2-methoxyphenyl)-1,3,4-oxadiazole × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.61 Å R-free 0.226
13XN PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1201620232 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 16 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 NZ1 5-methoxy-1,3-benzothiazol-2-amine × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.45 Å R-free 0.217
13XO PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1203107138 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 JH1 1-ethyl-N-[(4-fluorophenyl)methyl]-1H-pyrazole-4-carboxamide × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.34 Å R-free 0.206
13XP PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1203191681 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1AJ1 N-[(1H-imidazol-2-yl)methyl]acetamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.60 Å R-free 0.212
13XQ PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1220452176 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 HWH ~{N}-[2-(5-fluoranyl-1~{H}-indol-3-yl)ethyl]ethanamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.39 Å R-free 0.225
13XR PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1222424326 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 S7J 2-(trifluoromethyl)pyrimidine-5-carboxamide × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.47 Å R-free 0.223
13XS PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1230130478 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 14 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1C9Q N,N-dimethyl-2-[(propan-2-yl)amino]pyridine-3-carboxamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.34 Å R-free 0.210
13XT PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1230795916 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1BMO 1-methyl-N-(2-methylpropyl)-1H-imidazole-2-carboxamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.34 Å R-free 0.215
13XU PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1231609616 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 16 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1C9T 5-chloro-N-cyclopropylpyridine-2-carboxamide × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.34 Å R-free 0.211
13XV PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1250129088 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 14 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1C9S N-(3-hydroxy-4-methylphenyl)furan-2-carboxamide × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.53 Å R-free 0.221
13XW PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1265813904 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 14 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 R60 7-fluoranyl-~{N},~{N}-dimethyl-1-benzofuran-2-carboxamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.74 Å R-free 0.216
13XX PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1270393711 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 Z5C 5-(methoxymethyl)-1,2-oxazole-3-carboxamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.48 Å R-free 0.236
13XY PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1295863442 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 UR1 3-fluoro-5-methylbenzene-1-sulfonamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.34 Å R-free 0.211
13XZ PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z133716556 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 Z3H N-[(4R)-3,4-dihydro-2H-1-benzopyran-4-yl]methanesulfonamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.82 Å R-free 0.271
13YA PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1373445602 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 SZE 4-(3-fluoranylpyridin-2-yl)-1-methyl-piperazin-2-one × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.60 Å R-free 0.228
13YB PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1398461996 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 TM0 (1R)-1-(3-benzyl-1,2,4-oxadiazol-5-yl)ethan-1-amine × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.35 Å R-free 0.202
13YC PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1401276297 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1H97 (5~{R})-7-pyrazin-2-yl-2-oxa-7-azaspiro[4.4]nonane × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.34 Å R-free 0.208
13YD PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1428159350 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1C9U (1R)-1-(1-phenyl-1H-1,2,3-triazol-4-yl)ethan-1-amine × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.74 Å R-free 0.213
13YE PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1509191464 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 GOL GLYCEROL × 1 WKA N-(2,1,3-benzoxadiazol-4-yl)acetamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.34 Å R-free 0.211
13YF PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1563512128 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 M0J N-[(2S)-2-hydroxypropyl]-N'-phenylurea × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.45 Å R-free 0.207
13YG PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1685106505 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 TQC (3M)-5-cyclobutyl-3-(1-methyl-1H-imidazol-2-yl)-1,2,4-oxadiazole × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.81 Å R-free 0.238
13YH PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z169675004 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 YDX N-(1-methyl-1H-pyrazol-3-yl)-2-(1H-pyrazol-1-yl)acetamide × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.67 Å R-free 0.215
13YI PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1730522163 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1C9X 1-[(2R)-8-fluoro-2-methyl-2,3-dihydro-4H-1,4-benzoxazin-4-yl]ethan-1-one × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.39 Å R-free 0.205
13YJ PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z1891773476 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1BNE 1-[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]-N-methylmethanamine × 1 DMS DIMETHYL SULFOXIDE × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.62 Å R-free 0.225
13YK PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z190780124 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1C9Y N-[(1S)-1-cyclopropylethyl]-2-oxo-1,2-dihydropyridine-3-carboxamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.57 Å R-free 0.249
13YL PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z192955056 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 Q4L methyl 4-(4-fluorophenyl)piperazine-1-carboxylate × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.83 Å R-free 0.289
13YM PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z19727416 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 W0M (2R)-2-(4-chlorophenoxy)propanamide × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.34 Å R-free 0.205
13YN PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z19733482 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 14 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1AND N,N-dimethyl-2-(2-methylphenoxy)acetamide × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.77 Å R-free 0.221
13YO PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z19735981 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 14 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 VVY 2-phenoxy-1-(pyrrolidin-1-yl)ethan-1-one × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.47 Å R-free 0.226
13YP PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z19755216 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 TT3 2-(3-fluorophenoxy)-N,N-dimethylacetamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.57 Å R-free 0.210
13YQ PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z198194394 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 O1M 4-(4-fluorophenyl)piperazine-1-carboxamide × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.34 Å R-free 0.212
13YS PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z204776284 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1C9Z N~2~-cycloheptyl-N,N~2~-dimethylglycinamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.41 Å R-free 0.233
13YT PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z2092555279 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1BE7 (3R)-3-ethyl-1-(5-fluoropyridin-2-yl)pyrrolidin-3-ol × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.71 Å R-free 0.225
13YU PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z239127550 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 14 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1C90 2-(3-aminophenoxy)-1-(pyrrolidin-1-yl)ethan-1-one × 4 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.46 Å R-free 0.217
13YV PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z240297434 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 K0M 3-methyl-N-(1-methyl-1H-pyrazol-3-yl)-1,2-oxazole-5-carboxamide × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.34 Å R-free 0.202
13YW PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z26333448 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 GQP 1-[(4-fluorophenyl)methyl]benzimidazole × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.77 Å R-free 0.244
13YX PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z274555794 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 NZ4 N-(3-acetylphenyl)morpholine-4-carboxamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.55 Å R-free 0.223
13YY PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z275151340 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 JHP 4-chloro-N-cyclopentyl-1-methyl-1H-pyrazole-3-carboxamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.34 Å R-free 0.200
13YZ PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z285233820 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 KB3 (5M)-5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-amine × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.45 Å R-free 0.215
13ZA PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z2856434866 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1C92 (1r,4R)-4-ethyl-N-{[(2R)-oxolan-2-yl]methyl}cyclohexan-1-amine × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.40 Å R-free 0.209
13ZB PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z285782452 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 16 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 UVA N-methyl-2-(methylsulfonyl)aniline × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.44 Å R-free 0.210
13ZC PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z3015133857 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1C91 [1-(4-fluorophenyl)cyclobutyl][4-(methylamino)piperidin-1-yl]methanone × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.43 Å R-free 0.208
13ZD PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z30620520 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 14 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 GX4 cyclopropyl-[4-(4-fluorophenyl)piperazin-1-yl]methanone × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.59 Å R-free 0.223
13ZE PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z32367954 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 UXA ~{N}-cyclopropyl-1,3-benzodioxole-5-carboxamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.42 Å R-free 0.214
13ZF PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z374427992 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1BFG N-{[2-(dimethylamino)pyridin-4-yl]methyl}acetamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.66 Å R-free 0.214
13ZG PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z381408780 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 16 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1BFI N,N-dimethyl-1,2,3,4-tetrahydroquinoline-6-carboxamide × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.34 Å R-free 0.198
13ZH PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z381474098 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 SZX (2R)-N-(pyridin-2-yl)-1,4-dioxane-2-carboxamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.66 Å R-free 0.211
13ZI PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z384361454 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1BMW 3-methyl-N-{[(3S)-oxolan-3-yl]methyl}-1,2-oxazole-5-carboxamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.34 Å R-free 0.204
13ZJ PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z384362790 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1C93 N-{[(3S)-oxolan-3-yl]methyl}pyrazine-2-carboxamide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.50 Å R-free 0.210
13ZK PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z390185328 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 WL7 4-amino-N-(2-hydroxyethyl)-N-methylbenzene-1-sulfonamide × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.38 Å R-free 0.226
13ZL PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z415636694 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 NY4 N-{4-[(1S)-1-aminoethyl]phenyl}cyclopropanecarboxamide × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.34 Å R-free 0.200
13ZM PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z431546706 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 UQS N-[(2-fluorophenyl)methyl]-1H-pyrazol-4-amine × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.34 Å R-free 0.235
13ZN PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z432057220 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 UVG N,N-dimethyl-1H-pyrazole-4-carboxamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.76 Å R-free 0.292
13ZO PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z445191014 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 UXJ 2-fluoro-N-[(3-methyl-1H-pyrazol-4-yl)methyl]aniline × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.51 Å R-free 0.233
13ZP PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z45527714 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 X0S 2-chloro-N-methylbenzene-1-sulfonamide × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.72 Å R-free 0.230
13ZQ PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z509756472 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 JGG N-[(4-cyanophenyl)methyl]morpholine-4-carboxamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.80 Å R-free 0.259
13ZR PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z53860899 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 STV ~{N}-(1,3-benzodioxol-5-ylmethyl)ethanesulfonamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.50 Å R-free 0.225
13ZS PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z54226006 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 NX7 (2,6-difluorophenyl)(pyrrolidin-1-yl)methanone × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.60 Å R-free 0.217
13ZT PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z55222357 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 ZV2 2-(2-azanyl-1,3-thiazol-3-yl)-~{N}-(4-fluorophenyl)ethanamide × 2 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.34 Å R-free 0.209
13ZU PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z55993012 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1ANC 4-amino-N,N-diethylbenzamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.51 Å R-free 0.238
13ZV PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z56040660 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1C94 2-amino-N-[(2S)-butan-2-yl]benzamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.59 Å R-free 0.243
13ZW PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z56755030 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1C95 4-[(pyridin-4-yl)methyl]aniline × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.78 Å R-free 0.226
13ZX PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z56953052 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 14 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 A1BDK 1-(4-fluorobenzene-1-sulfonyl)piperazine × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.48 Å R-free 0.222
13ZY PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z57260516 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 B0V 2-methoxy-~{N}-(2,4,6-trimethylphenyl)ethanamide × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.34 Å R-free 0.206
13ZZ PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z57328552 Deposited 2026-03-06 Different ligand/ion Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 RX7 2-methyl-2-{[(3-methylthiophen-2-yl)methyl]amino}propan-1-ol × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1 M TRIS-HCl (pH 8.5), 16% PEG 3350, 16% Isopropanol
Resolution 1.52 Å R-free 0.242
14AA PanDDA analysis group deposition of ground-state model of Enterovirus D68 3Dpol Deposited 2026-03-18 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 15 PEG DI(HYDROXYETHYL)ETHER × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289 K；0.1M Tris-HCl, 16% PEG 3350, 16% Isopropanol
Resolution 1.34 Å R-free 0.200
5XE0 Crystal structure of EV-D68-3Dpol in complex with GTP Deposited 2017-03-30 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1732–2188（457 aa） Fragment：UNP residues 1732-2188
Mutation：V17A GTP GUANOSINE-5'-TRIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；289.15 K；0.1 M Tris-HCl pH 8.5, 20.1% isopropanol, 20.1% PEG 3350
Resolution 2.30 Å R-free 0.267

69 other PDB entries and 69 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name F1T146_HED68
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–457； UniProt 1732–2188

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 13yr

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 13yr
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2. Structure Basics 2. Structure Basics

Entry ID entry_id13yr
Deposition date deposition_date2026-03-06
最后修订 last_revision2026-03-18
Structure title titlePanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3Dpol in complex with Z198195770
Keywords keywordsSGC - Diamond I04-1 fragment screening, PanDDA, XChemExplorer, RNA-dependent RNA polymerase, TRANSFERASE; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier24.30 Å
Radius of gyration Rg (electron density) rg_electron23.16 Å
Forward intensity I(0) i043839400.00
Molecular weight molecular_weight52983.0 kDa
Excluded volume excluded_volume67107 ų
Envelope volume envelope_volume83181 ų
Hydration-shell volume shell_volume29246 ų
Envelope diameter envelope_diameter76.5 Å
Shell Rg shell_rg30.71 Å
Envelope Rg envelope_rg22.98 Å
Shape Rg shape_rg23.15 Å
Total Rg total_rg24.12 Å
Total atoms total_atoms3727
Residues n_residues457
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax77.4 Å
Rg (real space) rg_real24.09 Å
Rg uncertainty (real space) rg_real_error0.43 Å
I(0) (real space) i0_real4.3840e+07
I(0) uncertainty (real space) i0_real_error6.0810e+05
Rg (reciprocal space) rg_reciprocal24.14 Å
I(0) (reciprocal space) i0_reciprocal43840000.0000
Solution quality estimate total_estimate0.8148
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks1
Primary peak position r_peak_primary76.1 Å
Skewness Skewness skewness0.018
Kurtosis Kurtosis kurtosis-0.569
Angular range angular_range— – 0.3250 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha12770000.0000
Real-space data points n_real_points64
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.864; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.996; Smooth: 0.000
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (7)

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8. Citations (1)

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9. Files and Curves (10)