1a31
HUMAN RECONSTITUTED DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
1. 蛋白身份与相关结构 Protein Identity & Related Structures
当前条目没有可用的 UniProt 蛋白身份。
七张关系表仍保留该条目的 assembly 与组成信息，但缺少统一蛋白身份时，不能可靠建立跨 PDB 的同蛋白链接。
当前条目的 assembly 组成
| Assembly | 物理组成 | 蛋白状态 | 蛋白 / DNA / RNA / 其他聚合物 | 数据核对 |
|---|---|---|---|---|
| 1 | 蛋白–DNA | 单体 | 1 / 2 / 0 / 0 | 与全部聚合物一致 |
页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。
2. 结构基本信息 2. Structure Basics
| 条目编号 entry_id | 1a31 |
| 沉积日期 deposition_date | 1998-01-27 |
| 结构标题 title | HUMAN RECONSTITUTED DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX |
| 关键词 keywords | TOPOISOMERASE I/DNA, DNA, TOPOISOMERASE I, ISOMERASE-DNA COMPLEX; ISOMERASE/DNA |
| 实验方法 method | X-RAY DIFFRACTION |
3. Official assembly/model 理论 SAXS Official SAXS Profiles
页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。
1a31__assembly_1__model_1
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
1a31__assembly_1__model_1 | I(q)
1a31__assembly_1__model_1 | P(r) · Pending
| Rg（Guinier） | 26.32 Å |
| Rg（电子密度） | 26.15 Å |
| 总 Rg | 26.68 Å |
| 原子数 | 4582 |
| 残基数 | 491 |
| 排除体积 | 79032 ų |
| 最大 q | 0.500 Å⁻¹ |
4. 晶体学与实验 4. Crystallography & Experiment
5. 实体与聚合物信息 Entities & Polymers (4)
6. 折叠分类 (SCOP + CATH) 6 domains
SCOP 2.08 (2 domains)
| 结构域编号 domain_id | d1a31a1 |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.163 — DNA breaking-rejoining enzymes |
| 超家族 Superfamily superfamily | d.163.1 — DNA breaking-rejoining enzymes |
| 家族 Family family | d.163.1.2 — Eukaryotic DNA topoisomerase I, catalytic core |
| 结构域编号 domain_id | d1a31a2 |
| 类 Class class | e — Multi-domain proteins (alpha and beta) |
| 折叠类型 Fold fold | e.15 — Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment |
| 超家族 Superfamily superfamily | e.15.1 — Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment |
| 家族 Family family | e.15.1.1 — Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment |
CATH v4.4 (4 domains)
| 结构域编号 domain_id | 1a31A01 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 10 — Orthogonal Bundle |
| 拓扑 Topology topology | 10 — Arc Repressor Mutant, subunit A |
| 同源超家族 H-superfamily homologous superfamily | 41 — Yeast DNA topoisomerase - domain 1 |
| 结构域编号 domain_id | 1a31A02 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 170 — Beta Complex |
| 拓扑 Topology topology | 11 — DNA Topoisomerase I; domain 2 |
| 同源超家族 H-superfamily homologous superfamily | 10 — DNA Topoisomerase I, domain 2 |
| 结构域编号 domain_id | 1a31A03 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 90 — Alpha-Beta Complex |
| 拓扑 Topology topology | 15 — Topoisomerase I; Chain A, domain 3 |
| 同源超家族 H-superfamily homologous superfamily | 10 — Topoisomerase I; Chain A, domain 3 |
| 结构域编号 domain_id | 1a31A04 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 10 — Orthogonal Bundle |
| 拓扑 Topology topology | 132 — Topoisomerase I; Chain A, domain 4 |
| 同源超家族 H-superfamily homologous superfamily | 10 — |