1.9A STRUCTURE OF THE THERAPEUTIC ANTIBODY CAMPATH-1H FAB IN COMPLEX WITH A SYNTHETIC PEPTIDE ANTIGEN

entry_id	1ce1
deposition_date	1999-03-12
title	1.9A STRUCTURE OF THE THERAPEUTIC ANTIBODY CAMPATH-1H FAB IN COMPLEX WITH A SYNTHETIC PEPTIDE ANTIGEN
keywords	THERAPEUTIC, ANTIBODY, CD52, IMMUNE SYSTEM; IMMUNE SYSTEM
method	X-RAY DIFFRACTION

rg_guinier	24.93 Å
rg_electron	24.04 Å
i0	38493800.00
molecular_weight	47514.0 kDa
excluded_volume	59221 ų
envelope_volume	71348 ų
shell_volume	25008 ų
envelope_diameter	82.8 Å
shell_rg	30.89 Å
envelope_rg	23.78 Å
shape_rg	24.00 Å
total_rg	24.90 Å
total_atoms	3342
n_residues	438
n_harmonics	20
q_range	— – 0.5000 Å−1
n_points	101
shell_type	directional
solvent_density	0.3340 e/ų
contrast_shell	0.0300 e/ų
crysol_version	4.1.3

dmax	80.4 Å
rg_real	24.89 Å
rg_real_error	0.52 Å
i0_real	3.8490e+07
i0_real_error	5.4860e+05
rg_reciprocal	24.90 Å
i0_reciprocal	38490000.0000
total_estimate	0.9036
solution_quality	EXCELLENT a EXCELLENT solution
n_peaks	2
r_peak_primary	28.1 Å
skewness	0.261
kurtosis	-0.516
angular_range	— – 0.3200 Å−1
current_alpha	0.0000
highest_alpha	10500000.0000
n_real_points	64
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.926; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.974; Smooth: 0.992

Unit Cell

length_a	54.846 Å
length_b	60.672 Å
length_c	152.908 Å
angle_alpha	90.00 °
angle_beta	89.72 °
angle_gamma	89.85 °
z_pdb	4

Symmetry

space_group	P 21 21 21
int_tables_number	19
crystal_system	—

Refinement

resolution	1.900 Å
resolution_low	6.000 Å
r_factor	0.2200
r_work	0.2200
r_free	0.2700

Diffraction

temperature

100.0 K

Files (7)

• pr_distribution /app/data/pr_computation/ce/1ce1/pr_distribution.json
• pr_output /app/data/pr_computation/ce/1ce1/1ce1.pr.out
• pr_plot /app/data/visualization/pr_computation/ce/1ce1/1ce1_pr_distribution.png
• saxs_curve_dat /app/data/saxs_computation/ce/1ce1/1ce1.dat
• saxs_fit /app/data/saxs_computation/ce/1ce1/1ce1.fit
• saxs_log /app/data/saxs_computation/ce/1ce1/1ce1.log
• saxs_plot /app/data/visualization/saxs_computation/ce/1ce1/1ce1_saxs_profile.png

Curves (3)

fit	/app/data/saxs_computation/ce/1ce1/1ce1.fit
pddf	/app/data/pr_computation/ce/1ce1/1ce1.pr.out
profile	/app/data/saxs_computation/ce/1ce1/1ce1.dat