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1e8c

Structure of MurE the UDP-N-acetylmuramyl tripeptide synthetase from E. coli

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,6-DIAMINOPIMELATE LIGASE

ESCHERICHIA COLI

UniProt P22188

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 CHLORIDE ION × 1 URIDINE-5'-DIPHOSPHATE-N-ACETYLMURAMOYL-L-ALANINE-D-GLUTAMATE × 1 2,6-DIAMINOPIMELIC ACID × 1 water × 1 Consistent with protein count
2 Protein monomer Monomer Protein 1 URIDINE-5'-DIPHOSPHATE-N-ACETYLMURAMOYL-L-ALANINE-D-GLUTAMATE × 1 2,6-DIAMINOPIMELIC ACID × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1e8c 1e8c 7b53 7b53 7b60 7b60 7b61 7b61 7b68 7b68 7b6i 7b6i

32 assemblies; showing the first 12

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name MURE_ECOLI
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–494； UniProt 2–495 Author chain B； PDBConstruct 1–494； UniProt 2–495

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1e8c
Deposition date deposition_date2000-09-19
Structure title titleStructure of MurE the UDP-N-acetylmuramyl tripeptide synthetase from E. coli
Keywords keywordsLIGASE, PEPTIDOGLYCAN BIOSYNTHESIS; LIGASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1e8c__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1e8c__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1e8c__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）24.80 Å
Rg (electron density)24.08 Å
Total Rg25.10 Å
Atom count3826
Residues483
Excluded volume67597 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1e8c__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 1e8c__assembly_2__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 14 domains

SCOP 2.08 (8 domains)

Domain ID domain_idd1e8ca1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.98 — MurF and HprK N-domain-like
Superfamily Superfamily superfamilyc.98.1 — MurE/MurF N-terminal domain
Family Family familyc.98.1.1 — MurE/MurF N-terminal domain
Domain ID domain_idd1e8ca2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.59 — MurD-like peptide ligases, peptide-binding domain
Superfamily Superfamily superfamilyc.59.1 — MurD-like peptide ligases, peptide-binding domain
Family Family familyc.59.1.1 — MurCDEF C-terminal domain
Domain ID domain_idd1e8ca3
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.72 — Ribokinase-like
Superfamily Superfamily superfamilyc.72.2 — MurD-like peptide ligases, catalytic domain
Family Family familyc.72.2.1 — MurCDEF
Domain ID domain_idd1e8ca4
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd1e8cb1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.98 — MurF and HprK N-domain-like
Superfamily Superfamily superfamilyc.98.1 — MurE/MurF N-terminal domain
Family Family familyc.98.1.1 — MurE/MurF N-terminal domain
Domain ID domain_idd1e8cb2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.59 — MurD-like peptide ligases, peptide-binding domain
Superfamily Superfamily superfamilyc.59.1 — MurD-like peptide ligases, peptide-binding domain
Family Family familyc.59.1.1 — MurCDEF C-terminal domain
Domain ID domain_idd1e8cb3
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.72 — Ribokinase-like
Superfamily Superfamily superfamilyc.72.2 — MurD-like peptide ligases, catalytic domain
Family Family familyc.72.2.1 — MurCDEF
Domain ID domain_idd1e8cb4
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags

CATH v4.4 (6 domains)

Domain ID domain_id1e8cA01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology1390 — Udp-n-acetylmuramoylalanyl-d-glutamate--2,6- Diaminopimelate Ligase; Chain: A, domain 1
Homologous superfamily homologous superfamily10 — MurE/MurF, N-terminal domain
Domain ID domain_id1e8cA02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology1190 — UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase
Homologous superfamily homologous superfamily10 — Mur-like, catalytic domain
Domain ID domain_id1e8cA03
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology190 — Protein-Tyrosine Phosphatase; Chain A
Homologous superfamily homologous superfamily20 — Mur ligase, C-terminal domain
Domain ID domain_id1e8cB01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology1390 — Udp-n-acetylmuramoylalanyl-d-glutamate--2,6- Diaminopimelate Ligase; Chain: A, domain 1
Homologous superfamily homologous superfamily10 — MurE/MurF, N-terminal domain
Domain ID domain_id1e8cB02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology1190 — UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase
Homologous superfamily homologous superfamily10 — Mur-like, catalytic domain
Domain ID domain_id1e8cB03
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology190 — Protein-Tyrosine Phosphatase; Chain A
Homologous superfamily homologous superfamily20 — Mur ligase, C-terminal domain
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7. Citations (1)