1e9t

High resolution solution structure of human intestinal trefoil factor

Method: SOLUTION NMR

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1. Protein Identity and Related Structures Protein Identity & Related Structures

INTESTINAL TREFOIL FACTOR

HOMO SAPIENS

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein monomer	Monomer	Protein 1	No other associated polymer	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	ITF_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–59； UniProt 22–80

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	1e9t
Deposition date deposition_date	2000-10-26
Structure title title	High resolution solution structure of human intestinal trefoil factor
Keywords keywords	INTESTINAL TREFOIL FACTOR, SOLUTION STRUCTURE, TREFOIL DOMAIN, NMR SPECTROSCOPY, CELL MOTILITY FACTOR; CELL MOTILITY FACTOR
Experimental Method method	SOLUTION NMR

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1e9t__assembly_1__model_21

Assembly 1 · Model 21 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1e9t__assembly_1__model_21 | I(q)

100 plotted points; both axes use logarithmic scales.

1e9t__assembly_1__model_21 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	12.97 Å
Rg (electron density)	12.14 Å
Total Rg	13.23 Å
Atom count	878
Residues	59
Excluded volume	8013 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`1e9t__assembly_1__model_1`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	2	`1e9t__assembly_1__model_2`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	3	`1e9t__assembly_1__model_3`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	4	`1e9t__assembly_1__model_4`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	5	`1e9t__assembly_1__model_5`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	6	`1e9t__assembly_1__model_6`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	7	`1e9t__assembly_1__model_7`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	8	`1e9t__assembly_1__model_8`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	9	`1e9t__assembly_1__model_9`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	10	`1e9t__assembly_1__model_10`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	11	`1e9t__assembly_1__model_11`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	12	`1e9t__assembly_1__model_12`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	13	`1e9t__assembly_1__model_13`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	14	`1e9t__assembly_1__model_14`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	15	`1e9t__assembly_1__model_15`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	16	`1e9t__assembly_1__model_16`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	17	`1e9t__assembly_1__model_17`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	18	`1e9t__assembly_1__model_18`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	19	`1e9t__assembly_1__model_19`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	20	`1e9t__assembly_1__model_20`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	21	`1e9t__assembly_1__model_21`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	22	`1e9t__assembly_1__model_22`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	23	`1e9t__assembly_1__model_23`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	24	`1e9t__assembly_1__model_24`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	25	`1e9t__assembly_1__model_25`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	26	`1e9t__assembly_1__model_26`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	27	`1e9t__assembly_1__model_27`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	28	`1e9t__assembly_1__model_28`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	29	`1e9t__assembly_1__model_29`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	30	`1e9t__assembly_1__model_30`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	31	`1e9t__assembly_1__model_31`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	32	`1e9t__assembly_1__model_32`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	33	`1e9t__assembly_1__model_33`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	34	`1e9t__assembly_1__model_34`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	35	`1e9t__assembly_1__model_35`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	36	`1e9t__assembly_1__model_36`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	37	`1e9t__assembly_1__model_37`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	38	`1e9t__assembly_1__model_38`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	39	`1e9t__assembly_1__model_39`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	40	`1e9t__assembly_1__model_40`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	41	`1e9t__assembly_1__model_41`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	42	`1e9t__assembly_1__model_42`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	43	`1e9t__assembly_1__model_43`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	44	`1e9t__assembly_1__model_44`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	45	`1e9t__assembly_1__model_45`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	46	`1e9t__assembly_1__model_46`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	47	`1e9t__assembly_1__model_47`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	48	`1e9t__assembly_1__model_48`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	49	`1e9t__assembly_1__model_49`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	50	`1e9t__assembly_1__model_50`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	51	`1e9t__assembly_1__model_51`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	52	`1e9t__assembly_1__model_52`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	53	`1e9t__assembly_1__model_53`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	54	`1e9t__assembly_1__model_54`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	55	`1e9t__assembly_1__model_55`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	56	`1e9t__assembly_1__model_56`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	57	`1e9t__assembly_1__model_57`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	58	`1e9t__assembly_1__model_58`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	59	`1e9t__assembly_1__model_59`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	60	`1e9t__assembly_1__model_60`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	61	`1e9t__assembly_1__model_61`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	62	`1e9t__assembly_1__model_62`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	63	`1e9t__assembly_1__model_63`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	64	`1e9t__assembly_1__model_64`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	65	`1e9t__assembly_1__model_65`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	66	`1e9t__assembly_1__model_66`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	67	`1e9t__assembly_1__model_67`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	68	`1e9t__assembly_1__model_68`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	69	`1e9t__assembly_1__model_69`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	70	`1e9t__assembly_1__model_70`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	71	`1e9t__assembly_1__model_71`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	72	`1e9t__assembly_1__model_72`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	73	`1e9t__assembly_1__model_73`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	74	`1e9t__assembly_1__model_74`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	75	`1e9t__assembly_1__model_75`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	76	`1e9t__assembly_1__model_76`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	77	`1e9t__assembly_1__model_77`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	78	`1e9t__assembly_1__model_78`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	79	`1e9t__assembly_1__model_79`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	80	`1e9t__assembly_1__model_80`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	81	`1e9t__assembly_1__model_81`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	82	`1e9t__assembly_1__model_82`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	83	`1e9t__assembly_1__model_83`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	84	`1e9t__assembly_1__model_84`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
1	85	`1e9t__assembly_1__model_85`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (1)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_id	d1e9ta_
Class class	g — Small proteins
Fold Fold fold	g.16 — Trefoil/Plexin domain-like
Superfamily Superfamily superfamily	g.16.1 — Trefoil
Family Family family	g.16.1.1 — Trefoil

CATH v4.4 (1 domains)

Domain ID domain_id	1e9tA00
Class class	4 — Few Secondary Structures
Architecture architecture	10 — Irregular
Topology topology	110 — Spasmolytic Protein; domain 1
Homologous superfamily homologous superfamily	10 — Spasmolytic Protein, domain 1

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Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	1

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Description description	INTESTINAL TREFOIL FACTOR
Molecular weight formula_weight	6587.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer type type	polypeptide(L)
Chain IDs strand_id	A
Atom count atom_count	74630

Source organism organism	HOMO SAPIENS
Common name common_name	HUMAN
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	SACCHAROMYCES CEREVISIAE

High resolution solution structure of human intestinal trefoil factor

1. Protein Identity and Related Structures Protein Identity & Related Structures

INTESTINAL TREFOIL FACTOR

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

1e9t__assembly_1__model_21

1e9t__assembly_1__model_21 | I(q)

1e9t__assembly_1__model_21 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

5. Entities and Polymers Entities & Polymers (1)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

CATH v4.4 (1 domains)

7. Citations (1)

High resolution solution structure of human intestinal trefoil factor

1. Protein Identity and Related Structures Protein Identity & Related Structures

INTESTINAL TREFOIL FACTOR

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

1e9t__assembly_1__model_21

1e9t__assembly_1__model_21 | I(q)

1e9t__assembly_1__model_21 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

5. Entities and Polymers Entities & Polymers (1)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

CATH v4.4 (1 domains)

7. Citations (1)