1h4s
Prolyl-tRNA synthetase from Thermus thermophilus complexed with tRNApro(CGG) and a prolyl-adenylate analogue
1. Protein Identity and Related Structures Protein Identity & Related Structures
No usable UniProt protein identity is available for this entry.
The relationship tables retain this entry's assembly and composition data, but cross-PDB links for the same protein cannot be established reliably without a unified protein identity.
Assembly Composition of the Current Entry
| Assembly | Physical composition | Protein state | 蛋白 / DNA / RNA / 其他Polymer | Data consistency |
|---|---|---|---|---|
| 1 | Protein–RNA | Homooligomer | 2 / 0 / 1 / 0 | Consistent with all polymers |
The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.
2. Structure Basics 2. Structure Basics
| Entry ID entry_id | 1h4s |
| Deposition date deposition_date | 2001-05-14 |
| Structure title title | Prolyl-tRNA synthetase from Thermus thermophilus complexed with tRNApro(CGG) and a prolyl-adenylate analogue |
| Keywords keywords | AMINOACYL-TRNA SYNTHETASE, ATP + L-PROLINE + TRNA(PRO) AMP + PPI + L-PROLYL-TRNA(PRO), CLASS II AMINOACYL-TRNA SYNTHETASE; AMINOACYL-TRNA SYNTHETASE |
| Experimental Method method | X-RAY DIFFRACTION |
3. Official assembly/model SAXS Official SAXS Profiles
This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.
1h4s__assembly_1__model_1
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
1h4s__assembly_1__model_1 | I(q)
1h4s__assembly_1__model_1 | P(r) · Pending
| Rg（Guinier） | 34.55 Å |
| Rg (electron density) | 32.89 Å |
| Total Rg | 33.68 Å |
| Atom count | 9160 |
| Residues | 1011 |
| Excluded volume | 157090 ų |
| Maximum q | 0.500 Å⁻¹ |
4. Crystallography and Experiment 4. Crystallography & Experiment
5. Entities and Polymers Entities & Polymers (6)
6. Fold Classification (SCOP + CATH) 12 domains
SCOP 2.08 (6 domains)
| Domain ID domain_id | d1h4sa1 |
| Class class | c — Alpha and beta proteins (a/b) |
| Fold Fold fold | c.51 — Anticodon-binding domain-like |
| Superfamily Superfamily superfamily | c.51.1 — Class II aaRS ABD-related |
| Family Family family | c.51.1.1 — Anticodon-binding domain of Class II aaRS |
| Domain ID domain_id | d1h4sa2 |
| Class class | d — Alpha and beta proteins (a+b) |
| Fold Fold fold | d.104 — Class II aaRS and biotin synthetases |
| Superfamily Superfamily superfamily | d.104.1 — Class II aaRS and biotin synthetases |
| Family Family family | d.104.1.1 — Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain |
| Domain ID domain_id | d1h4sa3 |
| Class class | d — Alpha and beta proteins (a+b) |
| Fold Fold fold | d.68 — IF3-like |
| Superfamily Superfamily superfamily | d.68.5 — C-terminal domain of ProRS |
| Family Family family | d.68.5.1 — C-terminal domain of ProRS |
| Domain ID domain_id | d1h4sb1 |
| Class class | c — Alpha and beta proteins (a/b) |
| Fold Fold fold | c.51 — Anticodon-binding domain-like |
| Superfamily Superfamily superfamily | c.51.1 — Class II aaRS ABD-related |
| Family Family family | c.51.1.1 — Anticodon-binding domain of Class II aaRS |
| Domain ID domain_id | d1h4sb2 |
| Class class | d — Alpha and beta proteins (a+b) |
| Fold Fold fold | d.104 — Class II aaRS and biotin synthetases |
| Superfamily Superfamily superfamily | d.104.1 — Class II aaRS and biotin synthetases |
| Family Family family | d.104.1.1 — Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain |
| Domain ID domain_id | d1h4sb3 |
| Class class | d — Alpha and beta proteins (a+b) |
| Fold Fold fold | d.68 — IF3-like |
| Superfamily Superfamily superfamily | d.68.5 — C-terminal domain of ProRS |
| Family Family family | d.68.5.1 — C-terminal domain of ProRS |
CATH v4.4 (6 domains)
| Domain ID domain_id | 1h4sA01 |
| Class class | 3 — Alpha Beta |
| Architecture architecture | 30 — 2-Layer Sandwich |
| Topology topology | 930 — BirA Bifunctional Protein; domain 2 |
| Homologous superfamily homologous superfamily | 10 — Bira Bifunctional Protein; Domain 2 |
| Domain ID domain_id | 1h4sA02 |
| Class class | 3 — Alpha Beta |
| Architecture architecture | 40 — 3-Layer(aba) Sandwich |
| Topology topology | 50 — Rossmann fold |
| Homologous superfamily homologous superfamily | 800 — Anticodon-binding domain |
| Domain ID domain_id | 1h4sA03 |
| Class class | 3 — Alpha Beta |
| Architecture architecture | 30 — 2-Layer Sandwich |
| Topology topology | 110 — Translation Initiation Factor IF3 |
| Homologous superfamily homologous superfamily | 30 — C-terminal domain of ProRS |
| Domain ID domain_id | 1h4sB01 |
| Class class | 3 — Alpha Beta |
| Architecture architecture | 30 — 2-Layer Sandwich |
| Topology topology | 930 — BirA Bifunctional Protein; domain 2 |
| Homologous superfamily homologous superfamily | 10 — Bira Bifunctional Protein; Domain 2 |
| Domain ID domain_id | 1h4sB02 |
| Class class | 3 — Alpha Beta |
| Architecture architecture | 40 — 3-Layer(aba) Sandwich |
| Topology topology | 50 — Rossmann fold |
| Homologous superfamily homologous superfamily | 800 — Anticodon-binding domain |
| Domain ID domain_id | 1h4sB03 |
| Class class | 3 — Alpha Beta |
| Architecture architecture | 30 — 2-Layer Sandwich |
| Topology topology | 110 — Translation Initiation Factor IF3 |
| Homologous superfamily homologous superfamily | 30 — C-terminal domain of ProRS |