1hc1

CRYSTAL STRUCTURE OF HEXAMERIC HAEMOCYANIN FROM PANULIRUS INTERRUPTUS REFINED AT 3.2 ANGSTROMS RESOLUTION

Method: X-RAY DIFFRACTION

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

ARTHROPODAN HEMOCYANIN

Panulirus interruptus

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	蛋白同源多聚体	同源多聚体	蛋白 6	COPPER (II) ION × 12 water × 6	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	HCYA_PANIN
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 1–657； UniProt 1–657 作者链 B； PDB构建体 1–657； UniProt 1–657 作者链 C； PDB构建体 1–657； UniProt 1–657 作者链 D； PDB构建体 1–657； UniProt 1–657 作者链 E； PDB构建体 1–657； UniProt 1–657 作者链 F； PDB构建体 1–657； UniProt 1–657

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	1hc1
沉积日期 deposition_date	1991-05-15
结构标题 title	CRYSTAL STRUCTURE OF HEXAMERIC HAEMOCYANIN FROM PANULIRUS INTERRUPTUS REFINED AT 3.2 ANGSTROMS RESOLUTION
关键词 keywords	OXYGEN TRANSPORT; OXYGEN TRANSPORT
实验方法 method	X-RAY DIFFRACTION

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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

1hc1__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

1hc1__assembly_1__model_1 | I(q)

100 个绘图点；横轴和纵轴均采用对数尺度。

1hc1__assembly_1__model_1 | P(r) · Pending

P(r) 将按相同 assembly/model 分别计算和展示。

Rg（Guinier）	48.59 Å
Rg（电子密度）	47.58 Å
总 Rg	47.96 Å
原子数	31050
残基数	3804
排除体积	545390 Å³
最大 q	0.500 Å⁻¹

Assembly	Model	结构单元	聚集说明	状态	CRYSOL	操作
1	1	`1hc1__assembly_1__model_1`	hexameric （6）	成功	4.1.3-1-20251215 (887e7ef)	查看下载

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (3)

实体 1 Entity 1 polymer

描述 description	ARTHROPODAN HEMOCYANIN
分子量 formula_weight	75696.2 kDa
来源方法 src_method	man
拷贝数 entity_count	6

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	A,B,C,D,E,F
原子数 atom_count	32166

DALGTGNAQKQQDINHLLDKIYEPTKYPDLKDIAENFNPLGDTSIYNDHGAAVETLMKELNDHRLLEQRHWYSLFNTRQRKEALMLFAVLNQCKEWYCFRSNAAYFRERMNEGEFVYALYVSVIHSKLGDGIVLPPLYQITPHMFTNSEVIDKAYSAKMTQKPGTFNVSFTGTKKNREQRVAYFGEDIGMNIHHVTWHMDFPFWWEDSYGYHLDRKGELFFWVHHQLTARFDFERLSNWLDPVDELHWDRIIREGFAPLTSYKYGGEFPVRPDNIHFEDVDGVAHVHDLEITESRIHEAIDHGYITDSDGHTIDIRQPKGIELLGDIIESSKYSSNVQYYGSLHNTAHVMLGRQGDPHGKFNLPPGVMEHFETATRDPSFFRLHKYMDNIFKKHTDSFPPYTHDNLEFSGMVVNGVAIDGELITFFDEFQYSLINAVDSGENIEDVEINARVHRLNHNEFTYKITMSNNNDGERLATFRIFLCPIEDNNGITLTLDEARWFCIELDKFFQKVPSGPETIERSSKDSSVTVPDMPSFQSLKEQADNAVNGGHDLDLSAYERSCGIPDRMLLPKSKPEGMEFNLYVAVTDGDKDTEGHNGGHDYGGTHAQCGVHGEAYPDNRPLGYPLERRIPDERVIDGVSNIKHVVVKIVHHLEHHD

来源 Source

来源生物 organism	Panulirus interruptus
通用名 common_name	California spiny lobster
NCBI 分类编号 ncbi_taxonomy_id	6735

实体 2 Entity 2 non-polymer

描述 description	COPPER (II) ION
分子量 formula_weight	63.5 kDa
来源方法 src_method	syn
拷贝数 entity_count	12

实体 3 Entity 3 water

描述 description	water
分子量 formula_weight	18.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	1116

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6. 折叠分类 (SCOP + CATH) 15 domains

SCOP 2.08 (3 domains)

结构域编号 domain_id	d1hc1a1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.85 — Hemocyanin, N-terminal domain
超家族 Superfamily superfamily	a.85.1 — Hemocyanin, N-terminal domain
家族 Family family	a.85.1.1 — Hemocyanin, N-terminal domain

结构域编号 domain_id	d1hc1a2
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.86 — Di-copper centre-containing domain
超家族 Superfamily superfamily	a.86.1 — Di-copper centre-containing domain
家族 Family family	a.86.1.1 — Hemocyanin middle domain

结构域编号 domain_id	d1hc1a3
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.1 — Immunoglobulin-like beta-sandwich
超家族 Superfamily superfamily	b.1.18 — E set domains
家族 Family family	b.1.18.3 — Arthropod hemocyanin, C-terminal domain

CATH v4.4 (12 domains)

结构域编号 domain_id	1hc1A02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1280 — di-copper center containing domain from catechol oxidase
同源超家族 H-superfamily homologous superfamily	10 — Di-copper center containing domain from catechol oxidase

结构域编号 domain_id	1hc1A03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	60 — Sandwich
拓扑 Topology topology	40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily	1520 — Hemocyanin, C-terminal domain

结构域编号 domain_id	1hc1B02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1280 — di-copper center containing domain from catechol oxidase
同源超家族 H-superfamily homologous superfamily	10 — Di-copper center containing domain from catechol oxidase

结构域编号 domain_id	1hc1B03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	60 — Sandwich
拓扑 Topology topology	40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily	1520 — Hemocyanin, C-terminal domain

结构域编号 domain_id	1hc1C02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1280 — di-copper center containing domain from catechol oxidase
同源超家族 H-superfamily homologous superfamily	10 — Di-copper center containing domain from catechol oxidase

结构域编号 domain_id	1hc1C03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	60 — Sandwich
拓扑 Topology topology	40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily	1520 — Hemocyanin, C-terminal domain

结构域编号 domain_id	1hc1D02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1280 — di-copper center containing domain from catechol oxidase
同源超家族 H-superfamily homologous superfamily	10 — Di-copper center containing domain from catechol oxidase

结构域编号 domain_id	1hc1D03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	60 — Sandwich
拓扑 Topology topology	40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily	1520 — Hemocyanin, C-terminal domain

结构域编号 domain_id	1hc1E02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1280 — di-copper center containing domain from catechol oxidase
同源超家族 H-superfamily homologous superfamily	10 — Di-copper center containing domain from catechol oxidase

结构域编号 domain_id	1hc1E03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	60 — Sandwich
拓扑 Topology topology	40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily	1520 — Hemocyanin, C-terminal domain

结构域编号 domain_id	1hc1F02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1280 — di-copper center containing domain from catechol oxidase
同源超家族 H-superfamily homologous superfamily	10 — Di-copper center containing domain from catechol oxidase

结构域编号 domain_id	1hc1F03
类 Class class	2 — Mainly Beta
架构 Architecture architecture	60 — Sandwich
拓扑 Topology topology	40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily	1520 — Hemocyanin, C-terminal domain

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7. 引用文献 (8)

Crystal structure of hexameric haemocyanin from Panulirus interruptus refined at 3.2 A resolution.

J.Mol.Biol. (1989)

PMID: 2585484 · DOI: 10.1016/0022-2836(89)90276-3 PRIMARY

Spectroscopic Investigations of Panulirus Interruptus Hemocyanin in the Crystalline State

Eur.J.Biochem. (1989)

;Pseudo 2-Fold Symmetry in the Copper-Binding Domain of Arthropodan Haemocyanins. Possible Implications for the Evolution of Oxygen Transport Proteins ;

J.Mol.Biol. (1989)

;Panulirus Interruptus Hemocyanin. The Amino Acid Sequence of Subunit B and Anomalous Behavior of Subunits a and B on Polyacrylamide Gel Electrophoresis in the Presence of Sds ;

Eur.J.Biochem. (1988)

Panulirus Interruptus Hemocyanin. The Elucidation of the Complete Amino Acid Sequence of Subunit A

Eur.J.Biochem. (1987)

;Structure Determination of Panulirus Interruptus Haemocyanin at 3.2 Angstroms Resolution. Successful Phase Extension by Sixfold Density Averaging ;

J.Mol.Biol. (1986)

The Structure of Arthropod Hemocyanins

Science (1985)

3.2 Angstroms Structure of the Copper-Containing, Oxygen-Carrying Protein Panulirus Interruptus Haemocyanin

Nature (1984)

晶胞边长 a length_a	119.800 Å
晶胞边长 b length_b	193.100 Å
晶胞边长 c length_c	122.200 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	118.10 °
晶胞夹角 γ angle_gamma	90.00 °
晶胞分子数 Z z_pdb	12

空间群 space_group	P 1 21 1
空间群编号 int_tables_number	4
晶系 crystal_system	—

分辨率 resolution	3.200 Å
最低分辨率 resolution_low	8.000 Å
R 因子 r_factor	0.2010
R_work r_work	—
R_free r_free	—

CRYSTAL STRUCTURE OF HEXAMERIC HAEMOCYANIN FROM PANULIRUS INTERRUPTUS REFINED AT 3.2 ANGSTROMS RESOLUTION

1. 蛋白身份与相关结构 Protein Identity & Related Structures

ARTHROPODAN HEMOCYANIN

当前结构中的状态

数据库中的同蛋白其他状态

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

1hc1__assembly_1__model_1

1hc1__assembly_1__model_1 | I(q)

1hc1__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

5. 实体与聚合物信息 Entities & Polymers (3)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 non-polymer

实体 3 Entity 3 water

6. 折叠分类 (SCOP + CATH) 15 domains

SCOP 2.08 (3 domains)

CATH v4.4 (12 domains)

7. 引用文献 (8)

CRYSTAL STRUCTURE OF HEXAMERIC HAEMOCYANIN FROM PANULIRUS INTERRUPTUS REFINED AT 3.2 ANGSTROMS RESOLUTION

1. 蛋白身份与相关结构 Protein Identity & Related Structures

ARTHROPODAN HEMOCYANIN

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

1hc1__assembly_1__model_1

1hc1__assembly_1__model_1 | I(q)

1hc1__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

5. 实体与聚合物信息 Entities & Polymers (3)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 non-polymer

实体 3 Entity 3 water

6. 折叠分类 (SCOP + CATH) 15 domains

SCOP 2.08 (3 domains)

CATH v4.4 (12 domains)

7. 引用文献 (8)