1iqp

Crystal Structure of the Clamp Loader Small Subunit from Pyrococcus furiosus

Method: X-RAY DIFFRACTION

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

RFCS

Pyrococcus furiosus

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	蛋白同源多聚体	同源多聚体	蛋白 6	ADENOSINE-5'-DIPHOSPHATE × 4 water × 6	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	RFCS_PYRFU
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 60–327； UniProt 1–268 作者链 B； PDB构建体 60–327； UniProt 1–268 作者链 C； PDB构建体 60–327； UniProt 1–268 作者链 D； PDB构建体 60–327； UniProt 1–268 作者链 E； PDB构建体 60–327； UniProt 1–268 作者链 F； PDB构建体 60–327； UniProt 1–268

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	1iqp
沉积日期 deposition_date	2001-07-24
结构标题 title	Crystal Structure of the Clamp Loader Small Subunit from Pyrococcus furiosus
关键词 keywords	CLAMP LOADER, EXTENDED AAA-ATPASE DOMAIN, COMPLEX WITH ADP, REPLICATION; REPLICATION
实验方法 method	X-RAY DIFFRACTION

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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

1iqp__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

1iqp__assembly_1__model_1 | I(q)

100 个绘图点；横轴和纵轴均采用对数尺度。

1iqp__assembly_1__model_1 | P(r) · Pending

P(r) 将按相同 assembly/model 分别计算和展示。

Rg（Guinier）	43.29 Å
Rg（电子密度）	42.62 Å
总 Rg	42.85 Å
原子数	15787
残基数	1949
排除体积	283440 Å³
最大 q	0.500 Å⁻¹

Assembly	Model	结构单元	聚集说明	状态	CRYSOL	操作
1	1	`1iqp__assembly_1__model_1`	hexameric （6）	成功	4.1.3-1-20251215 (887e7ef)	查看下载

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (3)

实体 1 Entity 1 polymer

描述 description	RFCS
分子量 formula_weight	37458.5 kDa
来源方法 src_method	man
拷贝数 entity_count	6

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	A,B,C,D,E,F
原子数 atom_count	16031

MSEEIREVKVLEKPWVEKYRPQRLDDIVGQEHIVKRLKHYVKTGSMPHLLFAGPPGVGKTTAALALARELFGENWRHNFLELNASDERGINVIREKVKEFARTKPIGGASFKIIFLDEADALTQDAQQALRRTMEMFSSNVRFILSCNYSSKIIEPIQSRCAIFRFRPLRDEDIAKRLRYIAENEGLELTEEGLQAILYIAEGDMRRAINILQAAAALDKKITDENVFMVASRARPEDIREMMLLALKGNFLKAREKLREILLKQGLSGEDVLVQMHKEVFNLPIEEPKKVLLADKIGEYNFRLVEGANEIIQLEALLAQFTLIGKK

来源 Source

来源生物 organism	Pyrococcus furiosus
NCBI 分类编号 ncbi_taxonomy_id	2261
宿主生物 host_organism	Escherichia coli BL21(DE3)

实体 2 Entity 2 non-polymer

描述 description	ADENOSINE-5'-DIPHOSPHATE
分子量 formula_weight	427.2 kDa
来源方法 src_method	syn
拷贝数 entity_count	4

实体 3 Entity 3 water

描述 description	water
分子量 formula_weight	18.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	244

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6. 折叠分类 (SCOP + CATH) 30 domains

SCOP 2.08 (12 domains)

结构域编号 domain_id	d1iqpa1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.80 — post-AAA+ oligomerization domain-like
超家族 Superfamily superfamily	a.80.1 — post-AAA+ oligomerization domain-like
家族 Family family	a.80.1.1 — DNA polymerase III clamp loader subunits, C-terminal domain

结构域编号 domain_id	d1iqpa2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.37 — P-loop containing nucleoside triphosphate hydrolases
超家族 Superfamily superfamily	c.37.1 — P-loop containing nucleoside triphosphate hydrolases
家族 Family family	c.37.1.20 — Extended AAA-ATPase domain

结构域编号 domain_id	d1iqpb1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.80 — post-AAA+ oligomerization domain-like
超家族 Superfamily superfamily	a.80.1 — post-AAA+ oligomerization domain-like
家族 Family family	a.80.1.1 — DNA polymerase III clamp loader subunits, C-terminal domain

结构域编号 domain_id	d1iqpb2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.37 — P-loop containing nucleoside triphosphate hydrolases
超家族 Superfamily superfamily	c.37.1 — P-loop containing nucleoside triphosphate hydrolases
家族 Family family	c.37.1.20 — Extended AAA-ATPase domain

结构域编号 domain_id	d1iqpc1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.80 — post-AAA+ oligomerization domain-like
超家族 Superfamily superfamily	a.80.1 — post-AAA+ oligomerization domain-like
家族 Family family	a.80.1.1 — DNA polymerase III clamp loader subunits, C-terminal domain

结构域编号 domain_id	d1iqpc2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.37 — P-loop containing nucleoside triphosphate hydrolases
超家族 Superfamily superfamily	c.37.1 — P-loop containing nucleoside triphosphate hydrolases
家族 Family family	c.37.1.20 — Extended AAA-ATPase domain

结构域编号 domain_id	d1iqpd1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.80 — post-AAA+ oligomerization domain-like
超家族 Superfamily superfamily	a.80.1 — post-AAA+ oligomerization domain-like
家族 Family family	a.80.1.1 — DNA polymerase III clamp loader subunits, C-terminal domain

结构域编号 domain_id	d1iqpd2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.37 — P-loop containing nucleoside triphosphate hydrolases
超家族 Superfamily superfamily	c.37.1 — P-loop containing nucleoside triphosphate hydrolases
家族 Family family	c.37.1.20 — Extended AAA-ATPase domain

结构域编号 domain_id	d1iqpe1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.80 — post-AAA+ oligomerization domain-like
超家族 Superfamily superfamily	a.80.1 — post-AAA+ oligomerization domain-like
家族 Family family	a.80.1.1 — DNA polymerase III clamp loader subunits, C-terminal domain

结构域编号 domain_id	d1iqpe2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.37 — P-loop containing nucleoside triphosphate hydrolases
超家族 Superfamily superfamily	c.37.1 — P-loop containing nucleoside triphosphate hydrolases
家族 Family family	c.37.1.20 — Extended AAA-ATPase domain

结构域编号 domain_id	d1iqpf1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.80 — post-AAA+ oligomerization domain-like
超家族 Superfamily superfamily	a.80.1 — post-AAA+ oligomerization domain-like
家族 Family family	a.80.1.1 — DNA polymerase III clamp loader subunits, C-terminal domain

结构域编号 domain_id	d1iqpf2
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.37 — P-loop containing nucleoside triphosphate hydrolases
超家族 Superfamily superfamily	c.37.1 — P-loop containing nucleoside triphosphate hydrolases
家族 Family family	c.37.1.20 — Extended AAA-ATPase domain

CATH v4.4 (18 domains)

结构域编号 domain_id	1iqpA01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	300 — P-loop containing nucleotide triphosphate hydrolases

结构域编号 domain_id	1iqpA02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	8 — Helicase, Ruva Protein; domain 3
同源超家族 H-superfamily homologous superfamily	60 —

结构域编号 domain_id	1iqpA03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	272 — Zinc Finger, Delta Prime; domain 3
同源超家族 H-superfamily homologous superfamily	10 —

结构域编号 domain_id	1iqpB01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	300 — P-loop containing nucleotide triphosphate hydrolases

结构域编号 domain_id	1iqpB02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	8 — Helicase, Ruva Protein; domain 3
同源超家族 H-superfamily homologous superfamily	60 —

结构域编号 domain_id	1iqpB03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	272 — Zinc Finger, Delta Prime; domain 3
同源超家族 H-superfamily homologous superfamily	10 —

结构域编号 domain_id	1iqpC01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	300 — P-loop containing nucleotide triphosphate hydrolases

结构域编号 domain_id	1iqpC02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	8 — Helicase, Ruva Protein; domain 3
同源超家族 H-superfamily homologous superfamily	60 —

结构域编号 domain_id	1iqpC03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	272 — Zinc Finger, Delta Prime; domain 3
同源超家族 H-superfamily homologous superfamily	10 —

结构域编号 domain_id	1iqpD01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	300 — P-loop containing nucleotide triphosphate hydrolases

结构域编号 domain_id	1iqpD02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	8 — Helicase, Ruva Protein; domain 3
同源超家族 H-superfamily homologous superfamily	60 —

结构域编号 domain_id	1iqpD03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	272 — Zinc Finger, Delta Prime; domain 3
同源超家族 H-superfamily homologous superfamily	10 —

结构域编号 domain_id	1iqpE01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	300 — P-loop containing nucleotide triphosphate hydrolases

结构域编号 domain_id	1iqpE02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	8 — Helicase, Ruva Protein; domain 3
同源超家族 H-superfamily homologous superfamily	60 —

结构域编号 domain_id	1iqpE03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	272 — Zinc Finger, Delta Prime; domain 3
同源超家族 H-superfamily homologous superfamily	10 —

结构域编号 domain_id	1iqpF01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily	300 — P-loop containing nucleotide triphosphate hydrolases

结构域编号 domain_id	1iqpF02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	8 — Helicase, Ruva Protein; domain 3
同源超家族 H-superfamily homologous superfamily	60 —

结构域编号 domain_id	1iqpF03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	272 — Zinc Finger, Delta Prime; domain 3
同源超家族 H-superfamily homologous superfamily	10 —

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晶胞边长 a length_a	98.361 Å
晶胞边长 b length_b	105.608 Å
晶胞边长 c length_c	316.898 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	90.00 °
晶胞夹角 γ angle_gamma	90.00 °
晶胞分子数 Z z_pdb	24

空间群 space_group	P 21 21 21
空间群编号 int_tables_number	19
晶系 crystal_system	—

分辨率 resolution	2.800 Å
最低分辨率 resolution_low	15.000 Å
R 因子 r_factor	—
R_work r_work	0.2240
R_free r_free	0.2770

Crystal Structure of the Clamp Loader Small Subunit from Pyrococcus furiosus

1. 蛋白身份与相关结构 Protein Identity & Related Structures

RFCS

当前结构中的状态

数据库中的同蛋白其他状态

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

1iqp__assembly_1__model_1

1iqp__assembly_1__model_1 | I(q)

1iqp__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (3)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 non-polymer

实体 3 Entity 3 water

6. 折叠分类 (SCOP + CATH) 30 domains

SCOP 2.08 (12 domains)

CATH v4.4 (18 domains)

7. 引用文献 (3)

Crystal Structure of the Clamp Loader Small Subunit from Pyrococcus furiosus

1. 蛋白身份与相关结构 Protein Identity & Related Structures

RFCS

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

1iqp__assembly_1__model_1

1iqp__assembly_1__model_1 | I(q)

1iqp__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (3)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 non-polymer

实体 3 Entity 3 water

6. 折叠分类 (SCOP + CATH) 30 domains

SCOP 2.08 (12 domains)

CATH v4.4 (18 domains)

7. 引用文献 (3)