SAXSdb — 1jr2

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1. Protein Identity and Related Structures Protein Identity & Related Structures

UROPORPHYRINOGEN-III SYNTHASE

Homo sapiens

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein monomer	Monomer	Protein 1	water × 1	Consistent with protein count
2	Protein monomer	Monomer	Protein 1	water × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	HEM4_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 22–286； UniProt 1–265 Author chain B； PDBConstruct 22–286； UniProt 1–265

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	1jr2
Deposition date deposition_date	2001-08-10
Structure title title	Structure of Uroporphyrinogen III Synthase
Keywords keywords	Heme biosynthesis, heam biosynthesis, LYASE; LYASE
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1jr2__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1jr2__assembly_2__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

1jr2__assembly_2__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	23.48 Å
Rg (electron density)	22.40 Å
Total Rg	23.22 Å
Atom count	1977
Residues	260
Excluded volume	35428 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`1jr2__assembly_1__model_1`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
2	1	`1jr2__assembly_2__model_1`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 6 domains

SCOP 2.08 (2 domains)

Domain ID domain_id	d1jr2a_
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.113 — HemD-like
Superfamily Superfamily superfamily	c.113.1 — HemD-like
Family Family family	c.113.1.1 — HemD-like

Domain ID domain_id	d1jr2b_
Class class	c — Alpha and beta proteins (a/b)
Fold Fold fold	c.113 — HemD-like
Superfamily Superfamily superfamily	c.113.1 — HemD-like
Family Family family	c.113.1.1 — HemD-like

CATH v4.4 (4 domains)

Domain ID domain_id	1jr2A01
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	50 — Rossmann fold
Homologous superfamily homologous superfamily	10090 —

Domain ID domain_id	1jr2A02
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	50 — Rossmann fold
Homologous superfamily homologous superfamily	10090 —

Domain ID domain_id	1jr2B01
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	50 — Rossmann fold
Homologous superfamily homologous superfamily	10090 —

Domain ID domain_id	1jr2B02
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	50 — Rossmann fold
Homologous superfamily homologous superfamily	10090 —

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Unit-cell length a length_a	39.852 Å
Unit-cell length b length_b	59.251 Å
Unit-cell length c length_c	61.944 Å
Unit-cell angle α angle_alpha	80.47 °
Unit-cell angle β angle_beta	73.32 °
Unit-cell angle γ angle_gamma	88.33 °
Molecules per unit cell Z z_pdb	2

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	1.840 Å
Low-resolution limit resolution_low	58.720 Å
R factor r_factor	0.2031
R_work r_work	0.2004
R_free r_free	0.2510

Description description	UROPORPHYRINOGEN-III SYNTHASE
Molecular weight formula_weight	31189.4 kDa
EC 编号 ec_number	4.2.1.75
Source method src_method	man
Copy count entity_count	2

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B
Atom count atom_count	4537

Structure of Uroporphyrinogen III Synthase

1. Protein Identity and Related Structures Protein Identity & Related Structures

UROPORPHYRINOGEN-III SYNTHASE

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

1jr2__assembly_2__model_1

1jr2__assembly_2__model_1 | I(q)

1jr2__assembly_2__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (2)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 water

6. Fold Classification (SCOP + CATH) 6 domains

SCOP 2.08 (2 domains)

CATH v4.4 (4 domains)

7. Citations (1)

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	569

Structure of Uroporphyrinogen III Synthase

1. Protein Identity and Related Structures Protein Identity & Related Structures

UROPORPHYRINOGEN-III SYNTHASE

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

1jr2__assembly_2__model_1

1jr2__assembly_2__model_1 | I(q)

1jr2__assembly_2__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (2)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 water

6. Fold Classification (SCOP + CATH) 6 domains

SCOP 2.08 (2 domains)

CATH v4.4 (4 domains)

7. Citations (1)