1k1f

Structure of the Bcr-Abl Oncoprotein Oligomerization domain

Method: X-RAY DIFFRACTION

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1. Protein Identity and Related Structures Protein Identity & Related Structures

BREAKPOINT CLUSTER REGION PROTEIN

Homo sapiens

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein homooligomer	Homooligomer	Protein 4	water × 4	Consistent with protein count
2	Protein homooligomer	Homooligomer	Protein 4	water × 4	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	BCR_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–72； UniProt 1–72 Author chain B； PDBConstruct 1–72； UniProt 1–72 Author chain C； PDBConstruct 1–72； UniProt 1–72 Author chain D； PDBConstruct 1–72； UniProt 1–72 Author chain E； PDBConstruct 1–72； UniProt 1–72 Author chain F； PDBConstruct 1–72； UniProt 1–72 Author chain G； PDBConstruct 1–72； UniProt 1–72 Author chain H； PDBConstruct 1–72； UniProt 1–72

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	1k1f
Deposition date deposition_date	2001-09-25
Structure title title	Structure of the Bcr-Abl Oncoprotein Oligomerization domain
Keywords keywords	Oligomerization, coiled coil, Bcr-Abl kinase, TRANSFERASE; TRANSFERASE
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1k1f__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1k1f__assembly_2__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

1k1f__assembly_2__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	21.53 Å
Rg (electron density)	20.88 Å
Total Rg	21.73 Å
Atom count	2151
Residues	250
Excluded volume	38283 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`1k1f__assembly_1__model_1`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
2	1	`1k1f__assembly_2__model_1`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 16 domains

SCOP 2.08 (8 domains)

Domain ID domain_id	d1k1fa_
Class class	a — All alpha proteins
Fold Fold fold	a.147 — Bcr-Abl oncoprotein oligomerization domain
Superfamily Superfamily superfamily	a.147.1 — Bcr-Abl oncoprotein oligomerization domain
Family Family family	a.147.1.1 — Bcr-Abl oncoprotein oligomerization domain

Domain ID domain_id	d1k1fb_
Class class	a — All alpha proteins
Fold Fold fold	a.147 — Bcr-Abl oncoprotein oligomerization domain
Superfamily Superfamily superfamily	a.147.1 — Bcr-Abl oncoprotein oligomerization domain
Family Family family	a.147.1.1 — Bcr-Abl oncoprotein oligomerization domain

Domain ID domain_id	d1k1fc_
Class class	a — All alpha proteins
Fold Fold fold	a.147 — Bcr-Abl oncoprotein oligomerization domain
Superfamily Superfamily superfamily	a.147.1 — Bcr-Abl oncoprotein oligomerization domain
Family Family family	a.147.1.1 — Bcr-Abl oncoprotein oligomerization domain

Domain ID domain_id	d1k1fd_
Class class	a — All alpha proteins
Fold Fold fold	a.147 — Bcr-Abl oncoprotein oligomerization domain
Superfamily Superfamily superfamily	a.147.1 — Bcr-Abl oncoprotein oligomerization domain
Family Family family	a.147.1.1 — Bcr-Abl oncoprotein oligomerization domain

Domain ID domain_id	d1k1fe_
Class class	a — All alpha proteins
Fold Fold fold	a.147 — Bcr-Abl oncoprotein oligomerization domain
Superfamily Superfamily superfamily	a.147.1 — Bcr-Abl oncoprotein oligomerization domain
Family Family family	a.147.1.1 — Bcr-Abl oncoprotein oligomerization domain

Domain ID domain_id	d1k1ff_
Class class	a — All alpha proteins
Fold Fold fold	a.147 — Bcr-Abl oncoprotein oligomerization domain
Superfamily Superfamily superfamily	a.147.1 — Bcr-Abl oncoprotein oligomerization domain
Family Family family	a.147.1.1 — Bcr-Abl oncoprotein oligomerization domain

Domain ID domain_id	d1k1fg_
Class class	a — All alpha proteins
Fold Fold fold	a.147 — Bcr-Abl oncoprotein oligomerization domain
Superfamily Superfamily superfamily	a.147.1 — Bcr-Abl oncoprotein oligomerization domain
Family Family family	a.147.1.1 — Bcr-Abl oncoprotein oligomerization domain

Domain ID domain_id	d1k1fh_
Class class	a — All alpha proteins
Fold Fold fold	a.147 — Bcr-Abl oncoprotein oligomerization domain
Superfamily Superfamily superfamily	a.147.1 — Bcr-Abl oncoprotein oligomerization domain
Family Family family	a.147.1.1 — Bcr-Abl oncoprotein oligomerization domain

CATH v4.4 (8 domains)

Domain ID domain_id	1k1fA00
Class class	4 — Few Secondary Structures
Architecture architecture	10 — Irregular
Topology topology	280 — MYOD Basic-Helix-Loop-Helix Domain, subunit B
Homologous superfamily homologous superfamily	30 — Bcr-Abl oncoprotein oligomerisation domain

Domain ID domain_id	1k1fB00
Class class	4 — Few Secondary Structures
Architecture architecture	10 — Irregular
Topology topology	280 — MYOD Basic-Helix-Loop-Helix Domain, subunit B
Homologous superfamily homologous superfamily	30 — Bcr-Abl oncoprotein oligomerisation domain

Domain ID domain_id	1k1fC00
Class class	4 — Few Secondary Structures
Architecture architecture	10 — Irregular
Topology topology	280 — MYOD Basic-Helix-Loop-Helix Domain, subunit B
Homologous superfamily homologous superfamily	30 — Bcr-Abl oncoprotein oligomerisation domain

Domain ID domain_id	1k1fD00
Class class	4 — Few Secondary Structures
Architecture architecture	10 — Irregular
Topology topology	280 — MYOD Basic-Helix-Loop-Helix Domain, subunit B
Homologous superfamily homologous superfamily	30 — Bcr-Abl oncoprotein oligomerisation domain

Domain ID domain_id	1k1fE00
Class class	4 — Few Secondary Structures
Architecture architecture	10 — Irregular
Topology topology	280 — MYOD Basic-Helix-Loop-Helix Domain, subunit B
Homologous superfamily homologous superfamily	30 — Bcr-Abl oncoprotein oligomerisation domain

Domain ID domain_id	1k1fF00
Class class	4 — Few Secondary Structures
Architecture architecture	10 — Irregular
Topology topology	280 — MYOD Basic-Helix-Loop-Helix Domain, subunit B
Homologous superfamily homologous superfamily	30 — Bcr-Abl oncoprotein oligomerisation domain

Domain ID domain_id	1k1fG00
Class class	4 — Few Secondary Structures
Architecture architecture	10 — Irregular
Topology topology	280 — MYOD Basic-Helix-Loop-Helix Domain, subunit B
Homologous superfamily homologous superfamily	30 — Bcr-Abl oncoprotein oligomerisation domain

Domain ID domain_id	1k1fH00
Class class	4 — Few Secondary Structures
Architecture architecture	10 — Irregular
Topology topology	280 — MYOD Basic-Helix-Loop-Helix Domain, subunit B
Homologous superfamily homologous superfamily	30 — Bcr-Abl oncoprotein oligomerisation domain

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Unit-cell length a length_a	35.988 Å
Unit-cell length b length_b	121.173 Å
Unit-cell length c length_c	60.432 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	93.03 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	16

Space group space_group	P 1 21 1
Space-group number int_tables_number	4
Crystal system crystal_system	—

Resolution resolution	2.200 Å
Low-resolution limit resolution_low	10.000 Å
R factor r_factor	0.2620
R_work r_work	0.2620
R_free r_free	0.2950

Description description	BREAKPOINT CLUSTER REGION PROTEIN
Molecular weight formula_weight	8709.4 kDa
EC 编号 ec_number	2.7.1.-
Mutation mutation	C38A
Source method src_method	man
Copy count entity_count	8

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B,C,D,E,F,G,H
Atom count atom_count	4778

Structure of the Bcr-Abl Oncoprotein Oligomerization domain

1. Protein Identity and Related Structures Protein Identity & Related Structures

BREAKPOINT CLUSTER REGION PROTEIN

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

1k1f__assembly_2__model_1

1k1f__assembly_2__model_1 | I(q)

1k1f__assembly_2__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

5. Entities and Polymers Entities & Polymers (2)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 water

6. Fold Classification (SCOP + CATH) 16 domains

SCOP 2.08 (8 domains)

CATH v4.4 (8 domains)

7. Citations (1)

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	420

Structure of the Bcr-Abl Oncoprotein Oligomerization domain

1. Protein Identity and Related Structures Protein Identity & Related Structures

BREAKPOINT CLUSTER REGION PROTEIN

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

1k1f__assembly_2__model_1

1k1f__assembly_2__model_1 | I(q)

1k1f__assembly_2__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

5. Entities and Polymers Entities & Polymers (2)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 water

6. Fold Classification (SCOP + CATH) 16 domains

SCOP 2.08 (8 domains)

CATH v4.4 (8 domains)

7. Citations (1)