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1n6d

Tricorn protease in complex with tetrapeptide chloromethyl ketone derivative

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Tricorn protease

Thermoplasma acidophilum

UniProt P96086

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 12 RVRK × 6 DECANE × 6 water × 10 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers
1k32 1n6f

2 assemblies

Heteromeric or nucleic-acid complex
1n6d 1n6e

2 assemblies

View Construct and Data Evidence
UniProt name TRI_THEAC
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–1071； UniProt 1–1071 Author chain B； PDBConstruct 1–1071； UniProt 1–1071 Author chain C； PDBConstruct 1–1071； UniProt 1–1071 Author chain D； PDBConstruct 1–1071； UniProt 1–1071 Author chain E； PDBConstruct 1–1071； UniProt 1–1071 Author chain F； PDBConstruct 1–1071； UniProt 1–1071

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1n6d
Deposition date deposition_date2002-11-10
Structure title titleTricorn protease in complex with tetrapeptide chloromethyl ketone derivative
Keywords keywordstricorn protease, hydrolase, propeller; HYDROLASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1n6d__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1n6d__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1n6d__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）60.24 Å
Rg (electron density)59.65 Å
Total Rg59.72 Å
Atom count49356
Residues6162
Excluded volume875650 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1n6d__assembly_1__model_1 dodecameric （12） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 54 domains

SCOP 2.08 (24 domains)

Domain ID domain_idd1n6da1
Class classb — All beta proteins
Fold Fold foldb.36 — PDZ domain-like
Superfamily Superfamily superfamilyb.36.1 — PDZ domain-like
Family Family familyb.36.1.3 — Tail specific protease PDZ domain
Domain ID domain_idd1n6da2
Class classb — All beta proteins
Fold Fold foldb.68 — 6-bladed beta-propeller
Superfamily Superfamily superfamilyb.68.7 — Tricorn protease N-terminal domain
Family Family familyb.68.7.1 — Tricorn protease N-terminal domain
Domain ID domain_idd1n6da3
Class classb — All beta proteins
Fold Fold foldb.69 — 7-bladed beta-propeller
Superfamily Superfamily superfamilyb.69.9 — Tricorn protease domain 2
Family Family familyb.69.9.1 — Tricorn protease domain 2
Domain ID domain_idd1n6da4
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.14 — ClpP/crotonase
Superfamily Superfamily superfamilyc.14.1 — ClpP/crotonase
Family Family familyc.14.1.2 — Tail specific protease, catalytic domain
Domain ID domain_idd1n6db1
Class classb — All beta proteins
Fold Fold foldb.36 — PDZ domain-like
Superfamily Superfamily superfamilyb.36.1 — PDZ domain-like
Family Family familyb.36.1.3 — Tail specific protease PDZ domain
Domain ID domain_idd1n6db2
Class classb — All beta proteins
Fold Fold foldb.68 — 6-bladed beta-propeller
Superfamily Superfamily superfamilyb.68.7 — Tricorn protease N-terminal domain
Family Family familyb.68.7.1 — Tricorn protease N-terminal domain
Domain ID domain_idd1n6db3
Class classb — All beta proteins
Fold Fold foldb.69 — 7-bladed beta-propeller
Superfamily Superfamily superfamilyb.69.9 — Tricorn protease domain 2
Family Family familyb.69.9.1 — Tricorn protease domain 2
Domain ID domain_idd1n6db4
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.14 — ClpP/crotonase
Superfamily Superfamily superfamilyc.14.1 — ClpP/crotonase
Family Family familyc.14.1.2 — Tail specific protease, catalytic domain
Domain ID domain_idd1n6dc1
Class classb — All beta proteins
Fold Fold foldb.36 — PDZ domain-like
Superfamily Superfamily superfamilyb.36.1 — PDZ domain-like
Family Family familyb.36.1.3 — Tail specific protease PDZ domain
Domain ID domain_idd1n6dc2
Class classb — All beta proteins
Fold Fold foldb.68 — 6-bladed beta-propeller
Superfamily Superfamily superfamilyb.68.7 — Tricorn protease N-terminal domain
Family Family familyb.68.7.1 — Tricorn protease N-terminal domain
Domain ID domain_idd1n6dc3
Class classb — All beta proteins
Fold Fold foldb.69 — 7-bladed beta-propeller
Superfamily Superfamily superfamilyb.69.9 — Tricorn protease domain 2
Family Family familyb.69.9.1 — Tricorn protease domain 2
Domain ID domain_idd1n6dc4
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.14 — ClpP/crotonase
Superfamily Superfamily superfamilyc.14.1 — ClpP/crotonase
Family Family familyc.14.1.2 — Tail specific protease, catalytic domain
Domain ID domain_idd1n6dd1
Class classb — All beta proteins
Fold Fold foldb.36 — PDZ domain-like
Superfamily Superfamily superfamilyb.36.1 — PDZ domain-like
Family Family familyb.36.1.3 — Tail specific protease PDZ domain
Domain ID domain_idd1n6dd2
Class classb — All beta proteins
Fold Fold foldb.68 — 6-bladed beta-propeller
Superfamily Superfamily superfamilyb.68.7 — Tricorn protease N-terminal domain
Family Family familyb.68.7.1 — Tricorn protease N-terminal domain
Domain ID domain_idd1n6dd3
Class classb — All beta proteins
Fold Fold foldb.69 — 7-bladed beta-propeller
Superfamily Superfamily superfamilyb.69.9 — Tricorn protease domain 2
Family Family familyb.69.9.1 — Tricorn protease domain 2
Domain ID domain_idd1n6dd4
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.14 — ClpP/crotonase
Superfamily Superfamily superfamilyc.14.1 — ClpP/crotonase
Family Family familyc.14.1.2 — Tail specific protease, catalytic domain
Domain ID domain_idd1n6de1
Class classb — All beta proteins
Fold Fold foldb.36 — PDZ domain-like
Superfamily Superfamily superfamilyb.36.1 — PDZ domain-like
Family Family familyb.36.1.3 — Tail specific protease PDZ domain
Domain ID domain_idd1n6de2
Class classb — All beta proteins
Fold Fold foldb.68 — 6-bladed beta-propeller
Superfamily Superfamily superfamilyb.68.7 — Tricorn protease N-terminal domain
Family Family familyb.68.7.1 — Tricorn protease N-terminal domain
Domain ID domain_idd1n6de3
Class classb — All beta proteins
Fold Fold foldb.69 — 7-bladed beta-propeller
Superfamily Superfamily superfamilyb.69.9 — Tricorn protease domain 2
Family Family familyb.69.9.1 — Tricorn protease domain 2
Domain ID domain_idd1n6de4
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.14 — ClpP/crotonase
Superfamily Superfamily superfamilyc.14.1 — ClpP/crotonase
Family Family familyc.14.1.2 — Tail specific protease, catalytic domain
Domain ID domain_idd1n6df1
Class classb — All beta proteins
Fold Fold foldb.36 — PDZ domain-like
Superfamily Superfamily superfamilyb.36.1 — PDZ domain-like
Family Family familyb.36.1.3 — Tail specific protease PDZ domain
Domain ID domain_idd1n6df2
Class classb — All beta proteins
Fold Fold foldb.68 — 6-bladed beta-propeller
Superfamily Superfamily superfamilyb.68.7 — Tricorn protease N-terminal domain
Family Family familyb.68.7.1 — Tricorn protease N-terminal domain
Domain ID domain_idd1n6df3
Class classb — All beta proteins
Fold Fold foldb.69 — 7-bladed beta-propeller
Superfamily Superfamily superfamilyb.69.9 — Tricorn protease domain 2
Family Family familyb.69.9.1 — Tricorn protease domain 2
Domain ID domain_idd1n6df4
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.14 — ClpP/crotonase
Superfamily Superfamily superfamilyc.14.1 — ClpP/crotonase
Family Family familyc.14.1.2 — Tail specific protease, catalytic domain

CATH v4.4 (30 domains)

Domain ID domain_id1n6dA01
Class class2 — Mainly Beta
Architecture architecture120 — 6 Propeller
Topology topology10 — Neuraminidase
Homologous superfamily homologous superfamily60 — Tricorn protease N-terminal domain
Domain ID domain_id1n6dA02
Class class2 — Mainly Beta
Architecture architecture130 — 7 Propeller
Topology topology10 — Methylamine Dehydrogenase; Chain H
Homologous superfamily homologous superfamily10 — YVTN repeat-like/Quinoprotein amine dehydrogenase
Domain ID domain_id1n6dA03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology750 — Transcription Regulator spoIIAA
Homologous superfamily homologous superfamily44 —
Domain ID domain_id1n6dA04
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology42 — Pdz3 Domain
Homologous superfamily homologous superfamily10 — PDZ domain
Domain ID domain_id1n6dA05
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology226 — 2-enoyl-CoA Hydratase; Chain A, domain 1
Homologous superfamily homologous superfamily10 — 2-enoyl-CoA Hydratase; Chain A, domain 1
Domain ID domain_id1n6dB01
Class class2 — Mainly Beta
Architecture architecture120 — 6 Propeller
Topology topology10 — Neuraminidase
Homologous superfamily homologous superfamily60 — Tricorn protease N-terminal domain
Domain ID domain_id1n6dB02
Class class2 — Mainly Beta
Architecture architecture130 — 7 Propeller
Topology topology10 — Methylamine Dehydrogenase; Chain H
Homologous superfamily homologous superfamily10 — YVTN repeat-like/Quinoprotein amine dehydrogenase
Domain ID domain_id1n6dB03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology750 — Transcription Regulator spoIIAA
Homologous superfamily homologous superfamily44 —
Domain ID domain_id1n6dB04
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology42 — Pdz3 Domain
Homologous superfamily homologous superfamily10 — PDZ domain
Domain ID domain_id1n6dB05
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology226 — 2-enoyl-CoA Hydratase; Chain A, domain 1
Homologous superfamily homologous superfamily10 — 2-enoyl-CoA Hydratase; Chain A, domain 1
Domain ID domain_id1n6dC01
Class class2 — Mainly Beta
Architecture architecture120 — 6 Propeller
Topology topology10 — Neuraminidase
Homologous superfamily homologous superfamily60 — Tricorn protease N-terminal domain
Domain ID domain_id1n6dC02
Class class2 — Mainly Beta
Architecture architecture130 — 7 Propeller
Topology topology10 — Methylamine Dehydrogenase; Chain H
Homologous superfamily homologous superfamily10 — YVTN repeat-like/Quinoprotein amine dehydrogenase
Domain ID domain_id1n6dC03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology750 — Transcription Regulator spoIIAA
Homologous superfamily homologous superfamily44 —
Domain ID domain_id1n6dC04
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology42 — Pdz3 Domain
Homologous superfamily homologous superfamily10 — PDZ domain
Domain ID domain_id1n6dC05
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology226 — 2-enoyl-CoA Hydratase; Chain A, domain 1
Homologous superfamily homologous superfamily10 — 2-enoyl-CoA Hydratase; Chain A, domain 1
Domain ID domain_id1n6dD01
Class class2 — Mainly Beta
Architecture architecture120 — 6 Propeller
Topology topology10 — Neuraminidase
Homologous superfamily homologous superfamily60 — Tricorn protease N-terminal domain
Domain ID domain_id1n6dD02
Class class2 — Mainly Beta
Architecture architecture130 — 7 Propeller
Topology topology10 — Methylamine Dehydrogenase; Chain H
Homologous superfamily homologous superfamily10 — YVTN repeat-like/Quinoprotein amine dehydrogenase
Domain ID domain_id1n6dD03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology750 — Transcription Regulator spoIIAA
Homologous superfamily homologous superfamily44 —
Domain ID domain_id1n6dD04
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology42 — Pdz3 Domain
Homologous superfamily homologous superfamily10 — PDZ domain
Domain ID domain_id1n6dD05
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology226 — 2-enoyl-CoA Hydratase; Chain A, domain 1
Homologous superfamily homologous superfamily10 — 2-enoyl-CoA Hydratase; Chain A, domain 1
Domain ID domain_id1n6dE01
Class class2 — Mainly Beta
Architecture architecture120 — 6 Propeller
Topology topology10 — Neuraminidase
Homologous superfamily homologous superfamily60 — Tricorn protease N-terminal domain
Domain ID domain_id1n6dE02
Class class2 — Mainly Beta
Architecture architecture130 — 7 Propeller
Topology topology10 — Methylamine Dehydrogenase; Chain H
Homologous superfamily homologous superfamily10 — YVTN repeat-like/Quinoprotein amine dehydrogenase
Domain ID domain_id1n6dE03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology750 — Transcription Regulator spoIIAA
Homologous superfamily homologous superfamily44 —
Domain ID domain_id1n6dE04
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology42 — Pdz3 Domain
Homologous superfamily homologous superfamily10 — PDZ domain
Domain ID domain_id1n6dE05
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology226 — 2-enoyl-CoA Hydratase; Chain A, domain 1
Homologous superfamily homologous superfamily10 — 2-enoyl-CoA Hydratase; Chain A, domain 1
Domain ID domain_id1n6dF01
Class class2 — Mainly Beta
Architecture architecture120 — 6 Propeller
Topology topology10 — Neuraminidase
Homologous superfamily homologous superfamily60 — Tricorn protease N-terminal domain
Domain ID domain_id1n6dF02
Class class2 — Mainly Beta
Architecture architecture130 — 7 Propeller
Topology topology10 — Methylamine Dehydrogenase; Chain H
Homologous superfamily homologous superfamily10 — YVTN repeat-like/Quinoprotein amine dehydrogenase
Domain ID domain_id1n6dF03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology750 — Transcription Regulator spoIIAA
Homologous superfamily homologous superfamily44 —
Domain ID domain_id1n6dF04
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology42 — Pdz3 Domain
Homologous superfamily homologous superfamily10 — PDZ domain
Domain ID domain_id1n6dF05
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology226 — 2-enoyl-CoA Hydratase; Chain A, domain 1
Homologous superfamily homologous superfamily10 — 2-enoyl-CoA Hydratase; Chain A, domain 1
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7. Citations (1)