Serotransferrin
Homo sapiens
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count | Chain A； UniProt 20–350 | Fragment：N-TERMINAL LOBE Mutation：L66W | CO3 CARBONATE ION × 1 FE FE (III) ION × 1 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, SITTING DROP；pH 7.7；293 K；0.2M POTASSIUM ACETATE, 20% PEG 3350, pH 7.7, VAPOR DIFFUSION, SITTING DROP, temperature 293K | Resolution 2.20 Å R-free 0.237 |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 1N7W | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1A8E HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE Deposited 1998-03-24 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–350（329 aa）
Fragment：N-TERMINAL LOBE
|
Not recorded | CO3 CARBONATE ION × 1 FE FE (III) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.75；277 K；PROTEIN WAS CRYSTALLIZED FROM 26% PEG 4000. BUFFER WAS 40MM NA CACODYLATE, PH 5.75, WITH 20MM NA BICARBONATE. CRYSTALS GROWN AT 4 DEGREES C USING THE HANGING DROP METHOD., vapor diffusion - hanging drop, temperature 277K
|
Resolution 1.60 Å |
| 1A8F HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE Deposited 1998-03-25 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–350（329 aa）
Fragment：N-TERMINAL LOBE
|
Not recorded | CO3 CARBONATE ION × 1 FE FE (III) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.1；PROTEIN WAS CRYSTALLIZED FROM 40% (V/V) ETHANOL WITH 50MM POTASSIUM CACODYLATE, PH 6.1. GROWN IN SITTING DROPS AT 277 K. RESERVOIRS CONTAINED 40% (V/V) ETHANOL, 50MM POTASSIUM CACODYLATE, PH 5.8 - 6.3. PRIOR TO CRYSTALLIZATION, THE PROTEIN WAS DIALYSED AGAINST SODIUM BICARBONATE, PH 8.1, vapor diffusion - sitting drop
|
Resolution 1.80 Å R-free 0.250 |
| 1B3E HUMAN SERUM TRANSFERRIN, N-TERMINAL LOBE, EXPRESSED IN PICHIA PASTORIS Deposited 1998-12-09 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
23–352（330 aa）
Fragment：N-TERMINAL LOBE
|
Not recorded | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.25；277 K；PROTEIN WAS CRYSTALLIZED FROM 40% (V/V) ETHANOL WITH 50MM SODIUM CACODYLATE,
PH 6.25. GROWN IN SITTING DROPS AT 277 K. RESERVOIRS CONTAINED 40% (V/V)
ETHANOL, 50MM SODIUM CACODYLATE, PH 5.8 - 6.3. PRIOR TO CRYSTALLIZATION, THE
PROTEIN WAS DIALYSED AGAINST SODIUM BICARBONATE, PH 8.1, VAPOR DIFFUSION, SITTING DROP, temperature 277.0K
|
Resolution 2.50 Å R-free 0.255 |
| 1BP5 HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE, APO FORM Deposited 1998-08-12 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–356（337 aa）
Fragment：N-TERMINAL LOBE
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.3；PROTEIN WAS CRYSTALLIZED FROM 35% MPD. BUFFER WAS 50MM POTASSIUM ACETATE, PH
5.3, WITH 50MM KCL, AND 20MM NA BICARBONATE CRYSTALS GROWN AT 4 DEGREES C
USING THE SITTING DROP METHOD.
|
Resolution 2.20 Å R-free 0.292 |
| 1BP5 HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE, APO FORM Deposited 1998-08-12 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
20–356（337 aa）
Fragment：N-TERMINAL LOBE
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.3；PROTEIN WAS CRYSTALLIZED FROM 35% MPD. BUFFER WAS 50MM POTASSIUM ACETATE, PH
5.3, WITH 50MM KCL, AND 20MM NA BICARBONATE CRYSTALS GROWN AT 4 DEGREES C
USING THE SITTING DROP METHOD.
|
Resolution 2.20 Å R-free 0.292 |
| 1BP5 HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE, APO FORM Deposited 1998-08-12 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
20–356（337 aa）
Fragment：N-TERMINAL LOBE
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.3；PROTEIN WAS CRYSTALLIZED FROM 35% MPD. BUFFER WAS 50MM POTASSIUM ACETATE, PH
5.3, WITH 50MM KCL, AND 20MM NA BICARBONATE CRYSTALS GROWN AT 4 DEGREES C
USING THE SITTING DROP METHOD.
|
Resolution 2.20 Å R-free 0.292 |
| 1BP5 HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE, APO FORM Deposited 1998-08-12 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
20–356（337 aa）
Fragment：N-TERMINAL LOBE
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.3；PROTEIN WAS CRYSTALLIZED FROM 35% MPD. BUFFER WAS 50MM POTASSIUM ACETATE, PH
5.3, WITH 50MM KCL, AND 20MM NA BICARBONATE CRYSTALS GROWN AT 4 DEGREES C
USING THE SITTING DROP METHOD.
|
Resolution 2.20 Å R-free 0.292 |
| 1BTJ HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE, APO FORM, CRYSTAL FORM 2 Deposited 1998-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–356（337 aa）
Fragment：N-TERMINAL LOBE
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.3；PROTEIN DROP: 20 MG/ML PROTEIN, 20MM NAHCO3, 50 MM KCL. RESERVOIR: 50 MM POTASSIUM ACETATE, PH 5.3, 35% MPD., VAPOR DIFFUSION, SITTING DROP
|
Resolution 3.20 Å R-free 0.312 |
| 1BTJ HUMAN SERUM TRANSFERRIN, RECOMBINANT N-TERMINAL LOBE, APO FORM, CRYSTAL FORM 2 Deposited 1998-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
20–356（337 aa）
Fragment：N-TERMINAL LOBE
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.3；PROTEIN DROP: 20 MG/ML PROTEIN, 20MM NAHCO3, 50 MM KCL. RESERVOIR: 50 MM POTASSIUM ACETATE, PH 5.3, 35% MPD., VAPOR DIFFUSION, SITTING DROP
|
Resolution 3.20 Å R-free 0.312 |
| 1D3K HUMAN SERUM TRANSFERRIN Deposited 1999-09-29 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–350（329 aa）
Fragment：N-TERMINAL LOBE
|
Mutation：K206Q | CO3 CARBONATE ION × 1 FE FE (III) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.75；277 K；PEG 4000, sodium bicarbonate, sodium cacodylate, pH 5.75, VAPOR DIFFUSION, HANGING DROP, temperature 277.0K
|
Resolution 1.80 Å R-free 0.225 |
| 1D4N HUMAN SERUM TRANSFERRIN Deposited 1999-10-04 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
22–350（329 aa）
Fragment：N-TERMINAL LOBE
|
Mutation：H207E | CO3 CARBONATE ION × 1 FE FE (III) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.75；277 K；PEG 4000, SODIUM BICARBONATE,
SODIUM CACODYLATE, pH 5.75, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.00 Å R-free 0.218 |
| 1DTG HUMAN TRANSFERRIN N-LOBE MUTANT H249E Deposited 2000-01-12 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–353（334 aa）
Fragment：N-TERMINAL HALF MOLECULE
|
Mutation：H249E | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.1；277 K；50 mM cacodylate
40% ethanol, pH 6.1, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 2.40 Å R-free 0.294 |
| 1FQE CRYSTAL STRUCTURES OF MUTANT (K206A) THAT ABOLISH THE DILYSINE INTERACTION IN THE N-LOBE OF HUMAN TRANSFERRIN Deposited 2000-09-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–350（331 aa）
Fragment：N-LOBE
|
Mutation：K206A | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 K POTASSIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；293 K；20-25% PolyEthyleneGlycol 3350,
100mM Potassium acetate, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.80 Å R-free 0.237 |
| 1FQF CRYSTAL STRUCTURES OF MUTANT (K296A) THAT ABOLISH THE DILYSINE INTERACTION IN THE N-LOBE OF HUMAN TRANSFERRIN Deposited 2000-09-04 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–350（331 aa）
Fragment：N-LOBE
|
Mutation：K296A | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；293 K；18% PolyEthyleneGlycol 3350,
100mM Potassium acetate, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.10 Å R-free 0.295 |
| 1JQF Human Transferrin N-Lobe Mutant H249Q Deposited 2001-08-06 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–353（334 aa）
Fragment：N-TERMINUS (Residues 20-353)
|
Mutation：H249Q | CO3 CARBONATE ION × 1 FE FE (III) ION × 1 K POTASSIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；291 K；Hanging drop. Protein solution 35 mg/ml
protein in
0.1M ammonium bicarbonate pH 7.4. Reservoir solution 0.1M potassium
acetate, pH 7.4,
20-25% PEG 3350. Equal volumes of protein and reservoir solutions mixed., VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 1.85 Å R-free 0.246 |
| 1N7X HUMAN SERUM TRANSFERRIN, N-LOBE Y45E MUTANT Deposited 2002-11-18 | Different mutation/modification Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–350（331 aa）
Fragment：N-TERMINAL LOBE
|
Mutation：Y45E | CO3 CARBONATE ION × 1 FE FE (III) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.7；293 K；0.2M POTASSIUM ACETATE, 20% PEG 3350, pH 7.7, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.10 Å R-free 0.243 |
| 1N84 HUMAN SERUM TRANSFERRIN, N-LOBE Deposited 2002-11-19 | Different mutation/modification Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–350（331 aa）
Fragment：N-TERMINAL LOBE
|
Not recorded | CO3 CARBONATE ION × 1 FE FE (III) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.7；293 K；0.2M POTASSIUM ACETATE, 20% PEG 3350, pH 7.7, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.05 Å R-free 0.228 |
| 1OQG Crystal structure of the D63E mutant of the N-lobe human transferrin Deposited 2003-03-09 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–356（337 aa）
Fragment：N-lobe
|
Mutation：D63E | CO3 CARBONATE ION × 1 FE FE (III) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；291 K；PEG 3350, potassium acetate, ammonium bicarbonate, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 1.90 Å R-free 0.261 |
| 1OQH Crystal Structure of the R124A mutant of the N-lobe human transferrin Deposited 2003-03-10 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–356（337 aa）
Fragment：N-lobe
|
Mutation：R124A | CO3 CARBONATE ION × 1 FE FE (III) ION × 1 K POTASSIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；291 K；PEG 3350, potassium acetate, ammonium bicarbonate, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.40 Å R-free 0.288 |
| 1RYO Human serum transferrin, N-lobe bound with oxalate Deposited 2003-12-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–346（327 aa）
Fragment：N-terminal lobe (residues 20-346)
|
Not recorded | OXL OXALATE ION × 1 FE FE (III) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.7；293 K；0.2M K-Acetate, 10mM KCl, 20% PEG 3350, pH 7.7, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 1.20 Å R-free 0.235 |
| 1SUV Structure of Human Transferrin Receptor-Transferrin Complex Deposited 2004-03-26 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain C
22–350（329 aa）
Fragment：repeat 1
Chain D
22–350（329 aa）
Fragment：repeat 1
|
Not recorded | CO3 CARBONATE ION × 4 FE FE (III) ION × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
|
Resolution 7.50 Å |
| 28MR X-ray structure of the adduct between human serum transferrin with Fe3+ bound at the C-lobe and diruthenium tetraacetate chloride Deposited 2026-02-08 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–698（679 aa）
|
Not recorded | FE FE (III) ION × 1 MLI MALONATE ION × 1 GOL GLYCEROL × 1 ACT ACETATE ION × 1 RU RUTHENIUM ION × 1 CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；15% (w/v) PEG 3350, 16% (v/v) glycerol,
8 mM disodium malonate,
150 mM Na-PIPES pH 6.5
|
Resolution 2.26 Å R-free 0.234 |
| 28MS X-ray structure of the adduct between human serum transferrin with Fe3+ bound at the C-lobe and dirhodium tetraacetate Deposited 2026-02-08 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–698（679 aa）
|
Not recorded | FE FE (III) ION × 1 MLI MALONATE ION × 1 ACT ACETATE ION × 3 PEG DI(HYDROXYETHYL)ETHER × 2 GOL GLYCEROL × 1 A1JZ3 Rhodium tetraacetate dihydrate × 9 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；15% (w/v) PEG 3350
16% (v/v) glycerol
8 mM disodium malonate
150 mM Na-PIPES pH 6.5
|
Resolution 2.37 Å R-free 0.244 |
| 2HAU Apo-Human Serum Transferrin (Non-Glycosylated) Deposited 2006-06-13 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
23–698（676 aa）
|
Mutation：N413D,N611D Non-standard monomer：Yes (specific site not provided by mmCIF) | CIT CITRIC ACID × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；293 K；15 mg/ml protein, 0.3 M ammonium citrate, 16-18% PEG 3350 , pH 6.5, VAPOR DIFFUSION, temperature 293K
|
Resolution 2.70 Å R-free 0.324 |
| 2HAU Apo-Human Serum Transferrin (Non-Glycosylated) Deposited 2006-06-13 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
23–698（676 aa）
|
Mutation：N413D,N611D Non-standard monomer：Yes (specific site not provided by mmCIF) | CIT CITRIC ACID × 3 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；293 K；15 mg/ml protein, 0.3 M ammonium citrate, 16-18% PEG 3350 , pH 6.5, VAPOR DIFFUSION, temperature 293K
|
Resolution 2.70 Å R-free 0.324 |
| 2HAV Apo-Human Serum Transferrin (Glycosylated) Deposited 2006-06-13 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
23–698（676 aa）
|
Not recorded | CIT CITRIC ACID × 3 GOL GLYCEROL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；294 K；30 mg/ml protein, 0.2 M ammonium citrate pH 7.0, 20% PEG-3350, 15% glycerol, VAPOR DIFFUSION, HANGING DROP, temperature 294K
|
Resolution 2.70 Å R-free 0.293 |
| 2HAV Apo-Human Serum Transferrin (Glycosylated) Deposited 2006-06-13 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
23–698（676 aa）
|
Not recorded | CIT CITRIC ACID × 4 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；294 K；30 mg/ml protein, 0.2 M ammonium citrate pH 7.0, 20% PEG-3350, 15% glycerol, VAPOR DIFFUSION, HANGING DROP, temperature 294K
|
Resolution 2.70 Å R-free 0.293 |
| 2O7U Crystal structure of K206E/K296E mutant of the N-terminal half molecule of human transferrin Deposited 2006-12-11 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
20–356（337 aa）
Fragment：N-lobe
|
Mutation：K206E, K296E | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；291 K；Protein: 35mg/ml, 0.1M ammonium bicarbonate. Well: 20% PEG 3350, 0.2 M potassium acetate, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.80 Å R-free 0.259 |
| 2O7U Crystal structure of K206E/K296E mutant of the N-terminal half molecule of human transferrin Deposited 2006-12-11 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–356（337 aa）
Fragment：N-lobe
|
Mutation：K206E, K296E | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；291 K；Protein: 35mg/ml, 0.1M ammonium bicarbonate. Well: 20% PEG 3350, 0.2 M potassium acetate, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.80 Å R-free 0.259 |
| 2O7U Crystal structure of K206E/K296E mutant of the N-terminal half molecule of human transferrin Deposited 2006-12-11 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
20–356（337 aa）
Fragment：N-lobe
|
Mutation：K206E, K296E | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；291 K；Protein: 35mg/ml, 0.1M ammonium bicarbonate. Well: 20% PEG 3350, 0.2 M potassium acetate, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.80 Å R-free 0.259 |
| 2O7U Crystal structure of K206E/K296E mutant of the N-terminal half molecule of human transferrin Deposited 2006-12-11 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
20–356（337 aa）
Fragment：N-lobe
|
Mutation：K206E, K296E | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；291 K；Protein: 35mg/ml, 0.1M ammonium bicarbonate. Well: 20% PEG 3350, 0.2 M potassium acetate, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.80 Å R-free 0.259 |
| 2O7U Crystal structure of K206E/K296E mutant of the N-terminal half molecule of human transferrin Deposited 2006-12-11 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain E
20–356（337 aa）
Fragment：N-lobe
|
Mutation：K206E, K296E | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；291 K；Protein: 35mg/ml, 0.1M ammonium bicarbonate. Well: 20% PEG 3350, 0.2 M potassium acetate, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.80 Å R-free 0.259 |
| 2O7U Crystal structure of K206E/K296E mutant of the N-terminal half molecule of human transferrin Deposited 2006-12-11 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain F
20–356（337 aa）
Fragment：N-lobe
|
Mutation：K206E, K296E | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；291 K；Protein: 35mg/ml, 0.1M ammonium bicarbonate. Well: 20% PEG 3350, 0.2 M potassium acetate, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.80 Å R-free 0.259 |
| 2O7U Crystal structure of K206E/K296E mutant of the N-terminal half molecule of human transferrin Deposited 2006-12-11 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 7 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain G
20–356（337 aa）
Fragment：N-lobe
|
Mutation：K206E, K296E | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；291 K；Protein: 35mg/ml, 0.1M ammonium bicarbonate. Well: 20% PEG 3350, 0.2 M potassium acetate, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.80 Å R-free 0.259 |
| 2O7U Crystal structure of K206E/K296E mutant of the N-terminal half molecule of human transferrin Deposited 2006-12-11 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 8 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain H
20–356（337 aa）
Fragment：N-lobe
|
Mutation：K206E, K296E | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；291 K；Protein: 35mg/ml, 0.1M ammonium bicarbonate. Well: 20% PEG 3350, 0.2 M potassium acetate, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.80 Å R-free 0.259 |
| 2O7U Crystal structure of K206E/K296E mutant of the N-terminal half molecule of human transferrin Deposited 2006-12-11 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 9 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain I
20–356（337 aa）
Fragment：N-lobe
|
Mutation：K206E, K296E | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；291 K；Protein: 35mg/ml, 0.1M ammonium bicarbonate. Well: 20% PEG 3350, 0.2 M potassium acetate, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.80 Å R-free 0.259 |
| 2O84 Crystal structure of K206E mutant of N-lobe human transferrin Deposited 2006-12-12 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain X
20–356（337 aa）
Fragment：N-lobe
|
Mutation：K206E | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 K POTASSIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；293 K；Protein: 35mg/ml, 0.1M ammonium bicrbonate. Well: 18% PEG3350, 0.2M potassium acetate, pH 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.60 Å R-free 0.269 |
| 3FGS Crystal structure of G65R/K206E double mutant of the N-lobe human transferrin Deposited 2008-12-08 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–356（337 aa）
Fragment：Peptidase S60 1 domain
|
Mutation：G65R, K206E | CO3 CARBONATE ION × 1 FE FE (III) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.7；293 K；200 mM potassium acetate buffer (pH 7.7) containing 10 mM KCl and 18% polyethylene glycol 3350. Concentration of the mutant was 17.5 mg/mL. Crystals appeared in approximately a week following micro-seeding with wild-type N-lobe, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.80 Å R-free 0.246 |
| 3QYT Diferric bound human serum transferrin Deposited 2011-03-03 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–698（679 aa）
|
Not recorded | FE FE (III) ION × 2 CO3 CARBONATE ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.4；271 K；0.01M HEPES, 15% PEG3000, pH 7.4, vapor diffusion, sitting drop, temperature 271K
|
Resolution 2.80 Å R-free 0.275 |
| 3S9L Complex between transferrin receptor 1 and transferrin with iron in the N-Lobe, cryocooled 2 Deposited 2011-06-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain C
20–698（679 aa）
Fragment：UNP residues 20-698
|
Mutation：N427D,Y440F, Y531F N625D | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 CA CALCIUM ION × 2 FE FE (III) ION × 2 CO3 CARBONATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；5% PEG 3350, 0.2 M MgCl2, 10% 1,2-propanediol, pH Hepes 7.5, vapor diffusion, hanging drop, temperature 293K
|
Resolution 3.22 Å R-free 0.314 |
| 3S9L Complex between transferrin receptor 1 and transferrin with iron in the N-Lobe, cryocooled 2 Deposited 2011-06-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain D
20–698（679 aa）
Fragment：UNP residues 20-698
|
Mutation：N427D,Y440F, Y531F N625D | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 CA CALCIUM ION × 2 FE FE (III) ION × 2 CO3 CARBONATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；5% PEG 3350, 0.2 M MgCl2, 10% 1,2-propanediol, pH Hepes 7.5, vapor diffusion, hanging drop, temperature 293K
|
Resolution 3.22 Å R-free 0.314 |
| 3S9M Complex between transferrin receptor 1 and transferrin with iron in the N-Lobe, cryocooled 1 Deposited 2011-06-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain C
20–698（679 aa）
Fragment：UNP residues 20-698
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 CA CALCIUM ION × 2 CO3 CARBONATE ION × 2 FE FE (III) ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；5% PEG 3350, 0.2 M MgCl2, 20% 1,2-propanediol, pH Hepes 7.5, vapor diffusion, hanging drop, temperature 293K
|
Resolution 3.32 Å R-free 0.332 |
| 3S9M Complex between transferrin receptor 1 and transferrin with iron in the N-Lobe, cryocooled 1 Deposited 2011-06-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain D
20–698（679 aa）
Fragment：UNP residues 20-698
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 CA CALCIUM ION × 2 CO3 CARBONATE ION × 2 FE FE (III) ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；5% PEG 3350, 0.2 M MgCl2, 20% 1,2-propanediol, pH Hepes 7.5, vapor diffusion, hanging drop, temperature 293K
|
Resolution 3.32 Å R-free 0.332 |
| 3S9N Complex between transferrin receptor 1 and transferrin with iron in the N-Lobe, room temperature Deposited 2011-06-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain C
20–698（679 aa）
Fragment：UNP residues 20-698
|
Mutation：N427D, Y531F | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 CA CALCIUM ION × 2 FE FE (III) ION × 2 CO3 CARBONATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；5% PEG 3350, 0.2 M MgCl2, 10% 1,2-propanediol, pH Hepes 7.5, vapor diffusion, hanging drop, temperature 293K
|
Resolution 3.25 Å R-free 0.289 |
| 3S9N Complex between transferrin receptor 1 and transferrin with iron in the N-Lobe, room temperature Deposited 2011-06-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain D
20–698（679 aa）
Fragment：UNP residues 20-698
|
Mutation：N427D, Y531F | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 CA CALCIUM ION × 2 FE FE (III) ION × 2 CO3 CARBONATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；5% PEG 3350, 0.2 M MgCl2, 10% 1,2-propanediol, pH Hepes 7.5, vapor diffusion, hanging drop, temperature 293K
|
Resolution 3.25 Å R-free 0.289 |
| 3SKP The structure of apo-human transferrin C-lobe with bound sulfate ions Deposited 2011-06-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
358–698（341 aa）
Fragment：iron binding protein
|
Not recorded | SO4 SULFATE ION × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；294 K；0.2 M potassium sulfate, 2.2 M ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 294K
|
Resolution 1.70 Å R-free 0.198 |
| 3SKP The structure of apo-human transferrin C-lobe with bound sulfate ions Deposited 2011-06-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
358–698（341 aa）
Fragment：iron binding protein
|
Not recorded | SO4 SULFATE ION × 32 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；294 K；0.2 M potassium sulfate, 2.2 M ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 294K
|
Resolution 1.70 Å R-free 0.198 |
| 3SKP The structure of apo-human transferrin C-lobe with bound sulfate ions Deposited 2011-06-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
358–698（341 aa）
Fragment：iron binding protein
|
Not recorded | SO4 SULFATE ION × 16 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；294 K；0.2 M potassium sulfate, 2.2 M ammonium sulfate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 294K
|
Resolution 1.70 Å R-free 0.198 |
| 3V83 The 2.1 angstrom crystal structure of diferric human transferrin Deposited 2011-12-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–698（698 aa）
|
Not recorded | BCT BICARBONATE ION × 2 FE FE (III) ION × 2 SO4 SULFATE ION × 5 P6G HEXAETHYLENE GLYCOL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；100mM HEPES, pH 7.5, 1.6 M ammonium sulfate, and 2% PEG 1000, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.230 |
| 3V83 The 2.1 angstrom crystal structure of diferric human transferrin Deposited 2011-12-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
1–698（698 aa）
|
Not recorded | BCT BICARBONATE ION × 2 FE FE (III) ION × 2 SO4 SULFATE ION × 9 P6G HEXAETHYLENE GLYCOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；100mM HEPES, pH 7.5, 1.6 M ammonium sulfate, and 2% PEG 1000, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.230 |
| 3V83 The 2.1 angstrom crystal structure of diferric human transferrin Deposited 2011-12-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
1–698（698 aa）
|
Not recorded | BCT BICARBONATE ION × 2 FE FE (III) ION × 2 SO4 SULFATE ION × 7 P6G HEXAETHYLENE GLYCOL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；100mM HEPES, pH 7.5, 1.6 M ammonium sulfate, and 2% PEG 1000, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.230 |
| 3V83 The 2.1 angstrom crystal structure of diferric human transferrin Deposited 2011-12-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
1–698（698 aa）
|
Not recorded | BCT BICARBONATE ION × 2 FE FE (III) ION × 2 SO4 SULFATE ION × 9 P6G HEXAETHYLENE GLYCOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；100mM HEPES, pH 7.5, 1.6 M ammonium sulfate, and 2% PEG 1000, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.230 |
| 3V83 The 2.1 angstrom crystal structure of diferric human transferrin Deposited 2011-12-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain E
1–698（698 aa）
|
Not recorded | BCT BICARBONATE ION × 2 FE FE (III) ION × 2 SO4 SULFATE ION × 9 P6G HEXAETHYLENE GLYCOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；100mM HEPES, pH 7.5, 1.6 M ammonium sulfate, and 2% PEG 1000, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.230 |
| 3V83 The 2.1 angstrom crystal structure of diferric human transferrin Deposited 2011-12-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain F
1–698（698 aa）
|
Not recorded | BCT BICARBONATE ION × 2 FE FE (III) ION × 2 SO4 SULFATE ION × 5 P6G HEXAETHYLENE GLYCOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；100mM HEPES, pH 7.5, 1.6 M ammonium sulfate, and 2% PEG 1000, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.230 |
| 3V89 The crystal structure of transferrin binding protein A (TbpA) from Neisseria meningitidis serogroup B in complex with the C-lobe of human transferrin Deposited 2011-12-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
356–698（343 aa）
Fragment：C-lobe (UNP residues 356-698)
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；21% PEG 1000, 100mM sodium acetate buffer (pH 4.8), 200mM NaCl, 0.1% LDAO and 3% heptane-1,2,3-triol, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.10 Å R-free 0.287 |
| 3V8X The crystal structure of transferrin binding protein A (TbpA) from Neisserial meningitidis serogroup B in complex with full length human transferrin Deposited 2011-12-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
1–698（698 aa）
|
Not recorded | C8E (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；20% Peg3350 and 200 mM BaBr2, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.60 Å R-free 0.267 |
| 3VE1 The 2.9 angstrom crystal structure of Transferrin binding protein B (TbpB) from serogroup B M982 Neisseria meningitidis in complex with human transferrin Deposited 2012-01-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
20–698（679 aa）
|
Not recorded | GOL GLYCEROL × 8 CO3 CARBONATE ION × 1 FE FE (III) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.1M sodium cacodylate pH 6.5, 14% PEG 3350, 0.1M sodium malonate, and 20% glycerol, vapor diffusion, hanging drop, temperature 293K
|
Resolution 2.96 Å R-free 0.249 |
| 3VE1 The 2.9 angstrom crystal structure of Transferrin binding protein B (TbpB) from serogroup B M982 Neisseria meningitidis in complex with human transferrin Deposited 2012-01-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain D
20–698（679 aa）
|
Not recorded | GOL GLYCEROL × 5 CO3 CARBONATE ION × 1 FE FE (III) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.1M sodium cacodylate pH 6.5, 14% PEG 3350, 0.1M sodium malonate, and 20% glycerol, vapor diffusion, hanging drop, temperature 293K
|
Resolution 2.96 Å R-free 0.249 |
| 4H0W Bismuth bound human serum transferrin Deposited 2012-09-10 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–698（679 aa）
|
Not recorded | FE FE (III) ION × 1 CO3 CARBONATE ION × 2 BS3 Bismuth(III) ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 NTA NITRILOTRIACETIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.4；271 K；0.01M HEPES, 15% PEG3000, PH 7.4, VAPOR DIFFUSION, SITTING DROP, temperature 271K
|
Resolution 2.40 Å R-free 0.256 |
| 4X1B Human serum transferrin with ferric ion bound at the C-lobe only Deposited 2014-11-24 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–698（679 aa）
|
Not recorded | FE FE (III) ION × 1 MLI MALONATE ION × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；0.1M PIPES, 17% PEG3350, 18% Glycerol
|
Resolution 2.45 Å R-free 0.227 |
| 4X1D Ytterbium-bound human serum transferrin Deposited 2014-11-24 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–698（679 aa）
|
Not recorded | YB YTTERBIUM (III) ION × 1 MLI MALONATE ION × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；0.1M PIPES, 17% PEG3350, 18% Glycerol
|
Resolution 2.80 Å R-free 0.231 |
| 4X1D Ytterbium-bound human serum transferrin Deposited 2014-11-24 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
20–698（679 aa）
|
Not recorded | YB YTTERBIUM (III) ION × 1 MLI MALONATE ION × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；0.1M PIPES, 17% PEG3350, 18% Glycerol
|
Resolution 2.80 Å R-free 0.231 |
| 5DYH Ti(IV) bound human serum transferrin Deposited 2015-09-24 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–698（698 aa）
|
Not recorded | CIT CITRIC ACID × 6 4TI TITANIUM ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.4；296 K；10-13% PEG3350
100 mM Ammonium Citrate buffer
|
Resolution 2.68 Å R-free 0.237 |
| 5DYH Ti(IV) bound human serum transferrin Deposited 2015-09-24 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
1–698（698 aa）
|
Not recorded | CIT CITRIC ACID × 5 4TI TITANIUM ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.4；296 K；10-13% PEG3350
100 mM Ammonium Citrate buffer
|
Resolution 2.68 Å R-free 0.237 |
| 5H52 Structure of Titanium-bound human serum transferrin Deposited 2016-11-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–698（679 aa）
|
Not recorded | MLI MALONATE ION × 1 4TI TITANIUM ION × 2 CIT CITRIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；298 K；PIPES-Na 0.1M, PEG 3350 17%, disodium malonate 8mM, glycerol 18%
|
Resolution 3.00 Å R-free 0.224 |
| 5WTD Structure of human serum transferrin bound ruthenium at N-lobe Deposited 2016-12-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–698（679 aa）
|
Not recorded | FE FE (III) ION × 1 MLI MALONATE ION × 1 RU RUTHENIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.6；298 K；PIPES-Na 100 mM, disodium malonate 8 mM, PEG3350 17%, glycerol 18%
|
Resolution 2.50 Å R-free 0.214 |
| 5X5P Human serum transferrin bound to ruthenium NTA Deposited 2017-02-17 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–698（679 aa）
|
Not recorded | MLI MALONATE ION × 1 FE FE (III) ION × 1 RU RUTHENIUM ION × 4 NTA NITRILOTRIACETIC ACID × 2 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.6；298 K；PIPES-Na 100mM pH 6.6, disodium malonate 8mM, PEG 3350 18%, glycerol 17%
|
Resolution 2.70 Å R-free 0.219 |
| 5Y6K Human serum trnasferrin bound to a fluorescent probe Deposited 2017-08-12 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–698（679 aa）
|
Not recorded | MLI MALONATE ION × 1 FE FE (III) ION × 2 8R6 (2S)-6-[2-(7-azido-4-methyl-2-oxidanylidene-chromen-3-yl)ethanoylamino]-2-[bis(2-hydroxy-2-oxoethyl)amino]hexanoic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.6；298 K；PIPES-Na 0.1M pH 6.6, disodium malonate 8mM, PEG 3350 17%, glycerol 18%
|
Resolution 2.86 Å R-free 0.235 |
| 6CTC Crystal structure of human transferrin bound to Triferic FPC iron pyrophosphate Deposited 2018-03-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–698（679 aa）
|
Not recorded | FE FE (III) ION × 2 CO3 CARBONATE ION × 1 POP PYROPHOSPHATE 2- × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；291 K；Apo human transferrin (ProSpec pro-325 purified by Q-sepharose) at 56 mg/mL (0.76 mM) against Morpheus screen condition D4 12.5% PEG 1000, 12.5% PEG3350, 12.5% MPD, 0.02 M each 1,6-hexanediol, 1-butanol, RS-1,2-propanediol, 2-propanol, 1,4-butanediol, 1,3-propanediol, 0.1 M MES/imidazole pH 6.5, crystal tracking ID 246352d4, unique puck ID suv0-5
|
Resolution 2.60 Å R-free 0.253 |
| 6D03 Cryo-EM structure of a Plasmodium vivax invasion complex essential for entry into human reticulocytes; one molecule of parasite ligand. Deposited 2018-04-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric |
Chain C
1–698（698 aa）
Chain D
1–698（698 aa）
|
Not recorded | CA CALCIUM ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 FE FE (III) ION × 4 CO3 CARBONATE ION × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.68 Å |
| 6D04 Cryo-EM structure of a Plasmodium vivax invasion complex essential for entry into human reticulocytes; two molecules of parasite ligand, subclass 1. Deposited 2018-04-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric |
Chain C
1–698（698 aa）
Chain D
1–698（698 aa）
|
Not recorded | CA CALCIUM ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 FE FE (III) ION × 4 CO3 CARBONATE ION × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.74 Å |
| 6D05 Cryo-EM structure of a Plasmodium vivax invasion complex essential for entry into human reticulocytes; two molecules of parasite ligand, subclass 2. Deposited 2018-04-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric |
Chain C
1–698（698 aa）
Chain D
1–698（698 aa）
|
Not recorded | CA CALCIUM ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 FE FE (III) ION × 4 CO3 CARBONATE ION × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.80 Å |
| 6JAS Human serum transferrin with iron citrate bound Deposited 2019-01-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–698（679 aa）
|
Not recorded | FE FE (III) ION × 2 MLI MALONATE ION × 1 CIT CITRIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 6.6；298 K；PIPES-NaOH 0.1M pH 6.6, di-sodium malonate 8 mM, glycerol 18%, PEG3350 17%
|
Resolution 2.50 Å R-free 0.219 |
| 6SOY Trypanosoma brucei transferrin receptor in complex with human transferrin Deposited 2019-08-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
22–698（677 aa）
|
Not recorded | FE FE (III) ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；12% (w/v) PEG 5000 MME,
12% 2-methyl-2,4-pentanediol,
0.1 M MES, pH 6.5
|
Resolution 2.75 Å R-free 0.233 |
| 6SOZ Glycosylated Trypanosoma brucei transferrin receptor in complex with human transferrin Deposited 2019-08-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
22–698（677 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 FE FE (III) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；12% (w/v) PEG 5000 MME,
12% 2-methyl-2,4-pentanediol,
0.1 M MES, pH 6.5
|
Resolution 3.42 Å R-free 0.241 |
| 7FFM Human serum transferrin with five osmium binding sites Deposited 2021-07-23 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–698（679 aa）
|
Not recorded | 4TI TITANIUM ION × 1 MLI MALONATE ION × 1 NTA NITRILOTRIACETIC ACID × 1 OS OSMIUM ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.6；298 K；PIPES-Na 100mM pH 6.5, di-sodium malonate 8mM, PEG3350 17%, glycerol 18%
|
Resolution 3.06 Å R-free 0.212 |
| 7FFU Osmium-bound human serum transferrin Deposited 2021-07-23 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–698（679 aa）
|
Not recorded | FE FE (III) ION × 1 MLI MALONATE ION × 1 OS OSMIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.6；298 K；PIPES-NaOH 0.1M pH 6.6, disodium malonate 8mM, glycerol 18%, PEG 3350 17%
|
Resolution 2.60 Å R-free 0.229 |
| 7Q1L Glycosilated Human Serum Apo-tranferrin Deposited 2021-10-20 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
23–698（676 aa）
|
Not recorded | GOL GLYCEROL × 5 EDO 1,2-ETHANEDIOL × 1 MG MAGNESIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；291.5 K；0.2 M Ammonium Citrate pH 7.0, 20% PEG 3350
|
Resolution 3.00 Å R-free 0.249 |
| 7Q1L Glycosilated Human Serum Apo-tranferrin Deposited 2021-10-20 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
23–698（676 aa）
|
Not recorded | GOL GLYCEROL × 2 EDO 1,2-ETHANEDIOL × 1 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；291.5 K；0.2 M Ammonium Citrate pH 7.0, 20% PEG 3350
|
Resolution 3.00 Å R-free 0.249 |
| 8BRC Crystal structure of the adduct between human serum transferrin and cisplatin Deposited 2022-11-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–698（679 aa）
|
Not recorded | FE FE (III) ION × 1 MLI MALONATE ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 PT PLATINUM (II) ION × 1 NH3 AMMONIA × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；15% w/v PEG 3350, 16% v/v glycerol, 8 mM disodium malonate, and 150 mM Na-PIPES pH 6.5
|
Resolution 3.17 Å R-free 0.243 |
| 9CDQ Transferrin Binding Protein A in complex with transferrin (iron bound in N lobe only) Deposited 2024-06-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain F
1–698（698 aa）
|
Not recorded | BCT BICARBONATE ION × 1 FE FE (III) ION × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.76 Å |
| 9CLM Transferrin Binding Protein A in complex with transferrin binding protein B and two molecules of transferrin Deposited 2024-07-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain F
1–698（698 aa）
Chain G
1–698（698 aa）
|
Not recorded | BCT BICARBONATE ION × 3 FE FE (III) ION × 3 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.30 Å |
| 9CLT Transferrin Binding Protein A in complex with transferrin binding protein B and transferrin (iron bound to N lobe only) Deposited 2024-07-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain F
1–698（698 aa）
|
Not recorded | BCT BICARBONATE ION × 1 FE FE (III) ION × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.60 Å |
| 9CMG Transferrin Binding Protein A in complex with transferrin binding protein B and transferrin (iron bound in both lobes of Tf) Deposited 2024-07-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain F
1–698（698 aa）
|
Not recorded | BCT BICARBONATE ION × 2 FE FE (III) ION × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.71 Å |
| 9DC4 Transferrin Binding Protein A in complex with transferrin binding protein B, transferrin and globular domain of TonB Deposited 2024-08-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain F
1–696（696 aa）
|
Not recorded | BCT BICARBONATE ION × 1 FE FE (III) ION × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9H49 Crystal structure of the adduct between human serum transferrin (apo-form) and cisplatin Deposited 2024-10-17 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–698（679 aa）
|
Not recorded | CIT CITRIC ACID × 3 PT PLATINUM (II) ION × 2 NH3 AMMONIA × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；20% w/v PEG 3350 and 200 mM ammonium citrate pH 7.0
|
Resolution 3.52 Å R-free 0.249 |
| 9H49 Crystal structure of the adduct between human serum transferrin (apo-form) and cisplatin Deposited 2024-10-17 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
20–698（679 aa）
|
Not recorded | CIT CITRIC ACID × 3 PT PLATINUM (II) ION × 2 NH3 AMMONIA × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；20% w/v PEG 3350 and 200 mM ammonium citrate pH 7.0
|
Resolution 3.52 Å R-free 0.249 |
| 9H4V Crystal structure of the adduct formed upon reaction of aurothiomalate with human serum transferrin (apo-form) Deposited 2024-10-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–698（679 aa）
|
Not recorded | CIT CITRIC ACID × 4 AU GOLD ION × 9 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；20% w/v PEG 3350 and 200 mM trisodium citrate
|
Resolution 3.02 Å R-free 0.296 |
| 9H4V Crystal structure of the adduct formed upon reaction of aurothiomalate with human serum transferrin (apo-form) Deposited 2024-10-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
20–698（679 aa）
|
Not recorded | CIT CITRIC ACID × 4 AU GOLD ION × 10 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；20% w/v PEG 3350 and 200 mM trisodium citrate
|
Resolution 3.02 Å R-free 0.296 |
| 9PA8 NmTbpB and Tf protein complex Deposited 2025-06-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain F
1–698（698 aa）
|
Not recorded | BCT BICARBONATE ION × 2 FE FE (III) ION × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9THO Crystal structure of the adduct formed upon reaction of [V(IV)O(acetylacetonate)2] with human serum transferrin with Fe(III) bound at the C-lobe only Deposited 2025-12-03 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain AAA
20–698（679 aa）
|
Not recorded | BCT BICARBONATE ION × 11 GOL GLYCEROL × 2 FE FE (III) ION × 1 MLA MALONIC ACID × 1 A1JJT bis(oxidanyl)-oxidanylidene-(oxidanyl(oxidanylidene)vanadio)oxy-vanadium × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；15% (w/v) PEG 3350, 16% (v/v) glycerol, 8 mM disodium malonate, 150 mM Na-PIPES pH 6.5
|
Resolution 2.55 Å R-free 0.249 |
| 9THQ Crystal structure of the human serum transferrin with Fe(III) bound at the C-lobe only Deposited 2025-12-03 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain AAA
20–698（679 aa）
|
Not recorded | FE FE (III) ION × 1 MLA MALONIC ACID × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 GOL GLYCEROL × 1 BCT BICARBONATE ION × 9 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；15% (w/v) PEG 3350, 16% (v/v) glycerol,
8 mM disodium malonate,
150 mM Na-PIPES pH 6.5
|
Resolution 2.44 Å R-free 0.231 |
| 9THR Crystal structure of the human serum transferrin with Fe(III) bound at the C-lobe only (treated with DMSO) Deposited 2025-12-03 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain AAA
20–698（679 aa）
|
Not recorded | FE FE (III) ION × 1 MLA MALONIC ACID × 1 GOL GLYCEROL × 1 BCT BICARBONATE ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；15% (w/v) PEG 3350, 16% (v/v) glycerol,
8 mM disodium malonate,
150 mM Na-PIPES pH 6.5
|
Resolution 3.20 Å R-free 0.249 |
| 9YZ4 Neisseria gonorrhoeae Transferrin Binding Protein A in complex with Transferrin Binding Protein B and transferrin (iron bound in N lobe only) Deposited 2025-10-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain F
1–698（698 aa）
|
Not recorded | BCT BICARBONATE ION × 1 FE FE (III) ION × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.26 Å |
64 other PDB entries and 94 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | TRFE_HUMAN |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–331； UniProt 20–350 |
