1nen

Complex II (Succinate Dehydrogenase) From E. Coli with Dinitrophenol-17 inhibitor co-crystallized at the ubiquinone binding site

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Succinate dehydrogenase flavoprotein subunit

Escherichia coli

UniProt P0AC41

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 4 Succinate dehydrogenase iron-sulfur protein × 1 (P07014) Succinate dehydrogenase cytochrome b-556 subunit × 1 (P69054) Succinate dehydrogenase hydrophobic membrane anchor protein × 1 (P0AC44) OXALOACETATE ION × 1 CALCIUM ION × 2 FLAVIN-ADENINE DINUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 2-[1-METHYLHEXYL]-4,6-DINITROPHENOL × 1 CARDIOLIPIN × 1 L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE × 1 water × 4 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 12 Succinate dehydrogenase iron-sulfur protein × 3 (P07014) Succinate dehydrogenase cytochrome b-556 subunit × 3 (P69054) Succinate dehydrogenase hydrophobic membrane anchor protein × 3 (P0AC44) OXALOACETATE ION × 3 CALCIUM ION × 6 FLAVIN-ADENINE DINUCLEOTIDE × 3 FE2/S2 (INORGANIC) CLUSTER × 3 IRON/SULFUR CLUSTER × 3 FE3-S4 CLUSTER × 3 PROTOPORPHYRIN IX CONTAINING FE × 3 2-[1-METHYLHEXYL]-4,6-DINITROPHENOL × 3 CARDIOLIPIN × 3 L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE × 3 water × 12 与蛋白数一致
3 蛋白异源复合物 异源复合物 蛋白 8 Succinate dehydrogenase iron-sulfur protein × 2 (P07014) Succinate dehydrogenase cytochrome b-556 subunit × 2 (P69054) Succinate dehydrogenase hydrophobic membrane anchor protein × 2 (P0AC44) OXALOACETATE ION × 2 CALCIUM ION × 4 FLAVIN-ADENINE DINUCLEOTIDE × 2 FE2/S2 (INORGANIC) CLUSTER × 2 IRON/SULFUR CLUSTER × 2 FE3-S4 CLUSTER × 2 PROTOPORPHYRIN IX CONTAINING FE × 2 2-[1-METHYLHEXYL]-4,6-DINITROPHENOL × 2 CARDIOLIPIN × 2 L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE × 2 water × 8 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 DHSA_ECOLI
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–588; UniProt 1–588

Succinate dehydrogenase iron-sulfur protein

Escherichia coli

UniProt P07014

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 4 Succinate dehydrogenase flavoprotein subunit × 1 (P0AC41) Succinate dehydrogenase cytochrome b-556 subunit × 1 (P69054) Succinate dehydrogenase hydrophobic membrane anchor protein × 1 (P0AC44) OXALOACETATE ION × 1 CALCIUM ION × 2 FLAVIN-ADENINE DINUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 2-[1-METHYLHEXYL]-4,6-DINITROPHENOL × 1 CARDIOLIPIN × 1 L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE × 1 water × 4 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 12 Succinate dehydrogenase flavoprotein subunit × 3 (P0AC41) Succinate dehydrogenase cytochrome b-556 subunit × 3 (P69054) Succinate dehydrogenase hydrophobic membrane anchor protein × 3 (P0AC44) OXALOACETATE ION × 3 CALCIUM ION × 6 FLAVIN-ADENINE DINUCLEOTIDE × 3 FE2/S2 (INORGANIC) CLUSTER × 3 IRON/SULFUR CLUSTER × 3 FE3-S4 CLUSTER × 3 PROTOPORPHYRIN IX CONTAINING FE × 3 2-[1-METHYLHEXYL]-4,6-DINITROPHENOL × 3 CARDIOLIPIN × 3 L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE × 3 water × 12 与蛋白数一致
3 蛋白异源复合物 异源复合物 蛋白 8 Succinate dehydrogenase flavoprotein subunit × 2 (P0AC41) Succinate dehydrogenase cytochrome b-556 subunit × 2 (P69054) Succinate dehydrogenase hydrophobic membrane anchor protein × 2 (P0AC44) OXALOACETATE ION × 2 CALCIUM ION × 4 FLAVIN-ADENINE DINUCLEOTIDE × 2 FE2/S2 (INORGANIC) CLUSTER × 2 IRON/SULFUR CLUSTER × 2 FE3-S4 CLUSTER × 2 PROTOPORPHYRIN IX CONTAINING FE × 2 2-[1-METHYLHEXYL]-4,6-DINITROPHENOL × 2 CARDIOLIPIN × 2 L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE × 2 water × 8 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 DHSB_ECOLI
Isoform —
PDB实体 2
链与序列区间 作者链 B; PDB构建体 1–238; UniProt 1–238

Succinate dehydrogenase cytochrome b-556 subunit

Escherichia coli

UniProt P69054

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 4 Succinate dehydrogenase flavoprotein subunit × 1 (P0AC41) Succinate dehydrogenase iron-sulfur protein × 1 (P07014) Succinate dehydrogenase hydrophobic membrane anchor protein × 1 (P0AC44) OXALOACETATE ION × 1 CALCIUM ION × 2 FLAVIN-ADENINE DINUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 2-[1-METHYLHEXYL]-4,6-DINITROPHENOL × 1 CARDIOLIPIN × 1 L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE × 1 water × 4 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 12 Succinate dehydrogenase flavoprotein subunit × 3 (P0AC41) Succinate dehydrogenase iron-sulfur protein × 3 (P07014) Succinate dehydrogenase hydrophobic membrane anchor protein × 3 (P0AC44) OXALOACETATE ION × 3 CALCIUM ION × 6 FLAVIN-ADENINE DINUCLEOTIDE × 3 FE2/S2 (INORGANIC) CLUSTER × 3 IRON/SULFUR CLUSTER × 3 FE3-S4 CLUSTER × 3 PROTOPORPHYRIN IX CONTAINING FE × 3 2-[1-METHYLHEXYL]-4,6-DINITROPHENOL × 3 CARDIOLIPIN × 3 L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE × 3 water × 12 与蛋白数一致
3 蛋白异源复合物 异源复合物 蛋白 8 Succinate dehydrogenase flavoprotein subunit × 2 (P0AC41) Succinate dehydrogenase iron-sulfur protein × 2 (P07014) Succinate dehydrogenase hydrophobic membrane anchor protein × 2 (P0AC44) OXALOACETATE ION × 2 CALCIUM ION × 4 FLAVIN-ADENINE DINUCLEOTIDE × 2 FE2/S2 (INORGANIC) CLUSTER × 2 IRON/SULFUR CLUSTER × 2 FE3-S4 CLUSTER × 2 PROTOPORPHYRIN IX CONTAINING FE × 2 2-[1-METHYLHEXYL]-4,6-DINITROPHENOL × 2 CARDIOLIPIN × 2 L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE × 2 water × 8 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 DHSC_ECOLI
Isoform —
PDB实体 3
链与序列区间 作者链 C; PDB构建体 1–129; UniProt 1–129

Succinate dehydrogenase hydrophobic membrane anchor protein

Escherichia coli

UniProt P0AC44

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 4 Succinate dehydrogenase flavoprotein subunit × 1 (P0AC41) Succinate dehydrogenase iron-sulfur protein × 1 (P07014) Succinate dehydrogenase cytochrome b-556 subunit × 1 (P69054) OXALOACETATE ION × 1 CALCIUM ION × 2 FLAVIN-ADENINE DINUCLEOTIDE × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 2-[1-METHYLHEXYL]-4,6-DINITROPHENOL × 1 CARDIOLIPIN × 1 L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE × 1 water × 4 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 12 Succinate dehydrogenase flavoprotein subunit × 3 (P0AC41) Succinate dehydrogenase iron-sulfur protein × 3 (P07014) Succinate dehydrogenase cytochrome b-556 subunit × 3 (P69054) OXALOACETATE ION × 3 CALCIUM ION × 6 FLAVIN-ADENINE DINUCLEOTIDE × 3 FE2/S2 (INORGANIC) CLUSTER × 3 IRON/SULFUR CLUSTER × 3 FE3-S4 CLUSTER × 3 PROTOPORPHYRIN IX CONTAINING FE × 3 2-[1-METHYLHEXYL]-4,6-DINITROPHENOL × 3 CARDIOLIPIN × 3 L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE × 3 water × 12 与蛋白数一致
3 蛋白异源复合物 异源复合物 蛋白 8 Succinate dehydrogenase flavoprotein subunit × 2 (P0AC41) Succinate dehydrogenase iron-sulfur protein × 2 (P07014) Succinate dehydrogenase cytochrome b-556 subunit × 2 (P69054) OXALOACETATE ION × 2 CALCIUM ION × 4 FLAVIN-ADENINE DINUCLEOTIDE × 2 FE2/S2 (INORGANIC) CLUSTER × 2 IRON/SULFUR CLUSTER × 2 FE3-S4 CLUSTER × 2 PROTOPORPHYRIN IX CONTAINING FE × 2 2-[1-METHYLHEXYL]-4,6-DINITROPHENOL × 2 CARDIOLIPIN × 2 L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE × 2 water × 8 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 DHSD_ECOLI
Isoform —
PDB实体 4
链与序列区间 作者链 D; PDB构建体 1–115; UniProt 1–115

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id1nen
沉积日期 deposition_date2002-12-11
结构标题 titleComplex II (Succinate Dehydrogenase) From E. Coli with Dinitrophenol-17 inhibitor co-crystallized at the ubiquinone binding site
关键词 keywordsmembrane protein, respiratory complex, OXIDOREDUCTASE-ELECTRON TRANSPORT COMPLEX; OXIDOREDUCTASE/ELECTRON TRANSPORT
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

1nen__assembly_3__model_1

Assembly 3 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

1nen__assembly_3__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

1nen__assembly_3__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)57.26 Å
Rg(电子密度)56.92 Å
总 Rg56.54 Å
原子数17110
残基数2136
排除体积306390 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 1nen__assembly_1__model_1 tetrameric (4) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 1 1nen__assembly_2__model_1 dodecameric (12) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
3 1 1nen__assembly_3__model_1 octameric (8) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (15)

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6. 折叠分类 (SCOP + CATH) 15 domains

SCOP 2.08 (7 domains)

结构域编号 domain_idd1nena1
类 Class classa — All alpha proteins
折叠类型 Fold folda.7 — Spectrin repeat-like
超家族 Superfamily superfamilya.7.3 — Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
家族 Family familya.7.3.1 — Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
结构域编号 domain_idd1nena2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.3 — FAD/NAD(P)-binding domain
超家族 Superfamily superfamilyc.3.1 — FAD/NAD(P)-binding domain
家族 Family familyc.3.1.4 — Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain
结构域编号 domain_idd1nena3
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.168 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
超家族 Superfamily superfamilyd.168.1 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
家族 Family familyd.168.1.1 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
结构域编号 domain_idd1nenb1
类 Class classa — All alpha proteins
折叠类型 Fold folda.1 — Globin-like
超家族 Superfamily superfamilya.1.2 — alpha-helical ferredoxin
家族 Family familya.1.2.1 — Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain
结构域编号 domain_idd1nenb2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.15 — beta-Grasp (ubiquitin-like)
超家族 Superfamily superfamilyd.15.4 — 2Fe-2S ferredoxin-like
家族 Family familyd.15.4.2 — 2Fe-2S ferredoxin domains from multidomain proteins
结构域编号 domain_idd1nenc_
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.21 — Heme-binding four-helical bundle
超家族 Superfamily superfamilyf.21.2 — Fumarate reductase respiratory complex transmembrane subunits
家族 Family familyf.21.2.2 — Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)
结构域编号 domain_idd1nend_
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.21 — Heme-binding four-helical bundle
超家族 Superfamily superfamilyf.21.2 — Fumarate reductase respiratory complex transmembrane subunits
家族 Family familyf.21.2.2 — Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)

CATH v4.4 (8 domains)

结构域编号 domain_id1nenA01
类 Class class3 — Alpha Beta
架构 Architecture architecture50 — 3-Layer(bba) Sandwich
拓扑 Topology topology50 — FAD/NAD(P)-binding domain
同源超家族 H-superfamily homologous superfamily60 — FAD/NAD(P)-binding domain
结构域编号 domain_id1nenA02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology700 — Flavocytochrome C3; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
结构域编号 domain_id1nenA03
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily100 — Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain
结构域编号 domain_id1nenA04
类 Class class4 — Few Secondary Structures
架构 Architecture architecture10 — Irregular
拓扑 Topology topology80 — Rhinovirus 14, subunit 4
同源超家族 H-superfamily homologous superfamily40 — succinate dehydrogenase protein domain
结构域编号 domain_id1nenB01
类 Class class3 — Alpha Beta
架构 Architecture architecture10 — Roll
拓扑 Topology topology20 — Ubiquitin-like (UB roll)
同源超家族 H-superfamily homologous superfamily30 — Beta-grasp domain
结构域编号 domain_id1nenB02
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology1060 — Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2
同源超家族 H-superfamily homologous superfamily10 — Alpha-helical ferredoxin
结构域编号 domain_id1nenC00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1300 — 3 helical TM bundles of succinate and fumarate reductases
同源超家族 H-superfamily homologous superfamily10 — Fumarate reductase/succinate dehydrogenase, transmembrane subunit
结构域编号 domain_id1nenD01
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1300 — 3 helical TM bundles of succinate and fumarate reductases
同源超家族 H-superfamily homologous superfamily10 — Fumarate reductase/succinate dehydrogenase, transmembrane subunit
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7. 引用文献 (1)