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1nnu

Crystal Structure Analysis of Plasmodium falciparum enoyl-acyl-carrier-protein reductase with Triclosan Analog

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

enoyl-acyl carrier reductase

Plasmodium falciparum

UniProt Q9BH77

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 4 NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 2 6-(4-CHLORO-2-HYDROXY-PHENOXY)-NAPHTHALEN-2-OL × 2 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 8 NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 4 6-(4-CHLORO-2-HYDROXY-PHENOXY)-NAPHTHALEN-2-OL × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
1vrw 1vrw

2 assemblies

Homotetramer
1nhg 1nhw 1nnu 1vrw 1zw1 2o2y 2ol4 2oos 2op0 2op1

10 assemblies

Other homooligomers
1nhg 1nhw 1nnu 2nq8

4 assemblies

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name Q9BH77_PLAFA
Isoform —
PDB entities 1, 2
Chains and sequence ranges Author chain A； PDBConstruct 1–229； UniProt 97–325 Author chain B； PDBConstruct 1–229； UniProt 97–325 Author chain C； PDBConstruct 1–60； UniProt 366–425 Author chain D； PDBConstruct 1–60； UniProt 366–425

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1nnu
Deposition date deposition_date2003-01-14
Structure title titleCrystal Structure Analysis of Plasmodium falciparum enoyl-acyl-carrier-protein reductase with Triclosan Analog
Keywords keywordsrossmann fold, nadh, short chain dehydrogenase reductase, OXIDOREDUCTASE; OXIDOREDUCTASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1nnu__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1nnu__assembly_2__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1nnu__assembly_2__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）31.50 Å
Rg (electron density)30.59 Å
Total Rg31.38 Å
Atom count9404
Residues1156
Excluded volume167990 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1nnu__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 1nnu__assembly_2__model_1 octameric （8） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 6 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd1nnu.1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
Superfamily Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
Family Family familyc.2.1.2 — Tyrosine-dependent oxidoreductases
Domain ID domain_idd1nnu.2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.2 — NAD(P)-binding Rossmann-fold domains
Superfamily Superfamily superfamilyc.2.1 — NAD(P)-binding Rossmann-fold domains
Family Family familyc.2.1.2 — Tyrosine-dependent oxidoreductases

CATH v4.4 (4 domains)

Domain ID domain_id1nnuA00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
Domain ID domain_id1nnuB00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily720 — NAD(P)-binding Rossmann-like Domain
Domain ID domain_id1nnuC00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology8 — Helicase, Ruva Protein; domain 3
Homologous superfamily homologous superfamily400 — Enoyl acyl carrier protein reductase
Domain ID domain_id1nnuD00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology8 — Helicase, Ruva Protein; domain 3
Homologous superfamily homologous superfamily400 — Enoyl acyl carrier protein reductase
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7. Citations (1)