1qk1

CRYSTAL STRUCTURE OF HUMAN UBIQUITOUS MITOCHONDRIAL CREATINE KINASE

Method: X-RAY DIFFRACTION

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

CREATINE KINASE, UBIQUITOUS MITOCHONDRIAL

HOMO SAPIENS

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	蛋白同源多聚体	同源多聚体	蛋白 8	PHOSPHATE ION × 8 water × 8	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	KCRU_HUMAN
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 1–379； UniProt 1–379 作者链 B； PDB构建体 1–379； UniProt 1–379 作者链 C； PDB构建体 1–379； UniProt 1–379 作者链 D； PDB构建体 1–379； UniProt 1–379 作者链 E； PDB构建体 1–379； UniProt 1–379 作者链 F； PDB构建体 1–379； UniProt 1–379 作者链 G； PDB构建体 1–379； UniProt 1–379 作者链 H； PDB构建体 1–379； UniProt 1–379

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	1qk1
沉积日期 deposition_date	1999-07-08
结构标题 title	CRYSTAL STRUCTURE OF HUMAN UBIQUITOUS MITOCHONDRIAL CREATINE KINASE
关键词 keywords	;TRANSFERASE (CREATINE KINASE), MITOCHONDRIAL CREATINE KINASE, CANCER, CELLULAR ENERGY METABOLISM, GUANIDINO KINASE, MITOCHONDRIAL PERMEABILITY TRANSITION, OCTAMER STABILITY ;; TRANSFERASE (CREATINE KINASE)
实验方法 method	X-RAY DIFFRACTION

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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

1qk1__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

1qk1__assembly_1__model_1 | I(q)

100 个绘图点；横轴和纵轴均采用对数尺度。

1qk1__assembly_1__model_1 | P(r) · Pending

P(r) 将按相同 assembly/model 分别计算和展示。

Rg（Guinier）	49.70 Å
Rg（电子密度）	49.32 Å
总 Rg	49.57 Å
原子数	24320
残基数	3032
排除体积	428920 Å³
最大 q	0.500 Å⁻¹

Assembly	Model	结构单元	聚集说明	状态	CRYSOL	操作
1	1	`1qk1__assembly_1__model_1`	octameric （8）	成功	4.1.3-1-20251215 (887e7ef)	查看下载

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (3)

实体 1 Entity 1 polymer

描述 description	CREATINE KINASE, UBIQUITOUS MITOCHONDRIAL
分子量 formula_weight	43216.1 kDa
EC 编号 ec_number	2.7.3.2
来源方法 src_method	man
拷贝数 entity_count	8

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	A,B,C,D,E,F,G,H
原子数 atom_count	24613

AASERRRLYPPSAEYPDLRKHNNCMASHLTPAVYARLCDKTTPTGWTLDQCIQTGVDNPGHPFIKTVGMVAGDEETYEVFADLFDPVIQERHNGYDPRTMKHTTDLDASKIRSGYFDERYVLSSRVRTGRSIRGLSLPPACTRAERREVERVVVDALSGLKGDLAGRYYRLSEMTEAEQQQLIDDHFLFDKPVSPLLTAAGMARDWPDARGIWHNNEKSFLIWVNEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHIKLPLLSKDSRFPKILENLRLQKRGTGGVDTAATGGVFDISNLDRLGKSEVELVQLVIDGVNYLIDCERRLERGQDIRIPTPVIHTKH

来源 Source

来源生物 organism	HOMO SAPIENS
通用名 common_name	HUMAN
NCBI 分类编号 ncbi_taxonomy_id	9606
宿主生物 host_organism	ESCHERICHIA COLI BL21(DE3)

实体 2 Entity 2 non-polymer

描述 description	PHOSPHATE ION
分子量 formula_weight	95.0 kDa
来源方法 src_method	syn
拷贝数 entity_count	8

实体 3 Entity 3 water

描述 description	water
分子量 formula_weight	18.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	293

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6. 折叠分类 (SCOP + CATH) 32 domains

SCOP 2.08 (16 domains)

结构域编号 domain_id	d1qk1a1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.83 — Guanido kinase N-terminal domain
超家族 Superfamily superfamily	a.83.1 — Guanido kinase N-terminal domain
家族 Family family	a.83.1.1 — Guanido kinase N-terminal domain

结构域编号 domain_id	d1qk1a2
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.128 — Glutamine synthetase/guanido kinase
超家族 Superfamily superfamily	d.128.1 — Glutamine synthetase/guanido kinase
家族 Family family	d.128.1.2 — Guanido kinase catalytic domain

结构域编号 domain_id	d1qk1b1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.83 — Guanido kinase N-terminal domain
超家族 Superfamily superfamily	a.83.1 — Guanido kinase N-terminal domain
家族 Family family	a.83.1.1 — Guanido kinase N-terminal domain

结构域编号 domain_id	d1qk1b2
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.128 — Glutamine synthetase/guanido kinase
超家族 Superfamily superfamily	d.128.1 — Glutamine synthetase/guanido kinase
家族 Family family	d.128.1.2 — Guanido kinase catalytic domain

结构域编号 domain_id	d1qk1c1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.83 — Guanido kinase N-terminal domain
超家族 Superfamily superfamily	a.83.1 — Guanido kinase N-terminal domain
家族 Family family	a.83.1.1 — Guanido kinase N-terminal domain

结构域编号 domain_id	d1qk1c2
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.128 — Glutamine synthetase/guanido kinase
超家族 Superfamily superfamily	d.128.1 — Glutamine synthetase/guanido kinase
家族 Family family	d.128.1.2 — Guanido kinase catalytic domain

结构域编号 domain_id	d1qk1d1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.83 — Guanido kinase N-terminal domain
超家族 Superfamily superfamily	a.83.1 — Guanido kinase N-terminal domain
家族 Family family	a.83.1.1 — Guanido kinase N-terminal domain

结构域编号 domain_id	d1qk1d2
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.128 — Glutamine synthetase/guanido kinase
超家族 Superfamily superfamily	d.128.1 — Glutamine synthetase/guanido kinase
家族 Family family	d.128.1.2 — Guanido kinase catalytic domain

结构域编号 domain_id	d1qk1e1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.83 — Guanido kinase N-terminal domain
超家族 Superfamily superfamily	a.83.1 — Guanido kinase N-terminal domain
家族 Family family	a.83.1.1 — Guanido kinase N-terminal domain

结构域编号 domain_id	d1qk1e2
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.128 — Glutamine synthetase/guanido kinase
超家族 Superfamily superfamily	d.128.1 — Glutamine synthetase/guanido kinase
家族 Family family	d.128.1.2 — Guanido kinase catalytic domain

结构域编号 domain_id	d1qk1f1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.83 — Guanido kinase N-terminal domain
超家族 Superfamily superfamily	a.83.1 — Guanido kinase N-terminal domain
家族 Family family	a.83.1.1 — Guanido kinase N-terminal domain

结构域编号 domain_id	d1qk1f2
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.128 — Glutamine synthetase/guanido kinase
超家族 Superfamily superfamily	d.128.1 — Glutamine synthetase/guanido kinase
家族 Family family	d.128.1.2 — Guanido kinase catalytic domain

结构域编号 domain_id	d1qk1g1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.83 — Guanido kinase N-terminal domain
超家族 Superfamily superfamily	a.83.1 — Guanido kinase N-terminal domain
家族 Family family	a.83.1.1 — Guanido kinase N-terminal domain

结构域编号 domain_id	d1qk1g2
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.128 — Glutamine synthetase/guanido kinase
超家族 Superfamily superfamily	d.128.1 — Glutamine synthetase/guanido kinase
家族 Family family	d.128.1.2 — Guanido kinase catalytic domain

结构域编号 domain_id	d1qk1h1
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.83 — Guanido kinase N-terminal domain
超家族 Superfamily superfamily	a.83.1 — Guanido kinase N-terminal domain
家族 Family family	a.83.1.1 — Guanido kinase N-terminal domain

结构域编号 domain_id	d1qk1h2
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.128 — Glutamine synthetase/guanido kinase
超家族 Superfamily superfamily	d.128.1 — Glutamine synthetase/guanido kinase
家族 Family family	d.128.1.2 — Guanido kinase catalytic domain

CATH v4.4 (16 domains)

结构域编号 domain_id	1qk1A01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	135 — Transferase Creatine Kinase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — ATP:guanido phosphotransferase, N-terminal domain

结构域编号 domain_id	1qk1A02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	590 — Creatine Kinase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Glutamine synthetase/guanido kinase, catalytic domain

结构域编号 domain_id	1qk1B01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	135 — Transferase Creatine Kinase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — ATP:guanido phosphotransferase, N-terminal domain

结构域编号 domain_id	1qk1B02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	590 — Creatine Kinase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Glutamine synthetase/guanido kinase, catalytic domain

结构域编号 domain_id	1qk1C01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	135 — Transferase Creatine Kinase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — ATP:guanido phosphotransferase, N-terminal domain

结构域编号 domain_id	1qk1C02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	590 — Creatine Kinase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Glutamine synthetase/guanido kinase, catalytic domain

结构域编号 domain_id	1qk1D01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	135 — Transferase Creatine Kinase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — ATP:guanido phosphotransferase, N-terminal domain

结构域编号 domain_id	1qk1D02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	590 — Creatine Kinase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Glutamine synthetase/guanido kinase, catalytic domain

结构域编号 domain_id	1qk1E01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	135 — Transferase Creatine Kinase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — ATP:guanido phosphotransferase, N-terminal domain

结构域编号 domain_id	1qk1E02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	590 — Creatine Kinase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Glutamine synthetase/guanido kinase, catalytic domain

结构域编号 domain_id	1qk1F01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	135 — Transferase Creatine Kinase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — ATP:guanido phosphotransferase, N-terminal domain

结构域编号 domain_id	1qk1F02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	590 — Creatine Kinase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Glutamine synthetase/guanido kinase, catalytic domain

结构域编号 domain_id	1qk1G01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	135 — Transferase Creatine Kinase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — ATP:guanido phosphotransferase, N-terminal domain

结构域编号 domain_id	1qk1G02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	590 — Creatine Kinase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Glutamine synthetase/guanido kinase, catalytic domain

结构域编号 domain_id	1qk1H01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	135 — Transferase Creatine Kinase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — ATP:guanido phosphotransferase, N-terminal domain

结构域编号 domain_id	1qk1H02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	590 — Creatine Kinase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Glutamine synthetase/guanido kinase, catalytic domain

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晶胞边长 a length_a	91.811 Å
晶胞边长 b length_b	125.868 Å
晶胞边长 c length_c	212.074 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	96.71 °
晶胞夹角 γ angle_gamma	90.00 °
晶胞分子数 Z z_pdb	16

空间群 space_group	P 1 21 1
空间群编号 int_tables_number	4
晶系 crystal_system	—

分辨率 resolution	2.700 Å
最低分辨率 resolution_low	50.000 Å
R 因子 r_factor	0.1950
R_work r_work	0.1950
R_free r_free	0.2190

CRYSTAL STRUCTURE OF HUMAN UBIQUITOUS MITOCHONDRIAL CREATINE KINASE

1. 蛋白身份与相关结构 Protein Identity & Related Structures

CREATINE KINASE, UBIQUITOUS MITOCHONDRIAL

当前结构中的状态

数据库中的同蛋白其他状态

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

1qk1__assembly_1__model_1

1qk1__assembly_1__model_1 | I(q)

1qk1__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (3)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 non-polymer

实体 3 Entity 3 water

6. 折叠分类 (SCOP + CATH) 32 domains

SCOP 2.08 (16 domains)

CATH v4.4 (16 domains)

7. 引用文献 (2)

CRYSTAL STRUCTURE OF HUMAN UBIQUITOUS MITOCHONDRIAL CREATINE KINASE

1. 蛋白身份与相关结构 Protein Identity & Related Structures

CREATINE KINASE, UBIQUITOUS MITOCHONDRIAL

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

1qk1__assembly_1__model_1

1qk1__assembly_1__model_1 | I(q)

1qk1__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (3)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 non-polymer

实体 3 Entity 3 water

6. 折叠分类 (SCOP + CATH) 32 domains

SCOP 2.08 (16 domains)

CATH v4.4 (16 domains)

7. 引用文献 (2)