← Back to search
1qpq

Structure of Quinolinic Acid Phosphoribosyltransferase from Mycobacterium Tuberculosis: A Potential TB Drug Target

Method: X-RAY DIFFRACTION
▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

QUINOLINATE PHOSPHORIBOSYLTRANSFERASE

Mycobacterium tuberculosis H37Rv

UniProt O06594

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 SULFATE ION × 2 QUINOLINIC ACID × 2 water × 2 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 2 SULFATE ION × 2 QUINOLINIC ACID × 2 water × 2 Consistent with protein count
3 Protein homooligomer Homooligomer Protein 2 SULFATE ION × 2 QUINOLINIC ACID × 2 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
1qpn 1qpn 1qpn 1qpo 1qpo 1qpo 1qpq 1qpq 1qpq 1qpr 1qpr 1qpr

12 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name NADC_MYCTU
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–284； UniProt 2–285 Author chain B； PDBConstruct 1–284； UniProt 2–285 Author chain C； PDBConstruct 1–284； UniProt 2–285 Author chain D； PDBConstruct 1–284； UniProt 2–285 Author chain E； PDBConstruct 1–284； UniProt 2–285 Author chain F； PDBConstruct 1–284； UniProt 2–285

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id1qpq
Deposition date deposition_date1998-11-20
Structure title titleStructure of Quinolinic Acid Phosphoribosyltransferase from Mycobacterium Tuberculosis: A Potential TB Drug Target
Keywords keywords;TYPE II PRTASE, DE NOVO NAD BIOSYNTHESIS, PRPP, PHOSPHORIBOSYL TRANSFERASE, QUINOLINIC ACID, Structural Genomics, PSI, Protein Structure Initiative, TB Structural Genomics Consortium, TBSGC, TRANSFERASE ;; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
▼

3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1qpq__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1qpq__assembly_2__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1qpq__assembly_2__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）26.02 Å
Rg (electron density)25.30 Å
Total Rg26.03 Å
Atom count4224
Residues568
Excluded volume74950 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1qpq__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 1qpq__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 1qpq__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
▶

4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (4)

▼

6. Fold Classification (SCOP + CATH) 24 domains

SCOP 2.08 (12 domains)

Domain ID domain_idd1qpqa1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.1 — TIM beta/alpha-barrel
Superfamily Superfamily superfamilyc.1.17 — Nicotinate/Quinolinate PRTase C-terminal domain-like
Family Family familyc.1.17.1 — NadC C-terminal domain-like
Domain ID domain_idd1qpqa2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.41 — alpha/beta-Hammerhead
Superfamily Superfamily superfamilyd.41.2 — Nicotinate/Quinolinate PRTase N-terminal domain-like
Family Family familyd.41.2.1 — NadC N-terminal domain-like
Domain ID domain_idd1qpqb1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.1 — TIM beta/alpha-barrel
Superfamily Superfamily superfamilyc.1.17 — Nicotinate/Quinolinate PRTase C-terminal domain-like
Family Family familyc.1.17.1 — NadC C-terminal domain-like
Domain ID domain_idd1qpqb2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.41 — alpha/beta-Hammerhead
Superfamily Superfamily superfamilyd.41.2 — Nicotinate/Quinolinate PRTase N-terminal domain-like
Family Family familyd.41.2.1 — NadC N-terminal domain-like
Domain ID domain_idd1qpqc1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.1 — TIM beta/alpha-barrel
Superfamily Superfamily superfamilyc.1.17 — Nicotinate/Quinolinate PRTase C-terminal domain-like
Family Family familyc.1.17.1 — NadC C-terminal domain-like
Domain ID domain_idd1qpqc2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.41 — alpha/beta-Hammerhead
Superfamily Superfamily superfamilyd.41.2 — Nicotinate/Quinolinate PRTase N-terminal domain-like
Family Family familyd.41.2.1 — NadC N-terminal domain-like
Domain ID domain_idd1qpqd1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.1 — TIM beta/alpha-barrel
Superfamily Superfamily superfamilyc.1.17 — Nicotinate/Quinolinate PRTase C-terminal domain-like
Family Family familyc.1.17.1 — NadC C-terminal domain-like
Domain ID domain_idd1qpqd2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.41 — alpha/beta-Hammerhead
Superfamily Superfamily superfamilyd.41.2 — Nicotinate/Quinolinate PRTase N-terminal domain-like
Family Family familyd.41.2.1 — NadC N-terminal domain-like
Domain ID domain_idd1qpqe1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.1 — TIM beta/alpha-barrel
Superfamily Superfamily superfamilyc.1.17 — Nicotinate/Quinolinate PRTase C-terminal domain-like
Family Family familyc.1.17.1 — NadC C-terminal domain-like
Domain ID domain_idd1qpqe2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.41 — alpha/beta-Hammerhead
Superfamily Superfamily superfamilyd.41.2 — Nicotinate/Quinolinate PRTase N-terminal domain-like
Family Family familyd.41.2.1 — NadC N-terminal domain-like
Domain ID domain_idd1qpqf1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.1 — TIM beta/alpha-barrel
Superfamily Superfamily superfamilyc.1.17 — Nicotinate/Quinolinate PRTase C-terminal domain-like
Family Family familyc.1.17.1 — NadC C-terminal domain-like
Domain ID domain_idd1qpqf2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.41 — alpha/beta-Hammerhead
Superfamily Superfamily superfamilyd.41.2 — Nicotinate/Quinolinate PRTase N-terminal domain-like
Family Family familyd.41.2.1 — NadC N-terminal domain-like

CATH v4.4 (12 domains)

Domain ID domain_id1qpqA01
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology1170 — Aldehyde Oxidoreductase; domain 3
Homologous superfamily homologous superfamily20 — Quinolinate phosphoribosyl transferase, N-terminal domain
Domain ID domain_id1qpqA02
Class class3 — Alpha Beta
Architecture architecture20 — Alpha-Beta Barrel
Topology topology20 — TIM Barrel
Homologous superfamily homologous superfamily70 — Aldolase class I
Domain ID domain_id1qpqB01
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology1170 — Aldehyde Oxidoreductase; domain 3
Homologous superfamily homologous superfamily20 — Quinolinate phosphoribosyl transferase, N-terminal domain
Domain ID domain_id1qpqB02
Class class3 — Alpha Beta
Architecture architecture20 — Alpha-Beta Barrel
Topology topology20 — TIM Barrel
Homologous superfamily homologous superfamily70 — Aldolase class I
Domain ID domain_id1qpqC01
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology1170 — Aldehyde Oxidoreductase; domain 3
Homologous superfamily homologous superfamily20 — Quinolinate phosphoribosyl transferase, N-terminal domain
Domain ID domain_id1qpqC02
Class class3 — Alpha Beta
Architecture architecture20 — Alpha-Beta Barrel
Topology topology20 — TIM Barrel
Homologous superfamily homologous superfamily70 — Aldolase class I
Domain ID domain_id1qpqD01
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology1170 — Aldehyde Oxidoreductase; domain 3
Homologous superfamily homologous superfamily20 — Quinolinate phosphoribosyl transferase, N-terminal domain
Domain ID domain_id1qpqD02
Class class3 — Alpha Beta
Architecture architecture20 — Alpha-Beta Barrel
Topology topology20 — TIM Barrel
Homologous superfamily homologous superfamily70 — Aldolase class I
Domain ID domain_id1qpqE01
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology1170 — Aldehyde Oxidoreductase; domain 3
Homologous superfamily homologous superfamily20 — Quinolinate phosphoribosyl transferase, N-terminal domain
Domain ID domain_id1qpqE02
Class class3 — Alpha Beta
Architecture architecture20 — Alpha-Beta Barrel
Topology topology20 — TIM Barrel
Homologous superfamily homologous superfamily70 — Aldolase class I
Domain ID domain_id1qpqF01
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology1170 — Aldehyde Oxidoreductase; domain 3
Homologous superfamily homologous superfamily20 — Quinolinate phosphoribosyl transferase, N-terminal domain
Domain ID domain_id1qpqF02
Class class3 — Alpha Beta
Architecture architecture20 — Alpha-Beta Barrel
Topology topology20 — TIM Barrel
Homologous superfamily homologous superfamily70 — Aldolase class I
▶

7. Citations (1)