Homo sapiens
| Assembly | Physical composition | Protein state | Molecular copy count | Associated components | Data consistency |
|---|---|---|---|---|---|
| 1 | Protein monomer | Monomer | Protein 1 | ZINC ION × 1 water × 1 | Consistent with protein count |
| UniProt name | MEPD_HUMAN |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain P； PDBConstruct 1–674； UniProt 15–688 |
The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.
| Entry ID entry_id | 1s4b |
| Deposition date deposition_date | 2004-01-15 |
| Structure title title | Crystal structure of human thimet oligopeptidase. |
| Keywords keywords | Zinc metallopeptidase domain, HYDROLASE; HYDROLASE |
| Experimental Method method | X-RAY DIFFRACTION |
This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
| Rg（Guinier） | 27.66 Å |
| Rg (electron density) | 26.53 Å |
| Total Rg | 27.38 Å |
| Atom count | 5305 |
| Residues | 654 |
| Excluded volume | 94042 ų |
| Maximum q | 0.500 Å⁻¹ |
| Domain ID domain_id | d1s4bp_ |
| Class class | d — Alpha and beta proteins (a+b) |
| Fold Fold fold | d.92 — Zincin-like |
| Superfamily Superfamily superfamily | d.92.1 — Metalloproteases ('zincins'), catalytic domain |
| Family Family family | d.92.1.5 — Neurolysin-like |
| Domain ID domain_id | 1s4bP01 |
| Class class | 1 — Mainly Alpha |
| Architecture architecture | 20 — Up-down Bundle |
| Topology topology | 1050 — Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 |
| Homologous superfamily homologous superfamily | 40 — Endopeptidase. Chain P; domain 1 |
| Domain ID domain_id | 1s4bP02 |
| Class class | 1 — Mainly Alpha |
| Architecture architecture | 10 — Orthogonal Bundle |
| Topology topology | 1370 — Neurolysin; domain 3 |
| Homologous superfamily homologous superfamily | 10 — Neurolysin, domain 3 |
| Domain ID domain_id | 1s4bP03 |
| Class class | 3 — Alpha Beta |
| Architecture architecture | 40 — 3-Layer(aba) Sandwich |
| Topology topology | 390 — Collagenase (Catalytic Domain) |
| Homologous superfamily homologous superfamily | 10 — Collagenase (Catalytic Domain) |