1u0m

Crystal Structure of 1,3,6,8-Tetrahydroxynaphthalene Synthase (THNS) from Streptomyces coelicolor A3(2): a Bacterial Type III Polyketide Synthase (PKS) Provides Insights into Enzymatic Control of Reactive Polyketide Intermediates

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

putative polyketide synthase

Streptomyces coelicolor

UniProt Q9FCA7

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白同源多聚体 同源多聚体 蛋白 2 POLYETHYLENE GLYCOL (N=34) × 2 GLYCEROL × 2 water × 2 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 Q9FCA7_STRCO
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 9–382; UniProt 1–374 作者链 B; PDB构建体 9–382; UniProt 1–374

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id1u0m
沉积日期 deposition_date2004-07-13
结构标题 titleCrystal Structure of 1,3,6,8-Tetrahydroxynaphthalene Synthase (THNS) from Streptomyces coelicolor A3(2): a Bacterial Type III Polyketide Synthase (PKS) Provides Insights into Enzymatic Control of Reactive Polyketide Intermediates
关键词 keywords;type III polyketide synthase, PKS, bacterial, thiolase fold, alpha-beta-alpha-beta-alpha fold, catalytic triad, CHS-like, THNS, tetrahydroxynaphthalene synthase, chalcone/stilbene synthase superfamily, malonyl-CoA, BIOSYNTHETIC PROTEIN ;; BIOSYNTHETIC PROTEIN
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

1u0m__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

1u0m__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

1u0m__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)26.08 Å
Rg(电子密度)24.87 Å
总 Rg25.65 Å
原子数5356
残基数696
排除体积95144 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 1u0m__assembly_1__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (4)

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6. 折叠分类 (SCOP + CATH) 8 domains

SCOP 2.08 (4 domains)

结构域编号 domain_idd1u0ma1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.95 — Thiolase-like
超家族 Superfamily superfamilyc.95.1 — Thiolase-like
家族 Family familyc.95.1.2 — Chalcone synthase-like
结构域编号 domain_idd1u0ma2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.95 — Thiolase-like
超家族 Superfamily superfamilyc.95.1 — Thiolase-like
家族 Family familyc.95.1.2 — Chalcone synthase-like
结构域编号 domain_idd1u0mb1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.95 — Thiolase-like
超家族 Superfamily superfamilyc.95.1 — Thiolase-like
家族 Family familyc.95.1.2 — Chalcone synthase-like
结构域编号 domain_idd1u0mb2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.95 — Thiolase-like
超家族 Superfamily superfamilyc.95.1 — Thiolase-like
家族 Family familyc.95.1.2 — Chalcone synthase-like

CATH v4.4 (4 domains)

结构域编号 domain_id1u0mA01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology47 — Peroxisomal Thiolase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Thiolase/Chalcone synthase
结构域编号 domain_id1u0mA02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology47 — Peroxisomal Thiolase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Thiolase/Chalcone synthase
结构域编号 domain_id1u0mB01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology47 — Peroxisomal Thiolase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Thiolase/Chalcone synthase
结构域编号 domain_id1u0mB02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology47 — Peroxisomal Thiolase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Thiolase/Chalcone synthase
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7. 引用文献 (1)