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1xpr

Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic 5a-formylbicyclomycin (FB)

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Rho transcription termination factor

Escherichia coli

UniProt P22869

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 单体 蛋白 1 RNA 1 5'-R(*CP*UP*CP*UP*CP*UP*CP*U)-3' × 1 MAGNESIUM ION × 1 PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER × 1 与全部聚合物一致
2 蛋白–RNA 单体 蛋白 1 RNA 1 5'-R(*CP*UP*CP*UP*CP*UP*CP*U)-3' × 1 MAGNESIUM ION × 1 PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER × 1 5A-FORMYLBICYCLOMYCIN × 1 与全部聚合物一致
3 蛋白–RNA 单体 蛋白 1 RNA 1 5'-R(*CP*UP*CP*UP*CP*UP*CP*U)-3' × 1 MAGNESIUM ION × 1 PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER × 1 5A-FORMYLBICYCLOMYCIN × 1 与全部聚合物一致
4 蛋白–RNA 单体 蛋白 1 RNA 1 5'-R(*CP*UP*CP*UP*CP*UP*CP*U)-3' × 1 MAGNESIUM ION × 1 PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER × 1 5A-FORMYLBICYCLOMYCIN × 1 与全部聚合物一致
5 蛋白–RNA 单体 蛋白 1 RNA 1 5'-R(*CP*UP*CP*UP*CP*UP*CP*U)-3' × 1 MAGNESIUM ION × 1 PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER × 1 5A-FORMYLBICYCLOMYCIN × 1 与全部聚合物一致
6 蛋白–RNA 单体 蛋白 1 RNA 1 5'-R(*CP*UP*CP*UP*CP*UP*CP*U)-3' × 1 MAGNESIUM ION × 1 PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER × 1 5A-FORMYLBICYCLOMYCIN × 1 与全部聚合物一致

数据库中的同蛋白其他状态

单体

暂无

同源二聚体

暂无

同源四聚体

暂无

其他同源多聚体

暂无

异源或核酸复合物
1fyz 1fz0 1fz1 1fz2 1fz3 1fz4 1fz5 1fz6 1fz7 1fz8 1fz9 1fzh

共 48 个 assembly，这里只显示前 12 个

查看构建体与数据证据
UniProt名称 MEMA_METCA
Isoform —
PDB实体 2
链与序列区间 作者链 A； PDB构建体 1–419； UniProt 1–419 作者链 B； PDB构建体 1–419； UniProt 1–419 作者链 C； PDB构建体 1–419； UniProt 1–419 作者链 D； PDB构建体 1–419； UniProt 1–419 作者链 E； PDB构建体 1–419； UniProt 1–419 作者链 F； PDB构建体 1–419； UniProt 1–419

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id1xpr
沉积日期 deposition_date2004-10-09
结构标题 titleStructural mechanism of inhibition of the Rho transcription termination factor by the antibiotic 5a-formylbicyclomycin (FB)
关键词 keywordsRho; 5a-formylbicyclomycin; FB; ATPgammaS, TRANSCRIPTION-RNA COMPLEX; TRANSCRIPTION/RNA
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

1xpr__assembly_4__model_1

Assembly 4 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

1xpr__assembly_4__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 个绘图点；横轴和纵轴均采用对数尺度。

1xpr__assembly_4__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置，不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg（Guinier）24.62 Å
Rg（电子密度）23.83 Å
总 Rg24.70 Å
原子数3308
残基数410
排除体积58980 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 1xpr__assembly_1__model_1 dimeric （2） 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 1 1xpr__assembly_2__model_1 dimeric （2） 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
3 1 1xpr__assembly_3__model_1 dimeric （2） 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
4 1 1xpr__assembly_4__model_1 dimeric （2） 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
5 1 1xpr__assembly_5__model_1 dimeric （2） 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
6 1 1xpr__assembly_6__model_1 dimeric （2） 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (5)

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6. 折叠分类 (SCOP + CATH) 30 domains

SCOP 2.08 (18 domains)

结构域编号 domain_idd1xpra1
类 Class classa — All alpha proteins
折叠类型 Fold folda.140 — LEM/SAP HeH motif
超家族 Superfamily superfamilya.140.3 — Rho N-terminal domain-like
家族 Family familya.140.3.1 — Rho termination factor, N-terminal domain
结构域编号 domain_idd1xpra2
类 Class classb — All beta proteins
折叠类型 Fold foldb.40 — OB-fold
超家族 Superfamily superfamilyb.40.4 — Nucleic acid-binding proteins
家族 Family familyb.40.4.5 — Cold shock DNA-binding domain-like
结构域编号 domain_idd1xpra3
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
超家族 Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
家族 Family familyc.37.1.11 — RecA protein-like (ATPase-domain)
结构域编号 domain_idd1xprb1
类 Class classa — All alpha proteins
折叠类型 Fold folda.140 — LEM/SAP HeH motif
超家族 Superfamily superfamilya.140.3 — Rho N-terminal domain-like
家族 Family familya.140.3.1 — Rho termination factor, N-terminal domain
结构域编号 domain_idd1xprb2
类 Class classb — All beta proteins
折叠类型 Fold foldb.40 — OB-fold
超家族 Superfamily superfamilyb.40.4 — Nucleic acid-binding proteins
家族 Family familyb.40.4.5 — Cold shock DNA-binding domain-like
结构域编号 domain_idd1xprb3
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
超家族 Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
家族 Family familyc.37.1.11 — RecA protein-like (ATPase-domain)
结构域编号 domain_idd1xprc1
类 Class classa — All alpha proteins
折叠类型 Fold folda.140 — LEM/SAP HeH motif
超家族 Superfamily superfamilya.140.3 — Rho N-terminal domain-like
家族 Family familya.140.3.1 — Rho termination factor, N-terminal domain
结构域编号 domain_idd1xprc2
类 Class classb — All beta proteins
折叠类型 Fold foldb.40 — OB-fold
超家族 Superfamily superfamilyb.40.4 — Nucleic acid-binding proteins
家族 Family familyb.40.4.5 — Cold shock DNA-binding domain-like
结构域编号 domain_idd1xprc3
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
超家族 Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
家族 Family familyc.37.1.11 — RecA protein-like (ATPase-domain)
结构域编号 domain_idd1xprd1
类 Class classa — All alpha proteins
折叠类型 Fold folda.140 — LEM/SAP HeH motif
超家族 Superfamily superfamilya.140.3 — Rho N-terminal domain-like
家族 Family familya.140.3.1 — Rho termination factor, N-terminal domain
结构域编号 domain_idd1xprd2
类 Class classb — All beta proteins
折叠类型 Fold foldb.40 — OB-fold
超家族 Superfamily superfamilyb.40.4 — Nucleic acid-binding proteins
家族 Family familyb.40.4.5 — Cold shock DNA-binding domain-like
结构域编号 domain_idd1xprd3
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
超家族 Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
家族 Family familyc.37.1.11 — RecA protein-like (ATPase-domain)
结构域编号 domain_idd1xpre1
类 Class classa — All alpha proteins
折叠类型 Fold folda.140 — LEM/SAP HeH motif
超家族 Superfamily superfamilya.140.3 — Rho N-terminal domain-like
家族 Family familya.140.3.1 — Rho termination factor, N-terminal domain
结构域编号 domain_idd1xpre2
类 Class classb — All beta proteins
折叠类型 Fold foldb.40 — OB-fold
超家族 Superfamily superfamilyb.40.4 — Nucleic acid-binding proteins
家族 Family familyb.40.4.5 — Cold shock DNA-binding domain-like
结构域编号 domain_idd1xpre3
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
超家族 Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
家族 Family familyc.37.1.11 — RecA protein-like (ATPase-domain)
结构域编号 domain_idd1xprf1
类 Class classa — All alpha proteins
折叠类型 Fold folda.140 — LEM/SAP HeH motif
超家族 Superfamily superfamilya.140.3 — Rho N-terminal domain-like
家族 Family familya.140.3.1 — Rho termination factor, N-terminal domain
结构域编号 domain_idd1xprf2
类 Class classb — All beta proteins
折叠类型 Fold foldb.40 — OB-fold
超家族 Superfamily superfamilyb.40.4 — Nucleic acid-binding proteins
家族 Family familyb.40.4.5 — Cold shock DNA-binding domain-like
结构域编号 domain_idd1xprf3
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
超家族 Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
家族 Family familyc.37.1.11 — RecA protein-like (ATPase-domain)

CATH v4.4 (12 domains)

结构域编号 domain_id1xprA01
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily140 — Nucleic acid-binding proteins
结构域编号 domain_id1xprA02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
结构域编号 domain_id1xprB01
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily140 — Nucleic acid-binding proteins
结构域编号 domain_id1xprB02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
结构域编号 domain_id1xprC01
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily140 — Nucleic acid-binding proteins
结构域编号 domain_id1xprC02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
结构域编号 domain_id1xprD01
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily140 — Nucleic acid-binding proteins
结构域编号 domain_id1xprD02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
结构域编号 domain_id1xprE01
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily140 — Nucleic acid-binding proteins
结构域编号 domain_id1xprE02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
结构域编号 domain_id1xprF01
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily140 — Nucleic acid-binding proteins
结构域编号 domain_id1xprF02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
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7. 引用文献 (1)