← Back to search
1xsb

Structure of the nudix enzyme AP4A hydrolase from homo sapiens (E63A mutant) in complex with ATP. No ATP restraints included

Method: SOLUTION NMR
▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

Bis(5'-nucleosyl)-tetraphosphatase

Homo sapiens

UniProt P50583

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 No other associated polymer Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1xsa 1xsb 1xsc 3u53 3u53 3u53 3u53 4ick 4ick 4ijx 4ijx

11 assemblies

Homodimer
4ijx

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name AP4A_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 6–152； UniProt 0–146

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id1xsb
Deposition date deposition_date2004-10-18
Structure title titleStructure of the nudix enzyme AP4A hydrolase from homo sapiens (E63A mutant) in complex with ATP. No ATP restraints included
Keywords keywordsnudix enzyme, human AP4A hydrolase, alpha-beta, HYDROLASE; HYDROLASE
Experimental Method methodSOLUTION NMR
▼

3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1xsb__assembly_1__model_32

Assembly 1 · Model 32 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1xsb__assembly_1__model_32 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1xsb__assembly_1__model_32 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）16.53 Å
Rg (electron density)15.17 Å
Total Rg16.40 Å
Atom count2453
Residues153
Excluded volume21671 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1xsb__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 1xsb__assembly_1__model_2 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 1xsb__assembly_1__model_3 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 1xsb__assembly_1__model_4 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 1xsb__assembly_1__model_5 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 1xsb__assembly_1__model_6 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 1xsb__assembly_1__model_7 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 1xsb__assembly_1__model_8 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 1xsb__assembly_1__model_9 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 1xsb__assembly_1__model_10 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 1xsb__assembly_1__model_11 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 1xsb__assembly_1__model_12 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 1xsb__assembly_1__model_13 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 1xsb__assembly_1__model_14 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 1xsb__assembly_1__model_15 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 16 1xsb__assembly_1__model_16 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 17 1xsb__assembly_1__model_17 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 18 1xsb__assembly_1__model_18 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 19 1xsb__assembly_1__model_19 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 20 1xsb__assembly_1__model_20 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 21 1xsb__assembly_1__model_21 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 22 1xsb__assembly_1__model_22 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 23 1xsb__assembly_1__model_23 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 24 1xsb__assembly_1__model_24 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 25 1xsb__assembly_1__model_25 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 26 1xsb__assembly_1__model_26 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 27 1xsb__assembly_1__model_27 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 28 1xsb__assembly_1__model_28 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 29 1xsb__assembly_1__model_29 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 30 1xsb__assembly_1__model_30 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 31 1xsb__assembly_1__model_31 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 32 1xsb__assembly_1__model_32 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 33 1xsb__assembly_1__model_33 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 34 1xsb__assembly_1__model_34 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 35 1xsb__assembly_1__model_35 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 36 1xsb__assembly_1__model_36 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 37 1xsb__assembly_1__model_37 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 38 1xsb__assembly_1__model_38 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 39 1xsb__assembly_1__model_39 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
▶

4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (1)

▼

6. Fold Classification (SCOP + CATH) 4 domains

SCOP 2.08 (3 domains)

Domain ID domain_idd1xsba1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.113 — Nudix
Superfamily Superfamily superfamilyd.113.1 — Nudix
Family Family familyd.113.1.1 — MutT-like
Domain ID domain_idd1xsba2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd1xsba3
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags

CATH v4.4 (1 domains)

Domain ID domain_id1xsbA00
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology79 — Nucleoside Triphosphate Pyrophosphohydrolase
Homologous superfamily homologous superfamily10 — Nucleoside Triphosphate Pyrophosphohydrolase
▶

7. Citations (1)