1za2

Structure of wild-type E. coli Aspartate Transcarbamoylase in the presence of CTP, carbamoyl phosphate at 2.50 A resolution

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Aspartate carbamoyltransferase catalytic chain

Escherichia coli

UniProt P00479

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 12 Aspartate carbamoyltransferase regulatory chain × 6 (P00478) SODIUM ION × 3 PHOSPHORIC ACID MONO(FORMAMIDE)ESTER × 12 ZINC ION × 6 CYTIDINE-5'-TRIPHOSPHATE × 6 water × 12 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 PYRB_ECOLI
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–310; UniProt 1–310 作者链 C; PDB构建体 1–310; UniProt 1–310

Aspartate carbamoyltransferase regulatory chain

Escherichia coli

UniProt P00478

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 12 Aspartate carbamoyltransferase catalytic chain × 6 (P00479) SODIUM ION × 3 PHOSPHORIC ACID MONO(FORMAMIDE)ESTER × 12 ZINC ION × 6 CYTIDINE-5'-TRIPHOSPHATE × 6 water × 12 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 PYRI_ECOLI
Isoform —
PDB实体 2
链与序列区间 作者链 B; PDB构建体 2–153; UniProt 1–152 作者链 D; PDB构建体 2–153; UniProt 1–152

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id1za2
沉积日期 deposition_date2005-04-05
结构标题 titleStructure of wild-type E. coli Aspartate Transcarbamoylase in the presence of CTP, carbamoyl phosphate at 2.50 A resolution
关键词 keywordsordered substrate binding, cooperativity, TRANSFERASE; TRANSFERASE
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

1za2__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

1za2__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

1za2__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)44.31 Å
Rg(电子密度)43.47 Å
总 Rg43.85 Å
原子数21531
残基数2724
排除体积382540 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 1za2__assembly_1__model_1 dodecameric (12) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (7)

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6. 折叠分类 (SCOP + CATH) 16 domains

SCOP 2.08 (8 domains)

结构域编号 domain_idd1za2a1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.78 — ATC-like
超家族 Superfamily superfamilyc.78.1 — Aspartate/ornithine carbamoyltransferase
家族 Family familyc.78.1.1 — Aspartate/ornithine carbamoyltransferase
结构域编号 domain_idd1za2a2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.78 — ATC-like
超家族 Superfamily superfamilyc.78.1 — Aspartate/ornithine carbamoyltransferase
家族 Family familyc.78.1.1 — Aspartate/ornithine carbamoyltransferase
结构域编号 domain_idd1za2b1
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.58 — Ferredoxin-like
超家族 Superfamily superfamilyd.58.2 — Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain
家族 Family familyd.58.2.1 — Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain
结构域编号 domain_idd1za2b2
类 Class classg — Small proteins
折叠类型 Fold foldg.41 — Rubredoxin-like
超家族 Superfamily superfamilyg.41.7 — Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain
家族 Family familyg.41.7.1 — Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain
结构域编号 domain_idd1za2c1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.78 — ATC-like
超家族 Superfamily superfamilyc.78.1 — Aspartate/ornithine carbamoyltransferase
家族 Family familyc.78.1.1 — Aspartate/ornithine carbamoyltransferase
结构域编号 domain_idd1za2c2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.78 — ATC-like
超家族 Superfamily superfamilyc.78.1 — Aspartate/ornithine carbamoyltransferase
家族 Family familyc.78.1.1 — Aspartate/ornithine carbamoyltransferase
结构域编号 domain_idd1za2d1
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.58 — Ferredoxin-like
超家族 Superfamily superfamilyd.58.2 — Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain
家族 Family familyd.58.2.1 — Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain
结构域编号 domain_idd1za2d2
类 Class classg — Small proteins
折叠类型 Fold foldg.41 — Rubredoxin-like
超家族 Superfamily superfamilyg.41.7 — Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain
家族 Family familyg.41.7.1 — Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain

CATH v4.4 (8 domains)

结构域编号 domain_id1za2A01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily1370 — Aspartate/ornithine carbamoyltransferase
结构域编号 domain_id1za2A02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily1370 — Aspartate/ornithine carbamoyltransferase
结构域编号 domain_id1za2B01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology70 — Alpha-Beta Plaits
同源超家族 H-superfamily homologous superfamily140 — Aspartate carbamoyltransferase regulatory subunit, N-terminal domain
结构域编号 domain_id1za2B02
类 Class class2 — Mainly Beta
架构 Architecture architecture30 — Roll
拓扑 Topology topology30 — SH3 type barrels.
同源超家族 H-superfamily homologous superfamily20 — Aspartate carbamoyltransferase regulatory subunit, C-terminal domain
结构域编号 domain_id1za2C01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily1370 — Aspartate/ornithine carbamoyltransferase
结构域编号 domain_id1za2C02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily1370 — Aspartate/ornithine carbamoyltransferase
结构域编号 domain_id1za2D01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology70 — Alpha-Beta Plaits
同源超家族 H-superfamily homologous superfamily140 — Aspartate carbamoyltransferase regulatory subunit, N-terminal domain
结构域编号 domain_id1za2D02
类 Class class2 — Mainly Beta
架构 Architecture architecture30 — Roll
拓扑 Topology topology30 — SH3 type barrels.
同源超家族 H-superfamily homologous superfamily20 — Aspartate carbamoyltransferase regulatory subunit, C-terminal domain
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7. 引用文献 (1)