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1zh1

Structure of the zinc-binding domain of HCV NS5A

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

non-structural polyprotein

Hepatitis C virus

UniProt Q9WMX2

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 ZINC ION × 2 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2jy0 2kwt 2kwz 3fql 3q0z 3q0z 3qgd 3qgd 3qge 3qge 3qgf 3qgf

39 assemblies; showing the first 12

Homodimer
1zh1 3fqm 3fqq 3q0z

4 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3kqh 3kqh 3kqk 3kqk 3kql 3kql 3kqn 3kqn 3kqu 3kqu

10 assemblies

View Construct and Data Evidence
UniProt name POLG_9HEPC
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–163； UniProt 1199–1361 Author chain B； PDBConstruct 1–163； UniProt 1199–1361

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1zh1
Deposition date deposition_date2005-04-22
Structure title titleStructure of the zinc-binding domain of HCV NS5A
Keywords keywordsHCV, nonstructural protein 5A, NS5A, Domain I, METAL BINDING PROTEIN; METAL BINDING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1zh1__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1zh1__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1zh1__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）22.41 Å
Rg (electron density)21.74 Å
Total Rg22.58 Å
Atom count2526
Residues326
Excluded volume44693 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1zh1__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 4 domains

CATH v4.4 (4 domains)

Domain ID domain_id1zh1A01
Class class2 — Mainly Beta
Architecture architecture20 — Single Sheet
Topology topology25 — N-terminal domain of TfIIb
Homologous superfamily homologous superfamily210 — Hepatitis C NS5A, domain 1B
Domain ID domain_id1zh1A02
Class class2 — Mainly Beta
Architecture architecture20 — Single Sheet
Topology topology25 — N-terminal domain of TfIIb
Homologous superfamily homologous superfamily220 — Hepatitis C virus NS5A, 1B domain
Domain ID domain_id1zh1B01
Class class2 — Mainly Beta
Architecture architecture20 — Single Sheet
Topology topology25 — N-terminal domain of TfIIb
Homologous superfamily homologous superfamily210 — Hepatitis C NS5A, domain 1B
Domain ID domain_id1zh1B02
Class class2 — Mainly Beta
Architecture architecture20 — Single Sheet
Topology topology25 — N-terminal domain of TfIIb
Homologous superfamily homologous superfamily220 — Hepatitis C virus NS5A, 1B domain
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7. Citations (1)