2aaz

Cryptococcus neoformans thymidylate synthase complexed with substrate and an antifolate

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Thymidylate synthase

Filobasidiella neoformans

UniProt P45351

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白同源多聚体 同源多聚体 蛋白 2 ;2'-DEOXYURIDINE 5'-MONOPHOSPHATE ; × 2 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID × 2 water × 2 与蛋白数一致
2 蛋白同源多聚体 同源多聚体 蛋白 2 ;2'-DEOXYURIDINE 5'-MONOPHOSPHATE ; × 2 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID × 2 water × 2 与蛋白数一致
3 蛋白同源多聚体 同源多聚体 蛋白 2 ;2'-DEOXYURIDINE 5'-MONOPHOSPHATE ; × 2 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID × 2 water × 2 与蛋白数一致
4 蛋白同源多聚体 同源多聚体 蛋白 2 ;2'-DEOXYURIDINE 5'-MONOPHOSPHATE ; × 2 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID × 2 water × 2 与蛋白数一致
5 蛋白同源多聚体 同源多聚体 蛋白 2 ;2'-DEOXYURIDINE 5'-MONOPHOSPHATE ; × 2 与蛋白数一致
6 蛋白同源多聚体 同源多聚体 蛋白 2 ;2'-DEOXYURIDINE 5'-MONOPHOSPHATE ; × 2 与蛋白数一致
7 蛋白同源多聚体 同源多聚体 蛋白 2 ;2'-DEOXYURIDINE 5'-MONOPHOSPHATE ; × 2 与蛋白数一致
8 蛋白同源多聚体 同源多聚体 蛋白 2 ;2'-DEOXYURIDINE 5'-MONOPHOSPHATE ; × 2 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 TYSY_CRYNE
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–317; UniProt 1–317 作者链 B; PDB构建体 1–317; UniProt 1–317 作者链 C; PDB构建体 1–317; UniProt 1–317 作者链 D; PDB构建体 1–317; UniProt 1–317 作者链 E; PDB构建体 1–317; UniProt 1–317 作者链 F; PDB构建体 1–317; UniProt 1–317 作者链 G; PDB构建体 1–317; UniProt 1–317 作者链 H; PDB构建体 1–317; UniProt 1–317 作者链 I; PDB构建体 1–317; UniProt 1–317 作者链 J; PDB构建体 1–317; UniProt 1–317 作者链 K; PDB构建体 1–317; UniProt 1–317 作者链 L; PDB构建体 1–317; UniProt 1–317 作者链 M; PDB构建体 1–317; UniProt 1–317 作者链 N; PDB构建体 1–317; UniProt 1–317 作者链 O; PDB构建体 1–317; UniProt 1–317 作者链 P; PDB构建体 1–317; UniProt 1–317

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id2aaz
沉积日期 deposition_date2005-07-14
结构标题 titleCryptococcus neoformans thymidylate synthase complexed with substrate and an antifolate
关键词 keywordsMethyl transferase, Nucleotide biosynthesis, Transferase; TRANSFERASE
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

2aaz__assembly_1__model_4

Assembly 1 · Model 4 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

2aaz__assembly_1__model_4 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

2aaz__assembly_1__model_4 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)25.07 Å
Rg(电子密度)23.80 Å
总 Rg24.70 Å
原子数4968
残基数610
排除体积88319 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 2aaz__assembly_1__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
1 2 2aaz__assembly_1__model_2 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
1 3 2aaz__assembly_1__model_3 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
1 4 2aaz__assembly_1__model_4 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 1 2aaz__assembly_2__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 2 2aaz__assembly_2__model_2 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 3 2aaz__assembly_2__model_3 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 4 2aaz__assembly_2__model_4 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
3 1 2aaz__assembly_3__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
3 2 2aaz__assembly_3__model_2 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
3 3 2aaz__assembly_3__model_3 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
3 4 2aaz__assembly_3__model_4 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
4 1 2aaz__assembly_4__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
4 2 2aaz__assembly_4__model_2 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
4 3 2aaz__assembly_4__model_3 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
4 4 2aaz__assembly_4__model_4 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
5 1 2aaz__assembly_5__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
5 2 2aaz__assembly_5__model_2 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
5 3 2aaz__assembly_5__model_3 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
5 4 2aaz__assembly_5__model_4 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
6 1 2aaz__assembly_6__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
6 2 2aaz__assembly_6__model_2 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
6 3 2aaz__assembly_6__model_3 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
6 4 2aaz__assembly_6__model_4 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
7 1 2aaz__assembly_7__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
7 2 2aaz__assembly_7__model_2 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
7 3 2aaz__assembly_7__model_3 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
7 4 2aaz__assembly_7__model_4 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
8 1 2aaz__assembly_8__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
8 2 2aaz__assembly_8__model_2 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
8 3 2aaz__assembly_8__model_3 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
8 4 2aaz__assembly_8__model_4 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (4)

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6. 折叠分类 (SCOP + CATH) 32 domains

SCOP 2.08 (16 domains)

结构域编号 domain_idd2aaza_
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.117 — Thymidylate synthase/dCMP hydroxymethylase
超家族 Superfamily superfamilyd.117.1 — Thymidylate synthase/dCMP hydroxymethylase
家族 Family familyd.117.1.1 — Thymidylate synthase/dCMP hydroxymethylase
结构域编号 domain_idd2aazb_
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.117 — Thymidylate synthase/dCMP hydroxymethylase
超家族 Superfamily superfamilyd.117.1 — Thymidylate synthase/dCMP hydroxymethylase
家族 Family familyd.117.1.1 — Thymidylate synthase/dCMP hydroxymethylase
结构域编号 domain_idd2aazc_
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.117 — Thymidylate synthase/dCMP hydroxymethylase
超家族 Superfamily superfamilyd.117.1 — Thymidylate synthase/dCMP hydroxymethylase
家族 Family familyd.117.1.1 — Thymidylate synthase/dCMP hydroxymethylase
结构域编号 domain_idd2aazd_
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.117 — Thymidylate synthase/dCMP hydroxymethylase
超家族 Superfamily superfamilyd.117.1 — Thymidylate synthase/dCMP hydroxymethylase
家族 Family familyd.117.1.1 — Thymidylate synthase/dCMP hydroxymethylase
结构域编号 domain_idd2aaze_
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.117 — Thymidylate synthase/dCMP hydroxymethylase
超家族 Superfamily superfamilyd.117.1 — Thymidylate synthase/dCMP hydroxymethylase
家族 Family familyd.117.1.1 — Thymidylate synthase/dCMP hydroxymethylase
结构域编号 domain_idd2aazf_
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.117 — Thymidylate synthase/dCMP hydroxymethylase
超家族 Superfamily superfamilyd.117.1 — Thymidylate synthase/dCMP hydroxymethylase
家族 Family familyd.117.1.1 — Thymidylate synthase/dCMP hydroxymethylase
结构域编号 domain_idd2aazg_
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.117 — Thymidylate synthase/dCMP hydroxymethylase
超家族 Superfamily superfamilyd.117.1 — Thymidylate synthase/dCMP hydroxymethylase
家族 Family familyd.117.1.1 — Thymidylate synthase/dCMP hydroxymethylase
结构域编号 domain_idd2aazh_
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.117 — Thymidylate synthase/dCMP hydroxymethylase
超家族 Superfamily superfamilyd.117.1 — Thymidylate synthase/dCMP hydroxymethylase
家族 Family familyd.117.1.1 — Thymidylate synthase/dCMP hydroxymethylase
结构域编号 domain_idd2aazi_
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.117 — Thymidylate synthase/dCMP hydroxymethylase
超家族 Superfamily superfamilyd.117.1 — Thymidylate synthase/dCMP hydroxymethylase
家族 Family familyd.117.1.1 — Thymidylate synthase/dCMP hydroxymethylase
结构域编号 domain_idd2aazj_
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.117 — Thymidylate synthase/dCMP hydroxymethylase
超家族 Superfamily superfamilyd.117.1 — Thymidylate synthase/dCMP hydroxymethylase
家族 Family familyd.117.1.1 — Thymidylate synthase/dCMP hydroxymethylase
结构域编号 domain_idd2aazk_
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.117 — Thymidylate synthase/dCMP hydroxymethylase
超家族 Superfamily superfamilyd.117.1 — Thymidylate synthase/dCMP hydroxymethylase
家族 Family familyd.117.1.1 — Thymidylate synthase/dCMP hydroxymethylase
结构域编号 domain_idd2aazl_
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.117 — Thymidylate synthase/dCMP hydroxymethylase
超家族 Superfamily superfamilyd.117.1 — Thymidylate synthase/dCMP hydroxymethylase
家族 Family familyd.117.1.1 — Thymidylate synthase/dCMP hydroxymethylase
结构域编号 domain_idd2aazm_
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.117 — Thymidylate synthase/dCMP hydroxymethylase
超家族 Superfamily superfamilyd.117.1 — Thymidylate synthase/dCMP hydroxymethylase
家族 Family familyd.117.1.1 — Thymidylate synthase/dCMP hydroxymethylase
结构域编号 domain_idd2aazn_
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.117 — Thymidylate synthase/dCMP hydroxymethylase
超家族 Superfamily superfamilyd.117.1 — Thymidylate synthase/dCMP hydroxymethylase
家族 Family familyd.117.1.1 — Thymidylate synthase/dCMP hydroxymethylase
结构域编号 domain_idd2aazo_
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.117 — Thymidylate synthase/dCMP hydroxymethylase
超家族 Superfamily superfamilyd.117.1 — Thymidylate synthase/dCMP hydroxymethylase
家族 Family familyd.117.1.1 — Thymidylate synthase/dCMP hydroxymethylase
结构域编号 domain_idd2aazp_
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.117 — Thymidylate synthase/dCMP hydroxymethylase
超家族 Superfamily superfamilyd.117.1 — Thymidylate synthase/dCMP hydroxymethylase
家族 Family familyd.117.1.1 — Thymidylate synthase/dCMP hydroxymethylase

CATH v4.4 (16 domains)

结构域编号 domain_id2aazA00
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology572 — Thymidylate Synthase; Chain A
同源超家族 H-superfamily homologous superfamily10 — Thymidylate synthase/dCMP hydroxymethylase domain
结构域编号 domain_id2aazB00
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology572 — Thymidylate Synthase; Chain A
同源超家族 H-superfamily homologous superfamily10 — Thymidylate synthase/dCMP hydroxymethylase domain
结构域编号 domain_id2aazC00
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology572 — Thymidylate Synthase; Chain A
同源超家族 H-superfamily homologous superfamily10 — Thymidylate synthase/dCMP hydroxymethylase domain
结构域编号 domain_id2aazD00
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology572 — Thymidylate Synthase; Chain A
同源超家族 H-superfamily homologous superfamily10 — Thymidylate synthase/dCMP hydroxymethylase domain
结构域编号 domain_id2aazE00
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology572 — Thymidylate Synthase; Chain A
同源超家族 H-superfamily homologous superfamily10 — Thymidylate synthase/dCMP hydroxymethylase domain
结构域编号 domain_id2aazF00
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology572 — Thymidylate Synthase; Chain A
同源超家族 H-superfamily homologous superfamily10 — Thymidylate synthase/dCMP hydroxymethylase domain
结构域编号 domain_id2aazG00
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology572 — Thymidylate Synthase; Chain A
同源超家族 H-superfamily homologous superfamily10 — Thymidylate synthase/dCMP hydroxymethylase domain
结构域编号 domain_id2aazH00
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology572 — Thymidylate Synthase; Chain A
同源超家族 H-superfamily homologous superfamily10 — Thymidylate synthase/dCMP hydroxymethylase domain
结构域编号 domain_id2aazI00
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology572 — Thymidylate Synthase; Chain A
同源超家族 H-superfamily homologous superfamily10 — Thymidylate synthase/dCMP hydroxymethylase domain
结构域编号 domain_id2aazJ00
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology572 — Thymidylate Synthase; Chain A
同源超家族 H-superfamily homologous superfamily10 — Thymidylate synthase/dCMP hydroxymethylase domain
结构域编号 domain_id2aazK00
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology572 — Thymidylate Synthase; Chain A
同源超家族 H-superfamily homologous superfamily10 — Thymidylate synthase/dCMP hydroxymethylase domain
结构域编号 domain_id2aazL00
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology572 — Thymidylate Synthase; Chain A
同源超家族 H-superfamily homologous superfamily10 — Thymidylate synthase/dCMP hydroxymethylase domain
结构域编号 domain_id2aazM00
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology572 — Thymidylate Synthase; Chain A
同源超家族 H-superfamily homologous superfamily10 — Thymidylate synthase/dCMP hydroxymethylase domain
结构域编号 domain_id2aazN00
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology572 — Thymidylate Synthase; Chain A
同源超家族 H-superfamily homologous superfamily10 — Thymidylate synthase/dCMP hydroxymethylase domain
结构域编号 domain_id2aazO00
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology572 — Thymidylate Synthase; Chain A
同源超家族 H-superfamily homologous superfamily10 — Thymidylate synthase/dCMP hydroxymethylase domain
结构域编号 domain_id2aazP00
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology572 — Thymidylate Synthase; Chain A
同源超家族 H-superfamily homologous superfamily10 — Thymidylate synthase/dCMP hydroxymethylase domain
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7. 引用文献 (3)