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2ai2

Purine nucleoside phosphorylase from calf spleen

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Purine nucleoside phosphorylase

OrganismNot specified

UniProt P55859

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 3 MAGNESIUM ION × 3 ZINC ION × 3 TRIS-HYDROXYMETHYL-METHYL-AMMONIUM × 3 ;((2S,3AS,4R,6S)-4-(HYDROXYMETHYL)-6-(4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-TETRAHYDROFURO[3,4-D][1,3]DIOXO L-2-YL)METHYLPHOSPHONIC ACID ; × 3 water × 3 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 3 MAGNESIUM ION × 3 ZINC ION × 3 TRIS-HYDROXYMETHYL-METHYL-AMMONIUM × 3 ;((2S,3AS,4R,6S)-4-(HYDROXYMETHYL)-6-(4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-TETRAHYDROFURO[3,4-D][1,3]DIOXO L-2-YL)METHYLPHOSPHONIC ACID ; × 3 water × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1b8n 1b8o 1fxu

3 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers
1a9o 1a9p 1a9q 1a9r 1a9s 1a9t 1b8n 1b8o 1fxu 1fxu 1lv8 1lvu

26 assemblies; showing the first 12

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name PNPH_BOVIN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–289； UniProt 1–289

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2ai2
Deposition date deposition_date2005-07-28
Structure title titlePurine nucleoside phosphorylase from calf spleen
Keywords keywordspurine nucleoside phosphorylase, multisubstrate analog inhibitor, transferase; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2ai2__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2ai2__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2ai2__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）29.16 Å
Rg (electron density)28.06 Å
Total Rg28.91 Å
Atom count6453
Residues822
Excluded volume114210 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2ai2__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 2ai2__assembly_2__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd2ai2a_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.56 — Phosphorylase/hydrolase-like
Superfamily Superfamily superfamilyc.56.2 — Purine and uridine phosphorylases
Family Family familyc.56.2.1 — Purine and uridine phosphorylases

CATH v4.4 (1 domains)

Domain ID domain_id2ai2A00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily1580 — Nucleoside phosphorylase domain
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7. Citations (2)