2cww

Crystal structure of Thermus thermophilus TTHA1280, a putative SAM-dependent RNA methyltransferase, in complex with S-adenosyl-L-homocysteine

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

putative SAM-dependent RNA methyltransferase

Thermus thermophilus

UniProt Q5SIT4

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白同源多聚体 同源多聚体 蛋白 2 S-ADENOSYL-L-HOMOCYSTEINE × 2 ACETIC ACID × 2 GLYCEROL × 2 water × 2 与蛋白数一致
2 蛋白同源多聚体 同源多聚体 蛋白 2 S-ADENOSYL-L-HOMOCYSTEINE × 2 water × 2 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 Q5SIT4_THET8
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–382; UniProt 1–382 作者链 B; PDB构建体 1–382; UniProt 1–382

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id2cww
沉积日期 deposition_date2005-06-27
结构标题 titleCrystal structure of Thermus thermophilus TTHA1280, a putative SAM-dependent RNA methyltransferase, in complex with S-adenosyl-L-homocysteine
关键词 keywords;Structural genomics, SAM-dependent RNA methyltransferase, S-adenosyl-L-homocysteine, NPPSFA, National Project on Protein Structural and Functional Analyses, RIKEN Structural Genomics/Proteomics Initiative, RSGI, TRANSFERASE ;; TRANSFERASE
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

2cww__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

2cww__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

2cww__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)29.13 Å
Rg(电子密度)28.14 Å
总 Rg28.99 Å
原子数6068
残基数752
排除体积107760 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 2cww__assembly_1__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 1 2cww__assembly_2__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (5)

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6. 折叠分类 (SCOP + CATH) 10 domains

SCOP 2.08 (4 domains)

结构域编号 domain_idd2cwwa1
类 Class classb — All beta proteins
折叠类型 Fold foldb.122 — PUA domain-like
超家族 Superfamily superfamilyb.122.1 — PUA domain-like
家族 Family familyb.122.1.9 — Hypothetical RNA methyltransferase domain (HRMD)
结构域编号 domain_idd2cwwa2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.66 — S-adenosyl-L-methionine-dependent methyltransferases
超家族 Superfamily superfamilyc.66.1 — S-adenosyl-L-methionine-dependent methyltransferases
家族 Family familyc.66.1.51 — hypothetical RNA methyltransferase
结构域编号 domain_idd2cwwb1
类 Class classb — All beta proteins
折叠类型 Fold foldb.122 — PUA domain-like
超家族 Superfamily superfamilyb.122.1 — PUA domain-like
家族 Family familyb.122.1.9 — Hypothetical RNA methyltransferase domain (HRMD)
结构域编号 domain_idd2cwwb2
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.66 — S-adenosyl-L-methionine-dependent methyltransferases
超家族 Superfamily superfamilyc.66.1 — S-adenosyl-L-methionine-dependent methyltransferases
家族 Family familyc.66.1.51 — hypothetical RNA methyltransferase

CATH v4.4 (6 domains)

结构域编号 domain_id2cwwA01
类 Class class2 — Mainly Beta
架构 Architecture architecture30 — Roll
拓扑 Topology topology130 — Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4
同源超家族 H-superfamily homologous superfamily10 — PUA domain
结构域编号 domain_id2cwwA02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology750 — Transcription Regulator spoIIAA
同源超家族 H-superfamily homologous superfamily80 — RNA methyltransferase domain (HRMD) like
结构域编号 domain_id2cwwA03
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily150 — Vaccinia Virus protein VP39
结构域编号 domain_id2cwwB01
类 Class class2 — Mainly Beta
架构 Architecture architecture30 — Roll
拓扑 Topology topology130 — Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4
同源超家族 H-superfamily homologous superfamily10 — PUA domain
结构域编号 domain_id2cwwB02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology750 — Transcription Regulator spoIIAA
同源超家族 H-superfamily homologous superfamily80 — RNA methyltransferase domain (HRMD) like
结构域编号 domain_id2cwwB03
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily150 — Vaccinia Virus protein VP39
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7. 引用文献 (1)