2erj

Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Interleukin-2 receptor alpha chain

Homo sapiens

UniProt P01589

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 4 其他聚合物 4 Interleukin-2 receptor beta chain × 1 (P14784) Cytokine receptor common gamma chain × 1 (P31785) Interleukin-2 × 1 (P60568) ;beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 与蛋白数一致
2 其他组合 异源复合物 蛋白 4 其他聚合物 4 Interleukin-2 receptor beta chain × 1 (P14784) Cytokine receptor common gamma chain × 1 (P31785) Interleukin-2 × 1 (P60568) ;beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 IL2RA_HUMAN
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 6–217; UniProt 22–233 作者链 E; PDB构建体 6–217; UniProt 22–233

Interleukin-2 receptor beta chain

Homo sapiens

UniProt P14784

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 4 其他聚合物 4 Interleukin-2 receptor alpha chain × 1 (P01589) Cytokine receptor common gamma chain × 1 (P31785) Interleukin-2 × 1 (P60568) ;beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 与蛋白数一致
2 其他组合 异源复合物 蛋白 4 其他聚合物 4 Interleukin-2 receptor alpha chain × 1 (P01589) Cytokine receptor common gamma chain × 1 (P31785) Interleukin-2 × 1 (P60568) ;beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 IL2RB_HUMAN
Isoform —
PDB实体 2
链与序列区间 作者链 B; PDB构建体 6–211; UniProt 25–230 作者链 F; PDB构建体 6–211; UniProt 25–230

Cytokine receptor common gamma chain

Homo sapiens

UniProt P31785

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 4 其他聚合物 4 Interleukin-2 receptor alpha chain × 1 (P01589) Interleukin-2 receptor beta chain × 1 (P14784) Interleukin-2 × 1 (P60568) ;beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 与蛋白数一致
2 其他组合 异源复合物 蛋白 4 其他聚合物 4 Interleukin-2 receptor alpha chain × 1 (P01589) Interleukin-2 receptor beta chain × 1 (P14784) Interleukin-2 × 1 (P60568) ;beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 IL2RG_HUMAN
Isoform —
PDB实体 3
链与序列区间 作者链 C; PDB构建体 6–238; UniProt 23–255 作者链 G; PDB构建体 6–238; UniProt 23–255

Interleukin-2

Homo sapiens

UniProt P60568

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 4 其他聚合物 4 Interleukin-2 receptor alpha chain × 1 (P01589) Interleukin-2 receptor beta chain × 1 (P14784) Cytokine receptor common gamma chain × 1 (P31785) ;beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 与蛋白数一致
2 其他组合 异源复合物 蛋白 4 其他聚合物 4 Interleukin-2 receptor alpha chain × 1 (P01589) Interleukin-2 receptor beta chain × 1 (P14784) Cytokine receptor common gamma chain × 1 (P31785) ;beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 IL2_HUMAN
Isoform —
PDB实体 4
链与序列区间 作者链 D; PDB构建体 1–133; UniProt 21–153 作者链 H; PDB构建体 1–133; UniProt 21–153

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id2erj
沉积日期 deposition_date2005-10-25
结构标题 titleCrystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2
关键词 keywords;INTERLEUKIN-2, INTERLEUKIN-2 ALPHA RECEPTOR, INTERLEUKIN-2 BETA RECEPTOR, INTERLEUKIN-2 GAMMA RECEPTOR, IMMUNE SYSTEM-CYTOKINE COMPLEX ;; IMMUNE SYSTEM/CYTOKINE
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

2erj__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

2erj__assembly_2__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

2erj__assembly_2__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)31.84 Å
Rg(电子密度)30.82 Å
总 Rg31.46 Å
原子数5592
残基数658
排除体积99007 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 2erj__assembly_1__model_1 tetrameric (4) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 1 2erj__assembly_2__model_1 tetrameric (4) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (10)

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6. 折叠分类 (SCOP + CATH) 30 domains

SCOP 2.08 (16 domains)

结构域编号 domain_idd2erja1
类 Class classg — Small proteins
折叠类型 Fold foldg.18 — Complement control module/SCR domain
超家族 Superfamily superfamilyg.18.1 — Complement control module/SCR domain
家族 Family familyg.18.1.1 — Complement control module/SCR domain
结构域编号 domain_idd2erja2
类 Class classg — Small proteins
折叠类型 Fold foldg.18 — Complement control module/SCR domain
超家族 Superfamily superfamilyg.18.1 — Complement control module/SCR domain
家族 Family familyg.18.1.1 — Complement control module/SCR domain
结构域编号 domain_idd2erjb1
类 Class classb — All beta proteins
折叠类型 Fold foldb.1 — Immunoglobulin-like beta-sandwich
超家族 Superfamily superfamilyb.1.2 — Fibronectin type III
家族 Family familyb.1.2.1 — Fibronectin type III
结构域编号 domain_idd2erjb2
类 Class classb — All beta proteins
折叠类型 Fold foldb.1 — Immunoglobulin-like beta-sandwich
超家族 Superfamily superfamilyb.1.2 — Fibronectin type III
家族 Family familyb.1.2.1 — Fibronectin type III
结构域编号 domain_idd2erjb3
类 Class classl — Artifacts
折叠类型 Fold foldl.1 — Tags
超家族 Superfamily superfamilyl.1.1 — Tags
家族 Family familyl.1.1.1 — Tags
结构域编号 domain_idd2erjc1
类 Class classb — All beta proteins
折叠类型 Fold foldb.1 — Immunoglobulin-like beta-sandwich
超家族 Superfamily superfamilyb.1.2 — Fibronectin type III
家族 Family familyb.1.2.1 — Fibronectin type III
结构域编号 domain_idd2erjc2
类 Class classb — All beta proteins
折叠类型 Fold foldb.1 — Immunoglobulin-like beta-sandwich
超家族 Superfamily superfamilyb.1.2 — Fibronectin type III
家族 Family familyb.1.2.1 — Fibronectin type III
结构域编号 domain_idd2erjd_
类 Class classa — All alpha proteins
折叠类型 Fold folda.26 — 4-helical cytokines
超家族 Superfamily superfamilya.26.1 — 4-helical cytokines
家族 Family familya.26.1.2 — Short-chain cytokines
结构域编号 domain_idd2erje1
类 Class classg — Small proteins
折叠类型 Fold foldg.18 — Complement control module/SCR domain
超家族 Superfamily superfamilyg.18.1 — Complement control module/SCR domain
家族 Family familyg.18.1.1 — Complement control module/SCR domain
结构域编号 domain_idd2erje2
类 Class classg — Small proteins
折叠类型 Fold foldg.18 — Complement control module/SCR domain
超家族 Superfamily superfamilyg.18.1 — Complement control module/SCR domain
家族 Family familyg.18.1.1 — Complement control module/SCR domain
结构域编号 domain_idd2erjf1
类 Class classb — All beta proteins
折叠类型 Fold foldb.1 — Immunoglobulin-like beta-sandwich
超家族 Superfamily superfamilyb.1.2 — Fibronectin type III
家族 Family familyb.1.2.1 — Fibronectin type III
结构域编号 domain_idd2erjf2
类 Class classb — All beta proteins
折叠类型 Fold foldb.1 — Immunoglobulin-like beta-sandwich
超家族 Superfamily superfamilyb.1.2 — Fibronectin type III
家族 Family familyb.1.2.1 — Fibronectin type III
结构域编号 domain_idd2erjf3
类 Class classl — Artifacts
折叠类型 Fold foldl.1 — Tags
超家族 Superfamily superfamilyl.1.1 — Tags
家族 Family familyl.1.1.1 — Tags
结构域编号 domain_idd2erjg1
类 Class classb — All beta proteins
折叠类型 Fold foldb.1 — Immunoglobulin-like beta-sandwich
超家族 Superfamily superfamilyb.1.2 — Fibronectin type III
家族 Family familyb.1.2.1 — Fibronectin type III
结构域编号 domain_idd2erjg2
类 Class classb — All beta proteins
折叠类型 Fold foldb.1 — Immunoglobulin-like beta-sandwich
超家族 Superfamily superfamilyb.1.2 — Fibronectin type III
家族 Family familyb.1.2.1 — Fibronectin type III
结构域编号 domain_idd2erjh_
类 Class classa — All alpha proteins
折叠类型 Fold folda.26 — 4-helical cytokines
超家族 Superfamily superfamilya.26.1 — 4-helical cytokines
家族 Family familya.26.1.2 — Short-chain cytokines

CATH v4.4 (14 domains)

结构域编号 domain_id2erjA01
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology70 — Complement Module; domain 1
同源超家族 H-superfamily homologous superfamily10 — Complement Module, domain 1
结构域编号 domain_id2erjA02
类 Class class2 — Mainly Beta
架构 Architecture architecture20 — Single Sheet
拓扑 Topology topology28 — Rubrerythrin, domain 2
同源超家族 H-superfamily homologous superfamily230 —
结构域编号 domain_id2erjB01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id2erjB02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id2erjC01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id2erjC02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id2erjD00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1250 — Growth Hormone; Chain: A;
同源超家族 H-superfamily homologous superfamily10 —
结构域编号 domain_id2erjE01
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology70 — Complement Module; domain 1
同源超家族 H-superfamily homologous superfamily10 — Complement Module, domain 1
结构域编号 domain_id2erjE02
类 Class class2 — Mainly Beta
架构 Architecture architecture20 — Single Sheet
拓扑 Topology topology28 — Rubrerythrin, domain 2
同源超家族 H-superfamily homologous superfamily230 —
结构域编号 domain_id2erjF01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id2erjF02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id2erjG01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id2erjG02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id2erjH00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1250 — Growth Hormone; Chain: A;
同源超家族 H-superfamily homologous superfamily10 —
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7. 引用文献 (1)