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2f63

Solution structure of HPPK in complex with inhibitor analogs AMPCPP and HP-1

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

Escherichia coli

UniProt P26281

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 No other associated polymer Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1dy3 1eq0 1eqm 1ex8 1f9h 1g4c 1g4c 1hka 1hq2 1im6 1kbr 1q0n

68 assemblies; showing the first 12

Homodimer
3ip0

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name HPPK_ECOLI
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–158； UniProt 1–158

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2f63
Deposition date deposition_date2005-11-28
Structure title titleSolution structure of HPPK in complex with inhibitor analogs AMPCPP and HP-1
Keywords keywordsalpha-beta-alpha fold, transferase; TRANSFERASE
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2f63__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2f63__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2f63__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）16.02 Å
Rg (electron density)14.64 Å
Total Rg15.79 Å
Atom count2539
Residues158
Excluded volume22634 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2f63__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 2f63__assembly_1__model_2 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 2f63__assembly_1__model_3 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 2f63__assembly_1__model_4 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 2f63__assembly_1__model_5 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 2f63__assembly_1__model_6 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 2f63__assembly_1__model_7 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 2f63__assembly_1__model_8 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 2f63__assembly_1__model_9 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 2f63__assembly_1__model_10 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 2f63__assembly_1__model_11 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 2f63__assembly_1__model_12 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 2f63__assembly_1__model_13 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 2f63__assembly_1__model_14 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 2f63__assembly_1__model_15 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 16 2f63__assembly_1__model_16 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 17 2f63__assembly_1__model_17 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 18 2f63__assembly_1__model_18 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 19 2f63__assembly_1__model_19 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 20 2f63__assembly_1__model_20 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 21 2f63__assembly_1__model_21 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (1)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd2f63a_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.58 — Ferredoxin-like
Superfamily Superfamily superfamilyd.58.30 — 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
Family Family familyd.58.30.1 — 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK

CATH v4.4 (1 domains)

Domain ID domain_id2f63A00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily560 — 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK
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7. Citations (1)