2ffl
Crystal Structure of Dicer from Giardia intestinalis
1. Protein Identity and Related Structures Protein Identity & Related Structures
No usable UniProt protein identity is available for this entry.
The relationship tables retain this entry's assembly and composition data, but cross-PDB links for the same protein cannot be established reliably without a unified protein identity.
Assembly Composition of the Current Entry
| Assembly | Physical composition | Protein state | 蛋白 / DNA / RNA / 其他Polymer | Data consistency |
|---|---|---|---|---|
| 1 | Protein monomer | Monomer | 1 / 0 / 0 / 0 | Consistent with protein count |
| 2 | Protein monomer | Monomer | 1 / 0 / 0 / 0 | Consistent with protein count |
| 3 | Protein monomer | Monomer | 1 / 0 / 0 / 0 | Consistent with protein count |
| 4 | Protein monomer | Monomer | 1 / 0 / 0 / 0 | Consistent with protein count |
| 5 | Protein homooligomer | Homooligomer | 2 / 0 / 0 / 0 | Consistent with protein count |
The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.
2. Structure Basics 2. Structure Basics
| Entry ID entry_id | 2ffl |
| Deposition date deposition_date | 2005-12-19 |
| Structure title title | Crystal Structure of Dicer from Giardia intestinalis |
| Keywords keywords | RNA interference; RNAi; PAZ domain, TRANSLATION, HYDROLASE; TRANSLATION,HYDROLASE |
| Experimental Method method | X-RAY DIFFRACTION |
3. Official assembly/model SAXS Official SAXS Profiles
This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.
2ffl__assembly_1__model_1
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
2ffl__assembly_1__model_1 | I(q)
2ffl__assembly_1__model_1 | P(r) · Pending
| Rg（Guinier） | 34.57 Å |
| Rg (electron density) | 34.47 Å |
| Total Rg | 34.82 Å |
| Atom count | 5642 |
| Residues | 732 |
| Excluded volume | 101560 ų |
| Maximum q | 0.500 Å⁻¹ |
| Assembly | Model | Structure unit | Oligomeric description | Status | CRYSOL | Actions |
|---|---|---|---|---|---|---|
| 1 | 1 | 2ffl__assembly_1__model_1 |
monomeric （1） | Success | 4.1.3-1-20251215 (887e7ef) | View Download |
| 2 | 1 | 2ffl__assembly_2__model_1 |
monomeric （1） | Success | 4.1.3-1-20251215 (887e7ef) | View Download |
| 3 | 1 | 2ffl__assembly_3__model_1 |
monomeric （1） | Success | 4.1.3-1-20251215 (887e7ef) | View Download |
| 4 | 1 | 2ffl__assembly_4__model_1 |
monomeric （1） | Success | 4.1.3-1-20251215 (887e7ef) | View Download |
| 5 | 1 | 2ffl__assembly_5__model_1 |
dimeric （2） | Success | 4.1.3-1-20251215 (887e7ef) | View Download |
4. Crystallography and Experiment 4. Crystallography & Experiment
5. Entities and Polymers Entities & Polymers (3)
6. Fold Classification (SCOP + CATH) 20 domains
CATH v4.4 (20 domains)
| Domain ID domain_id | 2fflA02 |
| Class class | 2 — Mainly Beta |
| Architecture architecture | 170 — Beta Complex |
| Topology topology | 260 — paz domain |
| Homologous superfamily homologous superfamily | 10 — paz domain |
| Domain ID domain_id | 2fflA03 |
| Class class | 6 — Special |
| Architecture architecture | 10 — Helix non-globular |
| Topology topology | 250 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces |
| Homologous superfamily homologous superfamily | 1440 — |
| Domain ID domain_id | 2fflA04 |
| Class class | 1 — Mainly Alpha |
| Architecture architecture | 10 — Orthogonal Bundle |
| Topology topology | 1520 — Ribonuclease iii, N-terminal Endonuclease Domain; Chain A |
| Homologous superfamily homologous superfamily | 10 — Ribonuclease III domain |
| Domain ID domain_id | 2fflA05 |
| Class class | 1 — Mainly Alpha |
| Architecture architecture | 10 — Orthogonal Bundle |
| Topology topology | 1740 — Rna Polymerase Sigma Factor; Chain: A |
| Homologous superfamily homologous superfamily | 150 — |
| Domain ID domain_id | 2fflA06 |
| Class class | 1 — Mainly Alpha |
| Architecture architecture | 10 — Orthogonal Bundle |
| Topology topology | 1520 — Ribonuclease iii, N-terminal Endonuclease Domain; Chain A |
| Homologous superfamily homologous superfamily | 10 — Ribonuclease III domain |
| Domain ID domain_id | 2fflB02 |
| Class class | 2 — Mainly Beta |
| Architecture architecture | 170 — Beta Complex |
| Topology topology | 260 — paz domain |
| Homologous superfamily homologous superfamily | 10 — paz domain |
| Domain ID domain_id | 2fflB03 |
| Class class | 6 — Special |
| Architecture architecture | 10 — Helix non-globular |
| Topology topology | 250 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces |
| Homologous superfamily homologous superfamily | 1440 — |
| Domain ID domain_id | 2fflB04 |
| Class class | 1 — Mainly Alpha |
| Architecture architecture | 10 — Orthogonal Bundle |
| Topology topology | 1520 — Ribonuclease iii, N-terminal Endonuclease Domain; Chain A |
| Homologous superfamily homologous superfamily | 10 — Ribonuclease III domain |
| Domain ID domain_id | 2fflB05 |
| Class class | 1 — Mainly Alpha |
| Architecture architecture | 10 — Orthogonal Bundle |
| Topology topology | 1740 — Rna Polymerase Sigma Factor; Chain: A |
| Homologous superfamily homologous superfamily | 150 — |
| Domain ID domain_id | 2fflB06 |
| Class class | 1 — Mainly Alpha |
| Architecture architecture | 10 — Orthogonal Bundle |
| Topology topology | 1520 — Ribonuclease iii, N-terminal Endonuclease Domain; Chain A |
| Homologous superfamily homologous superfamily | 10 — Ribonuclease III domain |
| Domain ID domain_id | 2fflC02 |
| Class class | 2 — Mainly Beta |
| Architecture architecture | 170 — Beta Complex |
| Topology topology | 260 — paz domain |
| Homologous superfamily homologous superfamily | 10 — paz domain |
| Domain ID domain_id | 2fflC03 |
| Class class | 6 — Special |
| Architecture architecture | 10 — Helix non-globular |
| Topology topology | 250 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces |
| Homologous superfamily homologous superfamily | 1440 — |
| Domain ID domain_id | 2fflC04 |
| Class class | 1 — Mainly Alpha |
| Architecture architecture | 10 — Orthogonal Bundle |
| Topology topology | 1520 — Ribonuclease iii, N-terminal Endonuclease Domain; Chain A |
| Homologous superfamily homologous superfamily | 10 — Ribonuclease III domain |
| Domain ID domain_id | 2fflC05 |
| Class class | 1 — Mainly Alpha |
| Architecture architecture | 10 — Orthogonal Bundle |
| Topology topology | 1740 — Rna Polymerase Sigma Factor; Chain: A |
| Homologous superfamily homologous superfamily | 150 — |
| Domain ID domain_id | 2fflC06 |
| Class class | 1 — Mainly Alpha |
| Architecture architecture | 10 — Orthogonal Bundle |
| Topology topology | 1520 — Ribonuclease iii, N-terminal Endonuclease Domain; Chain A |
| Homologous superfamily homologous superfamily | 10 — Ribonuclease III domain |
| Domain ID domain_id | 2fflD02 |
| Class class | 2 — Mainly Beta |
| Architecture architecture | 170 — Beta Complex |
| Topology topology | 260 — paz domain |
| Homologous superfamily homologous superfamily | 10 — paz domain |
| Domain ID domain_id | 2fflD03 |
| Class class | 6 — Special |
| Architecture architecture | 10 — Helix non-globular |
| Topology topology | 250 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces |
| Homologous superfamily homologous superfamily | 1440 — |
| Domain ID domain_id | 2fflD04 |
| Class class | 1 — Mainly Alpha |
| Architecture architecture | 10 — Orthogonal Bundle |
| Topology topology | 1520 — Ribonuclease iii, N-terminal Endonuclease Domain; Chain A |
| Homologous superfamily homologous superfamily | 10 — Ribonuclease III domain |
| Domain ID domain_id | 2fflD05 |
| Class class | 1 — Mainly Alpha |
| Architecture architecture | 10 — Orthogonal Bundle |
| Topology topology | 1740 — Rna Polymerase Sigma Factor; Chain: A |
| Homologous superfamily homologous superfamily | 150 — |
| Domain ID domain_id | 2fflD06 |
| Class class | 1 — Mainly Alpha |
| Architecture architecture | 10 — Orthogonal Bundle |
| Topology topology | 1520 — Ribonuclease iii, N-terminal Endonuclease Domain; Chain A |
| Homologous superfamily homologous superfamily | 10 — Ribonuclease III domain |