2ffl
Crystal Structure of Dicer from Giardia intestinalis
1. 蛋白身份与相关结构 Protein Identity & Related Structures
当前条目没有可用的 UniProt 蛋白身份。
七张关系表仍保留该条目的 assembly 与组成信息，但缺少统一蛋白身份时，不能可靠建立跨 PDB 的同蛋白链接。
当前条目的 assembly 组成
| Assembly | 物理组成 | 蛋白状态 | 蛋白 / DNA / RNA / 其他聚合物 | 数据核对 |
|---|---|---|---|---|
| 1 | 蛋白单体 | 单体 | 1 / 0 / 0 / 0 | 与蛋白数一致 |
| 2 | 蛋白单体 | 单体 | 1 / 0 / 0 / 0 | 与蛋白数一致 |
| 3 | 蛋白单体 | 单体 | 1 / 0 / 0 / 0 | 与蛋白数一致 |
| 4 | 蛋白单体 | 单体 | 1 / 0 / 0 / 0 | 与蛋白数一致 |
| 5 | 蛋白同源多聚体 | 同源多聚体 | 2 / 0 / 0 / 0 | 与蛋白数一致 |
页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。
2. 结构基本信息 2. Structure Basics
| 条目编号 entry_id | 2ffl |
| 沉积日期 deposition_date | 2005-12-19 |
| 结构标题 title | Crystal Structure of Dicer from Giardia intestinalis |
| 关键词 keywords | RNA interference; RNAi; PAZ domain, TRANSLATION, HYDROLASE; TRANSLATION,HYDROLASE |
| 实验方法 method | X-RAY DIFFRACTION |
3. Official assembly/model 理论 SAXS Official SAXS Profiles
页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。
2ffl__assembly_4__model_1
Assembly 4 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
2ffl__assembly_4__model_1 | I(q)
2ffl__assembly_4__model_1 | P(r) · Pending
| Rg（Guinier） | 34.61 Å |
| Rg（电子密度） | 34.53 Å |
| 总 Rg | 34.84 Å |
| 原子数 | 5582 |
| 残基数 | 720 |
| 排除体积 | 100490 ų |
| 最大 q | 0.500 Å⁻¹ |
| Assembly | Model | 结构单元 | 聚集说明 | 状态 | CRYSOL | 操作 |
|---|---|---|---|---|---|---|
| 1 | 1 | 2ffl__assembly_1__model_1 |
monomeric （1） | 成功 | 4.1.3-1-20251215 (887e7ef) | 查看 下载 |
| 2 | 1 | 2ffl__assembly_2__model_1 |
monomeric （1） | 成功 | 4.1.3-1-20251215 (887e7ef) | 查看 下载 |
| 3 | 1 | 2ffl__assembly_3__model_1 |
monomeric （1） | 成功 | 4.1.3-1-20251215 (887e7ef) | 查看 下载 |
| 4 | 1 | 2ffl__assembly_4__model_1 |
monomeric （1） | 成功 | 4.1.3-1-20251215 (887e7ef) | 查看 下载 |
| 5 | 1 | 2ffl__assembly_5__model_1 |
dimeric （2） | 成功 | 4.1.3-1-20251215 (887e7ef) | 查看 下载 |
4. 晶体学与实验 4. Crystallography & Experiment
5. 实体与聚合物信息 Entities & Polymers (3)
6. 折叠分类 (SCOP + CATH) 20 domains
CATH v4.4 (20 domains)
| 结构域编号 domain_id | 2fflA02 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 170 — Beta Complex |
| 拓扑 Topology topology | 260 — paz domain |
| 同源超家族 H-superfamily homologous superfamily | 10 — paz domain |
| 结构域编号 domain_id | 2fflA03 |
| 类 Class class | 6 — Special |
| 架构 Architecture architecture | 10 — Helix non-globular |
| 拓扑 Topology topology | 250 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces |
| 同源超家族 H-superfamily homologous superfamily | 1440 — |
| 结构域编号 domain_id | 2fflA04 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 10 — Orthogonal Bundle |
| 拓扑 Topology topology | 1520 — Ribonuclease iii, N-terminal Endonuclease Domain; Chain A |
| 同源超家族 H-superfamily homologous superfamily | 10 — Ribonuclease III domain |
| 结构域编号 domain_id | 2fflA05 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 10 — Orthogonal Bundle |
| 拓扑 Topology topology | 1740 — Rna Polymerase Sigma Factor; Chain: A |
| 同源超家族 H-superfamily homologous superfamily | 150 — |
| 结构域编号 domain_id | 2fflA06 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 10 — Orthogonal Bundle |
| 拓扑 Topology topology | 1520 — Ribonuclease iii, N-terminal Endonuclease Domain; Chain A |
| 同源超家族 H-superfamily homologous superfamily | 10 — Ribonuclease III domain |
| 结构域编号 domain_id | 2fflB02 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 170 — Beta Complex |
| 拓扑 Topology topology | 260 — paz domain |
| 同源超家族 H-superfamily homologous superfamily | 10 — paz domain |
| 结构域编号 domain_id | 2fflB03 |
| 类 Class class | 6 — Special |
| 架构 Architecture architecture | 10 — Helix non-globular |
| 拓扑 Topology topology | 250 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces |
| 同源超家族 H-superfamily homologous superfamily | 1440 — |
| 结构域编号 domain_id | 2fflB04 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 10 — Orthogonal Bundle |
| 拓扑 Topology topology | 1520 — Ribonuclease iii, N-terminal Endonuclease Domain; Chain A |
| 同源超家族 H-superfamily homologous superfamily | 10 — Ribonuclease III domain |
| 结构域编号 domain_id | 2fflB05 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 10 — Orthogonal Bundle |
| 拓扑 Topology topology | 1740 — Rna Polymerase Sigma Factor; Chain: A |
| 同源超家族 H-superfamily homologous superfamily | 150 — |
| 结构域编号 domain_id | 2fflB06 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 10 — Orthogonal Bundle |
| 拓扑 Topology topology | 1520 — Ribonuclease iii, N-terminal Endonuclease Domain; Chain A |
| 同源超家族 H-superfamily homologous superfamily | 10 — Ribonuclease III domain |
| 结构域编号 domain_id | 2fflC02 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 170 — Beta Complex |
| 拓扑 Topology topology | 260 — paz domain |
| 同源超家族 H-superfamily homologous superfamily | 10 — paz domain |
| 结构域编号 domain_id | 2fflC03 |
| 类 Class class | 6 — Special |
| 架构 Architecture architecture | 10 — Helix non-globular |
| 拓扑 Topology topology | 250 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces |
| 同源超家族 H-superfamily homologous superfamily | 1440 — |
| 结构域编号 domain_id | 2fflC04 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 10 — Orthogonal Bundle |
| 拓扑 Topology topology | 1520 — Ribonuclease iii, N-terminal Endonuclease Domain; Chain A |
| 同源超家族 H-superfamily homologous superfamily | 10 — Ribonuclease III domain |
| 结构域编号 domain_id | 2fflC05 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 10 — Orthogonal Bundle |
| 拓扑 Topology topology | 1740 — Rna Polymerase Sigma Factor; Chain: A |
| 同源超家族 H-superfamily homologous superfamily | 150 — |
| 结构域编号 domain_id | 2fflC06 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 10 — Orthogonal Bundle |
| 拓扑 Topology topology | 1520 — Ribonuclease iii, N-terminal Endonuclease Domain; Chain A |
| 同源超家族 H-superfamily homologous superfamily | 10 — Ribonuclease III domain |
| 结构域编号 domain_id | 2fflD02 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 170 — Beta Complex |
| 拓扑 Topology topology | 260 — paz domain |
| 同源超家族 H-superfamily homologous superfamily | 10 — paz domain |
| 结构域编号 domain_id | 2fflD03 |
| 类 Class class | 6 — Special |
| 架构 Architecture architecture | 10 — Helix non-globular |
| 拓扑 Topology topology | 250 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces |
| 同源超家族 H-superfamily homologous superfamily | 1440 — |
| 结构域编号 domain_id | 2fflD04 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 10 — Orthogonal Bundle |
| 拓扑 Topology topology | 1520 — Ribonuclease iii, N-terminal Endonuclease Domain; Chain A |
| 同源超家族 H-superfamily homologous superfamily | 10 — Ribonuclease III domain |
| 结构域编号 domain_id | 2fflD05 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 10 — Orthogonal Bundle |
| 拓扑 Topology topology | 1740 — Rna Polymerase Sigma Factor; Chain: A |
| 同源超家族 H-superfamily homologous superfamily | 150 — |
| 结构域编号 domain_id | 2fflD06 |
| 类 Class class | 1 — Mainly Alpha |
| 架构 Architecture architecture | 10 — Orthogonal Bundle |
| 拓扑 Topology topology | 1520 — Ribonuclease iii, N-terminal Endonuclease Domain; Chain A |
| 同源超家族 H-superfamily homologous superfamily | 10 — Ribonuclease III domain |