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2hv7

Crystal structure of phosphotyrosyl phosphatase activator bound to ATPgammaS

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Protein phosphatase 2A, regulatory subunit B

Homo sapiens

UniProt Q15257

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 No other associated polymer Consistent with protein count
2 Protein monomer Monomer Protein 1 ADENOSINE-5'-DIPHOSPHATE × 1 Consistent with protein count
3 Protein monomer Monomer Protein 1 ADENOSINE-5'-DIPHOSPHATE × 1 Consistent with protein count
4 Protein monomer Monomer Protein 1 No other associated polymer Consistent with protein count
5 Protein monomer Monomer Protein 1 ADENOSINE-5'-DIPHOSPHATE × 1 Consistent with protein count
6 Protein monomer Monomer Protein 1 No other associated polymer Consistent with protein count
7 Protein monomer Monomer Protein 1 ADENOSINE-5'-DIPHOSPHATE × 1 Consistent with protein count
8 Protein monomer Monomer Protein 1 No other associated polymer Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2g62 2hv6 2hv6 2hv7 2hv7 2hv7 2hv7 2hv7 2hv7 2hv7 2hv7 2ixm

12 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4lac 4ny3 4ny3

3 assemblies

View Construct and Data Evidence
UniProt name PTPA_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–323； UniProt 1–323 Author chain B； PDBConstruct 1–323； UniProt 1–323 Author chain C； PDBConstruct 1–323； UniProt 1–323 Author chain D； PDBConstruct 1–323； UniProt 1–323 Author chain E； PDBConstruct 1–323； UniProt 1–323 Author chain F； PDBConstruct 1–323； UniProt 1–323 Author chain G； PDBConstruct 1–323； UniProt 1–323 Author chain H； PDBConstruct 1–323； UniProt 1–323

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2hv7
Deposition date deposition_date2006-07-27
Structure title titleCrystal structure of phosphotyrosyl phosphatase activator bound to ATPgammaS
Keywords keywordsphosphotyrosyl phosphatase activator, PP2A, phosphatase, phosphatase specificity, Unknown Function; UNKNOWN FUNCTION
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2hv7__assembly_7__model_1

Assembly 7 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2hv7__assembly_7__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2hv7__assembly_7__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）20.20 Å
Rg (electron density)18.90 Å
Total Rg19.92 Å
Atom count2465
Residues301
Excluded volume44157 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2hv7__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 2hv7__assembly_2__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 2hv7__assembly_3__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 2hv7__assembly_4__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 2hv7__assembly_5__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
6 1 2hv7__assembly_6__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
7 1 2hv7__assembly_7__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
8 1 2hv7__assembly_8__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 16 domains

SCOP 2.08 (8 domains)

Domain ID domain_idd2hv7a_
Class classa — All alpha proteins
Fold Fold folda.268 — PTPA-like
Superfamily Superfamily superfamilya.268.1 — PTPA-like
Family Family familya.268.1.1 — PTPA-like
Domain ID domain_idd2hv7b_
Class classa — All alpha proteins
Fold Fold folda.268 — PTPA-like
Superfamily Superfamily superfamilya.268.1 — PTPA-like
Family Family familya.268.1.1 — PTPA-like
Domain ID domain_idd2hv7c_
Class classa — All alpha proteins
Fold Fold folda.268 — PTPA-like
Superfamily Superfamily superfamilya.268.1 — PTPA-like
Family Family familya.268.1.1 — PTPA-like
Domain ID domain_idd2hv7d_
Class classa — All alpha proteins
Fold Fold folda.268 — PTPA-like
Superfamily Superfamily superfamilya.268.1 — PTPA-like
Family Family familya.268.1.1 — PTPA-like
Domain ID domain_idd2hv7e_
Class classa — All alpha proteins
Fold Fold folda.268 — PTPA-like
Superfamily Superfamily superfamilya.268.1 — PTPA-like
Family Family familya.268.1.1 — PTPA-like
Domain ID domain_idd2hv7f_
Class classa — All alpha proteins
Fold Fold folda.268 — PTPA-like
Superfamily Superfamily superfamilya.268.1 — PTPA-like
Family Family familya.268.1.1 — PTPA-like
Domain ID domain_idd2hv7g_
Class classa — All alpha proteins
Fold Fold folda.268 — PTPA-like
Superfamily Superfamily superfamilya.268.1 — PTPA-like
Family Family familya.268.1.1 — PTPA-like
Domain ID domain_idd2hv7h_
Class classa — All alpha proteins
Fold Fold folda.268 — PTPA-like
Superfamily Superfamily superfamilya.268.1 — PTPA-like
Family Family familya.268.1.1 — PTPA-like

CATH v4.4 (8 domains)

Domain ID domain_id2hv7A02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily1150 — Phosphotyrosyl phosphate activator, C-terminal lid domain
Domain ID domain_id2hv7B02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily1150 — Phosphotyrosyl phosphate activator, C-terminal lid domain
Domain ID domain_id2hv7C02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily1150 — Phosphotyrosyl phosphate activator, C-terminal lid domain
Domain ID domain_id2hv7D02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily1150 — Phosphotyrosyl phosphate activator, C-terminal lid domain
Domain ID domain_id2hv7E02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily1150 — Phosphotyrosyl phosphate activator, C-terminal lid domain
Domain ID domain_id2hv7F02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily1150 — Phosphotyrosyl phosphate activator, C-terminal lid domain
Domain ID domain_id2hv7G02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily1150 — Phosphotyrosyl phosphate activator, C-terminal lid domain
Domain ID domain_id2hv7H02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily1150 — Phosphotyrosyl phosphate activator, C-terminal lid domain
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7. Citations (1)