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2i2r

Crystal structure of the KChIP1/Kv4.3 T1 complex

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Potassium voltage-gated channel subfamily D member 3

Rattus norvegicus

UniProt Q62897

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 8 Kv channel-interacting protein 1 × 4 （Q9NZI2） ZINC ION × 4 CALCIUM ION × 8 SODIUM ION × 4 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 8 Kv channel-interacting protein 1 × 4 （Q9NZI2） ZINC ION × 4 CALCIUM ION × 8 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 16 Kv channel-interacting protein 1 × 8 （Q9NZI2） ZINC ION × 8 CALCIUM ION × 16 SODIUM ION × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2i2r 2i2r 2i2r

3 assemblies

View Construct and Data Evidence
UniProt name KCND3_RAT
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 3–144； UniProt 2–143 Author chain B； PDBConstruct 3–144； UniProt 2–143 Author chain C； PDBConstruct 3–144； UniProt 2–143 Author chain D； PDBConstruct 3–144； UniProt 2–143 Author chain I； PDBConstruct 3–144； UniProt 2–143 Author chain J； PDBConstruct 3–144； UniProt 2–143 Author chain K； PDBConstruct 3–144； UniProt 2–143 Author chain L； PDBConstruct 3–144； UniProt 2–143

Kv channel-interacting protein 1

Homo sapiens

UniProt Q9NZI2

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 8 Potassium voltage-gated channel subfamily D member 3 × 4 （Q62897） ZINC ION × 4 CALCIUM ION × 8 SODIUM ION × 4 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 8 Potassium voltage-gated channel subfamily D member 3 × 4 （Q62897） ZINC ION × 4 CALCIUM ION × 8 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 16 Potassium voltage-gated channel subfamily D member 3 × 8 （Q62897） ZINC ION × 8 CALCIUM ION × 16 SODIUM ION × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1s1e

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2i2r 2i2r 2i2r 2nz0 2nz0 7e83 7e84 7e8e 7e8h 7f3f 7w6n 7w6t

12 assemblies

View Construct and Data Evidence
UniProt name KCIP1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain E； PDBConstruct 1–180； UniProt 48–227 Author chain F； PDBConstruct 1–180； UniProt 48–227 Author chain G； PDBConstruct 1–180； UniProt 48–227 Author chain H； PDBConstruct 1–180； UniProt 48–227 Author chain M； PDBConstruct 1–180； UniProt 48–227 Author chain N； PDBConstruct 1–180； UniProt 48–227 Author chain O； PDBConstruct 1–180； UniProt 48–227 Author chain P； PDBConstruct 1–180； UniProt 48–227

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2i2r
Deposition date deposition_date2006-08-16
Structure title titleCrystal structure of the KChIP1/Kv4.3 T1 complex
Keywords keywordsEF-Hand protein, complex, potassium channel, NCS protein, calcium binding protein, transport protein; TRANSPORT PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2i2r__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2i2r__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2i2r__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）41.18 Å
Rg (electron density)40.90 Å
Total Rg41.11 Å
Atom count9498
Residues1208
Excluded volume166910 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2i2r__assembly_1__model_1 octameric （8） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 2i2r__assembly_2__model_1 octameric （8） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 2i2r__assembly_3__model_1 hexadecameric （16） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 16 domains

CATH v4.4 (16 domains)

Domain ID domain_id2i2rA01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology710 — Potassium Channel Kv1.1; Chain A
Homologous superfamily homologous superfamily10 — Potassium Channel Kv1.1; Chain A
Domain ID domain_id2i2rB01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology710 — Potassium Channel Kv1.1; Chain A
Homologous superfamily homologous superfamily10 — Potassium Channel Kv1.1; Chain A
Domain ID domain_id2i2rC01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology710 — Potassium Channel Kv1.1; Chain A
Homologous superfamily homologous superfamily10 — Potassium Channel Kv1.1; Chain A
Domain ID domain_id2i2rD01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology710 — Potassium Channel Kv1.1; Chain A
Homologous superfamily homologous superfamily10 — Potassium Channel Kv1.1; Chain A
Domain ID domain_id2i2rE00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
Domain ID domain_id2i2rF00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
Domain ID domain_id2i2rG00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
Domain ID domain_id2i2rH00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
Domain ID domain_id2i2rI01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology710 — Potassium Channel Kv1.1; Chain A
Homologous superfamily homologous superfamily10 — Potassium Channel Kv1.1; Chain A
Domain ID domain_id2i2rJ01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology710 — Potassium Channel Kv1.1; Chain A
Homologous superfamily homologous superfamily10 — Potassium Channel Kv1.1; Chain A
Domain ID domain_id2i2rK01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology710 — Potassium Channel Kv1.1; Chain A
Homologous superfamily homologous superfamily10 — Potassium Channel Kv1.1; Chain A
Domain ID domain_id2i2rL01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology710 — Potassium Channel Kv1.1; Chain A
Homologous superfamily homologous superfamily10 — Potassium Channel Kv1.1; Chain A
Domain ID domain_id2i2rM00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
Domain ID domain_id2i2rN00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
Domain ID domain_id2i2rO00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
Domain ID domain_id2i2rP00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
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7. Citations (1)