2iou

Major Tropism Determinant P1 (Mtd-P1) Variant Complexed with Bordetella brochiseptica Virulence Factor Pertactin extracellular domain (Prn-E).

Method: X-RAY DIFFRACTION

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Major Tropism Determinant P1

Bordetella phage BPP-1

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	蛋白异源复合物	异源复合物	蛋白 8	Pertactin Extracellular Domain × 2 （Q03035） MAGNESIUM ION × 4	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	Q775D6_9CAUD
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 1–376； UniProt 5–380 作者链 B； PDB构建体 1–376； UniProt 5–380 作者链 C； PDB构建体 1–376； UniProt 5–380 作者链 D； PDB构建体 1–376； UniProt 5–380 作者链 E； PDB构建体 1–376； UniProt 5–380 作者链 F； PDB构建体 1–376； UniProt 5–380

Pertactin Extracellular Domain

Bordetella bronchiseptica

UniProt Q03035

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	蛋白异源复合物	异源复合物	蛋白 8	Major Tropism Determinant P1 × 6 （Q775D6） MAGNESIUM ION × 4	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	PERT_BORBR
Isoform	—
PDB实体	2
链与序列区间	作者链 G； PDB构建体 1–535； UniProt 38–572 作者链 H； PDB构建体 1–535； UniProt 38–572

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	2iou
沉积日期 deposition_date	2006-10-10
结构标题 title	Major Tropism Determinant P1 (Mtd-P1) Variant Complexed with Bordetella brochiseptica Virulence Factor Pertactin extracellular domain (Prn-E).
关键词 keywords	Mtd; Prn; pertactin, viral protein-membrane protein COMPLEX; viral protein/membrane protein
实验方法 method	X-RAY DIFFRACTION

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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

2iou__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

2iou__assembly_1__model_1 | I(q)

100 个绘图点；横轴和纵轴均采用对数尺度。

2iou__assembly_1__model_1 | P(r) · Pending

P(r) 将按相同 assembly/model 分别计算和展示。

Rg（Guinier）	61.60 Å
Rg（电子密度）	62.24 Å
总 Rg	62.25 Å
原子数	23900
残基数	3272
排除体积	419100 Å³
最大 q	0.500 Å⁻¹

Assembly	Model	结构单元	聚集说明	状态	CRYSOL	操作
1	1	`2iou__assembly_1__model_1`	octameric （8）	成功	4.1.3-1-20251215 (887e7ef)	查看下载

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (3)

实体 1 Entity 1 polymer

描述 description	Major Tropism Determinant P1
分子量 formula_weight	39037.9 kDa
来源方法 src_method	man
拷贝数 entity_count	6

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	A,B,C,D,E,F
原子数 atom_count	23900

VQFRGGTTAQHATFTGAAREITVDTDKNTVVVHDGATAGGFPLARHDLVKTAFIKADKSAVAFTRTGNATASIKAGTIVEVNGKLVQFTADTAITMPALTAGTDYAIYVCDDGTVRADSNFSAPTGYTSTTARKVGGFHYAPGSNAAAQAGGNTTAQINEYSLWDIKFRPAALDPRGMTLVAGAFWADIYLLGVNHLTDGTSKYNVTIADGSASPKKSTKFGGDGSAAYSDGAWYNFAEVMTHHGKRLPNYNEFQALAFGTTEATSSGGTDVPTTGVNGTGATSAWNIFTSKWGVVQASGCLWTWGNEFGGVNGASEYTANTGGRGSVYAQPAAALFGGAWNGTSLSGSRAALWYSGPSFSFAFFGARGVCDHLIL

来源 Source

来源生物 organism	Bordetella phage BPP-1
NCBI 分类编号 ncbi_taxonomy_id	194699
宿主生物 host_organism	Escherichia coli BL21(DE3)

实体 2 Entity 2 polymer

描述 description	Pertactin Extracellular Domain
分子量 formula_weight	54486.8 kDa
来源方法 src_method	man
拷贝数 entity_count	2

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	G,H

DWNNQSIIKAGERQHGIHIKQSDGAGVRTATGTTIKVSGRQAQGVLLENPAAELRFQNGSVTSSGQLFDEGVRRFLGTVTVKAGKLVADHATLANVSDTRDDDGIALYVAGEQAQASIADSTLQGAGGVRVERGANVTVQRSTIVDGGLHIGTLQPLQPEDLPPSRVVLGDTSVTAVPASGAPAAVSVFGANELTVDGGHITGGRAAGVAAMDGAIVHLQRATIRRGDAPAGGAVPGGAVPGGAVPGGFGPLLDGWYGVDVSDSTVDLAQSIVEAPQLGAAIRAGRGARVTVSGGSLSAPHGNVIETGGGARRFPPPASPLSITLQAGARAQGRALLYRVLPEPVKLTLAGGAQGQGDIVATELPPIPGASSGPLDVALASQARWTGATRAVDSLSIDNATWVMTDNSNVGALRLASDGSVDFQQPAEAGRFKVLMVDTLAGSGLFRMNVFADLGLSDKLVVMRDASGQHRLWVRNSGSEPASANTMLLVQTPRGSAATFTLANKDGKVDIGTYRYRLAANGNGQWSLVGAKAPP

来源 Source

来源生物 organism	Bordetella bronchiseptica
NCBI 分类编号 ncbi_taxonomy_id	257310
宿主生物 host_organism	Escherichia coli BL21(DE3)

实体 3 Entity 3 non-polymer

描述 description	MAGNESIUM ION
分子量 formula_weight	24.3 kDa
来源方法 src_method	syn
拷贝数 entity_count	4

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6. 折叠分类 (SCOP + CATH) 34 domains

SCOP 2.08 (14 domains)

结构域编号 domain_id	d2ioua1
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.163 — Pseudo beta-prism I
超家族 Superfamily superfamily	b.163.1 — Bacteriophage trimeric proteins domain
家族 Family family	b.163.1.1 — Mtd domain-like

结构域编号 domain_id	d2ioua2
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.169 — C-type lectin-like
超家族 Superfamily superfamily	d.169.1 — C-type lectin-like
家族 Family family	d.169.1.8 — Mtd variable domain

结构域编号 domain_id	d2ioub1
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.163 — Pseudo beta-prism I
超家族 Superfamily superfamily	b.163.1 — Bacteriophage trimeric proteins domain
家族 Family family	b.163.1.1 — Mtd domain-like

结构域编号 domain_id	d2ioub2
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.169 — C-type lectin-like
超家族 Superfamily superfamily	d.169.1 — C-type lectin-like
家族 Family family	d.169.1.8 — Mtd variable domain

结构域编号 domain_id	d2iouc1
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.163 — Pseudo beta-prism I
超家族 Superfamily superfamily	b.163.1 — Bacteriophage trimeric proteins domain
家族 Family family	b.163.1.1 — Mtd domain-like

结构域编号 domain_id	d2iouc2
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.169 — C-type lectin-like
超家族 Superfamily superfamily	d.169.1 — C-type lectin-like
家族 Family family	d.169.1.8 — Mtd variable domain

结构域编号 domain_id	d2ioud1
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.163 — Pseudo beta-prism I
超家族 Superfamily superfamily	b.163.1 — Bacteriophage trimeric proteins domain
家族 Family family	b.163.1.1 — Mtd domain-like

结构域编号 domain_id	d2ioud2
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.169 — C-type lectin-like
超家族 Superfamily superfamily	d.169.1 — C-type lectin-like
家族 Family family	d.169.1.8 — Mtd variable domain

结构域编号 domain_id	d2ioue1
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.163 — Pseudo beta-prism I
超家族 Superfamily superfamily	b.163.1 — Bacteriophage trimeric proteins domain
家族 Family family	b.163.1.1 — Mtd domain-like

结构域编号 domain_id	d2ioue2
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.169 — C-type lectin-like
超家族 Superfamily superfamily	d.169.1 — C-type lectin-like
家族 Family family	d.169.1.8 — Mtd variable domain

结构域编号 domain_id	d2iouf1
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.163 — Pseudo beta-prism I
超家族 Superfamily superfamily	b.163.1 — Bacteriophage trimeric proteins domain
家族 Family family	b.163.1.1 — Mtd domain-like

结构域编号 domain_id	d2iouf2
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.169 — C-type lectin-like
超家族 Superfamily superfamily	d.169.1 — C-type lectin-like
家族 Family family	d.169.1.8 — Mtd variable domain

结构域编号 domain_id	d2ioug_
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.80 — Single-stranded right-handed beta-helix
超家族 Superfamily superfamily	b.80.1 — Pectin lyase-like
家族 Family family	b.80.1.7 — Virulence factor P.69 pertactin

结构域编号 domain_id	d2iouh_
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.80 — Single-stranded right-handed beta-helix
超家族 Superfamily superfamily	b.80.1 — Pectin lyase-like
家族 Family family	b.80.1.7 — Virulence factor P.69 pertactin

CATH v4.4 (20 domains)

结构域编号 domain_id	2iouA01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	10 — Ribbon
拓扑 Topology topology	10 — Seminal Fluid Protein PDC-109 (Domain B)
同源超家族 H-superfamily homologous superfamily	30 —

结构域编号 domain_id	2iouA02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	80 — Trefoil
拓扑 Topology topology	20 — Tail fiber receptor-binding protein
同源超家族 H-superfamily homologous superfamily	10 — Tail fiber receptor-binding protein

结构域编号 domain_id	2iouA03
类 Class class	3 — Alpha Beta
架构 Architecture architecture	90 — Alpha-Beta Complex
拓扑 Topology topology	1580 — paralog of FGE (formylglycine-generating enzyme)
同源超家族 H-superfamily homologous superfamily	10 — paralog of FGE (formylglycine-generating enzyme)

结构域编号 domain_id	2iouB01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	10 — Ribbon
拓扑 Topology topology	10 — Seminal Fluid Protein PDC-109 (Domain B)
同源超家族 H-superfamily homologous superfamily	30 —

结构域编号 domain_id	2iouB02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	80 — Trefoil
拓扑 Topology topology	20 — Tail fiber receptor-binding protein
同源超家族 H-superfamily homologous superfamily	10 — Tail fiber receptor-binding protein

结构域编号 domain_id	2iouB03
类 Class class	3 — Alpha Beta
架构 Architecture architecture	90 — Alpha-Beta Complex
拓扑 Topology topology	1580 — paralog of FGE (formylglycine-generating enzyme)
同源超家族 H-superfamily homologous superfamily	10 — paralog of FGE (formylglycine-generating enzyme)

结构域编号 domain_id	2iouC01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	10 — Ribbon
拓扑 Topology topology	10 — Seminal Fluid Protein PDC-109 (Domain B)
同源超家族 H-superfamily homologous superfamily	30 —

结构域编号 domain_id	2iouC02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	80 — Trefoil
拓扑 Topology topology	20 — Tail fiber receptor-binding protein
同源超家族 H-superfamily homologous superfamily	10 — Tail fiber receptor-binding protein

结构域编号 domain_id	2iouC03
类 Class class	3 — Alpha Beta
架构 Architecture architecture	90 — Alpha-Beta Complex
拓扑 Topology topology	1580 — paralog of FGE (formylglycine-generating enzyme)
同源超家族 H-superfamily homologous superfamily	10 — paralog of FGE (formylglycine-generating enzyme)

结构域编号 domain_id	2iouD01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	10 — Ribbon
拓扑 Topology topology	10 — Seminal Fluid Protein PDC-109 (Domain B)
同源超家族 H-superfamily homologous superfamily	30 —

结构域编号 domain_id	2iouD02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	80 — Trefoil
拓扑 Topology topology	20 — Tail fiber receptor-binding protein
同源超家族 H-superfamily homologous superfamily	10 — Tail fiber receptor-binding protein

结构域编号 domain_id	2iouD03
类 Class class	3 — Alpha Beta
架构 Architecture architecture	90 — Alpha-Beta Complex
拓扑 Topology topology	1580 — paralog of FGE (formylglycine-generating enzyme)
同源超家族 H-superfamily homologous superfamily	10 — paralog of FGE (formylglycine-generating enzyme)

结构域编号 domain_id	2iouE01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	10 — Ribbon
拓扑 Topology topology	10 — Seminal Fluid Protein PDC-109 (Domain B)
同源超家族 H-superfamily homologous superfamily	30 —

结构域编号 domain_id	2iouE02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	80 — Trefoil
拓扑 Topology topology	20 — Tail fiber receptor-binding protein
同源超家族 H-superfamily homologous superfamily	10 — Tail fiber receptor-binding protein

结构域编号 domain_id	2iouE03
类 Class class	3 — Alpha Beta
架构 Architecture architecture	90 — Alpha-Beta Complex
拓扑 Topology topology	1580 — paralog of FGE (formylglycine-generating enzyme)
同源超家族 H-superfamily homologous superfamily	10 — paralog of FGE (formylglycine-generating enzyme)

结构域编号 domain_id	2iouF01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	10 — Ribbon
拓扑 Topology topology	10 — Seminal Fluid Protein PDC-109 (Domain B)
同源超家族 H-superfamily homologous superfamily	30 —

结构域编号 domain_id	2iouF02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	80 — Trefoil
拓扑 Topology topology	20 — Tail fiber receptor-binding protein
同源超家族 H-superfamily homologous superfamily	10 — Tail fiber receptor-binding protein

结构域编号 domain_id	2iouF03
类 Class class	3 — Alpha Beta
架构 Architecture architecture	90 — Alpha-Beta Complex
拓扑 Topology topology	1580 — paralog of FGE (formylglycine-generating enzyme)
同源超家族 H-superfamily homologous superfamily	10 — paralog of FGE (formylglycine-generating enzyme)

结构域编号 domain_id	2iouG00
类 Class class	2 — Mainly Beta
架构 Architecture architecture	160 — 3 Solenoid
拓扑 Topology topology	20 — Pectate Lyase C-like
同源超家族 H-superfamily homologous superfamily	20 —

结构域编号 domain_id	2iouH00
类 Class class	2 — Mainly Beta
架构 Architecture architecture	160 — 3 Solenoid
拓扑 Topology topology	20 — Pectate Lyase C-like
同源超家族 H-superfamily homologous superfamily	20 —

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晶胞边长 a length_a	413.464 Å
晶胞边长 b length_b	413.464 Å
晶胞边长 c length_c	98.859 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	90.00 °
晶胞夹角 γ angle_gamma	120.00 °
晶胞分子数 Z z_pdb	36

空间群 space_group	P 61
空间群编号 int_tables_number	169
晶系 crystal_system	—

分辨率 resolution	3.160 Å
最低分辨率 resolution_low	49.630 Å
R 因子 r_factor	0.2253
R_work r_work	0.2240
R_free r_free	0.2493

Major Tropism Determinant P1 (Mtd-P1) Variant Complexed with Bordetella brochiseptica Virulence Factor Pertactin extracellular domain (Prn-E).

1. 蛋白身份与相关结构 Protein Identity & Related Structures

Major Tropism Determinant P1

当前结构中的状态

数据库中的同蛋白其他状态

Pertactin Extracellular Domain

当前结构中的状态

数据库中的同蛋白其他状态

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

2iou__assembly_1__model_1

2iou__assembly_1__model_1 | I(q)

2iou__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (3)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 polymer

聚合物 Polymer

来源 Source

实体 3 Entity 3 non-polymer

6. 折叠分类 (SCOP + CATH) 34 domains

SCOP 2.08 (14 domains)

CATH v4.4 (20 domains)

7. 引用文献 (1)

Major Tropism Determinant P1 (Mtd-P1) Variant Complexed with Bordetella brochiseptica Virulence Factor Pertactin extracellular domain (Prn-E).

1. 蛋白身份与相关结构 Protein Identity & Related Structures

Major Tropism Determinant P1

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

Pertactin Extracellular Domain

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

2iou__assembly_1__model_1

2iou__assembly_1__model_1 | I(q)

2iou__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (3)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 polymer

聚合物 Polymer

来源 Source

实体 3 Entity 3 non-polymer

6. 折叠分类 (SCOP + CATH) 34 domains

SCOP 2.08 (14 domains)

CATH v4.4 (20 domains)

7. 引用文献 (1)