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2kkf

Solution structure of MLL CXXC domain in complex with palindromic CPG DNA

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Histone-lysine N-methyltransferase HRX

Homo sapiens

UniProt Q03164

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Monomer Protein 1 DNA 2 5'-D(*CP*CP*CP*TP*GP*CP*GP*CP*AP*GP*GP*G)-3' × 2 ZINC ION × 2 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
2j2s 2jyi 2kyu 2w5y 3lqh 5f5e

6 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2agh 2kkf 2ku7 2lxs 2lxt 2msr 2mtn 2w5z 3eg6 3lqi 3lqi 3lqi

57 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name HRX_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 3–59； UniProt 1147–1203

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2kkf
Deposition date deposition_date2009-06-18
Structure title titleSolution structure of MLL CXXC domain in complex with palindromic CPG DNA
Keywords keywords;PROTEIN-DNA COMPLEX, CXXC DOMAIN, MLL, CPG DNA, CHROMOSOMAL REARRANGEMENT, DNA-BINDING, METAL-BINDING, NUCLEUS, ZINC-FINGER, DNA BINDING PROTEIN-DNA COMPLEX, Alternative splicing, Apoptosis, Bromodomain, Chromatin regulator, Isopeptide bond, Methyltransferase, Phosphoprotein, Polymorphism, Proto-oncogene, S-adenosyl-L-methionine, Transcription, Transcription regulation, Transferase, Ubl conjugation, Zinc ;; DNA BINDING PROTEIN/DNA
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2kkf__assembly_1__model_7

Assembly 1 · Model 7 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2kkf__assembly_1__model_7 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2kkf__assembly_1__model_7 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）14.87 Å
Rg (electron density)14.16 Å
Total Rg14.99 Å
Atom count1658
Residues81
Excluded volume15009 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2kkf__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 2kkf__assembly_1__model_2 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 2kkf__assembly_1__model_3 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 2kkf__assembly_1__model_4 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 2kkf__assembly_1__model_5 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 2kkf__assembly_1__model_6 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 2kkf__assembly_1__model_7 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 2kkf__assembly_1__model_8 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 2kkf__assembly_1__model_9 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 2kkf__assembly_1__model_10 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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7. Citations (1)